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| 1 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 2 | 大熊猫人工授精的研究显示文摘繁殖大熊猫的目的是圈养种群的自我维持和保持遗传多样性。由于圈养种群中有自然交配能力的雄兽很少 ,人工授精则成为有效的遗传管理的重要手段。本研究的目的是确定单纯人工授精的效率。 1 998年至 2 0 0 0年期间 ,在中国保护大熊猫研究中心 ,对 7只大熊猫进行了人工授精 (每只连续 2d) ,精液通过人工采精方法从 6只不同的雄兽中获得 ,使用鲜精、冷藏精液和冻精多种方法进行人工授精。 6只雄兽的精液平均值是 :采精量 3.3±0 .5ml;精子密度 1 ,42 9.8± 2 35 .4× 1 0 6/ml;活力 81 .7± 2 .1 % ;运动状态 ( 0~ 5 ,5 =最好 )3 1± 0 .1 ;精子正常率 79 3± 9.2 %。对 7只大熊猫进行的 1 4次人工授精中 ,使用的精液体积为 2 4± 0 3ml;活力是 73.5± 2 .9% ;运动状态为 2 .5± 0 .1 ;每次人工授精总活动精子数是 684.2± 1 1 8.2× 1 0 6。 7只大熊猫有 4只受孕 ( 5 7.1 % ) ,共产 5仔。平均孕娠期 1 31 .5±9.7d ,每胎平均 1 .3± 0 .3仔。同时 ,运用自然交配与人工授精相结合的方法 ,进行了 1 8只次实验 ,成功 1 2只次 ,产仔 2 0只 ,繁殖成功率为 66.7%。本研究结果表明 ,人工授精能有效地使不能自然交配的雄性大熊猫参与繁殖 ,提高繁殖率 ,增加圈养大熊猫的遗传多样性。 | 黄炎 王鹏彦 张贵权 张和民 李德生 汤纯香 魏荣平 胡大明 冯莉 Howard J G | 2002 | Developmental and Reproductive Biology2002，11，2： | 6 |
| 3 | Improved Technique for the Routine Determination of Tritiated Water in Aqueous Samples显示文摘 | Warwick P E Croudace I W Howard A G | 1999 | Anal Chim Acta1999，382，： | 2 |
| 4 | Natural history of intraductal papillary mucinous neoplasia:How much do we really know?显示文摘Information on the natural history of intraductal papillary mucinous neoplasia(IPMN) is currently inadequate due to a lack of carefully orchestrated long-term followup on a large cohort of patients with asymptomatic disease.Based on the available data,one can draw the conclusions that main duct IPMN is commonly associated with malignancy and an aggressive operative stance should be taken with resection being offered to most patients who are suitable operative candidates.In contrast,the majority of branch type IPMN with a diameter of less than 3 cm can be safely followed with routine surveillance imaging provided they lack the high-risk covariates of age,symptomatology,nodularity or wall thickness. | Chad G Ball Thomas J Howard | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 2 |
| 5 | Accuracy of Orbscan pachymetry measurements and DHG ultrasound pachymetry in primary laser in situ keratomileusis and LASIK enhancement procedures显示文摘 | Nader G Iskander Ellen Anderson Penno N.Timothy Peters Howard V Gimbel Maria Ferensowicz | 2001 | Journal of Cataract & Refractive Surgery2001，，5： | 2 |
| 6 | Chestnut and hazel propagation by leafy summer euttings显示文摘 | Ponehia G Howard B H | 1988 | Aeta Hortieulturae1988，227，： | 1 |
| 7 | Optimum imaging for sinonasal malignancy 显示文摘 | Lloyd G Lund VJ Howard D | 2000 | J Laryngol Otol2000，114，7： | 1 |
| 8 | Development of a lipopepetide-based therapeutic vaccine to treat chronic HBV infection显示文摘 | Ishioka G Howard M | 1995 | J Clin Invest1995，95，： | 1 |
| 9 | Induction of antibodies against GD3 ganglioside in melanoma patients by vaccination with GD3-1actone-KLH conjugate plus immunological adjuvant QS-21 显示文摘 | Ragupathi G Meyers M Adluri S Howard L Musselli C Livingston PO | 2000 | Int J Cancer2000，85，5： | 1 |
| 10 | Multiple antennas in celluar CDMA systems: Transmission, detection, and spectral efficiency 显示文摘 | Howard H Viswanathan H Foshini G J | 2002 | IEEE Trans on Wireless Commu2002，1，3： | 1 |
| 11 | Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS) 显示文摘 | Festa A D'Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 12 | Chronic subclinical inflammation as part of the insulin-resistance syndrome: the insulin resistance atherosclerosis study (IRAS)显示文摘 | Festa A D Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 13 | When wildlife tourism goes wrong: acase study of stakeholder and management issues regarding Dingoes on Fraser Island,Australia显示文摘 | Burns G L Howard P | 2003 | Tourism Management2003，，6： | 1 |
| 14 | A Critique of Clinical Equi-poise: Therapeutic Misconception in the Ethics of Clinical Tri-als显示文摘 | Franklin G Miller Howard Brody | 2003 | The Hastings Center Report2003，，3： | 1 |
| 15 | Chronic sub-clinical inflammation as part of the insulin resistance syn-drome:the insulin restance atherosclerosis study(IRSA)显示文摘 | Festa A D Agostion R J R Howard G | 2000 | Circulation2000，102，： | 1 |
| 16 | Chronic sub clinical inflammation as part of the insulin resistance syn drome: the insulin resistance atherosclerosis study (IRAS) 显示文摘 | Festa A D'Agostino R Jr Howard G | 2000 | Circulation2000，102，1： | 1 |
| 17 | Are there other persistent organic pollutants? A challenge for environmental chemists显示文摘 | MUIR D C G HOWARD P H | 2006 | Environmental Science & Technology2006，40，23： | 1 |
| 18 | Stenting versus endarterectomy for treatment of carotid - artery stenosis 显示文摘 | Brott TG Hobson RW Howard G | 2010 | Journal of Vascular Surgery2010，52，3： | 1 |
| 19 | Chronic subclinical in- flammation as part of the insulin resistance syndrome:the Insu- lin Resistance Atherosclerosis Study (IRAS) 显示文摘 | Festa A D'Agostino R Howard G | 2000 | Circulation2000，102，1： | 1 |
| 20 | Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression显示文摘 | Lord GM Matarese G Howard JK | 1998 | Nature1998，394，： | 1 |
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