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| 1 | Plasmacytoid dendritic cells in antiviral immunity and autoimmunity显示文摘Plasmacytoid dendritic cells (pDCs) represent a unique and crucial immune cell population capable of producing large amounts of type I interferons (IFNs) in response to viral infection.The function of pDCs as the professional type I IFN-producing cells is linked to their selective expression of Toll-like receptor 7 (TLR7) and TLR9,which sense viral nucleic acids within the endosomal compartments.Type I IFNs produced by pDCs not only directly inhibit viral replication but also play an essential role in linking the innate and adaptive immune system.The aberrant activation of pDCs by self nucleic acids through TLR signaling and the ongoing production of type I IFNs do occur in some autoimmune diseases.Therefore,pDC may serve as an attractive target for therapeutic manipulations of the immune system to treat viral infectious diseases and autoimmune diseases. | TANG Fei1,2,DU Qiumei1,2 & LIU Yong-Jun3 1 Center for Infection and Immunity,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 Department of Immunology and Center for Cancer Immunology Research,University of Texas,M.D.Anderson Cancer Center,Houston,Texas 77030,USA | 2010 | Science China(Life Sciences)2010，53，2： | 23 |
| 2 | 2002—Emergence of the Gas-to-Liquids Industry:a Review of Global GTL Developments显示文摘This paper reviews the status of the gas-to-liquids (GTL) industry - including currentcommercial plants, announced projects and the technologies that are likely to be implemented in thesefuture projects. Today, only 35,000 B/D of GTL products (0.1% of market) are manufactured fromcommercial gas-based plants. Advances in technology have lowered the cost of plants to the point whereGTL plants can be profitable at crude oil prices of $16/B. The advanced stage of development of severalproposed GTL projects and attractive integrated economics, for both the gas field and plant, show thatGTL can be a significant alternative for monetizing natural gas in the 21st century. GTL technologiesincludes more than Fischer-Tropsch technology and extends to other liquid fuels, especially in the oxygenatefamily (methanol, dimethyl ether, etc.). | T.H.Fleisch,R.A.Sills,M.D.BriscoeBP Upstream Technology Group, P. O. Box 3092, Houston, TX 77253, USA | 2002 | Journal of Natural Gas Chemistry2002，11，1： | 22 |
| 3 | Molecular signal transduction in vascular cell apoptosis显示文摘Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical forces, reactive oxygen and nitrogen species, cytokines, growth factors, oxidized lipoproteins, etc., ma influence apoptosis of vascular cells. The Fas/Fas ligand/caspase death-signaling pathway, Bcl-2 protein family/mitochondria, the tumor suppressive gene p53, and the proto-oncogene c-myc may be activated in atherosclerotic lesions, and mediates vascular apoptosis during the development of atherosclerosis. Abnormal expression and dysfunction of these apoptosis-regulating genes may attenuate or accelerate vascular cell apoptosis and affect the integrity and stability of atherosclerotic plaques. Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and ii major complication, the acute vascular syndromes. | GENG YONG JIAN Center for Cardiovascular Biology and Atherosclerosis Research, Division of Cardiology, Department of Internal Medicine, University of Texas Houston Health Science Center Medical School, 6431 Fannin Street, MSB 6.045, Houston, TX 77030, USA | 2001 | Cell Research2001，11，4： | 20 |
| 4 | the role of nutrition and nutraceutical supplements in the treatment of hypertension显示文摘Vascular biology,endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension,cardiovascular disease and target organ damage.Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension.Macronutrients and micronutrients can prevent,control and treat hypertension through numerous mechanisms related to vascular biology.Oxidative stress,inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease.There is a role for the selected use of single and component nutraceutical supplements,vitamins,antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition,coupled with other lifestyle modifications. | Mark Houston | 2014 | World Journal of Cardiology2014，6，2： | 14 |
| 5 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 6 | Classification of rational holomorphic maps from B^2 into B^N with degree 2显示文摘Rational proper holomorphic maps from the unit ball in C 2 into the unit ball C N with degree 2 are classified, up to automorphisms of balls. | JI ShanYu 1 & ZHANG Yuan 2 1 Department of Mathematics, University of Houston, Houston, TX 77204, USA 2 Department of Mathematics, University of California at San Diego, La Jolla, CA 92093, USA | 2009 | Science China Mathematics2009，52，12： | 4 |
| 7 | Biomass derived porous nitrogen doped carbon for electrochemical devices显示文摘Biomass derived porous nanostructured nitrogen doped carbon(PNC) has been extensively investigated as the electrode material for electrochemical catalytic reactions and rechargeable batteries. Biomass with and without containing nitrogen could be designed and optimized to prepare PNC via hydrothermal carbonization, pyrolysis, and other methods. The presence of nitrogen in carbon can provide more active sites for ion absorption, improve the electronic conductivity, increase the bonding between carbon and sulfur, and enhance the electrochemical catalytic reaction. The synthetic methods of natural biomass derived PNC, heteroatomic co-or tri-doping into biomass derived carbon and the application of biomass derived PNC in rechargeable Li/Na batteries, high energy density Li-S batteries, supercapacitors, metal-air batteries and electrochemical catalytic reaction(oxygen reduction and evolution reactions, hydrogen evolution reaction) are summarized and discussed in this review. Biomass derived PNCs deliver high performance electrochemical storage properties for rechargeable batteries/supercapacitors and superior electrochemical catalytic performance toward hydrogen evolution, oxygen reduction and evolution, as promising electrodes for electrochemical devices including battery technologies, fuel cell and electrolyzer. | Litao Yan Jiuling Yu Jessica Houston Nancy Flores Hongmei Luo | 2017 | Green Energy & Environment2017，2，2： | 4 |
| 8 | Three-dimensional structure determination of capsid of Aedes albopicus C6/36 cell densovirus显示文摘The three-dimensional structure of capsid of Aedes albopictus C6/36 densovirus was determined to 14- resolution by electron cryomicroscopy and computer reconstruction. The triangulation number of the capsid is 1. There are 12 holes in each triangular face and a spike on each 5-fold vertex. The validity of the capsid and nucleic acid densities in the reconstructions was discussed. | CHENG Lingpeng1, CHEN Senxiong1, Jenifer M. Brannan2, Joanita Jakana3, ZHANG Qinfen1, Z. H. Zhou2 & ZHANG Jingqiang1 1. State Key Laboratory for Bio-control, Zhongshan University, Guangzhou 510275, China 2. Department of Pathology, Medicine University of Texas-Huston Medical School, Huston, TX77030, USA 3. National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, TX77, USA | 2004 | Science China(Life Sciences)2004，47，3： | 4 |
| 9 | Induced pluripotent stem cell-related genes influence biological behavior and 5-fluorouracil sensitivity of colorectal cancer cells显示文摘Objective:We aimed to perform a preliminary study of the association between induced pluripotent stem cell(iPS)-related genes and biological behavior of human colorectal cancer(CRC) cells,and the potential for developing anti-cancer drugs targeting these genes.Methods:We used real-time reverse transcriptase polymerase chain reaction(RT-PCR) to evaluate the transcript levels of iPS-related genes NANOG,OCT4,SOX2,C-MYC and KLF4 in CRC cell lines and cancer stem cells(CSCs)-enriched tumor spheres.NANOG was knockdowned in CRC cell line SW620 by lentiviral transduction.3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assays,plate colony formation,and a mouse xenograft model were used to evaluate alterations in biological behavior in NANOG-knockdown SW620 cells.Also,mock-knockdown and NANOG-knockdown cells were treated with 5-fluorouracil(5-FU) and survival rate was measured by MTT assay to evaluate drug sensitivity.Results:A significant difference in the transcript levels of iPS-related genes between tumor spheres and their parental bulky cells was observed.NANOG knockdown suppressed proliferation,colony formation,and in vivo tumorigenicity but increased the sensitivity to 5-FU of SW620 cells.5-FU treatment greatly inhibited the expression of the major stemness-associated genes NANOG,OCT4,and SOX2.Conclusions:These results collectively suggest an overlap between iPS-related genes and CSCs in CRC.Quenching a certain gene NANOG may truncate the aggressiveness of CRC cells. | Zhong SHI1,Rui BAI1,Zhi-xuan FU1,Yong-liang ZHU2,Rong-fu WANG3,Shu ZHENG1(1Cancer Institute(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China)(2Department of Gastroenterology,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China)(3Center for Cell and Gene Therapy,Department of Pathology and Immunology,Baylor College of Medicine,Houston,Texas 77030,USA) | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 4 |
| 10 | Comparison of Cold and Warm Ischemia During Partial Nephrectomy in 660 Solitary Kidneys Reveals Predominant Role of Nonmodifiable Factors in Determining Ultimate Renal Function显示文摘 | Brian R. Lane Paul Russo Robert G. Uzzo Adrian V. Hernandez Stephen A. Boorjian R. Houston Thompson Amr F. Fergany Thomas E. Love Steven C. Campbell | 2011 | The Journal of Urology2011，，2： | 3 |
| 11 | Rational holomorphic maps from B^2 into B^N with degree 2显示文摘Rational proper holomorphic maps from the unit ball in C2 into the unit ball CN with degree 2 are studied. Any such map must be equivalent to one of the four types of maps. | CHEN Zhihua, Jl Shanyu & XU Dekang Department of Mathematics, Tongji University, Shanghai 200092, China Department of Mathematics, University of Houston, Houston, TX 77204, USA | 2006 | Science China Mathematics2006，49，11： | 3 |
| 12 | Every Minute Counts When the Renal Hilum Is Clamped During Partial Nephrectomy 显示文摘 | R. Houston Thompson Brian R. Lane Christine M. Lohse Bradley C. Leibovich Amr Fergany Igor Frank Inderbir S. Gill Michael L. Blute Steven C. Campbell | 2010 | European Urology2010，，： | 3 |
| 13 | Structure comparisons of Aedes albopictus densovirus with other parvoviruses显示文摘Parvoviridae is a family of the smallest viruses known with a wide variety of hosts. The capsid structure of the Aedes albopictus C6/36 cell densovirus (C6/36 DNV) at 1.2-nm resolution was obtained by elec-tron cryomicroscopy (cryoEM) and three-dimensional (3D) image reconstruction. Structure compari-sons between the C6/36 DNV and other parvoviruses reveal that the degree of structural similarity be-tween C6/36 DNV and the human parvovirus B19 is higher than that between C6/36 DNV and other in-sect parvoviruses. The amino acid sequence comparisons of structural and non-structural proteins also reveal higher levels of similarity between C6/36 DNV and parvovirus B19 than those between C6/36 DNV and other parvoviruses. These findings indicate that C6/36 DNV is closely related to the human virus B19, and the former might evolve from the human species other than from other insect viruses. | CHENG LingPeng1,2, CHEN SenXiong2, Z. H. ZHOU3 & ZHANG JingQiang2 1 Department of Biomedical Engineering, School of Bioscience & Bioengineering, South China University of Technology, Guangzhou 510640, China 2 State Key Laboratory of Biocontrol, Sun Yat-sen University, Guangzhou 510275, China 3 Department of Pathology & Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX77030, USA | 2007 | Science China(Life Sciences)2007，50，1： | 3 |
| 14 | Creditor rights, information sharing, and bank risk taking显示文摘 | Joel F. Houston Chen Lin Ping Lin Yue Ma | 2010 | Journal of Financial Economics2010，，3： | 3 |
| 15 | CONVERGENCE OF CASCADE ALGORITHMS AND SMOOTHNESS OF REFINABLE DISTRIBUTIONS显示文摘In this paper, the author at first develops a method to study convergence of the cascadealgorithm in a Banach space without stable assumption on the initial (see Theorem 2.1), andthen applies the previous result on the convergence to characterizing compactly supportedrefinable distributions in fractional Sobolev spaces and Holder continuous spaces (see Theorems3.1, 3.3, and 3.4). Finally the author applies the above characterization to choosing appropriateinitial to guarantee the convergence of the cascade algorithm (see Theorem 4.2). | SUN QIYU Department of Mathematics, University of Houston, Houston, TX 77204, USA. Department of Mathematics, National University of Singapore, 10 Kent Ridge Crescent, 119260, Singapore. | 2003 | Chinese Annals of Mathematics,Series B2003，24，3： | 3 |
| 16 | WHAT DOES CHAOS HAVE TO DO WITH SYSTEMS AND CONTROL ENGINEERING?显示文摘Chaos as a very special type of complex dynamical behaviors has been studied for about four decades. Yet the traditional trend of analyzing and understanding chaos has evolved to controlling and utilizing chaos today. Research in the field of chaos modeling, control, and synchronization includes not only ordering chaos, which means to weaken or completely suppress chaos when it is harmful, but also chaotification, which refers to enhancing existing Chaos or creating chaos purposely when it is useful, by any means of control technology. This article offers a brief overview about the potential impact of controlled chaos on beneficial applications in science and engineering, and introduces some recent progress in chaotification via feedback control methods. | CHEN Guanrong (Department of Electrical and Computer Engineering, University of Houston, Houston, Texas 77204, USA Department of Electronic Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR, China) | 2001 | Journal of Systems Science & Complexity2001，14，1： | 3 |
| 17 | CEO compensation and bank risk Is compensation in banking structured to promote risk taking?显示文摘 | Joel F. Houston Christopher James | 1995 | Journal of Monetary Economics1995，，2： | 3 |
| 18 | Penetration resistance of lunar soils显示文摘 | Houston W N Namiq L I | 1971 | Journal of Terramechanics1971，8，1： | 2 |
| 19 | Comparative Effectiveness for Survival and Renal Function of Partial and Radical Nephrectomy for Localized Renal Tumors: A Systematic Review and Meta-Analysis显示文摘 | Simon P. Kim R. Houston Thompson Stephen A. Boorjian Christopher J. Weight Leona C. Han M. Hassan Murad Nathan D. Shippee Patricia J. Erwin Brian A. Costello George K. Chow Bradley C. Leibovich | 2012 | The Journal of Urology2012，，： | 2 |
| 20 | Evolution of a flexible rule for foraging that copes with environmental variation显示文摘 | Andrew D. HIGGINSON Tim W. FAWCETT Alasdair I. HOUSTON | 2015 | Current Zoology2015，61，2： | 2 |
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