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| 1 | An updated review of gastric cancer in the next-generation sequencing era:Insights from bench to bedside and vice versa显示文摘Gastric cancer(GC)is one of the most common malignancies and remains the second leading cause of cancer-related death worldwide.There is an increasing understanding of the roles that genetic and epigenetic alterations play in GCs.Recent studies using nextgeneration sequencing(NGS)have revealed a number of potential cancer-driving genes in GC.Whole-exome sequencing of GC has identified recurrent somatic mutations in the chromatin remodeling gene ARID1A and alterations in the cell adhesion gene FAT4,a member of the cadherin gene family.Mutations in chromatin remodeling genes(ARID1A,MLL3 and MLL)have been found in 47%of GCs.Whole-genome sequencing and whole-transcriptome sequencing analyses have also discovered novel alterations in GC.Recent studies of cancer epigenetics have revealed widespread alterations in genes involved in the epigenetic machinery,such as DNA methylation,histone modifications,nucleosome positioning,noncoding RNAs and microRNAs.Recent advances in molecular research on GC have resulted in the introduction of new diagnostic and therapeutic strategies into clinical settings.The antihuman epidermal growth receptor 2(HER2)antibody trastuzumab has led to an era of personalized therapy in GC.In addition,ramucirumab,a monoclonal antibody targeting vascular endothelial growth factor receptor(VEGFR)-2,is the first biological treatment that showed survival benefits as a single-agent therapy in patients with advanced GC who progressed after firstline chemotherapy.Using NGS to systematically identify gene alterations in GC is a promising approach with remarkable potential for investigating the pathogenesis of GC and identifying novel therapeutic targets,as well as useful biomarkers.In this review,we will summarize the recent advances in the understanding of the molecular pathogenesis of GC,focusing on the potential use of these genetic and epigenetic alterations as diagnostic biomarkers and novel therapeutic targets. | Hiroyuki Yamamoto Yoshiyuki Watanabe Tadateru Maehata Ryo Morita Yoshihito Yoshida Ritsuko Oikawa Shinya Ishigooka Shun-ichiro Ozawa Yasumasa Matsuo Kosuke Hosoya Masaki Yamashita Hiroaki Taniguchi Katsuhiko Nosho Hiromu Suzuki Hiroshi Yasuda Yasuhisa Shinomura Fumio Itoh | 2014 | World Journal of Gastroenterology2014，20，14： | 12 |
| 2 | 低围压至高围压下砂土的剪胀性和液化性分析显示文摘砂土的状态主要取决于孔隙比(密实度)和围压大小,它们极大地影响了砂土的力学特性(压缩性、剪胀性和液化性)。为研究低围压至高围压范围内砂土相对密度和围压对土体强度和变形特性的影响,对2种不同相对密实度砂土试样在低至高围压下(5~3 MPa)进行常规三轴固结排水剪切试验、常规三轴固结不排水试验和动三轴非排水试验,对砂土的静、动变形特性及静、动强度特性进行研究。试验结果表明:在单调加载条件下,在低围压范围(5~20 kPa),体积应变由剪缩向剪胀转变,且剪胀角具有明显的应力依存性,随着围压的减小而增大;在高围压范围(1~3 MPa),试样体积逐渐趋于剪缩;在循环加载条件下,砂土试样抵抗液化能力随着围压的减小而增强,轴向应变伴随着围压的增大从压缩状态向膨胀状态转变。同时,试验结果表明,应用文中的试验方法,橡皮膜的约束效应对低围压的试验结果影响较小。 | 顾琳琳 王振 HOSOYA Asa-hiro 张锋 | 2020 | Journal of Central South University2020，27，8： | 4 |
| 3 | Correlation between serum interleukin 6 and C-reactive protein concentrations in patients with adenoviral respiratory infection显示文摘 | YUKIHIKO KAWASAKI MITSUAKI HOSOYA MASAHIKO KATAYOSE HITOSHI SUZUKI | 2002 | The Pediatric Infectious Disease Journal2002，，5： | 3 |
| 4 | Altered expression of several genes in highly metastatic subpopulations of a human pulmonary adenocarcinoma cell line 显示文摘 | Gemma A Takenaka K Hosoya Y | 2001 | Euro J Cancer2001，37，： | 2 |
| 5 | Spatiotemporal changes of coxsackievirus and adenovirus receptor in rat hearts during postnatal development and in cultured cardiomyocytes of neonatal rat显示文摘 | Takeshi Kashimura Makoto Kodama Yuko Hotta Junichi Hosoya Kaori Yoshida Takuya Ozawa Ritsuo Watanabe Yuji Okura Kiminori Kato Haruo Hanawa Ryozo Kuwano Yoshifusa Aizawa | 2004 | Virchows Archiv2004，，3： | 2 |
| 6 | Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, and Beyond: Full-Layer Resection for Gastric Cancer with Nonexposure Technique (CLEAN-NET)显示文摘 | Haruhiro Inoue Haruo Ikeda Toshihisa Hosoya Akira Yoshida Manabu Onimaru Michitaka Suzuki Shin-ei Kudo | 2012 | Surgical Oncology Clinics of North America2012，，1： | 2 |
| 7 | Endocytoscopic visualization of squamous cell islands within Barrett's epithelium显示文摘AIM: To study the endocytoscopic visualization of squamous cell islands within Barrett's epithelium. METHODS: Endocytoscopy (ECS) has been studied in the surveillance of Barrett's esophagus, with controversial results. In initial studies, however, a soft catheter type endocytoscope was used, while only methylene blue dye was used for the staining of Barrett's mucosa. Integrated type endocytoscopes (GIF-Q260 EC, Olympus Corp, Tokyo, Japan) have been recently developed, with the incorporation of a high-power magnifying endocytoscope into a standard endoscope together with narrow-band imaging (NBI). Moreover, double staining with a mixture of 0.05% crystal violet and 0.1% of methylene blue (CM) during ECS enables higher quality images comparable to conventional hematoxylin eosin histopathological images.RESULTS: In vivo endocytoscopic visualization of papillary squamous cell islands within glandular Barrett's epithelium in a patient with long-segment Barrett's esophagus is reported. Conventional white light endoscopy showed typical long-segment Barrett's esophagus, with small squamous cell islands within normal Barrett's mucosa, which were better visualized by NBI endoscopy. ECS after double CM staining showed regular Barrett's esophagus, while higher magnification (×480) revealed the orifices of glandular structures better. Furthermore, typical squamous cell papillary protrusion, classified as endocytoscopic atypia classification (ECA) 2 according to ECA, was identified within regular glandular Barrett's mucosa. Histological examination of biopsies taken from the same area showed squamous epithelium within glandular Barrett's mucosa, corresponding well to endocytoscopic findings. CONCLUSION: To our knowledge, this is the first report of in vivo visualization of esophageal papillary squamous cell islands surrounded by glandular Barrett's epithelium. | Nicholas Eleftheriadis Haruhiro Inoue Haruo Ikeda Manabu Onimaru Akira Yoshida Toshihisa Hosoya Roberta Maselli Shin-ei Kudo | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，4： | 2 |
| 8 | Submucosal endoscopic tumor resection for subepithelial tumors in the esophagus and cardia显示文摘 | H. Inoue H. Ikeda T. Hosoya M. Onimaru A. Yoshida N. Eleftheriadis R. Maselli S. Kudo | 2012 | Endoscopy2012，，03： | 2 |
| 9 | 1个黑煤病菌新组合Metacapnodium neesii及其基于核酸序列的系统发育位置显示文摘2019年10月,在日本本州中部长野县的富士山冷杉树枝及树叶上采集到4种黑斑病致病菌标本,经鉴定为已知致病菌Capnobotrys neesii(Capnobotrys的模式种)。此外,通过单孢分离法培养出具有代表性的菌株JCM 39119,能产生具有瓶梗状的产孢细胞和分生孢子的念珠状菌丝、以及类似于在天然宿主上生长的分生孢子梗和小型分生孢子的菌丝。根据植物多形性真菌学名重新命名的原则,无性型类群C.neesii被划分至Metacapnodium,作为新组合Metacapnodium neesii。测定了JCM 39119菌株的nrL SU、nrS SU、ITS、RPB2和EFIa基因序列,并基于核糖体小亚基序列进行系统发育分析,将JCM 39119菌株定位在刺盾炱目Chaetothyriales的分类单元上,而非预期的煤炱目Capnodiales或格孢菌目Pleosporales分类单元。因此,必须进行进一步实验分析,通过对其他基因序列分析得到最终结论。本研究结果支持对以Metacapnodium为代表的假煤炱科Metacapnodiaceae的更高级别分类进行修订。 | Junta Sugiyama Kyung-Ok Nam Tsuyoshi Hosoya | 2020 | 菌物研究2020，18，4： | 2 |
| 10 | Micro-tensile bond strength of sound and caries-affected primary tooth dentin measured with original designed jig 显示文摘 | Hosoya Y Kawada E Ushigome T | 2006 | J Biomed Mater Res B Appl Biomater2006，7，2： | 1 |
| 11 | Genetic diversity of coxsackievirus A16 associated with hand, foot, and mouth disease epidemics in Japan from 1983 to 2003显示文摘 | Hosoya M Kawasaki Y Sato M | 2007 | J Clin Microbiol2007，5，1： | 1 |
| 12 | Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy显示文摘 | Leal EC Manivannan A Hosoya K | 2007 | Invest Ophthalmol Vis Sci2007，48，11： | 1 |
| 13 | Roles of the conjunctiva in ocular drug delivery: a review of eonjunctival transport mechanisms and their regulation 显示文摘 | Hosoya K Lee VH Kim KJ | 2005 | Eur J Pharm Biopharm2005，60，2： | 1 |
| 14 | Characterization of the Relation Among the Mechanical Behavior and the Textures in High Martensitic Dual Phase Steels 显示文摘 | Tomoyoshi Okita Yoshihiro Hosoya Kazuhide Nakaoka | 2005 | ISIJ International2005，45，11： | 1 |
| 15 | Protection of the cardiovascular system by imidapril,a versatile angiotensin - converting enzyme inhibitor 显示文摘 | Hosoya K Ishimitsu T | 2002 | Cardiovasc Drug Rev2002，20，2： | 1 |
| 16 | Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor显示文摘 | Tatemoto K Hosoya M Habata Y | 1998 | Biochem Biophy Res commun1998，251，2： | 1 |
| 17 | Correlation between serum interleukin 6 and C-reactive protein concentra tions in patients with adenoviral respiratory infection显示文摘 | Kawasaki Y Hosoya M Katayose M | 2002 | Pediatr Infect Dis J2002，21，5： | 1 |
| 18 | A G protein-coupled receptor responsive to bile acids显示文摘 | Kawamata Y Fujii R Hosoya M | 2003 | J Bid Chem2003，278，11： | 1 |
| 19 | Linear and nonlinear optical properties of sol-gel-derived Au nanometer-particle-doped alumina显示文摘 | Hosoya Y Suga T Yanagawa T | 1997 | JAppl Phys1997，81，： | 1 |
| 20 | Thioredoxin interacting protein(TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions显示文摘 | Perrone L Devi T S Hosoya K | | 0，，1： | 1 |
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