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| 1 | Acute lower gastrointestinal bleeding from a dieulafoy lesion proximal to the anorectal junction post-orthotopic liver transplant显示文摘A 67-year-old woman underwent an orthotopic liver transplantation for end stage liver disease secondary to chronic autoimmune hepatitis. She developed sudden massive hematochezia on post-operative day 23 with hemodynamic compromise. The source of hemorrhage was found at colonoscopy after careful irrigation and inspection to be a dieulafoy lesion situated just proximal to the anorectal junction. Hemostasis was achieved with epinephrine injection and thermal coagulation. | Wichian Apiratpracha Jin Kee Ho James J Powell Eric M Yoshida | 2006 | World Journal of Gastroenterology2006，12，46： | 12 |
| 2 | 遗传算法的群体模式多样性与模式生长方程(Ⅰ)显示文摘引入个体平均相似度来衡理群体的基因模式多生,分析讨论了遗传算子对个体平均相似度的影响。 | 伍永刚 Ho,M | 1999 | 水电能源科学1999，17，4： | 9 |
| 3 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 4 | Antioxidative and anti-endotoxin effects of propofol on endothelial cells显示文摘Objective To investigate the antioxidant and anti-endotoxin effects of propofol on endothelial cells and the possible mechanisms.Methods Cultured endothelial cells were treated with hydrogen peroxide (H 2O 2), propofol + H 2O 2, lipopolysaccharide (LPS) and propofol + LPS, respectively. Endothelial cell damage was monitored for possible lactic dehydrogenase (LDH) release. The transcription and the protein expression levels of endothelial nitric oxide synthase (eNOS) were measured.Results LDH release was higher in groups treated with H 2O 2 or LPS than in the control group. After pretreatment with propofol, the effects induced by H 2O 2 were attenuated, but propofol did not decrease the LDH release induced by LPS. Both H 2O 2 and LPS significantly increased the eNOS transcript levels and the increases were significantly attenuated after pretreatment with propofol. Both H 2O 2 and LPS significantly increased the eNOS protein expression and the increase was attenuated after pretreatment with propofol. Conclusion Propofol could protect endothelial cells against oxidative stress by inhibiting eNOS transcription and protein expression, but could not antagonise endotoxin induced cell injuries. | 彭志勇 罗敏 叶仕桥 Critchley Lester AH Joynt Gavin M Ho Anthony MH 姚尚龙 | 2003 | Chinese Medical Journal2003，，5： | 7 |
| 5 | Venous thromboembolism prophylaxis in hospitalized elderly patients: Time to consider a 'MUST' strategy显示文摘静脉的 thromboembolism ( VTE )是可防止的死亡在的最普通的原因 patients.Elderly 就医了病人因为 comorbidities 和在老病人的 VTE 的尖锐 illnesses.Clinical 诊断是的预先安排的高流行,有 VTE 的更高的风险特别地困难并且,这样足够的 VTE 预防具有在减少 VTE 预防的 VTE.Omission 的死亡和病态的枢轴的重要性然而,尽管有连续 education.A 。 | Kwok M Ho Edward Litton | 2011 | Journal of Geriatric Cardiology2011，8，2： | 6 |
| 6 | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection显示文摘Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy(BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research. | Darlene Vigil Nikifor K Konstantinov Marc Barry Antonia M Harford Karen S Servilla Young Ho Kim Yijuan Sun Kavitha Ganta Antonios H Tzamaloukas | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 7 | 铌酸锶钡薄膜的微结构与电光性能的研究显示文摘本文叙述了使用溶胶凝胶法在MgO(0 0 1)的衬底上制备铌酸锶钡薄膜的过程 ,膜层厚度可达 5 μm。通过X射线衍射、摇摆曲线、扫描、拉曼散射光谱等方法研究了薄膜的微结构性能 ,实验发现 ,铌酸锶钡薄膜具有了较好的 (0 0 1)方向的优先取向性能 ,并且随着薄膜厚度的增加 ,其晶体取向性也会随之不断改进。熔石英的透明衬底上生长的SBN薄膜具有较大的电致双折射效应 ,其有效电光系数能够高达 6 6 2× 10 -11m/V。 | 叶辉 Melanie M T Ho Mak C L | 2002 | 光学学报2002，22，10： | 4 |
| 8 | 造血微环境决定脐血造血干/祖细胞的早期分裂行为显示文摘目的 在特定生长因子的培养体系中 ,观察模拟造血微环境及粘附因素对人类脐血造血干 祖细胞早期分裂行为的影响。方法 ①应用流式细胞仪 (FACS)分选CD3 4+CD3 8- 细胞 ;②细胞培养体系中应用干细胞支持性基质AFT0 2 4及单一粘附因素纤维结合素 (Fn) ,并观察其对细胞早期分裂行为的影响。结果 ①在联合生长因子的条件下 ,人类脐血CD3 4+CD3 8- 细胞早期分裂呈现固定比例的静止、慢分裂、快分裂以及不对称分裂状态 ;②未观察到单一粘附因素Fn对其早期分裂行为的影响 ;③干细胞支持性基质AFT0 2 4所模拟的体外造血微环境可促使脐血造血干 祖细胞广泛增殖并更多地进行不对称分裂。结论 ①CD3 4+CD3 8- 细胞群体具有异质性 ,由具有不同增殖行为的亚群组成 ,在体外培养早期存在不对称分裂 ;②体外模拟的骨髓微环境AFT0 2 4基质滋养层较细胞因子及单一粘附因素能够更好地支持造血干 | 刘代红 M Punzel AD Ho | 2002 | 中华血液学杂志2002，23，10： | 4 |
| 9 | Improved biomass productivity and water use efficiency under water deficit conditions in transgenic wheat constitutively expressing the barley HVA 1 gene显示文摘 | Elumalai Sivamani Ahmed Bahieldin Jon M Wraith Thamir Al-Niemi William E Dyer Tuan-Hua David Ho Rongda Qu | 2000 | Plant Science2000，，1： | 2 |
| 10 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 11 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 12 | Improved biomass productivity and water use efficiency under water deficit conditions in transgenic wheat constitutively expressing the barley HVA 1 gene显示文摘 | Elumalai Sivamani Ahmed Bahieldin Jon M Wraith Thamir Al-Niemi William E Dyer Tuan-Hua David Ho Rongda Qu | 2000 | Plant Science2000，，1： | 2 |
| 13 | Assessment of menopause-induced myocardial changes by integrated backscatter during inotropic stimulation and atropine injection显示文摘 | HO Y L LIN L C YEN M L | 2002 | Ultrasound Med Biol2002，28，7： | 2 |
| 14 | CD95 (Fas)-dependen elimination of self-reactive B cells upon interaction with CD4+T cells 显示文摘 | Rathmell JC Cooke M P Ho W Y et aI | 1995 | Nature1995，376，6536： | 1 |
| 15 | Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity 显示文摘 | Mirjany M Ho L Pasinetti GM | 2002 | J Pharmacol Exp Ther2002，301，： | 1 |
| 16 | Outcome analysis of intraventricular thrombolytic therapy for intraventricular haemorrhage 显示文摘 | LEE M W PANG K Y HO W W | 2003 | Hong Kong Med J2003，9，5： | 1 |
| 17 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 18 | Early radiographic and clinical results of balloon kyphoplasty for the treatmene of osteoporotic vertebral compression fractures显示文摘 | Phillips FM Ho E Campbell Hupp M | 2003 | Spine2003，28，19： | 1 |
| 19 | Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population 显示文摘 | Horikoshi M Hara K ho C | 2007 | Diabetologia2007，50，12： | 1 |
| 20 | 显示文摘 | Gong H Wilk G D | 2002 | Appl Phys Lett2002，81，： | 1 |
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