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| 1 | Running-in process of Si-SiO_(x)/SiO_(2)pair at nanoscale-Sharp drops in friction and wear rate during initial cycles显示文摘Using an atomic force microscope,the running-in process of a single crystalline silicon wafer coated with native oxide layer(Si-SiO_(x))against a SiO_(2)microsphere was investigated under various normal loads and displacement amplitudes in ambient air.As the number of sliding cycles increased,both the friction force Ft of the Si-SiO_(x)/SiO_(2)pair and the wear rate of the silicon surface showed sharp drops during the initial 50 cycles and then leveled off in the remaining cycles.The sharp drop in Ft appeared to be induced mainly by the reduction of adhesion-related interfacial force between the Si-SiO_(x)/SiO_(2)pair.During the running-in process,the contact area of the Si-SiO_(x)/SiO_(2)pair might become hydrophobic due to removal of the hydrophilic oxide layer on the silicon surface and the surface change of the SiO_(2)tip,which caused the reduction of friction force and the wear rate of the Si-SiO_(x)/SiO_(2)pair.A phenomenological model is proposed to explain the running-in process of the Si-SiO_(x)/SiO_(2)pair in ambient air.The results may help us understand the mechanism of the running-in process of the Si-SiO_(x)/SiO_(2)pair at nanoscale and reduce wear failure in dynamic microelectromechanical systems(MEMS). | Lei CHEN Seong HKIM Xiaodong WANG Linmao QIAN | 2013 | Friction2013，1，1： | 5 |
| 2 | Proinflammatory cytokine TNFα promotes HPV-associated oral carcinogenesis by increasing cancer stemness显示文摘High-risk human papillomaviruses(HPVs) are involved in the development of several human cancers, including oropharyngeal squamous cell carcinomas. However, many studies have demonstrated that HPV alone is not sufficient for the oncogenic transformation of normal human epithelial cells, indicating that additional cofactors are required for the oncogenic conversion of HPV-infected cells. Inasmuch as chronic inflammation is also closely associated with carcinogenesis, we investigated the effect of chronic exposure to tumor necrosis factor α(TNFα), the major proinflammatory cytokine, on oncogenesis in two immortalized oral keratinocyte cell lines, namely, HPV16-immortalized and human telomerase reverse transcriptase(h TERT)-immortalized cells. TNFαtreatment led to the acquisition of malignant growth properties in HPV16-immortalized cells, such as(1) calcium resistance,(2)anchorage independence, and(3) increased cell proliferation in vivo. Moreover, TNFα increased the cancer stem cell-like population and stemness phenotype in HPV16-immortalized cells. However, such transforming effects were not observed in h TERTimmortalized cells, suggesting an HPV-specific role in TNFα-promoted oncogenesis. We also generated h TERT-immortalized cells that express HPV16 E6 and E7. Chronic TNFα exposure successfully induced the malignant growth and stemness phenotype in the E6-expressing cells but not in the control and E7-expressing cells. We further demonstrated that HPV16 E6 played a key role in TNFα-induced cancer stemness via suppression of the stemness-inhibiting micro RNAs mi R-203 and mi R-200 c. Overexpression of mi R-203 and mi R-200 c suppressed cancer stemness in TNFα-treated HPV16-immortalized cells. Overall, our study suggests that chronic inflammation promotes cancer stemness in HPV-infected cells, thereby promoting HPV-associated oral carcinogenesis. | Hannah SHong Jonathan Akhavan Sung Hee Lee Reuben HKim Mo KKang No-Hee Park Ki-Hyuk Shin | 2020 | International Journal of Oral Science2020，12，1： | 3 |
| 3 | The ERα/KDM6B regulatory axis modulates osteogenic differentiation in human mesenchymal stem cells显示文摘Osteoporosis is a highly prevalent public health burden associated with an increased risk of bone fracture, particularly in aging women. Estrogen, an important medicinal component for the preventative and therapeutic treatment of postmenopausal osteoporosis, induces osteogenesis by activating the estrogen receptor signaling pathway and upregulating the expression of osteogenic genes, such as bone morphogenetic proteins(BMPs). The epigenetic regulation of estrogen-mediated osteogenesis,however, is still unclear. In this report, we found that estrogen significantly induced the expression of lysine-specific demethylase 6B(KDM6B) and that KDM6B depletion by shRNAs led to a significant reduction in the osteogenic potential of DMSCs.Mechanistically, upon estrogen stimulation, estrogen receptor-α(ERα) was recruited to the KDM6B promoter, directly enhancing KDM6B expression. Subsequently, KDM6B was recruited to the BMP2 and HOXC6 promoters, resulting in the removal of H3K27me3 marks and activating the transcription of BMP2 and HOXC6, the master genes of osteogenic differentiation. Furthermore, we found that estrogen enhanced DMSC osteogenesis during calvarial bone regeneration and that estrogen’s pro-osteogenic effect was dependent on KDM6B in vivo. Taken together, our results demonstrate the vital role of the ERα/KDM6B regulatory axis in the epigenetic regulation of the estrogen-dependent osteogenic response. | Zhenqing Liu Hye-Lim Lee Jin Sook Suh Peng Deng Chang-Ryul Lee Olga Bezouglaia Mojan Mirnia Vivian Chen Michael Zhou Zhong-Kai Cui Reuben HKim Min Lee Tara Aghaloo Christine Hong Cun-Yu Wang | 2022 | Bone Research2022，10，1： | 2 |
| 4 | Application of neural network to fault diagnosis of power system显示文摘 | Hkim K | 1991 | Procceeding of ESAP 91Tokyo-kobe1991，8，7： | 1 |
| 5 | Caspase‐3/CPP32 immunoreactivity and its correlation with frequency of apoptotic bodies in human prostatic carcinomas and benign nodular hyperplasias显示文摘 | J HSohn D HKim N GChoi Y EPark J YRo | 2002 | Histopathology2002，，6： | 1 |
| 6 | Magnetic and structural properties of lithum salt doped polyaniline显示文摘 | C K Jeong J H Jung B Hkim | 2001 | Synth Met2001，，117： | 1 |
| 7 | Magnetic and structural properties of lithum salt doped polyaniline显示文摘 | Jeong C K Jung J H Hkim B | 2001 | Synthetic Metals2001，117，1： | 1 |
| 8 | Spontaneous rupture of the left common iliac vein associatedwith May - Thurner syndrome: successful management withsurgery and placement of an endovascular stent 显示文摘 | Y HKIM SMKO HTKIM | 2007 | The British Journal of Radiology2007，80，： | 1 |
| 9 | EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number显示文摘 | M AKim H SLee H ELee Y KJeon H KYang W HKim | 2008 | Histopathology2008，，： | 1 |
| 10 | A study of the couplant effects on contact ultrasonic testing显示文摘 | HKIM S J SONG S S LEE | 2002 | Korean Soc Nondestmet Test2002，22，6： | 1 |
| 11 | Magnetic and structural properties of lithum salt doped polyaniline显示文摘 | Jeong C K Jung J H Hkim B | 2001 | Synthetic Metals2001，117，1： | 1 |
| 12 | 通过计算流体力学进行离心泵叶轮和蜗壳的优化设计显示文摘在本项研究中,为了提高离心泵性能,进行了叶轮优化和蜗壳设计,针对叶轮设计,从叶片展开平面中选取设计参数,通过CFD和叶轮的响应曲面法来分析优化设计参数对水泵性能的影响。本项研究还提出依据水泵设计最优工况(效率为98.2%,扬程为64.5m)的数值分析结果,优化水泵叶轮几何形状以提高水泵性能。此外,还推荐了水泵设计方法,即根据斯捷潘诺夫理论和数值分析设计适用于优化后叶轮的蜗壳。 | J HKim | 2015 | 国外大电机2015，0，3： | 0 |
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