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| 1 | Optimal duration of the early and late recurrence of hepatocellular carcinoma after hepatectomy显示文摘AIM: To determine the best cut-off value between the early and late recurrence periods after the initial recurrence of hepatocellular carcinoma(HCC).METHODS: The clinical records of 404 patients who underwent macroscopic curative hepatectomy for HCC between 1980 and 2010 were retrospectively examined. We divided the 252 patients experienced a recurrence of HCC into two groups, the early and late recurrence groups using the 'minimum P-value' approach. Factors for early recurrence were investigated using all 404 patients, and factors related to late recurrence were investigated in the patients who were confirmed to be recurrence free at the end of the early recurrence period.RESULTS: For the 252 patients who experienced a recurrence, the optimal cut-off value for differentiating early and late recurrence based on the overall survival after initial recurrence was 17 mo(5-year overall survival after initial recurrence: 15.4% vs 36.3%, P = 0.000018). Cox proportional hazard analysis identified early recurrence(P = 0.003) as one of the independent prognostic factors associated with overall survival after initial recurrence. A logistic regression model showed that an alpha-fetoprotein level > 100 ng/m L(P < 0.001), multiple HCC(P < 0.001), serosal invasion(P = 0.031), and microvascular invasion(P = 0.012) were independent factors associated with early recurrence, whereas the only independent factor related to late recurrence was liver cirrhosis(P = 0.002).CONCLUSION: Seventeen months after hepatectomy is a useful cut-off value between early and late recurrence of HCC based on the prognosis and different etiologies. | Yusuke Yamamoto Hisashi Ikoma Ryo Morimura Hirotaka Konishi Yasutoshi Murayama Shuhei Komatsu Atsushi Shiozaki Yoshiaki Kuriu Takeshi Kubota Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Kazuma Okamoto Chouhei Sakakura Toshiya Ochiai Eigo Otsuji | 2015 | World Journal of Gastroenterology2015，21，4： | 14 |
| 2 | ^(18)F-fluorodeoxyglucose positron emission tomography in the diagnosis of small pancreatic cancer显示文摘AIM:To investigate the role of 18 F-fluorodeoxyglucose positron emission tomography(FDG-PET) in the diagnosis of small pancreatic cancer. METHODS:This study involved 31 patients with proven invasive ductal cancer of the pancreas.The patients were divided into 3 groups according to the maximum diameter of the tumor:TS1(maximum tumor size≤2.0 cm) ,TS2(>2.0 cm and≤4.0 cm) or TS3-4(>4.0 cm) .The relationships between the TS and various diagnostic tools,including FDG-PET with dual time point evaluation,were analyzed. RESULTS:The tumors ranged from 1.3 to 11.0 cm in diameter.Thirty of the 31 patients(97%) had a positive FDG-PET study.There were 5 patients classified as TS1,15 as TS2 and 11 as TS3-4.The sensitivity of FDG-PET,computed tomography(CT) and magnetic resonanceimaging(MRI) were 100%,40%,0%in TS1,93%,93%,89%in TS2 and 100%,100%,100%in TS3-4. The sensitivity of FDG-PET was significantly higher in comparison to CT and MRI in patients with TS1(P< 0.032) .The mean standardized uptake values(SUVs) did not show a significant difference in relation to the TS(TS1:5.8±4.5,TS2:5.7±2.2,TS3-4:8.2±3.9) ,respectively.All the TS1 tumors(from 13 to 20 mm) showed higher SUVs in FDG-PET with dual time point evaluation in the delayed phase compared with the early phase,which suggested the lesions were malignant. CONCLUSION:These results indicate that FDG-PET with dual time point evaluation is a useful modality for the detection of small pancreatic cancers with a diameter of less than 20 mm. | Keiichi Okano Keitaro Kakinoki Shintaro Akamoto Masanobu Hagiike Hisashi Usuki Yuka Yamamoto Yoshihiro Nishiyama Yasuyuki Suzuki | 2011 | World Journal of Gastroenterology2011，17，2： | 12 |
| 3 | Post-hepatectomy survival in advanced hepatocellular carcinoma with portal vein tumor thrombosis显示文摘AIM: To analyze hepatocellular carcinoma(HCC) patients with portal vein tumor thrombosis(PVTT) using the tumor-node-metastasis(TNM) staging system.METHODS: We retrospectively analyzed 372 patients with HCC who underwent hepatectomy between 1980 and 2009.We studied the outcomes of HCC patients with PVTT to evaluate the American Joint Committee on Cancer TNM staging system(7th edition) for stratifying and predicting the prognosis of a large cohort of HCC patients after hepatectomy in a single-center.Portal vein invasion(vp) 1 was defined as an invasion or tumor thrombus distal to the second branch of the portal vein,vp2 as an invasion or tumor thrombus in the second branch of the portal vein,vp3 as an invasion or tumor thrombus in the first branch of the portal vein,and vp4 as an invasion or tumor thrombus in the portal trunk or extending to a branch on the contralateral side.RESULTS: The cumulative 5-year overall survival(5yr OS) and 5-year disease-free survival(5yr DFS) rates of the 372 patients were 58.3% and 31.3%,respectively.The 5yr DFS and 5yr OS of vp3-4 patients(n = 10) were 20.0%,and 30.0%,respectively,which was comparable with the corresponding survival rates of vp1-2 patients(P = 0.466 and 0.586,respectively).In the subgroup analysis of patients with macroscopic PVTT(vp2-4),the OS of the patients who underwent preoperative transarterial chemoembolization was comparable to that of patients who did not(P = 0.747).There was a significant difference in the DFS between patients with stage Ⅰ HCC and those with stage Ⅱ HCC(5yr DFS 39.2% vs 23.1%,P < 0.001); however,theDFS for stage Ⅱ was similar to that for stage Ⅲ(5yrD FS 23.1% vs 13.8%,P = 0.330).In the subgroup analysis of stage Ⅱ-Ⅲ HCC(n = 148),only alpha-fetoprotein(AFP) > 100 mg/dL was independently associated with DFS.CONCLUSION: Hepatectomy for vp3-4 HCC results in a survival rate similar to hepatectomy for vp1-2.AFP stratified the stage Ⅱ-Ⅲ HCC patients according to prognosis. | Yusuke Yamamoto Hisashi Ikoma Ryo Morimura Katsutoshi Shoda Hirotaka Konishi Yasutoshi Murayama Shuhei Komatsu Atsushi Shiozaki Yoshiaki Kuriu Takeshi Kubota Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Kazuma Okamoto Chouhei Sakakura Toshiya Ochiai Eigo Otsuji | 2015 | World Journal of Gastroenterology2015，21，1： | 9 |
| 4 | High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer显示文摘 | Hideaki Shimada Nobuhiro Takiguchi Osamu Kainuma Hiroaki Soda Atsushi Ikeda Akihiro Cho Akinari Miyazaki Hisashi Gunji Hiroshi Yamamoto Matsuo Nagata | 2010 | Gastric Cancer2010，，3： | 4 |
| 5 | Endoscopic diagnosis of superficial non‐ampullary duodenal epithelial tumors in J apan: M ulticenter case series显示文摘 | Kenichi Goda Daisuke Kikuchi Yorimasa Yamamoto Kengo Takimoto Naomi Kakushima Yoshinori Morita Hisashi Doyama Takuji Gotoda Yuji Maehata Noritsugu Abe | 2014 | Digestive Endoscopy2014，，： | 2 |
| 6 | New reaction and new catalyst-a per- sonal perspective显示文摘 | Hisashi Yamamoto | 2007 | Tetrahedron2007，63，： | 1 |
| 7 | Bacteriological investigation of bile in patients with cholelithiasis显示文摘 | Hideki Ohdan Hisashi Oshiro Yasuji Yamamoto Issei Tanaka Kazuo Inagaki Kazuo Sumimoto Takao Hinoi | 1993 | Surgery Today1993，，5： | 1 |
| 8 | Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer显示文摘 | Ken-ichi Fujita Yuichi Ando Fumio Nagashima Wataru Yamamoto Hisashi Eodo Kazuhiro Araki Keiji Kodama Toshimichi Miya Masaru Narabayashi Yasutsuna Sasaki | 2007 | Cancer Chemotherapy and Pharmacology2007，，4： | 1 |
| 9 | Direct condensation of carboxylic acid with alcohols catalyzed by hafnium(IV)salts显示文摘 | Kazuaki Ishihara Suguru Ohara Hisashi Yamamoto | 2000 | Science2000，，290： | 1 |
| 10 | Catalytic,highly enantio-and diastereoselective pinacol coupling reaction with a new tethered bis(8-quinolinolato)ligand显示文摘 | NORITO TAKENAKA GUOYAO XIA HISASHI YAMAMOTO | 2004 | J Am Chem Soc2004，12，13： | 1 |
| 11 | A digital watermark technique based on the wavelet transform and its robustness on image compression and transformation显示文摘 | HISASHI AKIO MIYAZAKI AKIHIRO YAMAMOTO | 1999 | IEICE Trans Fundamentals1999，82，1： | 1 |
| 12 | Catalytic enantioselective synthesis of α-aminooxy and α-hydroxy ketone using nitrosobenzene显示文摘 | Node Momiyama Hisashi Yamamoto | | 0，，20： | 1 |
| 13 | High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer显示文摘 | Hideaki Shimada Nobuhiro Takiguchi Osamu Kainuma Hiroaki Soda Atsushi Ikeda Akihiro Cho Akinari Miyazaki Hisashi Gunji Hiroshi Yamamoto Matsuo Nagata | 2010 | Gastric Cancer2010，，3： | 1 |
| 14 | SiO2-P2O3- B2O3 Wood-Inorganic Composites Prepared by Metal Alkoxide Oligomers and their Fire-resisting Properties 显示文摘 | Hisashi Miyafuji Shiro Saka Akira Yamamoto | 1998 | Holzforschung1998，52，4： | 1 |
| 15 | A digital watermark technique based on the wavelet transform and its robustness on image compression and transformation显示文摘 | Hisashi Akio Miyazaki Akihiro Yamamoto | 1999 | IEICE Trans Fundamentals1999，82，1： | 1 |
| 16 | Diastereo- and enantioselecfive synthesis of nitroso diels-alder-type hicyeloketones using dienamine:mechanistic insight into sequential nitroso aldol/michael reaction and application for optically pure 1 'amino-3,4-diol synthesis显示文摘 | Norie Momiyama Yuhei Yamamoto Hisashi Yamamoto | | 0，，： | 1 |
| 17 | Laparoscopic major hepato-biliary-pancreatic surgery: formidable challenge to standardization显示文摘 | Akihiro Cho Hiroshi Yamamoto Matsuo Nagata Nobuhiro Takiguchi Hideaki Shimada Osamu Kainuma Hiroaki Souda Hisashi Gunji Akinari Miyazaki Atsushi Ikeda Tomoko Tohma Ikuko Matsumoto | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，6： | 1 |
| 18 | Diversity-based trategy for discovery of environmentally benign organocatalyst: diamine-protomic acid catalysts for asymmetric direct aldol reactions显示文摘 | MAKASAZU Nakadai SUSUMU Saito HISASHI Yamamoto | 2000 | Tetrahedron2000，58，： | 1 |
| 19 | Direct condensation of carboxylie acids with alcohols catalyzed by hafnium(Ⅳ) salts显示文摘 | Kazuki Ishihara Suguru Ohara Hisashi Yamamoto | 2000 | Science2000，290，5494： | 1 |
| 20 | Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer显示文摘 | Ken-ichi Fujita Yuichi Ando Fumio Nagashima Wataru Yamamoto Hisashi Eodo Kazuhiro Araki Keiji Kodama Toshimichi Miya Masaru Narabayashi Yasutsuna Sasaki | 2007 | Cancer Chemotherapy and Pharmacology2007，，4： | 1 |
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