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| 1 | Apoptosis and non-alcoholic fatty liver diseases显示文摘The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice. | Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki Toshikatsu Shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu Kazumichi Kuroda Mitsuhiko Moriyama | 2018 | World Journal of Gastroenterology2018，24，25： | 32 |
| 2 | 超声波辅助农杆菌介导CP基因转化番小瓜(Carioca papaya L.)的有效方法显示文摘本研究探索了通过农杆菌介导,超声波辅助处理,转化番木瓜胚性愈伤组织,获得转基因植株的有效方法。分别将含有日本PLDMV 外壳蛋白基因(PTi-Epj-TL-PLDMV)和含有台湾PRSV 菌株、美国夏威夷PRSV 菌株、泰国PRSV 菌株及日本PLDMV 菌株的多元外壳蛋白基因编码序列(PTi-NP-YKT)插入双元载体质粒pGA482G,借助于农杆菌系LBA4404将双元载体上的外壳蛋白基因和新霉素磷酸转移酶基因(nptⅡ)转移到番木瓜品种Sunset 的胚性愈伤组织中,从而获得抗卡那霉素的转化再生植株。试验着重在转化方法上进行探索。结果表明,农杆菌过夜培养后,用高渗透压培养液(1/2 MS+6%蔗糖+1%葡萄糖,pH 5.7)调整至光密度OD_(600(?)m)=0.15-0.20,然后用该菌液感染材料30min,其间辅以超声波处理,可以大大提高转化效率。用15ml 无菌离心管装载胚性愈伤材料进行15s 的超声波处理,在80块被转化的胚性愈伤中获得21个CP 基因G 转化系(26.3%),而在对照处理64块胚性愈伤中仅获得1个转化系(1.6%);在经过15s 的超声波处理48块被转化的胚性愈伤中获得8个CP 基因B 转化系(16.7%),而在对照处理25块胚性愈伤中未出现转化系。上述操作方法用在两种CP 基因转化上均表现出相似的效果。试验还表明:120mg/L 是卡那霉素抗性筛选的最佳浓度。抗性筛选9个月后,在421块胚性愈伤组织中产生了42个抗卡那霉素的转化系。所获得的转基因植株分别用PCR 和Southern 印迹杂交进行了鉴定。 | 姜玲 MAOKA Tetsuo KOMORI Sadao FUKAMACHI Hiroshi KATO Hidenori OGAWA Kazunori | 2004 | 实验生物学报2004，37，3： | 11 |
| 3 | Adipose tissues differentiated by adipose-derived stem cells harvested from transgenic mice显示文摘客观:为了由 adipose-derivedstromal 房间(ASC ) 在 vitro 导致 adipocyte 区别,与绿荧光灯的蛋白质(GFP ) 从转基因的老鼠收获了并且估计经由 ASC 的附件构造脂肪质的纸巾打字的可能性我骨胶原 scaffolds.Methods:从 GFP 转基因的老鼠的腹股沟的胖垫被酶为 ASC (主要文化) 的隔离消化。在到 ASC 的三个段落的扩大以后,房间被 ASC 在 vitro 在为二个星期,和 adipocyte 区别中等的 anadipogenic 孵化被词法观察和油红估计染色的 O。然后,他们被纳入为 12 个小时 andco 有教养的骨胶原脚手架,为 2months 由皮下注射的培植列在后面到裸体老鼠的背面的皮肤。最新形成的纸巾被检测由他染色。结果:有教养的主要干细胞是像成纤维细胞、显示出的活跃增长。在在 anadipocyte 区别媒介被孵化以后,在逐渐地并且最后积累的细胞质的类脂化合物微滴发展成成熟 adipocytes,它出现了在染色的油红 O 积极。0。5 厘米的 ~ 3new 组织块在裸体老鼠的背面的皮下面被发现,它被荧光灯的观察作为成熟脂肪质的纸巾证实并且他染色。结论:ASC 能成功地区分脂肪质的纸巾进成熟 adipocytes,它作为 intracytoplasmic 类脂化合物微滴展出象 adipocyte 一样形态学和快车。它是与 ASC 和类型设计的脂肪质的纸巾的一个有效模特儿我骨胶原脚手架。 | 鲁峰 高建华 Rei Ogawa Hiroshi Mizuro Hiki Hykusoku | 2006 | Chinese Journal of Traumatology2006，9，6： | 10 |
| 4 | Effect of periodontal treatment on adipokines in type 2 diabetes显示文摘The association between adipokines and inflammatory periodontal diseases has been studied over the last two decades. This review was intended to explore the observation that periodontal therapy may lead to an improvement of adipokines in diabetic patients. In summary, substantial evidence suggests that diabetes is associated with increased prevalence, extent and severity of periodontitis. Numerous mechanisms have been elucidated to explain the impact of diabetes on the periodontium. However, current knowledge concerning the role of major adipokines indicates only some of their associations with the pathogenesis of periodontitis in type 2 diabetes. Conversely, treatment of periodontal disease and reduction of oral inflammation may have positive effects on the diabetic condition, although evidence for this remains somewhat equivocal. | Hiroshi Ogawa Teerasak Damrongrungruang Sayaka Hori Kaname Nouno Kumiko Minagawa Misuzu Sato Hideo Miyazaki | 2014 | World Journal of Diabetes2014，5，6： | 8 |
| 5 | Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: Does hepatocellular adenoma arise in cirrhotic liver?显示文摘Hepatocellular adenoma(HCA) was recently classified into four pathological subtypes. There have been few studies describing the findings of contrast-enhanced ultrasonography(CEUS) of each type. Our case concerns a 78-year-old man who had undergone routine medical check-ups for hepatitis C for 11 years. Abdominal ultrasonography showed a 28 mm, hypo-echoic mass in the segment 4 of the liver. His integrating amount of drinking was 670 kg convert into ethanol. CEUS with Sonazoid demonstrated mild uniform hypo-enhancement with inflow of microbubbles from the periphery of the tumor in the arterial phase, and heterogeneously hypo-enhancement in the post vascular phase. Because the mass increased in size within 3 mo, a well differentiated hepatocellular carcinoma was suspected, and hepatic resection was performed. Microscopic findings showed homogeneous cell proliferation with low grade atypia, infiltration of inflammatory cells, ductular reactions, fatty deposit in part, and sinusoidal dilation. Immunohistochemistry revealed geographic positive for serum amyloid A(SAA), focal positive for glutaminesynthetase, diffuse and strong positive for C-reactive protein, and positive for liver-type fatty acid binding protein. These pathological features corresponded to that of an inflammatory HCA. However, we could not make a clear diagnosis, because HCAs were defined as not to arise in cirrhotic liver. Finally, this tumor was diagnosed as a SAA positive hepatocellular neoplasm. | Mariko Kumagawa Naoki Matsumoto Yukinobu Watanabe Midori Hirayama Takao Miura Hiroshi Nakagawara Masahiro Ogawa Shunichi Matsuoka Mitsuhiko Moriyama Tadatoshi Takayama Masahiko Sugitani | 2016 | World Journal of Hepatology2016，8，26： | 4 |
| 6 | Diagnostic problems in two-dimensional shear wave elastography of the liver显示文摘Two-dimensional shear wave elastography(2D-SWE)is used in the clinical setting for observation of the liver.Unfortunately,a wide spectrum of artifactual images are frequently encountered in 2D-SWE,the precise mechanisms of which remain incompletely understood.This review was designed to present many of the artifactual images seen in 2D-SWE of the liver and to analyze them by computer simulation models that support clinical observations.Our computer simulations yielded the following suggestions:(1)When performing 2D-SWE in patients with chronic hepatic disease,especially liver cirrhosis,it is recommended to measure shear wave values through the least irregular hepatic surface;(2)The most useful 2D-SWE in patients with focal lesion will detect lesions that are poorly visible on B-mode ultrasound and will differentiate true tumors from pseudo-tumors(e.g.,irregular fatty change);and(3)Measurement of shear wave values in the area posterior to a focal lesion must be avoided. | Hiroko Naganuma Hideaki Ishida Atsushi Uno Hiroshi Nagai Hidekatsu Kuroda Masahiro Ogawa | 2020 | World Journal of Radiology2020，12，5： | 3 |
| 7 | Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors显示文摘AIM:To evaluate the histopathological findings of type C liver disease to determine risk factors for development of hepatocellular carcinoma(HCC).METHODS:We studied 232 patients,who underwent liver biopsy for type C chronic liver disease between 1992 and 2009,with sustained virological response(SVR)after interferon therapy.The patients were divided into two groups according to the F stage 0+1+2 group(n = 182)and F3+4 group(n = 50).We prospectively observed and compared the incidence of HCC of the patients with SVR in the F0+1+2 and F3+4 groups.Then,the background factors and liver histopathological findings,including the degree of fibrosis,F stage,inflammation,necrosis,bile duct obstruction,fat deposition,and degree of irregular regeneration(IR)of hepatocytes,were correlated with the risk of developing HCC.RESULTS:HCC developed in three of 182(1.6%)patients in the F0+1+2 group,and four of 50(8.0%)in the F3+4 group.The cumulative incidence of HCC in the former group was found to be significantly lower than in the F3+4 group(log rank test P = 0.0224).The presence of atypical hepatocytes among IR of hepatocytes in the F3+4 group resulted in a higher cumulative incidence of HCC,and was significantly correlated with risk of HCC development(RR = 20.748,95%CI:1.335-322.5,P = 0.0303).CONCLUSION:Atypical hepatocytes among the histopathological findings of type C liver disease may be an important risk factor for HCC development along with progression of liver fibrosis. | Hiroshi Matsumura Kazushige Nirei Hitomi Nakamura Teruhisa Higuchi Yasuo Arakawa Masahiro Ogawa Naohide Tanaka Mitsuhiko Moriyama | 2013 | World Journal of Gastroenterology2013，19，30： | 3 |
| 8 | Endoscopic treatment of biliary complications after right-lobe living-donor liver transplantation with duct-to-duct biliary anastomosis显示文摘 | Shujiro Yazumi Takanobu Yoshimoto Hiroshi Hisatsune Kazunori Hasegawa Masaya Kida Shinsuke Tada Yoshito Uenoyama Junichi Yamauchi Seiji Shio Mureo Kasahara Kohei Ogawa Hiroto Egawa Koichi Tanaka Tsutomu Chiba | 2006 | Journal of Hepato-Biliary-Pancreatic Surgery2006，，6： | 2 |
| 9 | Improved Viability of Random Pattern Skin Flaps through the Use of Adipose-Derived Stem Cells显示文摘 | Feng Lu Hiroshi Mizuno Cagri A. Uysal Xiaobo Cai Rei Ogawa Hiko Hyakusoku | 2008 | Plastic and Reconstructive Surgery2008，，： | 2 |
| 10 | Rendezvous to asteroid with highly uncertain ephemeris: Hayabusa2’s Ryugu-approach operation result显示文摘This paper describes the guidance and navigation technique used by Hayabusa2 for the asteroid rendezvous operation to reach Ryugu.The operation results,including the achieved guidance and navigation performance,are also summarized.Multiple assessment and navigation teams worked closely to provide reliable navigation solutions with a short solution delivery cycle.Although the uncertainty of the Ryugu’s ephemeris was considerable before Hayabusa2’s arrival,a combination of radiometric-optical hybrid navigation and a stochastic-constrained optimum guidance method was able to achieve an accuracy of less than 100 m and 1 cm/s,and the arrival was precisely timed. | Yuichi Tsuda Hiroshi Takeuchi Naoko Ogawa Go Ono Shota Kikuchi Yusuke Oki Masateru Ishiguro Daisuke Kuroda Seitaro Urakawa Shin-ichiro Okumura Hayabusa2 Project Team | 2020 | Astrodynamics2020，4，2： | 2 |
| 11 | Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling显示文摘 | Kento Imajo Koji Fujita Masato Yoneda Yuichi Nozaki Yuji Ogawa Yoshiyasu Shinohara Shingo Kato Hironori Mawatari Wataru Shibata Hiroshi Kitani Kenichi Ikejima Hiroyuki Kirikoshi Noriko Nakajima Satoru Saito Shiro Maeyama Sumio Watanabe Koichiro Wada Atsus | 2012 | Cell Metabolism2012，，1： | 2 |
| 12 | The deep-space multi-object orbit determination system and its application to Hayabusa2’s asteroid proximity operations显示文摘The deep-space multi-object orbit determination system(DMOODS)and its application in the asteroid proximity operation of the Hayabusa2 mission are described.DMOODS was developed by the Japan Aerospace Exploration Agency(JAXA)for the primary purpose of determining the trajectory of deep-space spacecraft for JAXA’s planetary missions.The weighted least-squares batch filter is used for the orbit estimator of DMOODS.The orbit estimator supports more than 10 data types,some of which are used for relative trajectory measurements between multiple space objects including natural satellites and small bodies.This system consists of a set of computer programs running on Linux-based consumer PCs on the ground,which are used for orbit determination and the generation of radiometric tracking data,such as delta differential one-way ranging and doppler tracking data.During the asteroid proximity phase of Hayabusa2,this system played an essential role in operations that had very strict navigation requirements or operations in which few optical data were obtained owing to special constraints on the spacecraft attitude or distance from the asteroid.One example is orbit determination during the solar conjunction phase,in which the navigation accuracy is degraded by the effect of the solar corona.The large range bias caused by the solar corona was accurately estimated with DMOODS by combining light detection and ranging(LIDAR)and ranging measurements in the superior solar conjunction phase of Hayabusa2.For the orbiting operations of target markers and the MINERVA-II2 rover,the simultaneous estimation of six trajectories of four artificial objects and a natural object was made by DMOODS.This type of simultaneous orbit determination of multi-artificial objects in deep-space has never been accomplished before. | Hiroshi Takeuchi Kent Yoshikawa Yuto Takei Yusuke Oki Shota Kikuchi Hitoshi Ikeda Stefania Soldini Naoko Ogawa Yuya Mimasu Go Ono Fuyuto Terui Naoya Sakatani Manabu Yamada Toru Kouyama Shingo Kameda Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 2 |
| 13 | The Effect of Adipose-Derived Stem Cells on Ischemia-Reperfusion Injury: Immunohistochemical and Ultrastructural Evaluation显示文摘 | A Cagri Uysal Hiroshi Mizuno Morikuni Tobita Rei Ogawa Hiko Hyakusoku | 2009 | Plastic and Reconstructive Surgery2009，，： | 2 |
| 14 | Interleukin-8 is constitutively and commonly produced by various human carcinoma cell lines显示文摘 | Kiyoshi Sakamoto Takao Masuda Seiji Mita Taka-aki Ishiko Yasunari Nakashima Hirofumi Arakawa Hiroshi Egami Shinji Harada Kouji Matsushima Michio Ogawa | 1992 | International Journal of Clinical & Laboratory Research (-)1992，，1： | 1 |
| 15 | Expression of Δ6, Δ5 desaturase and GLELO elongase genes from Mortierella alpina for production of arachidonic acid in soybean [ Glycine max (L.) Merrill] seeds显示文摘 | Ren Chen Keisuke Matsui Miyuki Ogawa Mieko Oe Misa Ochiai Hiroshi Kawashima Eiji Sakuradani Sakayu Shimizu Masao Ishimoto Makoto Hayashi Yoshikatsu Murooka Yoshikazu Tanaka | 2005 | Plant Science2005，，2： | 1 |
| 16 | Vertical distribution of dissolved organic carbon and nitrogen in the Southern Ocean显示文摘 | Hiroshi Ogawa Rumi Fukuda I sao Koike | 1999 | Deep-Sea Research1999，46，： | 1 |
| 17 | The role of tumor necrosis factor-α in the aggravation of cerulein-induced pancreatitis in rats显示文摘 | Hirofumi Sameshima Satoshi Ikei Katsutaka Mori Yasuo Yamaguchi Hiroshi Egami Mikio Misumi Masaya Moriyasu Michio Ogawa | 1993 | International Journal of Pancreatology1993，，2： | 1 |
| 18 | Photoinitiated addition of diphenyl diselenides to acetylenes显示文摘 | AKIYA OGAWA HIROSHI YOKOYAMA KAZUYUKI YOKOYAMA | 1991 | J Org Chem1991，56，： | 1 |
| 19 | Dioxin reduction by sulfur component addition显示文摘 | Hiroshi Ogawa Norihiko Orita Mitsuhiro Horaguchi | 1996 | Chemoshere1996，32，： | 1 |
| 20 | Dioxin Reduction by Sulfur Component Addition显示文摘 | Hiroshi Ogawa Norihiko Orita Mitsuhiro Horaguchi | 1996 | Chemosphere1996，32，： | 1 |
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