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| 1 | A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone显示文摘Transforming growth factor-β(TGF-β)and bone morphogenetic protein(BMP)play important roles in bone metabolism.Smad ubiquitination regulatory factors(Smurfs)regulate TGF-β/BMP signaling via ubiquitination,resulting in degradation of signaling molecules to prevent excessive activation of TGF-β/BMP signaling.Though Smurf2 has been shown to negatively regulate TGF-β/Smad signaling,its involvement in BMP/Smad signaling in bone metabolism has not been thoroughly investigated.In the present study,we sought to evaluate the role of Smurf2 in BMP/Smad signaling in bone metabolism.Absorbable collagen sponges containing 3μg of recombinant human BMP2(rhBMP2)were implanted in the dorsal muscle pouches of wild type(WT)and Smurf2−/−mice.The rhBMP2-induced ectopic bone in Smurf2−/−mice showed greater bone mass,higher mineral apposition and bone formation rates,and greater osteoblast numbers than the ectopic bone in WT mice.In WT mice,the ectopic bone consisted of a thin discontinuous outer cortical shell and scant inner trabecular bone.In contrast,in Smurf2−/−mice,the induced bone consisted of a thick,continuous outer cortical shell and abundant inner trabecular bone.Additionally,rhBMP2-stimulated bone marrow stromal cells(BMSCs)from Smurf2−/−mice showed increased osteogenic differentiation.Smurf2 induced the ubiquitination of Smad1/5.BMP/Smad signaling was enhanced in Smurf2−/−BMSCs stimulated with rhBMP2,and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs.These findings demonstrate that Smurf2 negatively regulates BMP/Smad signaling,thereby identifying a new regulatory mechanism in bone metabolism. | Junichi Kushioka Takashi Kaito Rintaro Okada Hiroyuki Ishiguro Zeynep Bal Joe Kodama Ryota Chijimatsu Melanie Pye Masahiro Narimatsu Jeffrey LWrana Yasumichi Inoue Hiroko Ninomiya Shin Yamamoto Takashi Saitou Hideki Yoshikawa Takeshi Imamura | 2020 | Bone Research2020，8，4： | 6 |
| 2 | Acta Biomat:开发出可促进机体神经组织再生的新型网格纤维结构显示文摘近日。一项刊登在国际杂志Acta Biomaterialia上的研究报告中。来自日本大阪大学的研究人员通过研究开发出了一种网格结构。其能够被缠绕在损伤的周围神经组织上来帮助促进损伤神经的再生并且恢复其功能。 | Koji Suzuki Hiroyuki Tanaka Mitsuhiro Ebara Koichiro Uto Hozo Matsuoka Shunsuke Nishimoto Kiyoshi Okada Tsuyoshi Murase Hideki Yoshikawa | 2017 | 现代生物医学进展2017，17，18： | 4 |
| 3 | Pediatric living donor liver transplantation for congenital hepatic fibrosis using a mother's graft with von Meyenburg complex: A case report显示文摘This is the first report of living donor liver transplantation(LDLT) for congenital hepatic fibrosis(CHF) using a mother's graft with von Meyenburg complex. A 6-year-old girl with CHF, who suffered from recurrent gastrointestinal bleeding, was referred to our hospital for liver transplantation. Her 38-year-old mother was investigated as a living donor and multiple biliary hamartoma were seen on her computed tomography and magnetic resonance imaging scan. The mother's liver function tests were normal and she did not have any organ abnormality, including polycystic kidney disease. LDLT using the left lateral segment(LLS) graft from the donor was performed. The donor LLS graft weighed 250 g; the graft recipient weight ratio was 1.19%. The operation and post-operative course of the donor were uneventful and she was discharged on post-operative day(POD) 8. The graft liver function was good, and the recipient was discharged on POD 31. LDLT using a graft with von Meyenburg complex is safe and useful. Long-term follow-up is needed with respect to graft liver function and screening malignant tumors. | Naoya Yamada Yukihiro Sanada Takumi Katano Masahisa Tashiro Yuta Hirata Noriki Okada Yoshiyuki Ihara Atsushi Miki Hideki Sasanuma Taizen Urahashi Yasunaru Sakuma Koichi Mizuta | 2016 | World Journal of Gastroenterology2016，22，44： | 2 |
| 4 | Structural analysis and synthesis of oligosaccharides isolated from fermented beverage of plant extract显示文摘 | Hideki Okada Naoki Kawazoe Akira Yamamori | 2008 | Journal of Applied Glycoscience2008，，55： | 1 |
| 5 | Structural analysisand synthesis of oligosaccharides isolated from fermented beverage of plant extract显示文摘 | HIDEKI OKADA NAOKI KAWAZOE AKIRA YAMAMORI | 2008 | Journal of Applied Glycoscience2008，2008，： | 1 |
| 6 | Risk factor profiles, drug usage, and prevalence of aspirin-associated gastroduodenal injuries among high-risk cardiovascular Japanese patients: the results from the MAGIC study显示文摘 | Naomi Uemura Kentaro Sugano Hideyuki Hiraishi Kazuyuki Shimada Shinya Goto Shinichiro Uchiyama Yasushi Okada Hideki Origasa Yasuo Ikeda | 2014 | Journal of Gastroenterology2014，，： | 1 |
| 7 | Two novel oligosaccharides isolated from a beverage produced by fermentation of a plant extract显示文摘 | Naoki Kawazoe Hideki Okada Eri Fukushi | 2008 | Carbohydrate Research2008，343，： | 1 |
| 8 | Nitric oxide induces caspase-dependent apoptosis and necrosis in neonatal rat cardiomyocytes显示文摘 | Takamichi Uchiyama Hajime Otani Takayuki Okada Hideki Ninomiya Masakuni Kido Hiroji Imamura | 2002 | Mol Cell Cardiol2002，34，8： | 1 |
| 9 | Initial 3-month dynamics of dehydroepiandrosterone sulfate can predict responsiveness to primary androgen deprivation therapy in patients with metastatic prostate cancer显示文摘Dear Editor,Intensive treatments such as primary androgen deprivation therapy(pADT)plus docetaxel or abiraterone acetate are reportedly beneficial in metastatic prostate cancer(mPCa)patients with high-volume disease or high-risk features,respectively.1,2 High-volume or high-risk features are determined exclusively via pretreatment parameters.Predicting patient responsiveness to pADT,which is one of the major determinants of survival in these patients,would be advantageous with regard to making primary treatment decisions.If an initial 3-month period is possible,short-term serum parameter dynamics can be used to predict pADT responsiveness.Prostate-specific antigen(PSA)and alkaline phosphatase(ALP)dynamics have been indicated as potential predictors.3,4 Although pADT can reportedly cause a 20%-30%decrease in adrenal androgen levels,5 it is not known whether the dynamics of adrenal androgens shortly after the initiation of pADT can predict pADT responsiveness.The aim of the current study was to identify predictors of pADT responsiveness among pretreatment parameters and 3-month dynamics(D3m)of serum parameters including the adrenal androgen,dehydroepiandrosterone sulfate(DHEAS). | Akihiro Yano Makoto Kagawa Hideki Takeshita Yohei Okada Makoto Morozumi Satoru Kawakami | 2019 | Asian Journal of Andrology2019，21，6： | 1 |
| 10 | Structural analysis and synthesis of oligosaccharides isolated from fermented beverage of plant extract显示文摘 | Hideki Okada Naoki Kawazoe Akira Yamamori Shuiehi Onodera Norio Shiomi | 2008 | Journal of Applied Glycoscience2008，2008，： | 1 |
| 11 | One-Year Atherothrombotic Vascular Events Rates in Outpatients with Recent Non-Cardioembolic Ischemic Stroke: The EVEREST (Effective Vascular Event REduction after STroke) Registry显示文摘 | Norihiro Suzuki Motoki Sato Kiyohiro Houkin Yasuo Terayama Shinichiro Uchiyama Hiroyuki Daida Hiroshi Shigematsu Shinya Goto Kortaro Tanaka Hideki Origasa Susumu Miyamoto Kazuo Minematsu Masayasu Matsumoto Yasushi Okada | 2012 | Journal of Stroke and Cerebrovascular Diseases2012，，4： | 1 |
| 12 | Quantitative molecular diagnosis of peritoneal lavage fluid for predictionof peritoneal recurrence in gastric cancer显示文摘 | Yurika Sugita Yoshiyuki Fujiwara Hirokazu Taniguchi Takuji Mori Takaaki Ishii Hideki Niwa Yoshihiro Okada Shuji Takiguchi Takushi Yasuda Masahiko Yano Morito Monden | 2003 | International Journal of Oncology2003，，： | 1 |
| 13 | Enhanced protein secretion from multiprotease-deficient fission yeast by modification of its vacuolar protein sorting pathway显示文摘 | Alimjan Idiris Hideki Tohda Mayumi Sasaki Katsunori Okada Hiromichi Kumagai Yuko Giga-Hama Kaoru Takegawa | 2010 | Applied Microbiology and Biotechnology2010，，3： | 1 |
| 14 | Efficacy and safety of endoscopic submucosal dissection under general anesthesia显示文摘AIM: To evaluate the efficacy and safety of endoscopic submucosal dissection(ESD) under general anesthesia.METHODS: From January 2011 to July 2014, 206 consecutive patients had undergone ESD under general anesthesia for neoplasms of the stomach, esophagus, and colorectum were enrolled in this retrospective study. The efficacy and safety of ESD under general anesthesia were assessed.RESULTS: The en bloc resection rate of esophageal, gastric, and colorectal lesions was 100.0%, 98.3%, and 96.1%, respectively. The complication rate of perforationand bleeding were 0.0% and 0.0% in esophageal ESD, 1.7% and 1.7% in gastric ESD, and 3.9% and 2.0% in colorectal ESD, respectively. No cases of aspiration pneumonia were observed. All complications were managed by conservative treatment, with no surgical intervention required.CONCLUSION: With the cooperation of an anesthesiologist, ESD under general anesthesia appears to be a useful method, decreasing the risk of complications. | Kanefumi Yamashita Hironari Shiwaku Toshihiro Ohmiya Hideki Shimaoka Hiroki Okada Ryo Nakashima Richiko Beppu Daisuke Kato Takamitsu Sasaki Seiichiro Hoshino Satoshi Nimura Ken Yamaura Yuichi Yamashita | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，13： | 1 |
| 15 | Association of right-sided tumors with high thymidine phosphorylase gene expression levels and the response to oral uracil and tegafur/leucovorin chemotherapy among patients with colorectal cancer显示文摘 | Sotaro Sadahiro Toshiyuki Suzuki Akira Tanaka Kazutake Okada Hideki Nagase Junji Uchida | 2012 | Cancer Chemotherapy and Pharmacology2012，，2： | 1 |
| 16 | Structural anal- ysis and synthesis of oligosaccha-rides isolated from fermented bev- erage of plant extract显示文摘 | Hideki Okada Naoki Kawazoe Akira Yamamori | 2008 | Journal of Applied Glycoscience2008，55，： | 1 |
| 17 | Surgical treatment of an enormous aneurysmal portahepatic venous fistula: Report of a case显示文摘 | Akimitsu Miyauchi Setsuo Okada Tetsuaki Hashimoto Hisao Wakabayashi Takashi Maeba Satoshi Tanaka Hideki Hayashi | 1995 | Surgery Today1995，，9： | 1 |
| 18 | A clinicopathologic study of mucinous adenocarcinoma of the stomach显示文摘 | Hideki Kawamura Yukifumi Kondo Shohei Osawa Yasunori Nisida Kuniaki Okada Hiroyuki Isizu Takasi Uebayasi Manabu Takahasi Tunetake Hata | 2001 | Gastric Cancer2001，，2： | 1 |
| 19 | Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model显示文摘 | Kiyoshi Okada Hiroyuki Tanaka Ko Temporin Michio Okamoto Yusuke Kuroda Hisao Moritomo Tsuyoshi Murase Hideki Yoshikawa | 2009 | Experimental Neurology2009，，2： | 1 |
| 20 | Integrated genome-wide differentiation and association analyses identify causal genes underlying breeding-selected grain quality traits in japonica rice显示文摘Improving grain quality is a primary objective in contemporary rice breeding.Japanese modern rice breeding has developed two different types of rice,eating and sake-brewing rice,with different grain characteristics,indicating the selection of variant gene alleles during the breeding process.Given the critical importance of promptly and efficiently identifying genes selected in past breeding for future molecular breeding,we conducted genome scans for divergence,genome-wide association studies,and map-based cloning.Consequently,we successfully identified two genes,OsMnS and OsWOX9D,both contributing to rice grain traits.OsMnS encodes a mannan synthase that increases the white core frequency in the endosperm,a desirable trait for sake brewing but decreases the grain appearance quality.OsWOX9D encodes a grass-specific homeobox-containing transcription factor,which enhances grain width for better sake brewing.Furthermore,haplotype analysis revealed that their defective alleles were selected in East Asia,but not Europe,during modern improvement.In addition,our analyses indicate that a reduction in grain mannan content during African rice domestication may also be caused a defective OsMnS allele due to breeding selection.This study not only reveals the delicate balance between grain appearance quality and nutrition in rice but also provides a new strategy for isolating causal genes underlying complex traits,based on the concept of“breeding-assisted genomics”in plants. | Hideki Yoshida Satoshi Okada Fanmiao Wang Shohei Shiota Masaki Mori Mayuko Kawamura Xue Zhao Yiqiao Wang Naho Nishigaki Asako Kobayashi Kotaro Miura Shinya Yoshida Masaru Ikegami Akitoshi Ito Lin-Tzu Huang Yue-le Caroline Hsing Yoshiyuki Yamagata Yoichi Morinaka Masanori Yamasaki Toshihisa Kotake Eiji Yamamoto Jian Sun Ko Hirano Makoto Matsuoka | 2023 | Molecular Plant2023，16，9： | 0 |
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