|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | 高血糖、高血压及糖尿病视网膜病变的9年发病率:巴巴多斯眼病研究 | Leske M.C. Hennis A. 王大江 | 2005 | 世界核心医学期刊文摘(眼科学分册)2005，0，9： | 8 |
| 3 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 4 | “Isara400”超精密坐标测量机的设计与标定(英文)显示文摘介绍了Isara 400 3维超精坐标测量机标定的关键技术,包括平台标定和系统镜面台非垂直度标定。同时,提出了一种新的超精接触探针系统,给出了这种3维灵敏度探针的标定结果。 | Henny Spaan Ivo Widdershoven Rilpho Donker | 2011 | 光学精密工程2011，19，9： | 6 |
| 5 | General competencies of problem‐based learning (PBL) and non‐PBL graduates显示文摘 | Katinka J A HPrince Patrick W L JVan Eijs Henny P ABoshuizen Cees P MVan Der Vleuten Albert J J AScherpbier | 2005 | Medical Education2005，，4： | 5 |
| 6 | Mechanisms of temozolomide resistance in glioblastoma-a comprehensive review显示文摘Glioblastoma(GBM)is the most common primary malignant brain tumor in adults and has an exceedingly low median overall survival of only 15 months.Current standard-of-care for GBM consists of gross total surgical resection followed by radiation with concurrent and adjuvant chemotherapy.Temozolomide(TMZ)is the first-choice chemotherapeutic agent in GBM;however,the development of resistance to TMZ often becomes the limiting factor in effective treatment.While O6-methylguanine-DNA methyltransferase repair activity and uniquely resistant populations of glioma stem cells are the most well-known contributors to TMZ resistance,many other molecular mechanisms have come to light in recent years.Key emerging mechanisms include the involvement of other DNA repair systems,aberrant signaling pathways,autophagy,epigenetic modifications,microRNAs,and extracellular vesicle production.This review aims to provide a comprehensive overview of the clinically relevant molecular mechanisms and their extensive interconnections to better inform efforts to combat TMZ resistance. | Neha Singh Alexandra Miner Lauren Hennis Sandeep Mittal | 2021 | Cancer Drug Resistance2021，4，1： | 4 |
| 7 | Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas显示文摘AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic compounds.METHODS:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal cancer.Biopsies were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)reasons.After storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as substrates.RESULTS:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by histopathology.Enzyme activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the UGT.Analysis of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer patients.The means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for carcinomas.CONCLUSION:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range. | Harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters | 2013 | World Journal of Gastroenterology2013，19，36： | 3 |
| 8 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 9 | Static Analysis of Functionally Graded Sandwich Plates Using an Efficient and Simple Refined Theory显示文摘In this paper, a new displacement based high-order shear deformation theory is introduced for the static response of function-ally graded sandwich plate. Unlike any other theory, the number of unknown functions involved is only four, as against five in case of other shear deformation theories. The theory presented is variationally consistent, has strong similarity with classical plate theory in many aspects, does not require shear correction factor, and gives rise to transverse shear stress variation such that the transverse shear stresses vary parabolically across the thickness satisfying shear stress free surface conditions. Two common types of functionally graded sandwich plates, namely, the sandwich with functionally graded facesheet and homogeneous core and the sandwich with homogeneous facesheet and functionally graded core, are considered. Governing equations are derived from the principle of virtual displacements. The closed-form solution of a simply supported rectangular plate subjected to sinu-soidal loading has been obtained by using the Navier method. The validity of the present theory is investigated by comparing some of the present results with those of the classical, the first-order and the other higher-order theories. It can be concluded that the proposed theory is accurate and simple in solving the static bending behavior of functionally graded sandwich plates. | Hadj Henni ABDELAZIZ Hassen Ait ATMANE Ismail MECHAB Lakhdar BOUMIA Abdelouahed TOUNSI Adda Bedia El ABBAS | 2011 | Chinese Journal of Aeronautics2011，24，4： | 3 |
| 10 | 巴贝多眼科研究中9年期间糖尿病视网膜病变的发病率显示文摘Objective: To estimate the 9-year incidence of diabetic retinopathy (DR) in a population with the same ancestry as African Americans. Methods: Participants with diabetes mellitus and gradable photographs at the 9-year examination were evaluated (n=436). The incidences of minimum/moderate/severe DR,clinically significant macular edema (CSME),and sight threatening DR (severe DR plus CSME) were defined by the development of specific diabetic changes in persons without those conditions at baseline. Progression was defined as the development of severe/proliferative DR in persons with minimum/ moderate DR at baseline. Results: The 9-year DR incidence was 39.6% (38.0% for minimum,9.0% for moderate,and 2.6% for severe/proliferative DR). Incidence tended to increase with diabetes duration and treatment. Of persons with preexisting DR at baseline,8.2% progressed to proliferative DR. The CSME incidence was 8.7% ,and it increased with diabetes duration,accounting for most of the overall incidence of sight-threatening DR. Conclusions: The study provides new data on long-term incidence among persons of African origin. Results suggest a possible lower risk of severe/proliferative DR than in whites,while CSME incidence seems comparable or higher. The main component of sight-threatening DR was CSME,highlighting the importance of DR as a cause of vision loss in this population. | Leske M. C. Wu S. -Y. Hennis A. 曹绪胜(译) | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，2，6： | 2 |
| 11 | Nine-Year Incidence and Risk Factors for Pterygium in the Barbados Eye Studies显示文摘 | Barbara Nemesure Suh-Yuh Wu Anselm Hennis M. Cristina Leske | 2008 | Ophthalmology2008，，12： | 1 |
| 12 | Reaction kinetics of COz in aqueous 1-amino-2-propanol, 3-mino-l-propanol, and dimethylmonoethanolamine solutions in the temperature range of 298-313 K using the stopped-flow technique显示文摘 | Henni A Li J Tontiwachwuthikul P | 2008 | In- dustrial & Engineering Chemistry Research2008，47，7： | 1 |
| 13 | Oligosaeeharides of hyaluronan are potent activators of dentritie cells 显示文摘 | Termeer C Hennies J Voith V | 2000 | J Immunol2000，165，4： | 1 |
| 14 | Acquisition of Technological Capability inDevelopment:A Quantitative Case Study of Pakistan's Cap ital Goods Sector显示文摘 | HENNY R | 1997 | World Development1997，，2： | 1 |
| 15 | Corneal thickness and intraocular pressure in the Barbados eye studies显示文摘 | Nemesure B Wu SY Hennis A | 2003 | Arch Ophthalmol2003，121，： | 1 |
| 16 | Receptor binding Analgesia and antitussive potency of tramadol and other selected opioids显示文摘 | Hennis HH | 1988 | Arzneim Forsch Drug Res1988，38，： | 1 |
| 17 | Roel Dijksma Water flow and nitrate transport to a groundwater-fed stream in the Belgian-Dutch chalk region显示文摘 | Henny A J van Lanen | 1999 | Hydrology Processes1999，13，3： | 1 |
| 18 | Zinc exchange by blood cells in nearly physiologic standard conditions显示文摘 | Ton H. J. Naber Cornelis J. A. Hamer Wim J. M. Broek Hennie Roelofs | 1994 | Biological Trace Element Research (-)1994，，1： | 1 |
| 19 | General competencies of problem-base learning (PBL)and non-PBL graduates显示文摘 | Katinka JAH Prince Patrick WLJ van Eija Henny PA Boshuizen | 2005 | Medical Education2005，，39： | 1 |
| 20 | Hyperglycemia,blood Pressure,and the 9-year incidence of diabetic retinopathy显示文摘 | Wu SY Hennis A | 2005 | Ophthalmology2005，112，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员