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| 1 | Reconstruction of the spatial patterns of desert/loess boundary belt in North China during the Holocene显示文摘The desert/loess boundary belt is the transitional region between desert and loess, where aeolian sand and loess interlock in space and alternate in time. It, being seriously unstable in space-time, sensitive to climatic changes and with fragile ecological environment, is an ideal region for studying the global climate change. There are deposi-tional sequences of paleosol with sub-horizontal interbedded aeolian sand and loess, and the stratigraphical evidences show that there widely exist 3-4 layers paleosol in sand lands of northeastern China, 4-5 layers in Mu Us Sandy Land and Hunshandake Sandy Land, more than 4 layers in the Qinghai Lake region and the Gonghe Basin of Qinghai Province during the Holocene. These indicate that the desert has experienced several times of extending and compacting, along with which the desert/loess boundary belt vibrated. It possesses good coherence with global climate change and eustasy. The coherence shows that the monsoon change in East Asia is the primary driving | JIN Heling DONG Guangrong SU Zhizhu SUN Liangying | 2001 | Chinese Science Bulletin2001，46，12： | 15 |
| 2 | Cervical Cancer Screening Coverage — China, 2018–2019显示文摘What is already known about this topic?The World Health Organization set a 2030 target of 70%cervical cancer screening coverage for women aged 35–45 years.Coverage stood at 37%in China in 2015.What is added by this report?In 2018–2019,China’s cervical cancer screening coverage reached 43.4%in women aged 35–44 years and 36.8%in women aged 35–64 years.Screening coverage was still lower in rural areas as well as central and western regions;large variations existed across provincial-level administrative divisions.What are the implications for public health practice?National and local policy and financial support should be maintained for cervical cancer screening,along with more targeted health education and outreach efforts and strengthened accessibility of health services in the rural areas and central and western regions. | Mei Zhang Yijing Zhong Limin Wang Heling Bao Zhengjing Huang Zhenping Zhao Xiao Zhang Chun Li Kelly Liang Sun Jing Wu Xiaoying Zheng Linhong Wang | 2022 | China CDC weekly2022，4，48： | 11 |
| 3 | Millennial-scale evolution of Hunshandake Desert and climate change during the Holocene in Inner Mongolia,northern China显示文摘The Hunshandake Desert is located at the northern edge of the East Asian monsoon region,and its natural environment is sensitive to monsoonal changes.Geologic records suggest that desert evolution corresponding to climate change had experienced several cycles in the Holocene,and the evolutionary process can be distinguished by four dominant stages according to changing trends of the environment and climate.(1) Holocene Ameliorative Period(11.0-8.7 cal ka B.P.),when the desert area gradually shrank following an approaching warm-wet climate and strengthening summer monsoon.(2) Holocene Optimum(8.7-6.0 cal ka B.P.),when the majority of moving sand dunes were stabilized and vegetation coverage quickly expanded in a suitable warm-wet climate and a strong summer monsoon.(3) Holocene Multivariate Period(6.0-3.5 cal ka B.P.),during a low-amplitude desert transformed between moving and stabilized types under alternating functions of cold-dry with warm-wet climate,and winter monsoon with summer monsoon.(4) Holocene Decay Period(since 3.5 cal ka B.P.),when the desert area tended to expand along with a weakened summer monsoon and a dry climate. | HeLing Jin Liang Ying Sun Zhong Sun | 2010 | Research in Cold and Arid Regions2010，2，6： | 10 |
| 4 | Clinical features of seizures after cerebral venous sinus thrombosis and its effect on outcome among Chinese Han population显示文摘background and purpose Clinical features of epileptic seizures after cerebral venous sinus thrombosis(CVST)among Chinese patients are not known,and it is still controversial whether seizures would affect the outcome of CVST.Methods In a Chinese hospital-based study of consecutive patients with CVST between 2003 and 2015,we described the clinical features of seizures and determined the predictors of seizure onset using multivariable logistic regression analysis.We also compared the in-hospital case-fatality and short-term functional outcome(modified Rankin Scale(mRS)at discharge)in patients with versus without seizures using ordinal regression analysis.results Among 151 patients with CVST,52(34.4%)presented seizures,of which 42(80.8%)were generalised seizures.Male gender(OR 6.32,95% CI 2.06 to 19.35,p=0.001),motor deficits(OR 4.89,95% CI 1.52 to 15.68,p=0.008),intracerebral haemorrhage(OR 3.93,95% CI 1.16 to 13.26,p=0.027),cerebral infarction(OR 3.78,95% CI 1.15 to 12.36,p=0.029)and superior sagittal sinus thrombosis(OR 3.38,95% CI 91.16 to 9.86,p=0.026)were independent predictors for seizures.The overall in-hospital case-fatality rate was 2.0%(3/151),and 21(13.9%)had mRS>2 at discharge.Compared with patients without seizures,patients with seizures were more likely to have a worse outcome(p=0.02)at discharge,independent of age,gender,clinical presentation,clot burden and presence of parenchymal lesions.conclusions In Chinese Han patients,compared with patients without seizures,patients with seizures after CVST had a worse outcome.Risk factors such as male gender,paresis,parenchymal lesion and superior sagittal sinus thrombosis were independently associated with seizure onset after CVST.Generalised seizure was the main form of seizures after CVST,which was obviously different to seizures after strokes of arterial origin. | Hongyan Ding Yanan Xie Linxin Li Heling Chu Yuping Tang Qiang Dong Mei Cui | 2017 | Stroke & Vascular Neurology2017，2，4： | 8 |
| 5 | Holocene Moisture Variation Recorded by Aeolian Sand-Palaeosol Sequences of the Gonghe Basin, Northeastern Qinghai-Tibetan Plateau, China显示文摘The northeastern Qinghai-Tibetan Plateau(QTP) of China is located at the triple junction of the Asian winter and summer monsoons and the westerlies, where paleoclimatic evolution has an important scientific significance for recognizing the spatial-temporal pattern of Asian monsoons in the past and predicting environmental change in the future. Nevertheless, the framework of the Holocene moisture variation and related mechanisms remain controversial, owing to complex hydroclimatic conditions triggered by the landform of the large mountain-arid basin. Here, we employed geochemical proxies from typical aeolian sand-palaeosol sequences in the Gonghe Basin, northeastern QTP, together with Optically Stimulated Luminescence(OSL) dating, to reconstruct the pattern of effective moisture variation and associated mechanisms in this region. Our results indicate that the regional effective moisture was at its lowest until 9–8 ka, and approached a maximum during 8–4/3 ka of the middle Holocene. Afterwards, the climate became relatively dry in general, but with a transient humid interval around 2–1 ka. Our geochemical evidence indicates that the dry early Holocene probably can be attributed to a strong winter monsoon forced by remnant ice sheet, combined with the high evaporation caused by solar insolation. Also, shifts of humid-dry are closely linked to the Asian summer monsoonal strength and therefore the balance of evaporation-precipitation in the middle and late Holocene. Thus, the pattern of the Holocene effective moisture variation is characterized as the ‘monsoon model’ in a closed intermontane arid and semi-arid basin near the western Asian monsoonal limit. | LIU Bing ZHAO Hui JIN Heling CHEN Fahu | 2020 | Acta Geologica Sinica(English Edition)2020，94，3： | 7 |
| 6 | Geochemical weathering of aeolian sand and its palaeoclimatic implications in the Mu Us Desert,northern China,since the Late Holocene显示文摘In the semi-arid and arid regions of northern China,geochemical behavior of the aeolian deposit is closely related to climatic and environmental changes,which was used to reconstruct the past history of environmental evolution and possibly forcing mechanisms.However,the related result was still scarce due to the lack of detailed geochemical analysis results in the desert sediments.In the present study,we systematically analyzed the geochemical components and parameters of the paleo-aeolian sand dune and modern mobile sand deposits in the Mu Us Desert and discuss the climatic variation inferred from the paleo-aeolian sand dune during the past 4.2 ka BP.The results indicated that (1) geochemical composition of the sandy deposits were dominated by SiO_2,Al_2O_3 and Na_2O and the deposits probably originated from the widespread upper continental crust (UCC) and were formed by long-term weathering,transport and re-deposition;(2) these sandy deposits were subjected to weaker weathering or uneven weathering under cold and dry conditions,and had highly similar material sources and degrees of weathering and leaching in general;and (3) the direct OSL (Optically Stimulated Luminescence) dating ages and geochemical parameters from the palaeosol-aeolian sand dune indicated that the regional climate change experienced several typically cold and warm intervals.These intervals are 4.2,2.8 ka BP and Little Ice Age and Medieval Warm Period,which probably attributed to periodic variations of the Asian summer monsoonal strength and cold events of the northern Atlantic Ocean in low and high latitudes of the Northern Hemisphere.Our results suggest that the development of the sand dune in the Mu Us Desert provided a suitable archive for understanding the past local climatic change,which is linked to the global climatic change. | LIU Bing JIN Heling SUN Zhong ZHAO Shuang | 2016 | Journal of Arid Land2016，8，5： | 6 |
| 7 | Sedimentary characteristics of paleo-aeolian dune sands of Salawusu Formation in the Salawusu River Valley显示文摘在 Salawusu 河山谷的 Milanggouwan 节的 Salawusu 形成包括修理 paleo 、修理半的沙丘沙的 paleo 活动的沙丘沙,和 4 层的 7 层。他们的结构被观察了并且他们的谷物尺寸。 | OU Xianjiao LI Baosheng JIN Heling DONG Guangrong David Dian ZHANG WU Zheng WEN Xiaohao ZENG Lanhua OUYANG Chuntao YANG Yi LIU Yufei | 2008 | Journal of Geographical Sciences2008，18，2： | 6 |
| 8 | Vicissitude of Sogo Nur and environmental-climatic change during last 1500 years显示文摘Lakes in arid zone are sensitive to climatic changes. The lacustrine sediment sequence in Sogo Nur has well and truly recorded climatic events such as the Sui-Tang Dynasty Warm Period, the Song-Liao Dynasty Cold Period, the Medieval Warm Period, the Little Ice Age and the 20th Century Warm Period. Commonly, the climate in warm Periods was relatively humid,accordingly the lake area extended and water level rose, and vice versa. Apart from climatic change, human activity is also an important factor of influencing lake vicissitude, and they played the dominant role alternatively during different periods; the factor of climatic change predominated in historical period, while since the beginning of the 20th century the utilization of water resources by human has became decisive. | JIN Heling, XIAO Honglang, SUN Liangying, ZHANG Hong, SUN Zhong & LI XiaozeKey Laboratory of Desert and Desertification, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, China School of Resources and Environment, Lanzhou University, Lanzhou 730000, China | 2004 | Science China Earth Sciences2004，47，z1： | 6 |
| 9 | New views on age of the Salawusu Formation of Late Pleistocene in northern China显示文摘The Salawusu Formation in the Salawusu River basin of Inner Mongolia is a typical sequence of the Upper Pleistocene in northern China. However, there have been some different views about the division and age of stratigraphic facies since the establishment of the Salawusu Formation. According to the stratigraphic subdivision and dating of the Dishaogouwan section, it is thought that the fluviolacustrine-aeolian sand sequence from the Dishaogouwan section can be compared with loess, deep-sea deposit records and climatic fluctuations of glacial period. The Salawusu Formation of fluviolacustrine facies was formed in the last interglacial period from 140 to 70 ka BP, roughly corresponding to the fifth stage of deep-sea oxygen isotope, and developed in the same period as the palaeosol S1 on the Loess Plateau; the aeolian sand of the Chengchuan Formation was formed in the last glacial period from 70 to 10 ka BP, constituting the heteropic geological body along with the Malan Loess on the Loess Plateau; the | DONG Guangrong, SU Zhizhu and JIN Heling Institute of Desert Research , Chinese Academy of Sciences , Lanzhou 730000, China Xi an Laboratory of Loess and Quaternary Geology, Chinese Academy of Sciences , Xi’ an 710054, China Institute of Loess Plateau , Shanxi University, Taiyuan 030006, China | 1999 | Chinese Science Bulletin1999，44，7： | 5 |
| 10 | Breast Cancer Screening Rates Among Women Aged 20 Years and Above—China,2015显示文摘What is already known about this topic?Breast cancer is the most common cancer in women in China and around the world.By 2019,121 countries have instituted a national screening program as a secondary prevention measure for breast cancer.What is added by this report?Breast cancer screening rates in China were 18.9%in women aged 20 years and above,and 25.7%in women aged 35-64 years in 2015.The screening rate for women aged 20 years and above was significantly higher in urban areas than in rural areas(24.6%vs.15.0%),and in the eastern region than in the central and western regions(24.0%vs.15.1%and 15.3%). | Mei Zhang Yijing Zhong Heling Bao Zhenping Zhao Zhengjing Huang Xiao Zhang Chun Li Maigeng Zhou Limin Wang Jing Wu Xiaoying Zheng Linhong Wang | 2021 | China CDC weekly2021，3，13： | 5 |
| 11 | Discovery of Ordos Cretaceous dune rock and its significance显示文摘It has been found that there existed quite a large quantity of dune rocks in the red sandstone of the Zhidan Group of Ordos Cretaceous strata. Their sedimentary structure, grain size and micro-shape of sand grains show an obvious aeolian features. Both the temporal and spatial distribution and sedimentary characteristics of these dune rocks suggest that probably | Xiaoze Li Guangrong Dong Heling Jin Zhizhu Su Yuanping Wang | 1999 | Chinese Science Bulletin1999，44，22： | 5 |
| 12 | Relationship Between Hematoma Expansion Induced by Hypertension and Hyperglycemia and Blood-brain Barrier Disruption in Mice and Its Possible Mechanism:Role of Aquaporin-4 and Connexin43显示文摘We aimed to select an optimized hematoma expansion(HE)model and investigate the possible mechanism of blood-brain barrier(BBB)damage in mice.The results showed that HE occurred in the group with hypertension combined with hyperglycemia(HH-HE)from3 to 72 h after intracerebral hemorrhage;this was accompanied by neurological deficits and hardly influenced the survival rate.The receiver operating characteristic curve suggested the criterion for this model was hematoma volume expansion≥45.0%.Meanwhile,HH-HE aggravated BBB disruption.A protector of the BBB reduced HH-HE,while a BBB disruptor induced a further HH-HE.Aquaporin-4(AQP4)knock-out led to larger hematoma volume and more severe BBB disruption.Furthermore,hematoma volume and BBB disruption were reduced by multiple connexin43(Cx43)inhibitors in the wild-type group but not in the AQP4 knock-out group.In conclusion,the optimized HE model is induced by hypertension and hyperglycemia with the criterion of hematoma volume expanding≥45.0%.HH-HE leads to BBB disruption,which is dependent on AQP4 and Cx43. | Heling Chu Zidan Gao Chuyi Huang Jing Dong Yuping Tang Qiang Dong | 2020 | Neuroscience Bulletin2020，36，11： | 4 |
| 13 | A late Holocene winter monsoon record inferred from the palaeo-aeolian sand dune in the southeastern Mu Us Desert, northern China显示文摘Late Holocene;;winter monsoon;;palaeo-aeolian sand dune;;grain-size standard deviation model;;Mu Us | Bing Liu HeLing Jin Fan Yang | 2016 | Research in Cold and Arid Regions2016，8，5： | 4 |
| 14 | Aeolian Facies Belts in the Taklimakan Desert显示文摘At least at the beginning of the last glacial epoch, the facies belts of dune sand, sandy loam and loess formed by winds had existed in the Taklimakan desert and areas south of it. There were no appreciable changes in the NE and NW wind systems and their wind fqrces that deposited dune sand, sandy loam and loess in the global cold stage since the last glacial epoch (accordingly no marked shifts of the boundaries of these aeolian facies belts took place. In the global warm stage since then, the climate in the Taklimakan desert and areas south of it became warm and dry, resulting in ablation of substantial volumes of ice and snow in their surrounding mountains and thus forming alluvial and diluvial deposits in the region. The alluvial-diluvial actions, however, failed to change the general framework of aeolian facies belts. | Li Baosheng, Dong Guangrong, Zhang Jiasheng, Li Sen,Jin Heling, Chen Huizhong, Wen Xiangle, Wang Yao, Lanzhou Desert Research Institute, Chinese Academy of Sciences, Lamhou, Gansuand Zhu YizhiXi’an Open Laboratory of Loess and Quaternary Geology, Chinese Academy of Sciences, Xi’an, Gansu Fei Zhenbi | 1995 | Acta Geologica Sinica(English Edition)1995，69，3： | 4 |
| 15 | Geochemical evidences of dry climate in the Mid-Holocene in Gonghe Basin, northeastern Qinghai-Tibetan Plateau显示文摘Previous research on climatic change in the Mid-Holocene in China indicates that it was a warm and humid period, accompanied by stronger summer monsoons, and it is defined as the Megathermal in the Holocene, or the Holocene Optimum period. However, this conclusion is mainly directed at the monsoonal region in eastern China. In this research, we chose the Gonghe Basin in the northeastern Qinghai-Tibetan Plateau as the study area. Geochemical analysis of the profiles of paleosols and aeolian sand in the Santala area in the middle of the Gonghe Basin, along with OSL (optically stimulated luminescence) dating, indicates that the regional climate has experienced several warm-humid and cold-dry cycles since 11.8 ka. In particular, the Mid-Holocene (8.1-4.6 ka) was relatively cold and dry as evidenced by drastic fluctuations in chemical weathering degree and humidity, a higher aridity index, and sparse vegetation, accompanying increased winter monsoonal strength. In order to clarify whether this is an individual or local signal, we compared our geochemical analysis results with lake and peat records and aeolian deposits of the monsoonal boundary region. The results indicate that the climate deteriorated widely, with declines in temperature and moisture, in the Mid-Holocene in the modern monsoonal boundary zone. Furthermore, the duration of climate deterioration (relatively dry period) generally decreased from west to east in the aforementioned regions. Therefore, this dry phase in Gonghe Basin may be representative of dry events in Mid-Holocene in northern China. In addition, we discuss the reasons for this dry climate from several perspectives: (1) it probably can be attributed to a decline in summer monsoonal strength; (2) the regional evaporation loss (forced by high temperature) was not compensated by regional precipitation; (3) the thermal dynamic effect of the Qinghai-Tibetan Plateau. | Bing Liu HeLing Jin Zhong Sun ZhiZhu Su CaiXia Zhang | 2012 | Research in Cold and Arid Regions2012，4，6： | 2 |
| 16 | Identification of a small molecule activator of novel PKCs for promoting glucose-dependent insulin secretion显示文摘用为能影响 Golgi 形态学的小分子的一幅基于图象的屏幕,我们识别一个小分子, Sioc145,它能扩大 Golgi 分隔空间并且支持蛋白质分泌物。更重要地, Sioc145 加强以一种葡萄糖依赖者方式的胰岛素分泌物。我们证明 Sioc145 有选择地激活新奇蛋白质 kinase C (nPKCs;并且) 然而并非常规 PKC (cPKCs;,我和 II ) 在 INS-1E insulinoma 房间。相反, PMA, cPKCs 和 nPKCs 的非选择的使活跃之物,支持葡萄糖集中的胰岛素分泌物独立人士。而且,我们证明 Sioc145 和 PMA 在动摇显示出微分能力房间膜,并且建议 Sioc145 KATP 隧道下游地在放大小径支持胰岛素分泌物。在胰腺的小岛,有 Sioc145 的处理提高胰岛素分泌物的第二个阶段。近到血浆膜的增加的胰岛素小粒在 Sioc145 处理以后被观察。最后,到糖尿病的 GK 老鼠的 Sioc145 的管理增加他们的浆液胰岛素层次并且改进葡萄糖忍耐。一起,我们的研究经由有选择地激活 nPKCs 作为新奇葡萄糖依赖者 insulinotropic 混合物识别 Sioc145。 | Shuai Han Heling Pan Jianhua Zhang Li Tan Dawei Ma Junying Yuan Jia-Rui Wu | 2011 | Cell Research2011，21，4： | 2 |
| 17 | Runoff and nutrient losses in alfalfa(Medicago sativa L)production with tied-ridge-furrow rainwater harvesting on sloping land显示文摘Ridge-furrow rainwater harvesting(RFRH)is known to be effective in controlling water loss and soil erosion,and increasing soil moisture and crop yield in semiarid regions.However,it can cause water-logging,ridge overtopping,and harvest failure if not properly designed.A four consecutive-year field trial was carried out to assess the impacts of various slope gradients and tillage practices on soil moisture,runoff,sediment yield,associated soil nutrient losses,fodder yield,and water use efficiency(WUE)of alfalfa in the Loess Plateau,China.The trial adopted a split-plot design,taking slope gradient(5and 10)as main plot treatment and tillage practice(traditional tillage,open-ridging,and tied-ridging)as split-plot treatment,from 2015 to 2018.There were greater variations in runoff,sediment yield,and associ-ated soil nutrient losses than in fodder yield and WUE.Tied-ridging and open-ridging resulted in decreased runoff and reduced sediment transport and associated soil nutrient losses,and increased soil moisture,fodder yield,and WUE.Runoff,sediment transport,and associated soil nutrient losses inclined with increasing slope;while fodder yield and the WUE declined.For slopes of 5and 10,the average decrease in runoff,sediment yield,total nitrogen,total phosphorus,and organic matter losses for open-ridging were 47.7e56.2%,91.0e92.7%,90.4e93.1%,90.1e92.2%,and 88.9e90.2%,respectively,while these for tied-ridging were 62.4e68.4%,94.5e96.4%,93.6e95.5%,93.9e95.9%,and 93.0e94.9%,over 4 years as compared with traditional tillage.The mean annual runoff,sediment,total nitrogen,total phosphorus,and organic matter losses for slopes of 10were 1.31,1.96,1.87,1.99,and 1.64 times greater than the corresponding values for slopes of 5,respectively.The increase of fodder yield and WUE for open-ridging and tied-ridging was 40.1e45.6%and 16.0e17.5%,and 3.66e5.99 and 1.35e2.50 kg ha^(-1)mm^(-1),respectively,for slopes of 5and 10.The average fodder yield and WUE for slopes of 5were 1.19 and 1.23 times greater than corresponding values for slopes of 10,respectively.The disparities in fodder yield and WUE of alfalfa between slopes of 5and 10were not clear in dry years,but were evident in wet years.Tied-ridging was recommended for water and soil conservation,while open-ridging was recommended for increase of fodder yield and WUE of alfalfa.The implementation of RFRH in crop production should be evaluated by the use of a model in accordance with climatic conditions,soil type,and plant species. | Qi Wang Fuchun Li Xiaole Zhao Wucheng Zhao Dengkui Zhang Xujiao Zhou David JSample Xiaoyun Wang Qinglin Liu Xiaoling Li Guang Li Heling Wang Kai Zhang Jin Chen | 2022 | International Soil and Water Conservation Research2022，10，2： | 2 |
| 18 | Antimicrobial effect of irrigantcombinations within dentinal tubules显示文摘 | Heling I Chandler NP | 1998 | Int Endod J1998，31，1： | 1 |
| 19 | New anti-inflammatory therapies and targets for asthma and chronic obstructive pulmonary disease 显示文摘 | BELVISI MG HELE DJ BIRRELL MA | 2004 | Expert Opin Ther Targets2004，8，4： | 1 |
| 20 | Bactericidal and cytotoxic effects of sodium hypochlorite and sodium dichloroisocyanurate solutions iv vitro 显示文摘 | Heling I Rotstein I Dinur T | 2001 | J Endod2001，27，4： | 1 |
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