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| 1 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 2 | Doubly selective fading channel estimation in MIMO OFDM systems显示文摘High data transmission rates and high mobility give rise to time- and frequency-selectivity in wireless communication channels. This paper investigated time and frequency doubly selective channel estimation using pilot tones among Multi-Input Multi-Output (MIMO) orthogonal frequency division multiplexing (OFDM). Firstly, a complex exponential basis expansion channel model (BECM) was introduced to represent doubly selective channel during an OFDM symbol period; then, based on BECM, an effective MIMO-OFDM doubly selective channel estimation method was presented; finally, the optimality in designing pilot tones parameters was done according to the minimization of channel estimation MSE, mainly including the number, the placement and the structure of pilot tones. Simulation results show that the proposed estimation method has good performance in doubly selective channel scenarios and confirms the theoretical analysis findings. | YU Xiaoyan WANG Jiaqing YANG Luxi HE Zhenya | 2005 | Science in China(Series F)2005，48，6： | 4 |
| 3 | Extraction of palaeochannel information from remote sensing imagery in the east of Chaohu Lake, China显示文摘Palaeochannels 是 unconsolidated 沉积或在古老的、当前不活跃的河和流隧道系统里扔的巩固半的沉积岩石的存款。它从当前活跃的河隧道的 overbank 存款是不同的,包括定期不流动的短暂的水功课。我们介绍了一光谱从有特殊时间阶段的 SPOT-5 形象的基于特征的 palaeochannel 信息抽取模型,它被遥感机制的分析的优点造了并且光谱 palaeochannel 的特征,从空间分发与它的区别结合了并且光谱当前活跃的河隧道的特征,另外,随遥感判定的建立,在遥感的 palaeochannel 的特征想象。这个模型跟随监督分类的进程[箭头权利] 掩盖的农田和主要部件分析[箭头权利] 地下的 palaeochannel 信息抽取[箭头权利] 信息联合[箭头权利] palaeochannel 系统图象。在乔胡·莱克的东方的 Zhegao 河山谷作为一个学习区域被选择,并且 SPOT-5 形象被用作数据的来源。当这个方法成功地被使用了提取 palaeochannel 信息时,结果是令人满意的,它能为地区性的遥感考古学和 neotectonic 研究提供好参考。然而,这个方法的适用性需要作为空间特征在另外的区域进一步被测试并且光谱 palaeochannel 的反应可能是不同的[出版摘要] | Xinyuan WANG Zhenya GUO Li WU Cheng ZHU Hui HE | 2012 | Frontiers of Earth Science2012，6，1： | 4 |
| 4 | A Concept Discussion on Northeast Asia Power Grid Interconnection显示文摘Northeast Asia is one of world’s major economic and energy consumption centers.Countries in this region are undergoing rapid economic and social development,and energy security and greenhouse gas emission reduction have become prominent issues.In this region,clean energy resources including hydro,wind,and solar are concentrated in Russia,Mongolia,and Northeast China,whilst electricity load centers are in East China,Korea and Japan.Currently,an energy and electricity model has been developed to project electricity demand through 2030 for each country.Based on the idea of a Global Energy Interconnection,this article proposes to establish a Northeast Asia Grid Interconnection(NEAG),connecting Mongolia,China,Korea,Japan,and Russia with large volumes of transmission lines,in an effort to facilitate optimized resource allocation.The NEAG would be accomplished step by step along with identification of key interconnectors.China is set to play an important role in establishing the NEAG by providing a strong sending grid and necessary technological equipment.Tremendous economic,environmental,and social benefits are expected to be generated by the NEAG. | Zhenya Liu Gesong Chen Xiupeng Guan Qiankun Wang Wei He | 2016 | CSEE Journal of Power and Energy Systems2016，2，4： | 3 |
| 5 | CHAOTIC NEURAL NETWORK FOR ASSOCIATIVE MEMORY显示文摘Based on current research on applications of chaotic neuron network for information processing, the stability and convergence of chaotic neuron network are proved from the viewpoint of energy function. Moreover, a new auto-associative matrix is devised for artificial neural network composed of chaotic neurons, thus, an improved chaotic neuron network for associative memory is built up. Finally, the associative recalling process of the network is analyzed in detail and explanations of improvement are given. | Zhang Yifeng Yang Luxi He Zhenya(Department of Radio Engineering, Nanjing, 210018) | 1999 | Journal of Electronics(China)1999，16，2： | 1 |
| 6 | Extract rules from neural network by particle swarm optimization显示文摘 | He Zhenya Wei Chengjian Eberhart R C | 1998 | IEEE International Conference on Evolutionary Computation Anchorage Alaska USA1998，1998，： | 1 |
| 7 | Stability Analyzing of Chaotic Neural Network for Associative Memory显示文摘 | Zhang Yifeng He Zhenya We Chengjian | 2002 | IEEE Conference on Neural Networks2002，01，01： | 1 |
| 8 | A CROSS-REFERENCE METHOD OF PARAMETER ESTIMATION AND NOISE REDUCTION AND ITS APPLICATIONS显示文摘This paper proposes a cross-reference method of nonlinear time series analysis, combining the tasks of dynamical system parameter estimation and noise reduction which were fulfilled separately before. With the positive interaction between the two processing modules, the method is somewhat superior. Some prior works can be viewed as special cases of this general framework and effective new algorithms may be devised according to it. Two examples of chaotic time series analysis are also given to show the applicability of the proposed method. | Yang Luxi Chen Yang He Zhenya(Department of Radio Engineering, Southeast University, Nanjing 210096) | 1999 | Journal of Electronics(China)1999，16，3： | 1 |
| 9 | Blind Equalization of Nonlinear Communication Channels Using Recurrent Wavelet Neu- ral Networks 显示文摘 | He Shichun He Zhenya | 1997 | IEEE International Conference on Acousties Speech and Signal Processing Munich Ger- many1997，4，： | 1 |
| 10 | The theory and implementation of arbitrary-length linear - phase cosinemodulated filter bank 显示文摘 | GAO Xiqi HE Zhenya XIA Xianggen | 2000 | Signal Processing2000，80，： | 1 |
| 11 | Global exponential stability of delayed competitive neural networks with different time scales显示文摘 | Zhenya He | 2005 | Neural Networks2005，，18： | 1 |
| 12 | Robust time delay estimation of bioelectric signals using least absolute deviation neural network显示文摘 | Wang Zhiyue He Zhenya Chen Jiande | 2005 | IEEE Trans Biomedical Engineering2005，52，3： | 1 |
| 13 | Evolutionary Computation and its Application显示文摘On Mar. 23, 2006, a project in the Major Program of NSFC - 'Evolutionary computation and its application', managed by Prof. Licheng Jiao, Prof. Lishan Kang, Prof. Zhenya He, and Prof. Tao Xie, passed its Final Qualification Process and was evaluated as Excellent. | Licheng Jiao Lishan Kang Zhenya He Tao Xie | 2006 | Science Foundation in China2006，14，2： | 1 |
| 14 | Camera Calibration by Vanishing Point and Cross Ratio显示文摘 | Wei Guoqing He Zhenya Ma Song de | 1989 | Proc Ⅰ2 CASSP IEEE Int Conf Aooust Speech Signal Process1989，5，： | 1 |
| 15 | A sliding-exponential window RLS adaptive filtering algorithm:properties and applications显示文摘 | Liu Hanyu He Zhenya | 1995 | Signal Processing1995，，： | 1 |
| 16 | Blind source separation using clusterbased multivariate density estimation algorithm显示文摘 | He Zhenya Yang Luxi Liu Ju | 2000 | IEEE Trans on Signal Processing2000，48，2： | 1 |
| 17 | Blind source separation using cluster- based multivariate density estimation algorithm显示文摘 | He Zhenya Yang Luxi Liu Ju | 2000 | IEEE Trans on Signal Processing2000，48，2： | 1 |
| 18 | Blind separation by redundancy reduction in a recurrent neural network 显示文摘 | Nie Kaibao He Zhenya | 2001 | Chinese Journal of Electronics2001，10，3： | 1 |
| 19 | Blind separation of images using edge worth expansion based ICA algorithm 显示文摘 | Liu Ju Yang Luxi | 1999 | Chinese Journal of Electronics1999，8，3： | 1 |
| 20 | Transitional cell carcinoma of upper urinary tract vs. benign lesions: distinctive MSCT features显示文摘 | Jichen Wang He Wang Guangjian Tang Zhenya Hou Gang Wang | 2009 | Abdominal Imaging2009，，1： | 1 |
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