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| 1 | Quality Markers of Traditional Chinese Medicine:Concept,Progress,and Perspective显示文摘As the most important complementary medication against a variety of diseases,traditional Chinese medicines(TCMs)have been extensively applied over thousands of years.Current quality control of herbal medicines,however,is in great dispute.Unlike chemical drugs,which have clear and validated quality standards,the content of only one(or a few)compounds of many herbs and preparations is currently assessed as an indicator of quality,even though the assessed compound(s)is neither closely associated with the efficacy nor representative of the medicine as a whole.Based on the clinical use,compatibility of multiple component prescriptions,and manufacturing process of TCM,the new concept of a TCM quality marker that was proposed in previous work is discussed further here.In addition,practical technological approaches are described for the qualitative analysis and quantification of TCMs including herbs,processed products,and preparations,which lead to the discovery and identification of specific chemicals as quality markers and new quality control patterns.The progress that has been made in TCM quality control is also addressed.This work provides useful information for the quality control of herbal medicines in the future. | Yazhuo Li Ying Xie Yufei He Wenbin Hou Maoliang Liao Changxiao Liu | 2019 | Engineering2019，5，5： | 22 |
| 2 | Recent advances of wearable and flexible piezoresistivity pressure sensor devices and its future prospects显示文摘The human skin inspired soft electronic devices have attracted broadly research attention in the past decades as the promising potential applications in health monitoring and diagnosis,robotics,and prosthetics.The soft wearable piezoresistivity pressure sensor is one of the most attractive candidates for the development of advanced electronic skin for its simple mechanism,compact structure,low cost and power energy consumption and ease of signal acquisition and transforms advantages.In this review,we will explore the recent progress and achievements in the field of piezoresistivity pressure sensor,focusing on the fundamentals of the piezoresistivity pressure sensor and the materials related to the devices,including active materials,substrate materials,and electrode materials.Subsequently,the challenges and outlook are discussed.We list several current challenges perspectives on the development of pressure sensors.Several critical topics for the optimization of the sensitivity and working range of sensing devices toward practical applications are discussed.Finally,perspectives on the slip and force vectors sensors,the developing technologies for multi-function and high-resolution sensor systems and signals process technologies are examined to highlight the near future development tendency in piezoresistivity pressure sensor research field. | Jiang He Yufei Zhang Runhui Zhou Lirong Meng Tao Chen Wenjie Mai Caofeng Pan | 2020 | Journal of Materiomics2020，6，1： | 9 |
| 3 | Salivary mycobiome dysbiosis and its potential impact on bacteriome shifts and host immunity in oral lichen planus显示文摘The biodiversity of the mycobiome,an important component of the oral microbial community,and the roles of fungal–bacterial and fungal–immune system interactions in the pathogenesis of oral lichen planus (OLP) remain largely uncharacterized.In this study,we sequenced the salivary mycobiome and bacteriome associated with OLP.First,we described the dysbiosis of the microbiome in OLP patients,which exhibits lower levels of fungi and higher levels of bacteria.Significantly higher abundances of the fungi Candida and Aspergillus in patients with reticular OLP and of Alternaria and Sclerotiniaceae_unidentified in patients with erosive OLP were observed compared to the healthy controls.Aspergillus was identified as an “OLP-associated” fungus because of its detection at a higher frequency than in the healthy controls.Second,the co-occurrence patterns of the salivary mycobiome–bacteriome demonstrated negative associations between specific fungal and bacterial taxa identified in the healthy controls,which diminished in the reticular OLP group and even became positive in the erosive OLP group.Moreover,the oral cavities of OLP patients were colonized by dysbiotic oral flora with lower ecological network complexity and decreased fungal–Firmicutes and increased fungal–Bacteroidetes sub-networks.Third,several keystone fungal genera (Bovista,Erysiphe,Psathyrella,etc.) demonstrated significant correlations with clinical scores and IL-17 levels.Thus,we established that fungal dysbiosis is associated with the aggravation of OLP.Fungal dysbiosis could alter the salivary bacteriome or may reflect a direct effect of host immunity,which participates in OLP pathogenesis. | Yan Li Kun Wang Bo Zhang Qichao Tu Yufei Yao Bomiao Cui Biao Ren Jinzhi He Xin Shen Joy D.Van Nostrand Jizhong Zhou Wenyuan Shi Liying Xiao Changqing Lu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，3： | 8 |
| 4 | microRNAs-powerful repression comes from small RNAs显示文摘microRNAs (miRNAs) encode a novel class of small, non-coding RNAs that regulate gene expression post-trancriptionally. miRNAs comprise one of the major non-coding RNA families, whose diverse bio- logical functions and unusual capacity for gene regulation have attracted enormous interests in the RNA world. Over the past 16 years, genetic, biochemical and computational approaches have greatly shaped the growth of the field, leading to the identification of thousands of miRNA genes in nearly all metazoans. The key molecular machinery for miRNA biogenesis and silencing has been identified, yet the precise biochemical and regulatory mechanisms still remain elusive. However, recent findings have shed new light on how miRNAs are generated and how they function to repress gene expression. miRNAs provide a paradigm for endogenous small RNAs that mediate gene silencing at a genome-wide level. The gene silencing mediated by these small RNAs constitutes a major component of gene regu- lation during various developmental and physiological processes. The accumulating knowledge about their biogenesis and gene silencing mechanism will add a new dimension to our understanding about the complex gene regulatory networks. | MA Cong, LIU YuFei & HE Lin 535 LSA, Division of Cell and Developmental Biology, MCB Department, University of California at Berkeley, Berkeley, CA 94720-3200 | 2009 | Science China(Life Sciences)2009，52，4： | 7 |
| 5 | The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer显示文摘Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous cells1 that play crucial negative regulatory roles in immune-associated diseases,including infections,2 cancer,3 transplantation4,and autoimmunity.5 We and others have shown that mTOR signaling and its downstream metabolic pathways regulate MDSC recruitment and function in inflammation and autoimmunity. | Anna Jia Yuexin Wang Yufei Wang Yan Li Qiuli Yang Yejin Cao Ying He Lin Dong Yingjie Dong Yueru Hou Ruoning Wang Yujing Bi Guangwei Liu | 2021 | Cellular & Molecular Immunology2021，18，4： | 7 |
| 6 | Potential synergic mechanism of Wutou-Gancao herb-pair by inhibiting efflux transporter P-glycoprotein显示文摘Wutou-Gancao herb-pair is extensively used to attenuate the toxicity and enhance the efficacy of aconite.In this study,potential synergic mechanism of the herb pair was investigated by utilizing multiple ap-proaches.In silico and in vitro Caco-2 cell models were applied to study the potential binding mode of bioactive ingredients existing in liquorice with P-glycoprotein(P-gp),as well as the inhibition effects on P-gp.Additionally,anti-inflammatory activity of aconitine(AC)combined with active ingredients of liquorice,as well as pharmacokinetic patterns of AC after co-administration was investigated.Anti-inflammatory effect of AC(1 mg/kg)in rats was enhanced in combination with bioactive ingredients of liquorice(10 mg/kg).In the meanwhile,the exposure of AC in vivo was altered,in terms of Cmax and AUC.For instance,the Cmax and AUC were increased to 1.9 and 1.3 folds,respectively,when used in combination with liquiritigenin.The in silico study revealed the potential binding mode with outward facing conformation of P-gp.The resulting data obtained from transport of rhodamine-123(Rh-123)across Caco-2 cell monolayer further indicated that the function of P-gp was inhibited by chemicals in liquorice.The synergic effect was therefore proposed to be attributed to inhibition of P-gp by liquorice since AC has been demonstrated to be the substrate of P-gp.The resuls revealed that potential synergic mechanism of Wutou-Gancao herb-pair by inhibiting function of key efflux transporter P-gp to enhance the exposure of AC in systematic circulation,and further the anti-inflammatory effect,which helps clarify the compatibility rationale of these two herbs. | Yufei He Zihong Wei Ying Xie Xiulin Yi Yong Zeng Yazhuo Li Changxiao Liu | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 5 |
| 7 | Modeling of fast charging station equipped with energy storage显示文摘The popularization of EVs(electric vehicles) has brought an increasingly heavy burden to the development of charging facilities. To meet the demand of rapid energy supply during the driving period, it is necessary to establish a fast charging station in public area. However, EVs arrive at the charging station randomly and connect to the distribution network for fast charging, it causes the grid power to fluctuate greatly and the peak-valley loads to alternate frequently, which is harmful to the stability of distribution network. In order to reduce the power fluctuation of random charging, the energy storage is used for fast charging stations. The queuing model is determined to demonstrate the load characteristics of fast charging station, and the state space of fast charging station system is described by Markov chain. After that the power of grid and energy storage is quantified as the number of charging pile, and each type of power is configured rationally to establish the random charging model of energy storage fast charging station. Finally, the economic benefit is analyzed according to the queuing theory to verify the feasibility of the model. | Yu Zhang Yang He Xudong Wang Yufei Wang Chen Fang Hua Xue Chaoming Fang | 2018 | Global Energy Interconnection2018，1，2： | 5 |
| 8 | V_r:A new index to represent the variation rate of geomagnetic activity显示文摘By calculating the hourly standard deviation of the first-order differences of the horizontal geomagnetic component minute data,a new index Vr to represent the variation rate of the geomagnetic field was introduced.Vr-indices show similar trends in the temporal change at different observatories and have simultaneous peak values at the observatories covering a large span geographically,which reveals that the source of geomagnetic disturbances represented by Vr is in the magnetosphere.Based on the comparison among Vr,Kp and ap,it is found that generally Vr changes linearly with Kp and ap,which means that the rapid changes of magnetic field usually exist together with magnetic disturbances.But there are exceptions.As Vr can be easily produced by individual observatory in quasi real time and is more sensitive to the variation rate of geomagnetic field rather than the field itself,it can be expected to serve for monitoring or predicting the geomagnetic-induced event in a quick and intuitive way. | Dongmei Yang Yufei He Chuanhua Chen Jiadong Qian | 2010 | Earthquake Science2010，23，4： | 4 |
| 9 | Electrolyte for lithium protection: From liquid to solid显示文摘Lithium battery with high energy density and enhanced safety is undoubtedly the ideal choice for consumer electronics and electric vehicles.Metal anode such as lithium has been considered as the most effective way to enhance the energy density as it provides ultra-high theoretical capacity and the lowest redox potential.However,due to the low coulombic efficiency as well as safety concerns originated from dendrite issue of lithium,its further commercial utilization is hindered.Dendrite growth is a common phenomenon in metal electrodeposition while the plating process of Li is more complicated than other metals for its high reactivity nature.As a matter of fact,the Li plating process is accompanied with the generation of solid electrolyte interphase(SEI)in which the electrolyte plays a vital role.In this paper,recent advances of electrolytes for Li protect application are reviewed,from liquid to gel polymer and solid state,on which we find that although tremendous progress has been accomplished,there are still great challenges before Li metal anode could be commercially used. | Xiaohong Wu Kecheng Pan Mengmin Jia Yufei Ren Hongyan He Lan Zhang Suojiang Zhang | 2019 | Green Energy & Environment2019，4，4： | 4 |
| 10 | China Antihypertensive Trial in Acute Ischemic Stroke II (CATIS-2): rationale and design显示文摘Backgrounds Increased blood pressure(BP)for patients who had an acute ischaemic stroke is associated with poor functional outcome,however the optimal timing of antihypertensive therapy is unknown.Aims We aim to compare early antihypertensive treatment to delayed antihypertensive treatment for reducing the risk of composite major disability and mortality at 3 months in acute ischaemic stroke.Design The China Antihypertensive Trial in Acute Ischemic Stroke II(CATIS-2)trial is a multicentre,randomised,open-label,blinded-endpoints trial that will be conducted in 100 hospitals in China.The primary outcome is the composite of death and major disability(modified Rankin Scale score≥3)at 3 months of randomisation.Antihypertensive treatment will be received immediately after randomisation in the early treatment group,aimed at average systolic BP by 10%-20%reduction within the first 24 hours,and achieving an average BP level of<140/90 mm Hg within 5 days.Patients in the delayed treatment group will discontinue any antihypertension medications for the first 7 days of randomisation,and will receive antihypertensive therapy achieving a BP goal of<140/90 mm Hg after 7 days.Conclusion The CATIS-2 trial will be testing the hypotheses that early BP lowering leads to improved functional outcome without any other harms,and developing clinical guidelines of the BP management for patients who had an acute ischaemic stroke. | Liping Liu Yilong Wang Xuewei Xie Dacheng Liu Aili Wang Penglian Wang Suwen Shen Chongke Zhong Yufei Wei Tan Xu Yuesong Pan Yong Jiang Xia Meng David Wang Yonghong Zhang Jiang He Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 11 | RNA-Seq Study Reveals AP2-Domain-Containing Signalling Regulators Involved in Initial Imbibition of Seed Germination in Rice显示文摘A number of internal signals are required for seed germination.However,the precise signalling responses in the initial imbibition of seed germination are not yet fully understood in rice.In this study,the RNA sequencing(RNA-Seq)approach was conducted in 8 h imbibed seeds to understand the signalling responses in the initial imbibition of rice seed germination.A total of 563 differentially expressed genes(DEGs)with at least 4-fold change were identified in 8 h imbibed seeds compared to dry seeds.MapMan analysis revealed that the majority of signalling response-related DEGs were hormone-and transcription factor-related genes,in which the largest number of DEGs belong to the AP2-domain-containing regulators,and their expressions were significantly induced in the initial imbibition of seed germination in rice.Moreover,at least five AP2-domain-containing transcription factor OsDREBs were identified in the initial imbibition of rice seed germination,and the expressions of 251 DEGs were putatively regulated by OsDREBs through the dehydration-responsive element(DRE)cis-element assay.It suggested that the OsDREBs might play important roles in the regulation of initial seed imbibition in rice.The identified genes provide a valuable resource to study the signalling regulation of seed germination in the future. | HE Yongqi ZHAO Jia FENG Defeng HUANG Zhibo LIANG Jiaming ZHENG Yufei CHENG Jinping YING Jifeng WANG Zhoufei | 2020 | Rice science2020，27，4： | 2 |
| 12 | Discovery of carbon-based strongest and hardest amorphous material显示文摘Carbon is one of the most fascinating elements due to its structurally diverse allo tropic forms stemming from its bonding varieties(sp,sp^(2)and sp^(3)).Exploring new forms of carbon has been the eternal theme of scientific research.Herein,we report on amorphous(AM) carbon materials with a high fraction of sp^(3)bonding recovered from compression of fullerene C_(60) under high pressure and high temperature,previously unexplored.Analysis of photoluminescence and absorption spectra demonstrates that they are semiconducting with a bandgap range of 1.5-2.2 eV,comparable to that of widely used AM silicon.Comprehensive mechanical tests demonstrate that synthesized AM-Ⅲ carbon is the hardest and strongest AM material known to date,and can scratch diamond crystal and approach its strength.The produced AM carbon materials combine outstanding mechanical and electronic properties,and may potentially be used in photovoltaic applications that require ultrahigh strength and wear resistance. | Shuangshuang Zhang Zihe Li Kun Luo Julong He Yufei Gao Alexander V.Soldatov Vicente Benavides Kaiyuan Shi Anmin Nie Bin Zhang Wentao Hu Mengdong Ma Yong Liu Bin Wen Guoying Gao Bing Liu Yang Zhang Yu Shu Dongli Yu Xiang-Feng Zhou Zhisheng Zhao Bo Xu Lei Su Guoqiang Yang Olga P.Chernogorova Yongjun Tian | 2022 | National Science Review2022，9，1： | 2 |
| 13 | A novel chemiluminescence method for determination of terbutaline sulfate based on potassium ferricyanide oxidation sensitized by rhodamine 6G 显示文摘 | Yi Lv Zhujun Zhang Yufei Hu Deyong He Shuhua He | 2003 | Journal of Pharmaceutical and Biomedical Analysis2003，32，3： | 1 |
| 14 | Partial hy- drogenation of acetylene using highly stable dispersed bi- metallic Pd-Ga/MgO-A1203 catalyst 显示文摘 | HE Yufei LIANG Linlin LIU Yanan | 2014 | Journal of Ca- talysis2014，309，： | 1 |
| 15 | A Chance Constrained Optimal Reserve Scheduling Approach for Economic Dispatch Considering Wind Penetration显示文摘The volatile wind power generation brings a full spectrum of problems to power system operation and management, ranging from transient system frequency fluctuation to steady state supply and demand balancing issue. In this paper, a novel wind integrated power system day-ahead economic dispatch model, with the consideration of generation and reserve cost is modelled and investigated. The proposed problem is first formulated as a chance constrained stochastic nonlinear programming(CCSNLP), and then transformed into a deterministic nonlinear programming(NLP). To tackle this NLP problem, a three-stage framework consists of particle swarm optimization(PSO), sequential quadratic programming(SQP) and Monte Carlo simulation(MCS) is proposed. The PSO is employed to heuristically search the line power flow limits, which are used by the SQP as constraints to solve the NLP problem. Then the solution from SQP is verified on benchmark system by using MCS. Finally, the verified results are feedback to the PSO as fitness value to update the particles. Simulation study on IEEE30-bus system with wind power penetration is carried out, and the results demonstrate that the proposed dispatch model could be effectively solved by the proposed three-stage approach. | Yufei Tang Chao Luo Jun Yang Haibo He | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，2： | 1 |
| 16 | Controllable synthesis, structure, and catalytic activity of highly dis- persed Pd catalyst supported on whisker-modified spheri- cal alumina 显示文摘 | LI Yang FENG Junting HE Yufei | 2012 | Ind Eng Chem Res2012，51，11： | 1 |
| 17 | Variations of electron density and temperature in ionosphere based on the DEMETER ISL data显示文摘Observations of the Langmuir Probe Instrument(ISL,Instrument Sonde de Langmuir) onboard the DEMETER satellite during four years from 2006 to 2009 were used to analyze the tempo-spatial variations of electron density(Ne) and temperature(Te) in the ionosphere.Twenty four research bins with each covering an area with 10° in longitude and 2° in latitude were selected to study the spatial distributions of Ne and Te.The results indicate that both Ne and Te have strong annual variations in the topside ionosphere at 660 km altitude.The semiannual anomaly and equinoctial asymmetry which are usually well known as the features of F-layer also exist in the topside ionosphere at low-and mid-latitudes.The yearly variation of Ne is opposite to the peak electron density of the F2-layer(NmF2) at higher latitudes in daytime and both are similar in nighttime.Also the yearly variations of Te at low-latitude are contrary to that at 600 km in daytime and similar in nighttime.An interesting feature of nighttime Te at low-latitude is an obvious annual variation in the northern hemisphere and semiannual variation in the southern hemisphere.The yearly variations of Te in daytime have negative and positive correlation with Ne at mid-and high-latitudes,respectively.Both Ne and Te in the neighborhood bins at the same latitude have a high correlation.In ionospheric events analyzing,this information may help to understand the characteristics of the variation and to distinguish the reliable abnormality from the normal background map. | Yufei He Dongmei Yang Rong Zhu Jiadong Qian M Parrot | 2010 | Earthquake Science2010，23，4： | 1 |
| 18 | The spatial distribution of nitrogen removal functional genes in multimedia biofilters for sewage treatment 显示文摘 | Ji Guodong He Chunguang Tan Yufei | 2013 | Ecological Engineering2013，55，： | 1 |
| 19 | The PtoTCP20-miR396d-PtoGRF15 module regulates secondary vascular development in Populus显示文摘Secondary vascular development is a key biological characteristic of woody plants and the basis of wood formation.Our understanding of gene expression regulation and dynamic changes in microRNAs(miRNAs)during secondary vascular development is still limited.Here we present an integrated analysis of the miRNA and mRNA transcriptome of six phase-specific tissues-the shoot apex,procambium,primary vascular tissue,cambium,secondary phloem,and secondary xylem-in Populus tomentosa.Several novel regulatory modules,including the PtoTCP20-miR396d-PtoGRF15 module,were identified during secondary vascular development in Populus.A series of biochemical and molecular experiments confirmed that PtoTCP20 activated transcription of the miR396d precursor gene and that miR396d targeted PtoGRF15 to downregulate its expression.Plants overexpressing miR396d(35S:miR396d)showed enhanced secondary growth and increased xylem production.Conversely,during the transition from primary to secondary vascular development,plants with downregulated PtoTCP20expression(PtoTCP20-SRDX),downregulated miR396 expression(35S:STTM396),and PtoGRF15 overexpression(35S:PtoGRF15)showed delayed secondary growth.Novel regulatory modules were identified by integrated analysis of the miRNA and mRNA transcriptome,and the regulatory role of the PtoTCP20-miR396d-PtoGRF15 signaling cascade in secondary vascular development was validated in Populus,providing information to support improvements in forest cultivation and wood properties. | Lingyan Wang Jie Hou Huimin Xu Yufei Zhang Runzhou Huang Donghui Wang Xin-Qiang He | 2023 | Plant Communications2023，4，2： | 1 |
| 20 | Heat-treated glassy carbon under pressure exhibiting superior hardness,strength and elasticity显示文摘Glassy carbon(GC)is a type of non-graphitizing disordered carbon material at ambient pressure and high temperatures,which has been widely used due to its excellent mechanical properties.Here we report the changes in the microstructure and mechanical properties of GC treated at high pressures(up to 5 GPa)and high temperatures.The formation of intermediate sp2-sp3 phases is identified at moderate treatment temperatures before the complete graphitization of GC,by analyzing synchrotron X-ray diffraction,Raman spectra,and transmission electron microscopy images.The intermediate metastable carbon materials exhibit superior mechanical properties with hardness reaching up to 10 GPa and compressive strength reaching as high as 2.5 GPa,nearly doubling those of raw GC,and improving elasticity and thermal stability.The synthesis pressure used in this study can be achieved in the industry on a commercial scale,enabling the scalable synthesis of this type of strong,hard,and elastic carbon materials. | Meng Hu Shuangshuang Zhang Bing Liu Yingju Wu Kun Luo Zihe Li Mengdong Ma Dongli Yu Lingyu Liu Yufei Gao Zhisheng Zhao Yoshio Kono Ligang Bai Guoyin Shen Wentao Hu Yang Zhang Ralf Riedel Bo Xu Julong He Yongjun Tian | 2021 | Journal of Materiomics2021，7，1： | 1 |
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