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| 1 | Alzheimer's Disease and Methanol Toxicity (Part 2): Lessons from Four Rhesus Macaques (Macaca mulatta) Chronically Fed Methanol显示文摘 | Meifeng Yang Junye Miao Joshua Rizak Rongwei Zhai Zhengbo Wang Tanzeel Huma Ting Li Na Zheng Shihao Wu Yingwei Zheng Xiaona Fan Jianzhen Yang Jianhong Wang Shangchuan Yang Yuanye Ma Longbao Lü Rongqiao He Xintian Hu | 2014 | Journal of Alzheimer's Disease2014，，4： | 1 |
| 2 | Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder显示文摘Obsessive-compulsive disorder(OCD)is a chronic and debilitating psychiatric disorder that affects∼2%–3%of the population globally.Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder.In large rhesus monkey colonies,we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors(SMBs)in individual-specific sequences that were repetitive,time-consuming and stable over prolonged periods.Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans.Brain imaging showed that monkeys with SMBs had larger gray matter(GM)volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum.The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs.Notably,exposure to a stressor(human presence)significantly increased SMBs.In addition,fluoxetine,a serotonergic medication commonly used for OCD,decreased SMBs in these monkeys.These findings provide a novel foundation for developing better understanding and treatment of OCD. | Rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei Xiaocheng Zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan Zhang Yaqiu Tang Minghui Jin Yuxian Zhang He Li Zhi Yang Guan Ning Lin Dan JStein Zhi-Qi Xiong Zhen Wang | 2023 | National Science Review2023，10，11： | 1 |
| 3 | Projective spectrum and kernel bundle显示文摘For a tuple A=(A_1,A_2,…,A_n) of elements in a unital algebra B over C,its projective spectrum P(A) or p(A) is the collection of z∈C^n,or respectively z∈P^(n-1),such that A(z)=z_1A_1+z_2A_2+…+z_nA_n is not invertible in Β.The first half of this paper proves that if B is Banach then the resolvent set P^c(A) consists of domains of holomorphy.The second half computes the projective spectrum for the generating vectors of a Clifford algebra.The Chern character of an associated kernel bundle is shown to be nontrivial. | HE Wei YANG RongWei | 2015 | Science China Mathematics2015，58，11： | 1 |
| 4 | Unsymmetrical oxovanadium complexes derived from salieylaldehyde and phenanthroline : synthesis, DNA interactions, and antitumor activities 显示文摘 | LIAO Xiangwen PAN Weijian HE Rongwei | 2014 | Bio Drug Des2014，83，3： | 1 |
| 5 | On unitary equivalence of compact operator tuples显示文摘For a compact operator tuple A, if its projective spectrum P(A*) is smooth, then there exists a natural Hermitian holomorphic line bundle EAover P(A*) which is a unitary invariant for A. This paper shows that under some additional spectral conditions, EAis a complete unitary invariant, i.e., EAcan determine the compact operator tuple up to unitary equivalence. | Wei He Rongwei Yang | 2023 | Science China Mathematics2023，66，3： | 0 |
| 6 | Consensus on diagnostic criteria for Yin deficiency syndrome in hypertension:a modified Delphi study显示文摘OBJECTIVE:To reach consensus on the diagnostic criteria for Yin deficiency syndrome in hypertension(YDSH)patients by a modified Delphi method.METHODS:Our study was consistent with T/CACM 1032-2017.The methodology of RAND/UCLA appropriateness was used to develop consensus guidance statements.A nationwide panel of experienced clinical experts from 19 provinces was constructed.These experts were all prominent in Traditional Chinese Medicine(TCM)of cardiovascular diseases.This consensus process consisted of two rounds of questionnaires and a final round of consultation to analyze the weight score of each item.Moreover,the data extraction process is carried out independently by third-party researchers(LIANG Junya,SUN Yang,and DU Xiaona).When there is disagreement in all three rounds,the expert panel group(odd number)are invited to vote,and the one with more votes wins.In the questionnaires,participants were asked to rate the appropriateness of each syndrome item using a nine-point Likert scale.The consensus was defined as a panel median rating 1-3 or 7-9 without disagreement.And then the diagnostic criteria of YDSH were formed according to the weight score in the final round.RESULTS:Twenty-eight experts(84.8%)participated in the first round,and thirty-one(93.9%)finished the second round.After two rounds,the consensus of YDSH was reached on 11 items(25.6%),including symptoms,signs,and pulse condition.Twenty-one experts(63.6%)completed the final round in which they used a grading system for each item.Red tongue with scanty fur had the highest weighting(22.8%),followed by heat in the palms and soles(20.1%).CONCLUSIONS:The consensus-based diagnostic criteria for YDSH,formed by a modified Delphi method,can be widely incorporated in TCM.A further clinical study will be conducted to analyze the diagnosis value and cut-off score of our YDSH criteria. | HE Yun HE Jing XU Xiangru LI Haixiao SHI Rongwei LIANG Junya ZHOU Ying ZHU Yao CHEN Xiaohu TANG Shuhua XIAO Min ZHAN Libin PEI Yinghao JIANG Weimin | 2023 | Journal of Traditional Chinese Medicine2023，43，1： | 0 |
| 7 | Measurements of the concentration of organic solutions by femtosecond time-resolved ERE-CARS显示文摘A variant of all-resonant CARS named electronic-resonant enhancement CARS(ERE-CARS) is applied to measure the methanol-water solution concentration at room temperature.The measurements are performed using the ERE-CARS signal of the Raman vibrations near the C-H stretching modes(at 2835 and 2942 cm 1) in methanol.By changing the timing(t>0) of the laser pulses of this non-degenerate four wave mixing technique,the concentration information based on the vibrational dynamics of the C-H bonds can be successfully detected as the frequency-spread dephasing rate during the first few hundred fs in the ERE-CARS signal with high sensitivity and accuracy.Femtosecond time-resolved ERE-CARS technique is applied to the concentration analysis of a mixture of the organic solution.This investigation indicates that femtosecond time-resolved ERE-CARS technique might be a powerful tool for real-time detection for solution concentration of different liquids. | HE Ping WANG Ming WANG HuiLi FAN RongWei CHEN DeYing YU Xin WANG JiaLing JIANG YuGang | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，10： | 0 |
| 8 | Terahertz beats of vibrational modes in methanol and ethanol selectively excited by tr-CARS technique显示文摘A recently developed time-resolved coherent anti-Stokes Raman scattering(tr-CARS) technique allows the measurement of vibrational coherences with high frequency differences with the ambient environment.The method is based on the short spatial extension of femtosecond pulses with a broadband tunable nonlinear optical parametric amplifier(NOPA) and an internal time delay between the probe and pump/Stokes pulse pair in the CARS process.The different beat frequencies between Raman modes can be selectively detected as oscillations in the tr-CARS transient signal with the broadband tunable NOPA.In this work,we aim at the Raman C-H stretching vibrations from 2800 cm 1 to 3000 cm 1,within which the different vibrational modes in both ethanol and methanol are selectively excited and simultaneously detected.The high time resolution of the experimental set-up allows one to monitor the vibrational coherence dynamics and to observe the quantum beat phenomena on a terahertz scale.This investigation indicates that the femtosecond tr-CARS technique is a powerful tool for the real-time monitoring and detection of molecular and biological agents,including airborne contaminants such as bacterial spores,viruses and their toxins. | HE Ping WANG HuiLi FAN RongWei CHEN DeYing XIA YuanQin YU Xin WANG JiaLing JIANG YuGang | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 0 |
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