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| 1 | Geologic characteristics, controlling factors and hydrocarbon accumulation mechanisms of China’s Large Gas Provinces of low porosity and permeability显示文摘Based on the analysis of the geological characteristics and controlling factors, we analyzed the formation mechanism of different types of gas reservoirs. The main characteristics of gas provinces with low porosity and permeability are mainly as follows: large area, low abundance, small gas pools and large gas provinces; widely distributed excellent hydrocarbon source rocks with closely contacted source-reservoir-cap association; development mainly in large continental depressions or in paralic shallow-river delta systems; many kinds of traps coexisting in large areas, dominantly para-layered lithologic, digenetic and capillary pressure traps; double fluid flow mechanisms of Darcy flow and non-Darcy flow; complicated gas and water relations; and having the resource distribution of highly productive 'sweet spots', banding concentration, and macroscopically large areas integrated. The main controlling factors of large sandstone gas provinces with low porosity and permeability are stable dynamic backgrounds and gentle structural frameworks which control the extensive distribution of alternate (interbedded) sandstones and mudstones; weak hydropower of large gentle lake basins controlling the formation of discontinuous, low porosity and permeability reservoirs in shallow-water deltas; regionally differential diagenesis and no homogeneous digenetic facies controlling the development of favorable reservoirs and digenetic traps; and weak and dispersive reservoir-forming dynamic forces leading to the widely distributed small traps with low abundance. Low porosity and permeability gas provinces with different trap types have different formation mechanisms which include fluid diversion pressure difference interactive mechanism of lithologic-trap gas accumulations, separated differential collection mechanism of digenetic-trap gas accumulations, and the Non-Darcy flow mechanism of capillary-pressure gas accumulations. | ZOU CaiNeng TAO ShiZhen ZHANG XiangXiang HE DongBo ZHOU ChuanMin GAO XiaoHui | 2009 | Science China Earth Sciences2009，52，8： | 22 |
| 2 | G protein-coupled receptor 183 facilitates endothelial-to- hematopoietic transition via Notch1 inhibition显示文摘 | Panpan Zhang Qiuping He Dongbo Chen Weixiao Liu Lu Wang Chunxia Zhang Dongyuan Ma Wei Li Bing Liu Feng Liu | 2015 | Cell Research2015，25，10： | 7 |
| 3 | LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration显示文摘The adult mammalian heart is thought to be a terminally differentiated organ given the postmitotic nature of cardiomyocytes.Consequently,the potential for cardiac repair through cardiomyocyte proliferation is extremely limited.Low-density lipoprotein receptor-related protein 6(LRP6)is a Wnt co-receptor that is required for embryonic heart development.In this study we investigated the role of LRP6 in heart repair through regulation of cardiomyocyte proliferation.Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal,juvenile and adult mice.Cardiomyocyte-specific deletion of Lrp6 in the mouse heart induced a robust regenerative response after myocardial infarction(MI),led to reduced MI area and improvement in left ventricular systolic function.In vivo genetic lineage tracing revealed that the newly formed cardiomyocytes in Lrp6-deficient mouse hearts after MI were mainly derived from resident cardiomyocytes.Furthermore,we found that the pro-proliferative effect of Lrp6 deficiency was mediated by the ING5/P21 signaling pathway.Gene therapy using the adeno-associated virus(AAV)9 miRNAi-Lrp6 construct promoted the repair of heart injury in mice.Lrp6 deficiency also induced the proliferation of human induced pluripotent stem cell-derived cardiomyocytes(iPSC-CMs).Our study identifies LRP6 as a critical regulator of cardiomyocyte proliferation,which may lead to the development of a novel molecular strategy to promote myocardial regeneration and repair. | Yahan Wu Liping Zhou Hongyu Liu Ran Duan Huixing Zhou Fulei Zhang Xiaoyu He Dongbo Lu Ke Xiong Maolin Xiong Jinzhu Zhuang Yi Liu Li Li Dandan Liang Yi-Han Chen | 2021 | Cell Research2021，31，4： | 5 |
| 4 | Theory, technology and prospects of conventional and unconventional natural gas显示文摘The development of natural gas in China has entered a golden and leap-forward stage, which is a necessary bridge to clean energy. This in-depth study on the status quo, theory, technology and prospect of natural gas development shows:(1) The global remaining proven recoverable reserves of natural gas are 186×1012 m3, and the reserves-production ratio is 52.4, indicating a solid resource base for long-term and rapid development.(2) Ten formation and distribution laws of conventional and unconventional natural gas reservoirs have been proposed. In terms of exploration geology, the theory of conventional 'monolithic' giant gas fields with different gas sources, and an unconventional gas accumulation theory with continuous distribution of 'sweet areas' in different lithologic reservoirs have been established; in terms of development geology, a development theory of conventional structural gas reservoirs is oriented to 'controlling water intrusion', while a development theory of unconventional gas is concentrated on man-made gas reservoirs.(3) With the geological resources(excluding hydrates) of 210×1012 m3 and the total proven rate of the resources less than 2% at present, the natural gas in China will see a constant increase in reserve and production; by 2030, the proven geological reserves of natural gas are expected to reach about(6 000-7 000)×108 m3, the production of conventional and unconventional natural gas each will reach about 1 000×108 m3, and the gas consumption will reach 5 500×108 m3. The dependence on imported natural gas may be 64% by 2030, and 70% by 2050.(4) Ten measures for future development of natural gas have been proposed, including strengthening exploration in large-scale resource areas, increasing the development benefits of unconventional gas, and enhancing the peak adjusting capacity of gas storage and scale construction of liquified natural gas. | ZOU Caineng YANG Zhi HE Dongbo WEI Yunsheng LI Jian JIA Ailin CHEN Jianjun ZHAO Qun LI Yilong LI Jun YANG Shen | 2018 | Petroleum Exploration and Development2018，45，4： | 4 |
| 5 | Abundant Production of Reactive Water Radical Cations under Ambient Conditions显示文摘Water radical cations,the crucial intermediates in many aqueous reactions and biochemical processes,are difficult to investigate experimentally due to their short lifetime andlowabundance.Herein,ahomemade device based on energy-tunable discharge was employed to deposit suitable amounts of energy to atmospheric pressure pure water vapor for abundant production of water radical cations,stabilized as(H_(2)O)n^(+·)(n=2-5)with a maximal abundance of≥8.3×10^(6) cps for(H_(2)O)_(2)^(+·),characterized by mass spectrometry(MS).The abundance of water radical cations was optimized by adjusting the experimental parameters such as the discharge voltage(2.5 kV),temperature of the MS inlet(140℃),carrier gas flow(20mL/min),and the distance between the discharge tip and MS inlet(12 mm).The ambient formation of water radical cationswas further confirmedby thehigh reactivity of as-prepared water radical cations,which reacted with benzene,ethyl acetate,and dimethyl disulfide instantly,showing rich chemistry with ionic and radical characteristics.Moreover,the computations usingCCSD(T)//MP2 method and density functional theory confirmed that the O-O single-electron bound dimer(B),as well as the hydronium hydroxyl radical complex(A),accounted for the unusual chemistry of the water radical cations,providing a facile approach to access the high reactivity ofwater radical cations under the ambient conditions. | Meng Wang Xiao-Fei Gao Rui Su Peng He Yuan-Yuan Cheng Ke Li Dongbo Mi Xiaoping Zhang Xinglei Zhang Huanwen Chen R.Graham Cooks | 2022 | CCS Chemistry2022，4，4： | 3 |
| 6 | Characteristics and development model of karst reservoirs in the fourth member of Sinian Dengying Formation in central Sichuan Basin,SW China显示文摘The reservoir space,types and distribution characteristics of karst carbonate gas reservoirs in the fourth member of Sinian Dengying Formation(Deng 4 Member)in central Sichuan Basin are analyzed based on the drilling,logging and seismic data.A development model of karst reservoirs is constructed to support the high-efficiency development of gas pools.The research shows that the reservoirs in Deng 4 Member have mainly small-scale karst vugs and fractures as storage space,and can be divided into three types,fracture-vug,pore-vug and pore types.The development patterns of the karst reservoirs are determined.On the plane,the karst layers increase from 65 m to 170 m in thickness from the karst platform to the karst slope,and the high-quality reservoirs increase from 25.0 m to 42.2 m in thickness;vertically,the reservoirs at the top of Deng 4 Member appear in multiple layers,and show along-bedding and along fracture dissolution characteristics.The reservoirs at the bottom are characterized by the dissolution parallel to the water level during the karstification period,and have 3-5 large-scale fracture-cave systems.Based on the reservoir development characteristics and the genetic mechanism,three types of reservoir development models of karst reservoir are established,i.e.,bed-dissolved body,fracture-dissolved body and paleohorizon-dissolved body.The construction of karst reservoir development models and seismic response characteristics of the three types of reservoirs can provide parameter for well placement and trajectory design,and substantially improve productivity and development indices of individual wells and gas reservoirs.The designed production capacity of the gas reservoir has enhanced from the initial 3.6 billion to 6 billion cubic meters,making the profit of the reservoir development increase noticeably. | YAN Haijun HE Dongbo JIA Ailin LI Zhiping GUO Jianlin PENG Xian MENG Fankun LI Xinyu ZHU Zhanmei DENG Hui XIA Qinyu ZHENG Guoqiang YANG Shan SHI Xiaomin | 2022 | Petroleum Exploration and Development2022，49，4： | 1 |
| 7 | Fine Mapping of Xa2, a Bacterial Blight Resistance Gene in Rice显示文摘 | Qi He Dongbo Li Yongsheng Zhu Mingpu Tan Duanpin Zhang Xinghua Lin | 2006 | Molecular Breeding2006，，1： | 1 |
| 8 | Rate decline analysis of multiple fractured horizontal well in shale reservoir with triple con tinuum显示文摘 | Wang Junlei Yan Cunzhang Jia Ailin He Dongbo Wei Yunsheng Qi Yadong | 2014 | Journal of Central South University2014，21，： | 1 |
| 9 | The establishment of a new deliverability equation considering threshold pressure gradient显示文摘The flowing mechanism of a low permeability gas reservoir is different from a conventional gas reservoir,especially for that with higher irreducible water saturation the threshold pressure gradient exists. At present,in all the deliverability equation,the additional pressure drop caused by the threshold pressure gradient is viewed as constant,but this method has big error in the practical application. Based on the non-Darcy steady flow equation,the limited integral of the additional pressure drop is solved in this paper and it is realized that the additional pressure drop is not a constant but has something to do with production data,and a new deliverability equation is derived,with the relevant processing method for modified isochronal test data. The new deliverability equation turns out to be practical through onsite application. | Li Lezhong Li Xiangfang He Dongbo Xu Hanbing | 2009 | Engineering Sciences2009，7，3： | 1 |
| 10 | Generation of Hematopoietic Stem Cells from Purified Embryonic Endothelial Cells by a Simple and Efficient Strategy显示文摘Recent progress by versatile approaches supports the new hypothesis that multi-potent hematopoietic stem cells(HSCs) are directly formed from a rare population of endothelial cells in mid-gestation mouse embryos.This process is therefore known as the endothelial-tohematopoietic transition(EHT).Nevertheless,there is no functional evidence that documents the HSC transition from purified endothelial cells.In this study,we developed an OP9-DL1-based co-culture system that was able to facilitate the HSC specification and/or expansion in vitro of mouse embryonic day 10.5(E10.5) Tie2^+ cells remarkably.Then,the immunophenotypically defined endothelial cells were harvested by a combination of surface markers(Flk1^+CD31^+CD41^-CD45^-Ter119^-) from the caudal half of E10.0-E11.0 mouse cmbryos.The transplantation of the endothelia/OP9-DL1 co-cultures led to long-term,high-level,multi-lineage,and multi-organ hematopoietic reconstitution in the irradiated adult recipients.The induced HSC activity was initially observed at E10.5,and a significant increase was detected at E11.0,which suggests a temporally specific regulation.Taken together,for the first time,we provide functional evidence showing the HSC potential of purified embryonic endothelial cells,which is indispensable for the emerging EHT concept. Moreover,the newly defined co-culture system will aid the exploration of the key molecules governing the HSC transition from embryonic and even postnatal endothelial cells,which has enormous significance in basic and translational research. | Zhuan Li Fan Zhou Dongbo Chen Wenyan He Yanli Ni Lingfei Luo Bing Liu | 2013 | Journal of Genetics and Genomics2013，40，11： | 1 |
| 11 | 邻近腋窝的上皮样血管内皮瘤1例报道(英文)显示文摘We described a case of a 71-year-old woman with an epithelioid hemangioendothelioma (EHE) in her left axilla,a rare location which hasn’t been reported yet.The patient suffered from numbness,pain and decreased muscle strength of her left upper extremity. Sonography revealed a hypoechoic mass surrounded the axillary artery and brachial artery. No obvious capsule was demonstrated.CT showed a soft-tissue mass with some calcifications and peripheral ring-like enhancement. The MRI indicated a mass with mainly intermediate signal intensity on T1-weighted imagine and intermediate signal intensity on T2-weighted imagine. The diagnosis was confirmed by histopathologic examination after surgery. There are some correlations of these imaging features with its histopathologic characters. | Jie Zhang Yi Wang Xianghui He Ning Lu Dongbo Xu | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，6： | 0 |
| 12 | GEOCHEMISTRY STUDY OF GOLD SILVER DEPOSITS IN THE MIDDLE UPPER PROTEROZOIC SUBERATHEM IN SOUTHERN QINLING METALLOGENETIC ZONE显示文摘According to Ihe combinations of mctallogcnetic elements and minerals assemblages,the Au-Ag deposits in the Middle-Upper Proterozoic Suberathcm of the middle of northern margin of Yangtze Platform could be classified into four types,(l)Au-Ag-Pb-Zn type,(2)Au-Ag-Te type,(3)Au-quartz vein type,(4)Au-Ag-Pb-Zn-Ba type.The Yangpin formation and the upper Dangyuhe subformation,which belong to Wudangshan group,are regarded as favorable strata for Au-Ag mineralization by systematic assessments for Au-Ag bearing ability of the strata,as well as the felsic rocks of Bikou group.The mctallogcnetic physicochemical conditions and the stable isotopic compositions(S.Pb,H.O,C)have been studied in this paper.The sources of metallogenetic materials,origins of fluids and genesis of various deposits have also been studied. | Wang Dongbo He Xuefeng(Translated) | 1992 | Transactions of Nonferrous Metals Society of China1992，2，3： | 0 |
| 13 | Hepatocyte nuclear factor 1A suppresses innate immune response by inducing degradation of TBK1 to inhibit steatohepatitis显示文摘Non-alcoholic steatohepatitis(NASH),a progressive form of non-alcoholic fatty liver disease(NAFLD),is characterised by chronic liver inflammation,which can further prog-ress into complications such as liver cirrhosis and NASH-associated hepatocellular carcinoma(HCC)and therefore has become a growing health problem worldwide.The type I interferon(IFN)signaling pathway plays a pivotal role in chronic inflammation;however,the molecular mechanisms underlying NAFLD/NASH from the perspective of innate immune response has not yet been fully explored.In this study,we elucidated the mechanisms of how innate im-mune response modulates NAFLD/NASH pathogenesis,and demonstrated that hepatocyte nu-clear factor-1alpha(HNF1A)was suppressed and the typeⅠIFN production pathway was activated in liver tissues of patients with NAFLD/NASH.Further experiments suggested that HNF1A negatively regulates the TBK1-IRF3 signaling pathway by promoting autophagic degra-dation of phosphorylated-TBK1,which constrains IFN production,thereby inhibiting the activa-tion of type I IFN signaling.Mechanistically,HNF1A interacts with the phagophore membrane protein LC3 through its LIR-docking sites,and mutations of LIRs(LIR2,LIR3,LIR4,and LIRs)block the HNF1A-LC3 interaction.In addition,HNF1A was identified not only as a novel autop-hagic cargo receptor but also to specifically induce K33-linked ubiquitin chains on TBK1 at Lys670,thereby resulting in autophagic degradation of TBK1.Collectively,our study illustrates the crucial function of the HNF1A-TBK1 signaling axis in NAFLD/NASH pathogenesis via cross-talk between autophagy and innate immunity. | Jinyong He Cong Du Xuyun Peng Weilong Hong Dongbo Qiu Xiusheng Qiu Xingding Zhang Yunfei Qin Qi Zhang | 2023 | Genes & Diseases2023，10，4： | 0 |
| 14 | Oxidization characteristics and thermal miscible flooding of high pressure air injection in light oil reservoirs显示文摘Physical modeling,numerical simulation and field case analysis were carried out to find out the subsurface thermal oxidation state,thermal oxidation front characteristics and production dynamic characteristics of high pressure air injection thermal oxidation miscible flooding technology.The lighter the composition and the lower the viscosity of the crude oil,the lower the fuel consumption and the combustion temperature are.The thermal oxidation front of light oil and volatile oil can advance stably,and a medium-temperature thermal oxidation stable displacement state can be formed in the light oil reservoir under high pressure conditions.With strong thermal gasification and distillation,light oil and volatile oil are likely to form a single phase zone of gasification and distillation with thermal flue gas at the high-temperature and high-pressure heat front,finally,an air-injection thermal miscible front.In light oil reservoirs,the development process of high-pressure air-injection thermal miscible flooding can be divided into three stages:boosting pressure stage,low gas-oil ratio and high-efficiency stable production stage and high gas-oil ratio production stage.Approximately 70%of crude oil is produced during the boosting pressure stage and low gas-oil ratio high-efficiency and stable production stage. | XI Changfeng WANG Bojun ZHAO Fang LIU Tong QI Zongyao ZHANG Xialin TANG Junshi JIANG Youwei GUAN Wenlong WANG Hongzhuang HE Dongbo SONG Xinmin HUA Daode ZHANG Xiaokun | 2022 | Petroleum Exploration and Development2022，49，4： | 0 |
| 15 | Discussion on the limit recovery factor of carbon dioxide flooding in a permanent sequestration scenario显示文摘Based on practices of CO_(2) flooding tests in China and abroad,the recovery factor of carbon dioxide capture,utilization in displacing oil and storage(CCUS-EOR)in permanent sequestration scenario has been investigated in this work.Under the background of carbon neutrality,carbon dioxide injection into geological bodies should pursue the goal of permanent sequestration for effective carbon emission reduction.Hence,CCUS-EOR is an ultimate development method for oil reservoirs to maximize oil recovery.The limit recovery factor of CCUS-EOR development mode is put forward,the connotation differences between it and ultimate recovery factor and economically reasonable recovery factor are clarified.It is concluded that limit recovery factor is achievable with mature supporting technical base for the whole process of CCUS-EOR.Based on statistics of practical data of CO_(2) flooding projects in China and abroad such as North H79 block CO_(2) flooding pilot test at small well spacing in Jilin Oilfield etc.,the empirical relationship between the oil recovery factor of miscible CO_(2) flooding and cumulative CO_(2) volume injected is obtained by regression.Combined with the concept of oil production rate multiplier of gas flooding,a reservoir engineering method calculating CO_(2) flooding recovery factor under any miscible degree is established by derivation.It is found that when the cumulative CO_(2) volume injected is 1.5 times the hydrocarbon pore volume(HCPV),the relative deviation and the absolute difference between the recovery percentage and the limit recovery factor are less than 5%and less than 2.0 percentage points respectively.The limit recovery factor of CCUS-EOR can only be approached by large pore volume(PV)injection based on the technology of expanding swept volume.It needs to be realized from three aspects:large PV injection scheme design,enhancing miscibility degree and continuously expanding swept volume of injected CO_(2). | LIAO Guangzhi HE Dongbo WANG Gaofeng WANG Liangang WANG Zhengmao SU Chunmei QIN Qiang BAI Junhui HU Zhanqun HUANG Zhijia WANG Jinfang WANG Shengzhou | 2022 | Petroleum Exploration and Development2022，49，6： | 0 |
| 16 | Breeding and Cultivation Techniques for New Edible Orange-Fleshed Sweet Potato Variety Nanshu 012显示文摘The carotenoid in sweet potato has a high health value for the human body,and Harvest Plus has also carried out the breeding to improve the nutritional quality of sweet potatoes in order to address the health problems of people nutrient-deficient areas.Nanshu 012 is a new high-quality orange-fleshed sweet potato variety rich in carotenoid,bred by Nanchong Academy of Agricultural Sciences from the ' Boga × Sanheshu' hybrid.In the regional test of sweet potato varieties in Sichuan Province during 2009-2010,the average fresh potato yield was 24600 kg/ha,the average dry matter percentage was 29.0 % and the average preserved sweet potato yield was 7152.0 kg/ha;in the production test,the average fresh potato yield was 28410.0 kg/ha and the average preserved sweet potato yield was 8734.5 kg/ha.The multi-point sampling analysis showed that the total sugar content of fresh potato was 5.28 %,protein content was 1.43 %,vitamin C content was 28.9 mg/100 g and carotenoid content was 5.21 mg/100 g.This variety was identified by Sichuan Crop Variety Approval Committee in March 2012,with high fresh potato yield,sweetness,rich carotenoid and resistance to black spot.It is an orange-fleshed sweet potato variety suitable for eating and food processing,and it should be planted in the plot with moderate fertility or above,and should be planted and harvested as early as possible. | Mingshuang TANG Lisha LIU Quanlu ZHOU Yingdong HUANG Sulan HE Sheng LI Dongbo LI Hongqing ZHU Mei WANG Yujuan ZHANG Yuming LI | 2017 | Asian Agricultural Research2017，9，8： | 0 |
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