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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Loading rate dependence of class II rock behaviour in uniaxial and triaxial compression tests-an application of a proposed new control method显示文摘 | OKUBO S NISHIMATSU Y HE C R | 1990 | International Journal of Rock Mechanics and Mining Sciences and Geomechanics Abstracts1990，27，6： | 1 |
| 4 | Energetics of charged point defects in rutile TiO2 by density functional theory显示文摘 | LI X FINNIS M W HE J BEHERA R K PHILLPOT S R SINNOTT S B DICKEY E C | 2009 | Acta Materialia2009，57，： | 1 |
| 5 | Evolution of pore fractal dimensions for burning porous chars 显示文摘 | He R Xu X C Chen C H | 1998 | Fuel1998，77，： | 1 |
| 6 | Modification of membrane surface for anti-biofouling performance: Effect of anti-adhesion and anti-bacteria approaches显示文摘 | Liu C X Zhang D R He Y | 2010 | J Membr Sci2010，346，1： | 1 |
| 7 | Radiation enhances the invasiveness of irradiated amt nonirradiated bystander hepatoma cells through a VEGF-MMP2 pathway initiated by p53 显示文摘 | He M Dong C Ren R | 2013 | Radiat Res2013，180，： | 1 |
| 8 | Modification of membrane surface for anti-biofouling performance:Effect of anti-adhesion and anti-bacteria approaches显示文摘 | Liu C X Zhang D R He Y | 2010 | Journal of Membrane Science2010，346，1： | 1 |
| 9 | Trends and challenges in soil research2009:Linking global climate change to local long-team forest productivity显示文摘 | XU Z H CHEN C R HE J | 2009 | Soil Sediments2009，9，： | 1 |
| 10 | Effects of a purified sap-onin miture from alfalfa on plasma lipid metabolism in hyperlipidemic mice 显示文摘 | Yu C H Xie G He R R | 2011 | Journal of Health Science2011，57，5： | 1 |
| 11 | Viral genome phylogeny based on Lempel-Ziv complexity and Haus- dorff distance 显示文摘 | YU C LUCY HE R YAU S S-T | 2014 | Journal of theoretical biology2014，348，： | 1 |
| 12 | Regeneration of full-scale commercial honeycomb monolith catalyst(V2O5-WO3/Ti O2)used in coal-fired power plant显示文摘 | SHANG X S HU G R HE C | 2012 | J Ind Eng Chem2012，18，51： | 1 |
| 13 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 14 | Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction显示文摘 | Paczynski R P He Y Y Diringer M N Hsu C Y | 1997 | Stroke1997，28，： | 1 |
| 15 | Oleic acid coating on the monodisperse magnetite nanoparticles显示文摘 | Zhang L He R Gu H C | 2006 | Appl Surf Sci2006，253，5： | 1 |
| 16 | Modeling char combustion with fractal pore effects显示文摘 | He R Sato J Chen C | 2002 | Combust Sci and Tech2002，174，： | 1 |
| 17 | Effects of a purified saponin mixture from alfalfa on plasma lipid metabolism in hyperlipi- demic miee显示文摘 | Yu C H Xie G He R R etal | 2011 | Journal of Health Science2011，57，5： | 1 |
| 18 | Synthesis of ethylene carbonate from supercritical carbon dioxide/ethylene oxide mixture in the presence of bifunctional catalyst显示文摘 | Lu X B He R Bai C X | | 0，，： | 1 |
| 19 | Using the LANDIS model to evaluate forest harvesting and planting strategies under possible warming climates in Northeaster显示文摘 | Bu R C He H S Hu Y M | 2008 | Forest Ecology and Management2008，254，： | 1 |
| 20 | Functional characterization of the switchgrass (Panicum virgatum ) R2R3-MYB transcription factor PvMYB4 for improvement of lignocellulosic feedstocks 显示文摘 | SHEN H HE X Z POOVA1AH C R | 2012 | New Phytol2012，193，1： | 1 |
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