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| 1 | Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution显示文摘AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHODS: Steatotic livers were preserved for 24 h in IGL-1 solution supplemented with or without IGF-1 and then perfused 'ex vivo ' for 2 h at 37℃. We examined the effects of IGF-1 on hepatic damage and function (transaminases, percentage of sulfobromophthalein clearance in bile and vascular resistance). We also studied other factors associated with the poor tolerance of fatty livers to cold ischemia reperfusion injury such as mitochondrial damage, oxidative stress, nitric oxide, tumor necrosis factor-α (TNF-α) and mitogen-activated protein kinases.RESULTS: Steatotic livers preserved in IGL-1 solutionsupplemented with IGF-1 showed lower transaminase levels, increased bile clearance and a reduction in vascular resistance when compared to those preserved in IGL-1solution alone. These benefits are mediated by activation of AKT and constitutive endothelial nitric oxide synthase (eNOS), as well as the inhibition of inflammatory cytokines such as TNF-α. Mitochondrial damage and oxidative stress were also prevented.CONCLUSION: IGL-1 enrichment with IGF-1 increasedfatty liver graft preservation through AKT and eNOS activation, and prevented TNF-α release during normothermic reperfusion. | Mohamed Amine Zaouali Susagna Padrissa-Altés Ismail Ben Mosbah Hassen Ben Abdennebi Olivier Boillot Antoni Rimola Dalila Saidane-Mosbahi Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，45： | 6 |
| 2 | Phenolic constituents,anti-oxidant and antimicrobial activities of rosy garlic显示文摘 | Dziri S Hassen I Fatnassi S | | 0，，04： | 1 |
| 3 | Molecular features of new Peach Latent Mosaic Viroid variants suggest that recombination may have contributed to the evolution of this infectious RNA显示文摘 | Massart S Motard J | 2007 | Virology2007，360，： | 1 |
| 4 | Cytotoxicity, inhibition of DNA and protein syntheses and oxidative damage in cultured cells exposed to zearalenone显示文摘 | Abid-Essefi S Ouanes Z Hassen W ct al | 2004 | Toxicology in Vitro2004，18，4： | 1 |
| 5 | Production of energy from concent rated brines by pressure retarded osmosisⅡ: Experimental results and projected energy costs显示文摘 | Loeb S Hassen F V Shahaf D | 1976 | Membr Sci1976，，1： | 1 |
| 6 | Direct transcriptional regulation of BIM by FoxO3a mediates STI571-induced apoptosis in BCR-ABL expressing cells显示文摘 | ESSAFI A FERNANDEZ DE MATTOS S HASSEN Y A | 2005 | Oncogene2005，24，： | 1 |
| 7 | Cytotoxicity,inhibition of DNA and protein syntheses and oxidative damage in cultured cells exposes to zearalenone显示文摘 | Abid-Essfi S Ouanes Z Hassen W | 2004 | Toxicology in Vitro2004，18，： | 1 |
| 8 | MicroRNAs 146a and 147b Biomarkers for Colorectal Tumor’s Localization显示文摘 | Inés Omrane Nadia Kourda Nejla Stambouli Maud Privat Imen Medimegh Amira Arfaoui Nancy Uhrhammer Karim Bougatef Olfa Baroudi Hassen Bouzaienne Raja Marrakchi Yves-Jean Bignon Amel Benammar-Elgaaied Peng Zhang | 2014 | BioMed Research International2014，，： | 1 |
| 9 | Breast elas- ticity:principles,technique,results:an update and overview of commercially available software 显示文摘 | Balleyguier C Canale S Ben Hassen W | 2013 | Eur J Radiol2013，82，2： | 1 |
| 10 | Resistance of alginate-coatedsomatic embryos of canot to dessication and freezing in fiquidnitrogen:1-Effects of preculture显示文摘 | Dereuddre J Blandin S Hassen N | 1991 | Cryo-Letters1991，，12： | 1 |
| 11 | PSO based opti- mized fuzzy controllers for decoupled highly interacted distil lation process显示文摘 | Hassen T D Ahmed M E G Mohamed E E S | 2012 | Ain Shams Engineering Journal2012，3，3： | 1 |
| 12 | Transient thermal creep of concrete in accidental conditions at temperatures up to 400℃ 显示文摘 | Hassen S Colina H | 2006 | Magazine of Concrete Research2006，58，4： | 1 |
| 13 | DNA fragmentation, apoptosis and cell cycle arrest induced by zearalcnone in cultured DOK, Veto and Caco- 2 cells: prevention by Vitamin E显示文摘 | Abid - Essefi S Baudrimont I Hassen W | 2003 | Toxicology2003，192，23： | 1 |
| 14 | Cytotoxieity, inhibition of DNA and protein syntheses and oxidative damage in cultured cells exposed to zearalenone显示文摘 | Abid- Essefi S Ouanes Z Hassen W | 2004 | Toxicol In Vitro2004，18，4： | 1 |
| 15 | DNA fragmentation,apoptosis and cell cycle arrest induced by zearalenone in cultured DOK,Vero and Caco-2 cells:prevention by vitaminE显示文摘 | Abid-Essefi S Baudrimont I Hassen W | 2003 | Toxiology2003，192，23： | 1 |
| 16 | Preventive role of phyllosilicate clay on the Immunological and Biochemical toxicity of zearalenone in Balb/c mice显示文摘 | Samir Abbès Jalila Ben Salah-Abbès Zouhour Ouanes Zohra Houas Omar Othman Hassen Bacha Mosaad A. Abdel-Wahhab Ridha Oueslati | 2006 | International Immunopharmacology2006，，8： | 1 |
| 17 | Transient thermal creep of concrete in accidental conditions at temperatures up to 400C 显示文摘 | Hassen S Colina H | 2006 | Magazine of Concrete Research2006，58，4： | 1 |
| 18 | The use of alamar Blue assay for quantitative analysis of viability, migration and invasion of choriocarcinoma cells 显示文摘 | A1-Nasiry S Geusens N Hassens M | 2006 | Human Reproduction2006，22，5： | 1 |
| 19 | Optimal operation of residential energy hubs in smart grids显示文摘 | Bozchalui M C Hashmi S A Hassen H | 2012 | IEEE Transactions on Smart Grid2012，3，4： | 1 |
| 20 | Forage quality characterization of a chemically induced brown-midrib mutant in pead millet显示文摘 | Chemey J H Axtell J D Hassen M M Anliker K S | 1988 | Crop Sci1988，28，： | 1 |
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