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| 1 | 中国华北、华南陆块碰撞时代的钐-钕同位素年龄证据显示文摘本文报道了秦岭-大别山造山带的C型榴辉岩Sm-Nd同位素年龄(243.9±5.6Ma),和镁铁-超镁铁岩Sm-Nd同位素年龄(230.6±30.7Ma和40.62±17.4Ma)。这些年龄表明中国华北、华南地块在三叠纪初期就沿秦岭-大别山碰撞带连接在一起了。在两地块最后碰撞以前,在古生代,有一系列蛇绿岩套仰冲事件沿华北地块南缘向外逐次发生。 | 李曙光 S. R. Hart 郑双根 郭安林 刘德良 张国伟 | 1989 | 中国科学(B辑)1989，，3： | 168 |
| 2 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 3 | 北秦岭拉圾庙苏长辉长岩的痕量元素和Sr,Nd同位素地球化学显示文摘北秦岭拉圾庙苏长辉长岩体由辉长岩和苏长辉长岩组成。它们分属两个不同的岩浆系列:辉长岩属拉斑系列,TiO_2,Fe^(3+)/Fe^(2+)和REE丰度较高;苏长辉长岩属钙碱系列,低TiO_2,Fe^(3+)/Fe^(2+)和REE,特别是HREE。这说明后者源区较深并受榴辉岩相控制。两种岩石均有与岛弧玄武岩类似的地球化学特征,如较高的Ba,Pb,Sr和较低的Nb、Zr、Ni含量等。拉圾庙辉长岩和苏长辉长岩的Sr,Nd同位素特征与蛇绿岩类似,其ε_(Nd)值恒定在+2左右,ε^(Sr)变化范围较大(-6.4—+31.2),并与Na_2O,H_2O+,CO_2含量和Fe^(3+)/Fe^(2+)有正相关关系。在ε_(Nd—Nb/Th,ε_(Nd)-La/Nb和ε_(Nd)-Ba/Nb图中,清楚显示了该岩体的地幔源含较多的陆源沉积物组分。它说明古秦岭海板块在古生代俯冲时,携带有较多沉积物进入地幔。 | 李曙光 陈移之 张宗清 叶笑江 张国伟 郭安林 S. R. Hart | 1993 | 地质学报1993，67，4： | 32 |
| 4 | 缺血性卒中的一级预防——美国心脏协会/美国卒中协会卒中委员会指南 动脉粥样硬化性周围血管病跨学科工作组、心血管护理委员会、临床心脏病学委员会、营养、体力活动和代谢委员会以及医疗质量和转归研究跨学科工作组共同倡导显示文摘背景和目的本指南提供有关各种确定和潜在的卒中危险因素证据的概述,并提供降低卒中风险的推荐。方法写作组成员由委员会主席根据每位作者先前在相关课题领域中的工作提名,并经美国心脏协会(AHA)卒中委员会科学声明监督委员会批准。写作组采用系统文献回顾(涵盖时间段为2001年最后一次回顾发表到2005年1月),参考先前已发表的指南、个人文件和专家意见来概括现有的证据,指明现有知识的差距;如果合适,则根据标准的AHA标准做出简明的推荐。写作组全体成员在撰写过程中均有很多机会对推荐进行评论并认可这份声明的最终版本。在AHA科学咨询与协调委员会批准之前,本指南已进行过广泛的同行评议。结果对评价个体首次卒中风险的流程图进行评估。根据干预的可能性(不可干预、可干预或潜在可干预)和证据的强度(证据充分或证据不太充分),对首次卒中的危险因素或风险标记物进行分类。不可干预的危险因素包括年龄、性别、出生体重低、人种/种族和遗传因素。证据充分的可干预危险因素包括高血压、主动或被动吸烟、糖尿病、心房颤动和某些其他心脏病、血脂异常、颈动脉狭窄、镰状细胞病、绝经后激素治疗、不良饮食习惯、缺乏体力活动、肥胖和体脂分布。证据不太充分或潜在的可干预危险因素包括代谢综合征、酗酒、药物滥用、口服避孕药、睡眠呼吸障碍、偏头痛、高同型半胱氨酸血症、脂蛋白(a)升高、脂蛋白相关的磷脂酶升高、高凝状态、炎症和感染。对应用阿司匹林进行卒中一级预防的资料进行回顾。结论有大量证据可以用于确定增加首次卒中风险的各种特殊因素和提供降低这种风险的策略。 | Larry B. Goldstein Robert Adams Mark J. Alberts Lawrence J. Appel Lawrence M. Brass Cheryl D. Bushnell Antonio Culebras Thomas J. DeGraba Philip B. Gorelick John R. Guyton Robert G. Hart George Howard Margaret Kelly-Hayes J.V. (Ian) Nixon Ralph L. Sacco 苏克江 高宗恩 | 2006 | 国际脑血管病杂志2006，14，8： | 28 |
| 5 | Optoelectronic devices based on two-dimensional transition metal dichalcogenides显示文摘在过去几年里,二维(2D ) 转变金属 dichalcogenide (TMDC ) 材料吸引了研究社区的增加的注意由于他们的唯一的电子、光的性质,从当放大材料从时,联合到 indirect-to-direct bandgap 转变的山谷纺纱对单层多层。这些性质在通讯,计算,和保健的宽广领域里用重要应用正在恳求电子的小说和 optoelectronic 设备的发展。当材料厚度减少从时, TMDC 家庭的特色之一是发生的 indirect-to-direct bandgap 转变对单层多层,它为许多 photonic 应用是有利的。TMDC 也为与对他们也没有格子失配问题的层厚度的原子水平的控制构造大量 heterostructures 表明了崭新的灵活性和通用性。作为结果,在有另外的 2D 材料的联合的分层的 TMDC 为在宽广操作上认识到新奇高效的 optoelectronic 设备有潜力光谱范围。在这篇文章,我们在 2D TMDC 和 optoelectronic 设备研究的合成考察最近的进步。我们也讨论面对 2D 材料的家庭的可伸缩的应用的挑战并且在这些材料为 nanophotonics 技术的未来代提供的机会上提供我们的观点。 | He Tian Matthew L. Chin Sina Najmaei Qiushi Guo Fengnian Xia Hart Wang Madan Dubey | 2016 | Nano Research2016，9，6： | 22 |
| 6 | 贡嘎山东坡的鸟类多样性和区系显示文摘经过7年5次野外系统调查并综合有关文献,贡嘎山东坡分布有鸟类336种,其中,留鸟204种(60.7%),夏候鸟89种(26.5%),冬候鸟18种(5.4%),旅鸟25种(7.4%);东洋界物种205种(61.0%),古北界物种105种(31.3%),广布种26种(7.7%);雀形目Passeriformes鸟类245种(72.9%);繁殖鸟类293种(87.2%)。本地区有国家Ⅰ级重点保护鸟类3种,国家Ⅱ级重点保护鸟类29种;横断山-喜马拉雅地区特有鸟类53种;CITES附录Ⅰ鸟类3种,附录Ⅱ鸟类25种;世界自然保护联盟濒危物种红色名录濒危鸟类1种,易危鸟类2种。研究发现,东洋界物种的海拔分布下限平均、上限平均、中点平均和海拔跨度平均都低于古北界物种,但仅海拔分布中点平均和上限平均差异有统计学意义(P<0.05),体现了东洋界和古北界物种对高海拔环境适应能力的不同可能与其不同的生物地理演化历史有关;东洋界占优势的特有种(51/53)海拔分布下限平均、中点平均和上限平均显著高于非特有物种,体现出东洋界特有种对高山环境的适应也许与其特有化过程有关。贡嘎山东坡鸟类丰富度在中海拔1 800~2 800 m的落叶阔叶混交林和针阔叶混交林中最高,在高海拔和低海拔物种丰富度较低,物种丰富度呈中峰模式,鸟类生态群落随植物群落结构变化而呈现一定的垂直生态替代规律。 | 吴永杰 何兴成 Shane G.DuBay Andrew Hart Reeve Per Alstrom 周华明 和梅香 雍凡 张文文 雷富民 冉江洪 | 2017 | 四川动物2017，36，6： | 22 |
| 7 | 阿尔泰铁木尔特铅锌矿床的碳质流体组合及其地质意义显示文摘铁木尔特铅锌矿是阿尔泰克兰盆地内最主要的 VMS 型矿床。矿床受控于阿巴宫—库尔提断裂,铅锌矿体分布于该断裂 NE 逆冲盘的下泥盆统康布铁堡组地层绿泥石英片岩、大理岩或层状矽卡岩中。矿体形态多呈透镜状、似层状,并整合产于变质岩系中,发育多个矿化层。金属矿物有方铅矿、闪锌矿、黄铜矿、黄铁矿和磁黄铁矿等。铁木尔特铅锌矿床晚期发育多金属硫化物石英脉,至少可识别出3个流体包裹体组合(FIA)。FI0为高盐度流体包裹体组合,主要为含子矿物的多相包裹体(L-V-S 型),部分为气液两相包裹体(L-V 型),局限于单个石英颗粒内,包裹体呈无序分布,或呈孤立的单个包裹体分布, 包裹体的最终均一温度322~422.5℃。FI1为次生的CO_2-H_2O 流体包裹体组合,主要由单相(L_(CO_2))和两相(L_(CO_2)-L_(H_2O))的富CO_2包裹体组成,呈线性分布,穿透石英颗粒边界,明显属于次生包裹体范畴、FI2为碳质(CO_2-CH_4)流体包裹体组合,广泛发育,包裹体主要由单相(L_(CO_2)、L_(CO_2-CH_4)或 L_(CO_2-N_2))、少量两相(LCO,-LH'O)富CO。包裹体组成,大小5μm~20μm,成群定向分布,穿透石英颗粒边界并切断 FI1,是晚于 FI1的次生包裹体组合,反映晚期较大的构造—流体活动。对 FI2的详细研究表明,L_(CO_2)型包裹体的 T_(mCO_2)=-63.3~-57.7℃,T_(hCO_2)=-27.5~+29.7℃;L_(CO_2-CH_4)型或 L_(CO_2-N_2)型包裹体的 T_(mCO_2)=-80.5~-65.5℃,T_(hCO_2)=-56.0~-25.0℃;L_(CO_2)-L_(H_2O)型包裹体 CO_2相的 T_(mCO_2)=-66.9~-60.9℃,T_(hCO_2)=-13.3~+2.3℃,包裹体的最终均一温度 T_(h,total)=243.1~361.1℃。铁木尔特次生碳质流体组合,萨热阔布金矿主成矿阶段、赛都—多拉纳含金剪切带中早期透镜状石英脉碳质流体组合,以及阿舍勒等矿床的次生碳质流体组合,都具有相似的流体性质,均为高密度的CO_2-CH_2-N_2流体,其来源与石炭—二叠造山作用主期的区域动力热流变质作用有关。 | 徐九华 单立华 丁汝福 Craig J HART 王琳琳 卫晓锋 | 2008 | 岩石学报2008，24，9： | 17 |
| 8 | 卒中一级预防指南 美国心脏协会/美国卒中协会为医疗卫生专业人员制定的指南美国神经病学学会肯定本指南作为神经科医生继续教育工具的价值显示文摘背景和目的本指南对各种已确定和新出现的卒中危险因素的证据进行概述,以提供降低首次卒中风险的循证推荐。方法写作组成员由委员会主席根据每位成员先前在相关课题领域中的工作提名,并经美国心脏协会(American HeartAssociation,AHA)卒中委员会科学声明监督委员会批准。写作组采用系统文献回顾的方法(涵盖时间为2006年上一次回顾发表到2009年4月),参考先前已发表的指南、个人文件和专家意见来总结现有证据,并指出现有知识的差距;如果合适,则根据标准的AHA标准做出推荐。写作组全体成员均有机会对推荐进行评论并审核这份声明的最终文本。在AHA科学咨询和协调委员会考察和批准之前,本指南已南卒中委员会领导层和AIIA科学声明督察委员会进行过广泛的同行评议。结果对评价个体首次卒巾风险的流程图进行了评价。根据干预的町能性(不可于预、可于预或潜在可干预)和证据的强度(证据充分或证据不太充分),对首次卒中的危险因素或风险标记物进行分类。不可干预危险因素包括年龄、性别、低出生体质量、人种/种族和遗传倾向。证据充分的叮干预危险因素包括高血压、吸烟、糖尿病、心房颤动和某些其他心脏病、血脂异常、颈动脉狭窄、镰状细胞病、绝经后激素治疗、不良饮食习惯、体力活动过少以及肥胖和体脂分布。证据不太充分或潜在的可干预危险因素包括代谢综合征、酗酒、药物滥用、口服避孕药、睡眠呼吸障碍、偏头痛、高同型半胱氨酸血症、脂蛋白(a)升高、高凝状态、炎症和感染。对用阿司匹林进行卒中一级预防的资料进行了回顾。结论多方面的证据可用于确定能增高首次卒中风险的多种具体因素并提供降低这种风险的策略。 | Larry B. Goldstein Cheryl D. Bushnell Robert J. Adams Lawrence J. Appel Lynne T. Braun Seemant Chaturvedi Mark A. Creager Antonio Culebras Robert H. Eckel Robert G. Hart Judith A. Hinchey Virginia J. Howard Edward C. Jauch Steven R. Levine James F. Meschia Wesley S. Moore J.V. (Ian) Nixon Thomas A. Pearson 张霞(译) 尤寿江(译) 陈孝东(译) 卢涛声(译) 石际俊(译) 曹勇军(译) 徐兴顺(译) | 2010 | 国际脑血管病杂志2010，18，12： | 12 |
| 9 | HoLEP does not affect the overall sexual function of BPH patients: a prospective study显示文摘我们试图有希望地在良性的 prostatic 增生(BPH ) 的全面手术后的性功能上评估前列腺(HoLEP ) 的钬激光 enucleation 的影响有更低的尿道症状(LUTS ) 并且到的病人探索在性功能和 LUTS 之间的关系。从 2010 年 1 月到 2011 年 12 月,经历了 HoLEP 的有 BPH 的六十个性积极的连续病人有希望地在学习被注册。所有病人为他们的全面性功能和国际 Prostatic 症状分数(IPSS ) 的评估填写了男性健康问询表(MSHQ ) 为外科手术前、手术后他们的 voiding 症状的 6 月评估。LUTS 和性功能变化统计上被分析。病人的外科手术前、 6 个月手术后的地位用 uroflowmetry 和 IPSS 问询表被比较。分析揭示了跟随 HoLEP 的重要改进。在 MSHQ 的子域之中,包括勃起,射精,性满足,焦虑或性欲望,手术后的性功能显著地没在 HoLEP 以后变化(P >0.05 ) ,而满足分数稍微减少了由于后退在 38 个病人(63.3%) 的射精。性满足显著地改善了并且与所有 LUTS 和 quality-of-life (QoL ) 的改进被相关在在外科以后的 IPSS 的领域(QoL;相对风险[RR ] :− 0.293;全部的症状, RR:− 0.411;P <0.05 ) 。nocturia 分数与可勃起的功能分数被联系(机会比率 0.318, P = 0.029 ) 。在射精的分数的变化没证明有 IPSS 的重要协会得分。HoLEP 没影响全面性功能,包括可勃起的功能。另外,性满足与 LUTS 的改进在比例改善了。 | Sung Hart Kim Hyung-Kook Yang Hahn-Ey Lee Jae-Seung Paick Seung-June Oh | 2014 | Asian Journal of Andrology2014，16，6： | 11 |
| 10 | 局部麻醉药物治疗早泄的疗效和安全性:系统性回顾和荟萃分析显示文摘本文的目的是评估局部麻醉药物往治疗早泄方面的疗效及安全性。我们制定了原始文献纳入标准及检索策略,检索了Cochrane图忙馆,PUBMED[1EMBASE数据库,检索并收集相关麻醉药物治疗早泄的随机对照研究,观察指标包括15月道内射精潜伏期(IELT),患者报告结局指标(PRO)和药物不良事件。采用State11.0软件进行荟萃分析。实验结果显示,总共有7篇符合纳入标准的随机对照研究进入荟萃分析,治疗组56660,安慰组388例。荟萃分析结果表明,早泄患者应用局部麻醉药物治疗与安慰剂相比,IELT的标化平均差(SMD)变化为5.02(95%CI:3.03—7.00):与此同时,局部麻醉药物巧不良事件的发生率要比安慰剂高(OR:3.30。95%CI:1.71-36),但值得注意的是,这些不良事件都足局部不良反应;此外,药物治疗组患者的报告结局指标有明显的改善。 | Jia-Dong Xia You-Feng Hart Liu-Hua Zhou Yun Chen Yu-Tian Dai | 2013 | Asian Journal of Andrology2013，15，4： | 10 |
| 11 | Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic(type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease显示文摘AIM: To study clinical and histopathological features of nonalcoholic fatty liver disease(NAFLD) in patients with and without type 2 diabetes mellitus(T2DM) using updated nonalcoholic steatohepatitis clinical research network(NASH-CRN) grading system.METHODS: We retrospectively analyzed data of 235 patients with biopsy proven NAFLD with and without T2 DM.This database was utilized in the previously published study comparing ethnicity outcomes in NAFLD by the same corresponding author.The pathology database from University of Chicago was utilized for enrolling consecutive patients who met the criteria for NAFLD and their detailed clinical and histopathology findings were obtained for comparison.The relevant clinical profile of patients was collected from the Electronic Medical Records around the time of liver biopsy and the histology was read by a single well-trained histopathologist.The updated criteria for type 2 diabetes have been utilized for analysis.Background data of patients with NASH and NAFLD has been included.The mean differences were compared using χ2 and t-test along with regression analysis to evaluate the predictors of NASH and advanced fibrosis.RESULTS: Patients with NAFLD and T2 DM were significantly older(49.9 vs 43.0,P < 0.01),predominantly female(71.4 vs 56.3,P < 0.02),had higher rate of metabolic syndrome(88.7 vs 36.4,P < 0.01),had significantly higher aspartate transaminase(AST)/alanine transaminase(ALT) ratio(0.94 vs 0.78,P < 0.01) and Fib-4 index(1.65 vs 1.06,P < 0.01) as markers of NASH,showed higher mean NAFLD activity score(3.5 vs 3.0,P = 0.03) and higher mean fibrosis score(1.2 vs 0.52,P < 0.01) compared to patients with NAFLD without T2 DM.Furthermore,advanced fibrosis(32.5 vs 12.0,P < 0.01) and ballooning(27.3 vs 13.3,P < 0.01) was significantly higher among patients with NAFLD and T2 DM compared to patients with NAFLD without T2 DM.On multivariate analysis,T2 DM was independently associated with NASH(OR = 3.27,95%CI: 1.43-7.50,P < 0.01) and advanced fibrosis(OR = 3.45,95%CI: 1.53-7.77,P < 0.01) in all patients with NAFLD.There was a higher rate of T2DM(38.1 vs 19.4,P < 0.01) and cirrhosis(8.3 vs 0.0,P = 0.01) along with significantly higher mean Bilirubin(0.71 vs 0.56,P = 0.01) and AST(54.2 vs 38.3,P < 0.01) and ALT(78.7 vs 57.0,P = 0.01) level among patients with NASH when compared to patients with steatosis alone.The mean platelet count(247 vs 283,P < 0.01) and high-density lipoprotein cholesterol level(42.7 vs 48.1,P = 0.01) was lower among patients with NASH compared to patients with steatosis.CONCLUSION: Patients with NAFLD and T2 DM tend to have more advanced stages of NAFLD,particularly advanced fibrosis and higher rate of ballooning than patients with NAFLD without T2 DM. | Bharat K Puchakayala Siddharth Verma Pushpjeet Kanwar John Hart Raghavendra R Sanivarapu Smruti R Mohanty | 2015 | World Journal of Hepatology2015，7，25： | 10 |
| 12 | CD74 is a survival receptor on colon epithelial cells显示文摘AIM: To investigate the expression and function of CD74 in normal murine colon epithelial cells (CEC) and colon carcinoma cells. METHODS: Expression of CD74 mRNA and protein were measured by reverse transcriptase-polymerase chain reaction (RT-PCR), Western blotting and fluorescence-activated cell sorter (FACS). The effect of migration inhibitory factor (MIF) on the survival of normal CEC from C57BL/6, NOD/SCID, and CD74 def icient mice both in vitro and in vivo, and on the CT26 carcinoma cell line was analyzed by (quantitative) qRT-PCR, RTPCR, Western blotting and FACS. RESULTS: CD74 was found to be expressed on normalCEC. Stimulation of CD74 by MIF induced a signaling cascade leading to up-regulation of Bcl-2 expression, resulting in a signif icant increased survival of CEC. CD74 was also expressed on the CT26 colon carcinoma cell line and its stimulation by MIF resulted in enhanced cell survival, up-regulation of Akt phosphorylation and Bcl-2 expression. | Nitsan Maharshak Sivan Cohen Frida Lantner Gili Hart Richard Bucala Idit Shachar | 2010 | World Journal of Gastroenterology2010，16，26： | 9 |
| 13 | 广义地震应变能释放的多重分形特征显示文摘利用基于小波变换的多重分形谱估计方法,研究了以中国东西部地区为代表的板内地震活动和以新西兰、日本为代表的板缘地震活动广义应变能释放的多重分形特征。结果表明,中国东、西部地震活动广义应变能释放的多重分形特征有明显差别,新西兰与日本的地震活动广义应变能释放的多重分形特征也有明显不同;地震活动的多重分形特征与构造的复杂程度有关。 | 陈时军 David Harte 王丽凤 马丽 | 2003 | 地震学报2003，25，2： | 8 |
| 14 | 通过贻贝养殖改善海水水质:瑞典社会的可盈利性方案显示文摘沿海水域的富营养化是一个在全球范围内需要付出巨大社会代价的严重的环境问题。在斯卡格拉克海峡东部,富营养化的降低计划通过氮输入量的减少逐步实现,但目前还不清楚如何去减少氮的输入量。其中一个可能的方法是养殖紫贻贝等滤食性生物,这种贻贝能够在生产海产品、饲料和农业肥料的同时也能够除去氮,从而将营养盐由海洋再循环到了陆地上。在瑞典西海岸的古尔马峡湾,我们对贻贝养殖可能对氮循环产生的影响进行了模拟。结果显示,该峡湾口地区氮的净输送量(溶解氮和颗粒状氮的总和)下降了20%。现有的商业贻贝养殖场已经免费提供了这种服务,但它对社会带来的利益将会远远大于这些。我们建议,不应该向贻贝饲养人支付劳动报酬,而应引入营养交换体制以提高沿海水域的状况。在这样的背景下提出了一个通过养殖贻贝来替代在吕瑟希尔社区的污水处理厂中消减氮含量的选择方案。生体毒素的聚积已被确定为瑞典的商业贻贝养殖进一步扩大方面的最大障碍,但这一问题似乎可以通过新技术和管理战略得以解决。在现有和可能的规定和支付费用的基础上,我们提出了一些可能会实现双赢的解决方案。 | Odd Lindahl Rob Hart Bodil Hernroth Sven Kollberg Lars-Ove Loo Lars Olrog Ann-Sofi Rehnstam-Holm Jonny Svensson Susanne Svensson Ulf Syversen 许天虎 | 2005 | AMBIO-人类环境杂志2005，34，2： | 7 |
| 15 | 新西兰地区地震活动时空分布的多重分形特征研究显示文摘利用多重分形维数谱估计的Hill方法 ,讨论了新西兰地震活动区地震活动的震源分布、震中分布以及时间间隔分布的多重分形特征 .结果表明 ,该地区浅源地震的震中分布和震源分布在给定不同的起始震级的条件下均具有明显的丛集特征 ;对于中、深源地震这种特征不甚明显 .而地震活动时间间隔分布则无论对于浅源和中、深源地震均呈单重分形的性质 ,但具有分形性质的尺度范围有较大的差别 .这些结果表明 ,浅源地震与中、深源地震的活动特征显著不同 . | 陈时军 David Harte 马丽 王丽凤 | 2003 | 地震学报2003，25，3： | 7 |
| 16 | Molecular mechanisms of metastasis in prostate cancer显示文摘前列腺癌症(PCa ) 优先地转移到轴的骨骼的骨头髓基质。这项活动是 PCa 病态和死亡的主要原因。PCa 转移的准确机制当前是未知的,尽管可观的进步在在这进程决定关键播放器被取得了。在这评论,我们在场驾驶 PCa 转移到骨头的分子的过程的当前的理解。 | Noel W. Clarke Claire A. Hart Mick D. Brown | 2009 | Asian Journal of Andrology2009，11，1： | 7 |
| 17 | Explaining surface interactions for common associated gangues of rare earth minerals in response to the oxalic acid显示文摘In the flotation of rare earth minerals(REMs), oxalic acid is reportedly acting both as a depressant and p H modifier. Although results of testing have established the significance of oxalic acid in the flotation process, its specific role in either the recovery or selectivity of REMs over their common gangue minerals is not well understood. Pulp p H reduction trials with alternative acids have not shown the same effect on the REMs recovery or the depression of gangue phases. This work studies the effect of oxalic acid on the surface of common REMs gangue minerals(quartz and carbonates(dolomite and calcite)) in a series of conditioning tests. Gangue surface analyses by time of flight secondary ion mass spectroscopy(TOFSIMS) indicate that oxalic acid inhibits the transfer of secondary ions generated during the conditioning process from one mineral to another. In this regard, the oxalate anion acts to fix ions in solution through chelation, limiting their participation in surface adsorption. | Saeed Chehreh Chelgani Brian Hart | 2018 | International Journal of Mining Science and Technology2018，28，2： | 6 |
| 18 | Recent progress of fully synthetic carbohydrate-based vaccine using TLR agonist as build-in adjuvant显示文摘Fully synthetic vaccine, in which one or multi-molecular antigens are conjugated to a synthetic carrier with well-defined chemical structure, is a new direction to develop carbohydrate-based vaccine against cancer and pathogens. Toll like receptor(TLR) agonists with the ability to stimulate immune response have been widely investigated and been applied as build-in adjuvants to construct fully synthetic vaccines. In particular, remarkable progress has been achieved in recent years in the development of vaccines constructed with the agonists of TLR1/2, TLR2/6 and TLR4 and tumor-associated carbohydrate antigens(TACAs). These di-, tri-or multi-component vaccine candidates showed attractive immunological properties. This review highlights recent advances in developing full synthetic carbohydrate antigen based vaccines, with an emphasis on the structure-activity relationships that provide a primary basis for future vaccine design and immunotherapy developing. | Zhifang Zhou Hart Lin Chen Li Zhimeng Wu | 2018 | Chinese Chemical Letters2018，29，1： | 6 |
| 19 | Herbal hepatoxicity from Chinese skullcap: A case report显示文摘The use of herbal supplements has increased considerably over the last decade. We report a case of an elderly woman who began taking Move Free Advanced for arthritis, which in addition to glucosamine and chondroitin, contained two herbal ingredients, Chinese skullcap and Black Catechu. Our patient presented with significant cholestasis and hepatitis which significantly improved after discontinuation of the supplement. Since neither the patient nor the treating physician recognized this supplement as a potential hepatotoxin, she resumed taking the supplement and again suffered from considerable hepatotoxicity. Liver biopsy at that time was consistent with acute drug induced liver injury. She, once again, recovered after discontinuation of the supplement. Review of the literature confirms that Chinese skullcap has been implicated as a possible hepatotoxic agent which was demonstrated in this case. | Leslie Yang Andrew Aronsohn John Hart Donald Jensen | 2012 | World Journal of Hepatology2012，4，7： | 6 |
| 20 | Guidelines for the Primary Prevention of Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Larry B. Goldstein Cheryl D. Bushnell Robert J. Adams Lawrence J. Appel Lynne T. Braun Seemant Chaturvedi Mark A. Creager Antonio Culebras Robert H. Eckel Robert G. Hart Judith A. Hinchey Virginia J. Howard Edward C. Jauch Steven R. Levine James F. Meschi | 2011 | Stroke2011，，2： | 6 |
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