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| 1 | Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia显示文摘AIM:To study the relation between collagen 1,α-smooth muscle actin(α-SMA)and CD34 expression and the most essential portoenterostomy(PE)outcomes.METHODS:Liver specimens were obtained at PE from33 biliary atresia(BA)patients for immunohistochemical analysis of collagen 1,α-SMA and CD34.Liver biopsies from 35 organ donors were used as controls.Expression patterns were related to clinical data including age at PE,serum total and conjugated bilirubin concentration at the time of PE and during follow-up,incidence of esophageal varices in follow-up upper gastrointestinal endoscopies,and native liver survival as well as to detailed histopathological findings.RESULTS:Collagen 1(16.4%vs 4.5%,P<0.0001),α-SMA(17.9%vs 4.6%,P<0.0001)and CD34(4.9%vs 3.8%,P=0.017)were markedly overexpressed in BA patients compared with controls.Patients who underwent liver transplantation by age of two years had significantly higher expression of collagen 1(18.6%vs 13.7%,P=0.024),α-SMA(20.4%vs 15.4%,P=0.009)and CD34(5.9%vs 4.0%,P=0.029)at PE compared with native liver survivors.CD34-positive microvessels were identified in the centrizonal region close to central vein in every BA patient.In majority of BA cases(56%)neovascularization was frequent as CD34-positive microvessels were observed in over half of the hepatic lobules.In controls,the CD34-positive microvessels were rare as they were completely absent in 40%and were found in less than 5%of the hepatic lobules in the rest.The difference between BA patients and controls was significant(P<0.0001).Patients who developed esophageal varices by two years had significantly higher expression of CD34 at PE compared with patients without varices(5.6%vs 4.0%,P=0.019).Expression ofα-SMA(r=0.758,P<0.0001)and collagen 1(r=0.474,P=0.016),and the amount of CD34-positive microvessels(r=0.356,P=0.047)were related to patient age at PE.CONCLUSION:Hepatic myofibroblastic cell activation,fibrogenesis and neovascularization are enhanced in BA,progress with increasing PE age and relate to native liver survival and development of esophageal varices. | Janne S Suominen Hanna Lampela Pivi Heikkil Jouko Lohi Hannu Jalanko Mikko P Pakarinen | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 2 | The Quick hull Algorithm for Convex Hulls显示文摘 | C Bradford Barber David P Dobkin Hannu Huhdanpaa | 1996 | ACM Transactions on Mathematical Software1996，22，4： | 1 |
| 3 | Effect of processing on the extractability of oat β-glucan显示文摘 | Liisa Johansson P?ivi Tuomainen Heli Anttila Hannu Rita Liisa Virkki | 2007 | Food Chemistry2007，，4： | 1 |
| 4 | Surgical or Nonoperative Treatment for Lumbar Spinal Stenosis?: A Randomized Controlled Trial显示文摘 | Antti Malmivaara P?r Sl?tis Markku Heli?vaara P?ivi Sainio Heikki Kinnunen Jyrki Kankare Nina Dalin-Hirvonen Seppo Seitsalo Arto Herno Pirkko Kortekangas Timo Niinim?ki Hannu R?nty Kaj Tallroth Veli Turunen Paul Knekt Tommi H?rk?nen Heikki Hurri | 2007 | Spine2007，，1： | 1 |
| 5 | Does preoperative core needle biopsy increase surgical site infections in breast cancer surgery? Randomized study of antibiotic prophylaxis 显示文摘 | HANNU P A HEIKKI H E | 2009 | Surg Infect2009，10，4： | 1 |
| 6 | The quickhull algorithm for convex hull显示文摘 | Bradford B David P D Hannu H | 1996 | ACM Transactions on Mathematical Software1996，22，4： | 1 |
| 7 | Milk immunoglobulins and complement factors显示文摘 | Hannu Korhonen P Mamila H S Gill | 2000 | British Journal of Nutrition2000，84，1： | 1 |
| 8 | Value co-creation:theoretical approaches and practical implications显示文摘 | HANNU SAARIJARVI P K KANNAN HANNU KUUS- ELA | 2013 | European Business Review2013，1，25： | 1 |
| 9 | The quickhull algorithm for convex hulls显示文摘 | Bradford Barber C David P Dobkin Hannu Huhdanpaa | 1996 | ACM Transactions on Mathematical Software1996，22，4： | 1 |
| 10 | Modeling of chromatographic sep- aration process with Wiener-MLP representation 显示文摘 | ARTO V HANNU P HALME A | 2001 | Journal of Pro- cess Control2001，11，5： | 1 |
| 11 | Bioactive peptides: Production and Function- ality显示文摘 | HANNU K ANNE P | 2006 | International Dairy Journal2006，16，： | 1 |
| 12 | Tacit knowledge acquisi- tion and sharing in a project work context显示文摘 | KAJ U K PEKKA P HANNU V | 2003 | Intemational Journal of Project Management2003，21，： | 1 |
| 13 | Use of the Heimilich Valve for Treating Pneumothorax显示文摘 | NIEMI T HANNU KAINEN J AARNIO P | 1999 | Ann Chir Gynaecol(S0355-9521)1999，88，1： | 1 |
| 14 | Synthesis of hexameric lignin model compounds显示文摘 | likka K Asta T-W Hannu P | 1994 | Holzforschung1994，48，： | 1 |
| 15 | Multiple abstraction levels in modeling product structure 显示文摘 | TOMI M HANNU P TIMO S | 2001 | Data & Knowledge Engineer2001，36，： | 1 |
| 16 | Soil organic matter quality as a link between microbial community structure and vegetation composition along a successional gradient in a boreal forest显示文摘 | P?ivi Meril? Minna Malmivaara-L?ms? Peter Spetz Sari Stark Kati Vierikko John Derome Hannu Fritze | 2010 | Applied Soil Ecology2010，，2： | 1 |
| 17 | Tacit Knowledge Acquisition andSharing in a Project Work Context 显示文摘 | Kaj U Pekka P Hannu V | 2003 | International Journal ofProject Management2003，21，28： | 1 |
| 18 | Comparison of surface radiative flux parameterizations : Part I : Longwave radiation 显示文摘 | Sami Niemela P R Hannu Savijarvi | 2001 | Atmospheric Research2001，58，1： | 1 |
| 19 | The quickhuB algorithm for convex hulls 显示文摘 | Bradford Barber C David P Dobkin Hannu Huhdanpaa | 1996 | ACM Transactions on Mathematical Software1996，22，4： | 1 |
| 20 | Tool wear and machinability of X5CrMnNI8 stainless steels显示文摘 | JUKKA P HANNU H VEI J K | 2001 | Joumal of Materials Process- ing Technology2001，119，： | 1 |
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