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| 1 | Relationship between vitamin D and IL-23,IL-17 and macrophage chemoattractant protein-1 as markers of fibrosis in hepatitis C virus Egyptians显示文摘AIM:To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). METHODS:The study was conducted on 50 Egyptian hepatitis C virus (HCV) genotype number IV-infected patients and 25 ageand gender-matched healthy subjects. Venous blood samples were obtained. Samples were allowed to clot and sera were separated by centrifugation and stored at -20 ℃. A 25 hydroxy vitamin D assay was carried out using solid phase RIA. A 1,25 dihydroxy vitamin D assay was carried out using a commercial kit purchased from Incstar Corporation. IL-17 and -23 and MCP-1 were assayed by an enzyme immunoassay. Quantitative and qualitative polymerase chain reaction for HCV virus were done by TaqMan technology. Only HCV genotype IV-infected subjectswere included in the study. The mean ± SD were determined, a t-test for comparison of means of different parameters was used. Correlation analysis was done using Pearson's correlation. Differences among different groups were determined using the Kruskal-Wallis test. RESULTS:The mean vitamin D level in HCV patients (groupⅠ) was 15 ± 5.2 ng/mL while in control (group Ⅱ) was 39.7 ± 10.8. For active vitamin D in groupⅠas 16.6 ± 4.8 ng/mL while in group Ⅱ was 41.9 ± 7.9. IL-23 was 154 ± 97.8 in group Ⅰ and 6.7 ± 2.17 in group Ⅱ. IL-17 was 70.7 ± 72.5 in cases and 1.2 ± 0.4 in control. MCP-1 was 1582 ± 794.4 in group Ⅰand 216.1 ± 5.38 in group Ⅱ. Vitamin D deficiency affected 72% of HCV-infected patients and 0% of the control group. Vitamin D insufficiency existed in 28% of HCV-in-fected patients and 12% of the control group. One hundred percent of the cirrhotic patients and 40% of non cirrhotic HCV-infected patients had vitamin D deficiency. IL-23, IL-17, and MCP-1 were markedly increased in HCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and-23 and MCP-1 was detected. HCV-infected males and females showed no differences with respect to viral load, vitamin D levels, IL-17, IL-23 and MCP-1. The viral load was negatively correlated with vitamin D and active vitamin D (P = 0.0001 and P = 0.001, respectively), while positively correlated with IL-23, IL-17, and MCP-1. We classified the patients according to sonar findings into four groups. Group Ⅰa with bright hepatomegaly and included 14 patients. Group Ⅰb with perihepatic fibrosis and included 11 patients. Group Ⅰc with liver cirrhosis and included 11 patients. Group Ⅰd with he patocellular carcinoma (HCC) and included 14 patients. Vitamin D and active vitamin D were shown to be lower in cirrhotic patients and much lower in patients with HCC, and this difference was highly significant (P = 0.0001). IL-17 and-23 and MCP-1 were higher in advanced liver disease) and the differences were highly significant (P = 0.0001).CONCLUSION:Whether the deficiency of vitamin D is related to HCV-induced chronic liver disease or predisposing factor for higher viral load is a matter of debate. | Noha M El Husseiny Hala M Fahmy Waleed A Mohamed Hisham H Amin | 2012 | World Journal of Hepatology2012，4，8： | 12 |
| 2 | Octreotide ameliorates gastric lesions in chronically mild stressed rats显示文摘AIM:To evaluate the effect of chronic mild stress(CMS) on the emergence of gastric ulcers and possible modulation by octreotide,a synthetic somatostatin analogue. METHODS:Adult male Wistar rats were subjected to nine different unpredictable random stress procedures for 21 d,a multifactorial interactional animal model for CMS.Octreotide was administered daily for 21 d at two dose levels(50 and 90μg/kg)before exposure to stress procedure.Macro-and microscopical assessments were made,in addition to quantification of plasma corticosterone and gastric mucosal inflammatory,oxidative stress, and apoptotic biomarkers. RESULTS:Exposure to CMS elevated plasma corticosterone(28.3±0.6μg/dL,P=0.002),an event that was accompanied by gastric lesions(6.4±0.16 mm,P=0.01) and confirmed histopathologically.Moreover,the insult elevated gastric mucosal lipid peroxides(13±0.5 nmol/g tissue,P=0.001),tumor necrosis factor-α(3008.6±78.18 pg/g tissue,P<0.001),prostaglandin E2(117.1 ±4.31 pg/g tissue,P=0.002),and caspase-3 activity (2.4±0.14 OD/mg protein,P=0.002).Conversely,CMS mitigated interleukin-10(627.9±12.82 pg/g tissue,P= 0.001).Furthermore,in animals exposed to CMS,octreotide restored plasma corticosterone(61%and 71%from CMS,P=0.002)at both dose levels.These beneficial effects were associated with a remarkable suppression of gastric lesions(38%and 9%from CMS,P=0.01)and reversal of derangements in gastric mucosa. CONCLUSION:The current investigation provides evidence that exposure to CMS induces gastric ulceration, which was alleviated by administration of octreotide possibly possessing antioxidant,anti-inflammatory,and anti-apoptotic actions. | Noha N Nassar Mona F Schaalan Hala F Zaki Dalaal M Abdallah | 2011 | World Journal of Gastroenterology2011，17，9： | 6 |
| 3 | Precision Livestock Farming: Precision feeding technologies and sustainable livestock production显示文摘In order to be able to produce safe,uniform,cheap,environmentally-and welfare-friendly food products and market these products in an increasingly complex international agricultural market,livestock producers must have access to timely production related information.Especially the information related to feeding/nutritional issues is important,as feeding related costs are always significant part of variables costs for all types of livestock production.Therefore,automating the collection,analysis and use of production related information on livestock farms will be essential for improving livestock productivity in the future.Electronically-controlled livestock production systems with an information and communication technology(ICT)focus are required to ensure that information is collected in a cost effective and timely manner and readily acted upon on farms.New electronic and ICT related technologies introduced on farms as part of Precision Livestock Farming(PLF)systems will facilitate livestock management methods that are more responsive to market signals.The PLF technologies encompass methods for electronically measuring the critical components of the production system that indicate the efficiency of resource use,interpreting the information captured and controlling processes to ensure optimum efficiency of both resource use and livestock productivity.These envisaged real-time monitoring and control systems could dramatically improve production efficiency of livestock enterprises.However,further research and development is required,as some of the components of PLF systems are in different stages of development.In addition,an overall strategy for the adoption and commercial exploitation of PLF systems needs to be developed in collaboration with private companies.This article outlines the potential role PLF can play in ensuring that the best possible management processes are implemented on farms to improve farm profitability,quality of products,welfare of livestock and sustainability of the farm environment,especially as it related to intensive livestock species. | T M Banhazi L Babinszky V Halas M Tscharke | 2012 | International Journal of Agricultural and Biological Engineering2012，5，4： | 5 |
| 4 | Drainage vs. non-drainage after cholecystectomy for acute cholecystitis:a retrospective study显示文摘Many surgeons practice prophylactic drainage after cholecystectomy without reliable evidence,this study was conducted to answer the question whether to drain or not to drain after cholecystectomy for acute calculous cholecystitis.A retrospective review of all patients who had cholecystectomy for acute cholecystitis in Aseer Central Hospital,Abha,Saudi Arabia,was conducted from April 2010 to April 2012.Data were extracted from hospital case files.Preoperative data included clinical presentation,routine investigations and liver function tests.Operative data included excessive adhesions,bleeding,bile leak,and drain insertion.Complicated cases such as pericholecystic collections,mucocele and empyema were also reported.Patients who needed therapeutic drainage were excluded.Postoperative data included hospital stay,volume of drained fluid,time of drain removal,and drain site problems.The study included 103 patients allocated into two groups;group A(n = 38) for patients with operative drain insertion and group B(n = 65) for patients without drain insertion.The number of patients with preoperative diagnosis of acute non-complicated cholecystitis was significantly greater in group B(80%) than group A(36.8%)(P < 0.001).Operative time was significantly longer in group A.All patients who were converted from laparoscopic to open cholecystectomy were in group A.Multivariate analysis revealed that hospital stay was significantly(P < 0.001) longer in patients with preoperative complications.There was no added benefit for prophylactic drain insertion after cholecystectomy for acute calculous cholecystitis in non-complicated or in complicated cases. | Mohammed A Bawahab Walid M Abd El Maksoud Saeed A Alsareii Fahad S Al Amri Hala F Ali Abdul Rahman Nimeri Abdul Rahman M Al Amri Adel A Assiri Mohammed I Abdul Aziz | 2014 | The Journal of Biomedical Research2014，28，3： | 3 |
| 5 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 6 | Small-scale deceit:deception as a marker of two-,three-,and four-year-olds' early theories of mind显示文摘 | Fritz A S Hala S | 1989 | Child Development1989，，6： | 1 |
| 7 | Nomenclature for the chicken major histocompatibility (B and Y)complex显示文摘 | Miller M M Bacon L D Hala K | 2004 | Immunogenetics2004，56，： | 1 |
| 8 | A 52-week place- bo-controlled trial of evolocumab in hyperlipidemia显示文摘 | Blom DJ Hala T Bolognese M | 2014 | N Engl J Med2014，370，19： | 1 |
| 9 | Learning and memory disabilities in young adult rats from mildly zinc deficient dams显示文摘 | Halas E S Hunt C D Eberhardt M J | 1986 | Physiol Behav1986，37，3： | 1 |
| 10 | Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-Cl cells is due to insufficient glucocorticoid receptor expression显示文摘 | Geley S Hartmann BL Hala M | 1996 | Cancer Res1996，56，21： | 1 |
| 11 | C-flavonoidal glycosides from Erythrina caffra flowers 显示文摘 | El-Masry Sawsan Hammoda Hala M Radwan Mohamed M | 2010 | Nat Prod Sci2010，16，4： | 1 |
| 12 | Isolation of helicobacter pylori from sheep—implications for transmission to humans显示文摘 | Maria P Dore Antonia R Sepulveda Hala El-Zimaity Yoshio Yamaoka Michael S Osato Kato Mototsugu Antonio M Nieddu Giuseppe Realdi David Y Graham | 2001 | The American Journal of Gastroenterology2001，，5： | 1 |
| 13 | A rapid-curing alginate gel system:utility in periosteum-derived cartilage tissue engineering显示文摘 | Molly M S Hala F Q Robert L | 2004 | Biomaterials2004，25，： | 1 |
| 14 | Chitosan based nanofibers, review 显示文摘 | MAHER Z E HALA F N RANIA E M | 2012 | Materials Science and Engineering: C2012，32，7： | 1 |
| 15 | Learning and memory impairment in adult rats due to sever zinc deficiency lactation 显示文摘 | Halas E S Eberhardt M J Diers A | 1983 | Physiol Behav1983，30，3： | 1 |
| 16 | A Cellular Trojan Horse for delivery ofther apeutic nanoparticles into tumors显示文摘 | Choi M R Stanton - Maxey K J Stanley J K Levin C S Bardhan R Akin D Badve S Sturgis J Robinson J P Bashir B Halas H J and Clare S E | 2007 | Nano Letters2007，7，12： | 1 |
| 17 | Clinical results of coronary artery bybass grafting with use of the internal thoracic artery under low free flow conditions显示文摘 | Hala M Shiono M Orime Y | 2000 | J Thorac Cardiovasc Sury2000，119，1： | 1 |
| 18 | Fledgling theories of mind:Deception asa marker of three - year - oldsr understanding of false belief 显示文摘 | Hala S Chandler M Fritz A S | 1991 | ChildDevelopment1991，62，： | 1 |
| 19 | Malondialdehyde and coenzyme Q10 in platelets and serum in type 2 diabetes mellitus: correlation with glycemic control显示文摘 | Eman A El-ghoroury Hala M Raslan Ehsan A Badawy Gamila S El-Saaid Mervat H Agybi Ibrahem Siam Sohair I Salem | 2009 | Blood Coagulation & Fibrinolysis2009，，4： | 1 |
| 20 | Small-scale deceit: deception as a marker of two - , three - , and four - year - olds' early theories of mind显示文摘 | CHANDLER M FRrIZ A S HALA S | 1989 | Child Development1989，60，6： | 1 |
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