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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Prognostic impact of atrial fibrillation on clinical outcomes of acute coronary syndromes,heart failure and chronic kidney disease显示文摘Atrial fibrillation(AF) is the most common type of sustained arrhythmia,which is now on course to reach epidemic proportions in the elderly population. AF is a commonly encountered comorbidity in patients with cardiac and major non-cardiac diseases. Morbidity and mortality associated with AF makes it a major healthcare burden. The objective of our article is to determine the prognostic impact of AF on acute coronary syndromes,heart failure and chronic kidney disease. Multiple studies have been conducted to determine if AF has an independent role in the overall mortality of such patients. Our review suggests that AF has an independent adverse prognostic impact on the clinical outcomes of acute coronary syndromes,heart failure and chronic kidney disease. | Nileshkumar J Patel Aashay Patel Kanishk Agnihotri Dhaval Pau Samir Patel Badal Thakkar Nikhil Nalluri Deepak Asti Ritesh Kanotra Sabeeda Kadavath Shilpkumar Arora Nilay Patel Achint Patel Azfar Sheikh Neil Patel Apurva O Badheka Abhishek Deshmukh Hakan Paydak Juan Viles-Gonzalez | 2015 | World Journal of Cardiology2015，7，7： | 2 |
| 3 | An Analysis of Driver' Steering Behavior During Auditory or Haptic Warning for the Designing of Lane Departure Warning System 显示文摘 | SUZUKI K HAKAN J | 2003 | JSAE Review2003，24，： | 1 |
| 4 | Filitating transthoracic cardioversion of arial fibriliation with Ibutilide pretreatment显示文摘 | Hakan O Joseph J S Gregory F M | 1999 | The New England Journal of Medcini1999，24，1： | 1 |
| 5 | Buffer zones and constructed wetlands as filters for agricultural phosphorus显示文摘 | JAANA U K BENT B HAKAN J | 2000 | Journal Environmental Quality2000，29，： | 1 |
| 6 | Colonization extinction dynamics of an epiphyte metapopulation in a dynamic landscape 显示文摘 | Snoll T Ehrlen J Hakan R | 2005 | Ecology2005，86，1： | 1 |
| 7 | The Transcription Factors SOX9 and SOX10 Are vitiligo Autoantigens in autoimmune Polyendocrine Syndrome Type Ⅰ显示文摘 | Hakan H Olov Ekwall Mats J | 2001 | Journal of Biological Chemistry2001，276，35： | 1 |
| 8 | Gender Based Foacl Points显示文摘 | Holm Hakan J | 2000 | Games and Economic Behavior2000，32，2： | 1 |
| 9 | Dynamic emulation of mechanical loads using a vector-controlled induction motor-generator set显示文摘 | HAKAN AKPOLAT Z ASHER G M CLARE J C | 1999 | IEEE Trans on Industrial Electronics1999，46，2： | 1 |
| 10 | Postoperative Atrial Fibrillation显示文摘 | Krit J Hakan O | 2009 | Cardial Clin2009，27，： | 1 |
| 11 | Hemostatic factors as risk markers for intracerebral hemorrhage 显示文摘 | Lars J Jan - Hakan J Birgitta S | 2004 | Stroke2004，35，4： | 1 |
| 12 | Dynamic emulation of mechanical loads using a vector-controlled induction motor-generator set显示文摘 | Hakan Akpolat Z Asher G M Clare J C | 1999 | IEEE Transactions on Industrial Electronics1999，46，： | 1 |
| 13 | Effects of AZD0837,a novel direct thrombin inhibitor,on the electrophysiological properties of the human heart a randomized,double-blind,parallel-group,placebo-controlled study显示文摘 | Hakan W Birgitta J Anders E | | 0，，07： | 1 |
| 14 | Orbital tumors in the older adult population显示文摘 | Hakan Demirci Carol L Shields Jerry A Shields Santosh G Honavar Gary J Mercado Jose C Tovilla | 2002 | Ophthalmology2002，，2： | 1 |
| 15 | Dynamic emulation of mechanical loads using a vector - controlled induction motor - generator set显示文摘 | Hakan Akpolat Z Asher G M Clare J C | 1999 | Industrial Electronics IEEE Transactions on1999，46，： | 1 |
| 16 | Buffer zones and constructed wetlands as filters for agricultural phosphorus显示文摘 | Jaana U K Bent B Hakan J | 2000 | Journal of Environmental Quality2000，29，： | 1 |
| 17 | Controlling factors for water residence time and flow patterns in Ekeby treatment wetland, Sweden显示文摘 | Johan K Anders W Hakan J | 2007 | Advances in Water Resources2007，30，4： | 1 |
| 18 | Source separated urine-nutrient and heavy metal content, water saving and faecal contamination显示文摘 | Hakan J Thor-axel S Jan S | 1997 | Water Sci Tech1997，35，9： | 1 |
| 19 | Controlling factors for water residence time and flow patterns in Ekeby treatment wetland,Sweden显示文摘 | JOHAN K ANDERS W HAKAN J | 2007 | Advances in Water Resources2007，30，4： | 1 |
| 20 | Controlling factors for water residence time and flow patterns in Ekehy treatment wetland显示文摘 | J ohan K Anders W Hakan J | 2007 | Sweden Advances in Water Resources2007，30，4： | 1 |
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