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| 1 | Hepatoprotective effect of Solatium xanthocarpum fruit extract against CCl_4 induced acute liver toxicity in experimental animals显示文摘Objective:To investigate the hepatoprotective potential of Solonum xanthocarpum(Solanaceae) (S.xanthocarpum) in experimental rats to validate its traditional claim.Methods:50%ethanolic fruit extract of S.xanthocarpum(SXE,100.200 or 400 mg/kg hods weight) was administered daily for 14davs in experimental animals.Liver injury was induced chemically,by CCl4 administration (1 mL/kg i.p.).The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST),alanine aminotransferase(ALT).Serum alkaline phosphatise (SALP) and total bilirubin.Meanwhile,in vivo antioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH).superoxide dismutase(SOD) and calalase(CAT) were screened along with histopathological studies.Results:Obtained results demonstrated that the treatment with SXE significantly(P<0.05- <0.001) and dose-dcpendcntly prevented chemically induced increase in serum levels of hepatic enzymes.Furthermore.SXE significantly(up to P<0.001) reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes GSH,SOU and catalasc towards normal levels.Histopathology of the liver tissue showed that SXE attenuated the hepatocellular necrosis and led to reduction of inflammatory cells inflltration. Conclusions:The results of this study strongly indicate the protective effect of SXE against acute liver injun which may he attributed to its hepatoprotective activity,and there by scientifically support its traditional use. | Ramesh K Gupta Talib Hussain G.Panigrahi Avik Das Gireesh Narayan Singh K Sweety Md Faiyazuddin Chandana Venkateswara Rao | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，12： | 4 |
| 2 | Rapid Detection of Wheat Blast Pathogen Magnaporthe oryzae Triticum Pathotype Using Genome-Specific Primers and Cas12a-mediated Technology显示文摘Wheat blast,caused by the fungus Magnaporthe oryzae Triticum(MoT)pathotype,is a devastating disease persistent in South America and Bangladesh.Since MoT generally fails to cause visual symptoms in wheat until the heading stage when the infection would have advanced,disease control by fungicide application solely based on the detection of visual symptoms is ineffective.To develop an accurate and sensitive method to detect MoT at the seedling and vegetative stages for disease control,we sequenced the genomes of two MoT isolates from Brazil and identified two DNA fragments,MoT-6098 and MoT-6099,that are present in the MoT genome but not in the genome of the rice-infecting Magnaporthe oryzae Oryzae(MoO)pathotype.Using polymerase chain reaction(PCR),we confirmed the specificity of the two markers in 53 MoT and MoO isolates from South America and Bangladesh.To test the efficiency of the two markers,we first established a loop-mediated isothermal amplification(LAMP)method to detect MoT at isothermal conditions,without the use of a PCR machine.Following this,we used the Cas12a protein and guide RNAs(gRNAs)to target the MoT-6098 and MoT-6099 sequences.The activated Cas12a showed indiscriminate single-stranded deoxyribonuclease(ssDNase)activity.We then combined targetdependent Cas12a ssDNase activation with recombinase polymerase amplification(RPA)and nucleic acid lateral flow immunoassay(NALFIA)to develop a method that accurately,sensitively,and cost-effectively detects MoT-specific DNA sequences in infected wheat plants.This novel technique can be easily adapted for the rapid detection of wheat blast and other important plant diseases in the field. | Houxiang Kang Ye Peng Kangyu Hua Yufei Deng Maria Bellizzi Dipali Rani Gupta Nur Uddin Mahmud Alfredo S.Urashima Sanjoy Kumar Paul Gary Peterson Yilin Zhou Xueping Zhou Md Tofazzal Islam Guo-Liang Wang | 2021 | Engineering2021，7，9： | 4 |
| 3 | Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents显示文摘Objective:To assess the hepatoprotective effect of Solanum xanthocarpum(S. xanthocarpum) fruit extract against antitubercular drug-induced liver toxicity in experimental animals.Methods:Ethanolic(50%) fruit extract ofS. xanthocarpum(100, 200 and 400 mg/kg bw) was administered daily for 35 days in experimental animals. Liver toxicity was induced by combination of three antitubercular drugs [isoniazid(I) 7.5 mg/kg, rifampicin(R) 10 mg/kg and pyrazinamide(P) 35 mg/kg] given orally as suspension for 35 days in rats. The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatise(ALP), total bilirubin(TBL), albumin(ALB), total protein(TP), lactate dehydroginase(LDH), and serum cholesterol(CHL). Meanwhile,in vivoantioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH), superoxide dismutase(SOD) and catalase(CAT) were measured in rat liver homogenate. The biochemical observations were supplemented by histopathological examination.Results:The results demonstrated that treatment withS.xanthocarpumsignificantly(P<0.05-P<0.001) and dose-dependently prevented drug induced increase in serum levels of hepatic enzymes. Furthermore,S. xanthocarpumsignificantly(up toP<0.001) reduced the LPO in the liver tissue and restored activities of defence antioxidant enzymes GSH, SOD and CAT towards normal levels. Histopathology of the liver tissue showed that S. xanthocarpumattenuated the hepatocellular necrosis and led to reduction in inflammatory cells infiltration.Conclusions:The results of this study strongly indicate the protective effect of S. xanthocarpumagainst liver injury which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use. | Talib Hussain Ramesh K Gupta Sweety K Mohd Sajid Khan Md Sarfaraj Hussain Md Arif Arshad Hussain Md Faiyazuddin Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 4 | Noetumalacid breakthrough in children with reflux esophagitis taking proton pump inhibitors显示文摘 | Pfefferkorn MD Croffie JM Gupta SK | | 0，，02： | 1 |
| 5 | The treatment of melasma:a review of clinical trials显示文摘 | Gupta AK Gover MD Nouri K | 2006 | J Am Acad Dermatol2006，55，6： | 1 |
| 6 | The treatment of melasma: areview of clinical trials 显示文摘 | Gupta AK Gover MD Nouri K | 2006 | J Am Acad Dermatol2006，55，： | 1 |
| 7 | Expression of glypiean-3 in hepatoblastoma: an immtmohistochemieal study of 65 cases显示文摘 | Debra L Zynger MD Anita Gupta MD | 2008 | Human Patho-logy2008，39，： | 1 |
| 8 | Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid显示文摘 | Rosenbaum DM Rosenbaum PS Gupta A Michaelson MD Hall DH Kessler JA | 1997 | Vision Res1997，37，24： | 1 |
| 9 | Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation显示文摘 | Huq MD Gupta P Tsai NP | 2006 | Mol Cell Proteomics2006，5，11： | 1 |
| 10 | Association between the Glu298Asp and 4b/4a polymorphisms of endothelial nitric oxide synthase and coronary slow flow in the north Indian population显示文摘 | Gupta MD Akkarappatty C Girish MP | 2014 | Coron Artery Dis2014，25，3： | 1 |
| 11 | The treatment of melasma: a review of clinical trials 显示文摘 | Gupta AK Gover MD Nouri K | 2006 | J Am Acad Dermatol2006，55，： | 1 |
| 12 | The acute re- spiratory distress syndrome显示文摘 | Ariel M Modrykamien MD aPooja Gupta | 2015 | Proe2015，28，2： | 1 |
| 13 | Bietti crystalline dystrophy and choroidal neovascularisation 显示文摘 | Gupta B Parvizi S Mohamed MD | 2011 | Int Ophthalmo12011，1，： | 1 |
| 14 | Serum levels of an isoform of apolipoprotein A-II as a potential marker for prostate cancer 显示文摘 | Malik G Ward MD Gupta SK | 2005 | Clin Cancer Res2005，11，3： | 1 |
| 15 | Nitric oxide attenuates H2O2-induced endothelial barrier dysfunction:mechanisms of protection显示文摘 | Gupta MP Ober MD Patterson C | 2001 | Am J Physiol Lung Cell Mol Physiol2001，280，： | 1 |
| 16 | The treatment of melasma:a reriew of clinical trials 显示文摘 | Gupta AK Gover MD Nouri k | 2006 | J Am Acad Dermatol2006，55，： | 1 |
| 17 | Serum Levels of an Isoform of Apolipoprotein A-Ⅱ as a Potential Marker for Prostate Cancer显示文摘 | Malik G Ward MD Gupta SK | 2005 | Clinical Cancer Research2005，11，1： | 1 |
| 18 | Mesenchymal cells for skeletal tissue engineering显示文摘 | Slater BJ Kwan MD Gupta DM | 2008 | Expert Opin Biol Ther2008，7，： | 1 |
| 19 | Therapeutic Options for the Treatment of Tinea Capitis Caused by Trichophyton Species:Griseofulvin Versus the New Oral Antifungal Agents,Terbinafine,Itraconazole,and Fluconazole显示文摘 | Aditya K Gupta MD Paul Adam MD | 2001 | Pediatr Dermatol2001，18，5： | 1 |
| 20 | U wave: An impor- tant noninvasive electrocardiographic diagnostic marker 显示文摘 | Girish MP Gupta MD Mukhopadhyay S | 2005 | Indian Pacing Eleetrophysiol J2005，5，： | 1 |
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