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	题名	作者	年代	出处	被引量
1	Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model显示文摘AIM To investigate the therapeutic potential of two recombinant proteins, Survivin and luteinizing hormone-releasing hormone (LHRH) fusion protein [LHRH(6 leu)-LTB] for immunotherapy of breast cancer.METHODS Murine 4 T-1 breast cancer model was used to evaluate the efficacy of recombinant proteins in vivo. Twenty four Balb/c mice were divided into 4 groups of 6 mice each. Recombinant Survivin and LHRH fusion protein, alone or in combination, were administered along with immunomodulator Mycobacterium indicus pranii (MIP) in Balb/c mice. Unimmunized or control group mice were administered with phosphate buffer saline. Each group was then challenged with syngeneic 4 T-1 cells to induce the growth of breast tumor. Tumor growth was monitored to evaluate the efficacy of immune-response in preventing the growth of cancer cells.RESULTS Preventive immunization with 20 μg recombinant Survivin and MIP was effective in suppressing growth of 4 T-1 mouse model of breast cancer (P = 0.04) but 50 μg dose was ineffective in suppressing tumor growth. However, combination of Survivin and LHRH fusion protein was more effective in suppressing tumor growth (P = 0.02) as well as metastasis in vivo in comparison to LHRH fusion protein as vaccine antigen alone.CONCLUSION Recombinant Survivin and MIP suppress tumor growth significantly. Combining LHRH fusion protein with Survivin and MIP enhances tumor suppressive effects marginally which provides evidence for recombinant Survivin and LHRH fusion protein as candidates for translating the combination cancer immunotherapy approaches.	Himani Garg Rohit Singh Hada Jagdish C Gupta G P Talwar Shweta Dubey	2018	World Journal of Clinical Oncology2018，9，8：	2
2	Genetic algorithm for optimization of water distribution systems显示文摘	Indrahi G Gupta A Khanna P	1999	Environmensl Modelling and Software1999，4，5：	1
3	Genes that mediate breast cancer metastasis to lung显示文摘	Minn A J Gupta G P Siegel P M	2005	Nature2005，436，7050：	1
4	Corrosion and stress corrosion cracking in supercritical water显示文摘	Was G S Ampornrat P Gupta G	2007	J Nucl Mater2007，371，13：	1
5	Thermal-Mechanical Modeling of the Rolling-Plus-Sliding with Frictional Heating of a Locomotive Wheel 显示文摘	Gupta V Hahn G T Bostias P C et aI	1995	Transactions of ASME1995，117，8：	1
6	Three-to six-year follow-up of stand-alone BAK cages implanted by a single surgeon 显示文摘	Button G Gupta M Barrett C Cammack P Benson D	2005	Sline J2005，5，：	1
7	Mediators of vascular remodelling co-opted for sequential steps in lung metastasis 显示文摘	Gupta G P Nguyen D X Chiang A C	2007	Nature2007，446，7137：	1
8	Association between portal vein color Doppler findings and the severity of disease in cirrhotic patients with portal hypertension显示文摘	Mittal P Gupta R Mittal G	2011	Iran J Radiol2011，8，4：	1
9	Corrosion and stress corrosion cracking in supercritical water显示文摘	WAS G S AMPORNRAT P GUPTA G	2007	Journal of Nuclear Materials2007，371，13：	1
10	PSO andANN _ based Fault Classification for ProtectiveRelaying 显示文摘	Upenda J Gupta C P Singh G K	2010	IET Generation Transmission andDistribution2010，4，10：	1
11	Electrolytic plasma technology: Science and engineering-An overview 显示文摘	Gupta P Tenhundfeld G Daiglf E O	2007	Surface and Coatings Technology2007，201，21：	1
12	Corrosion and stress corrosion cracking in supercritical water 显示文摘	WAS G S AMPORNRAT P GUPTA G	2007	Journal of Nuclear Materials2007，371，13：	1
13	Silencing of acetylcholinesterase gene of Helicoverpa armigera by siRNA affects larval growth and its life cycle显示文摘	Kumar M Gupta G P Rajam M V		0，，03：	1
14	Cancer metastasis: building a frame- work显示文摘	Gupta G P Massagu6 J	2006	Cell2006，127，4：	1
15	Corrosion and stress corrosion cracking in supercritical water显示文摘	WAS G S AMPORNRAT P GUPTA G	2007	Journal of Nuclear Materials2007，371，：	1
16	Lorazepam Versus Diazepam-phenytoin Combination in the Treatment of Convulsive Status Epilepticus in Children:A Randomized Controlled Trial显示文摘	Sreenath T G Gupta P Sharma K K	2009	Eur J Paediatr Neurol2009，14，2：	1
17	Distribution of a Secale cereal DNA repeat sequence among 25 Hordeum species显示文摘	Gupta P K Fedeak G Molnar S J	1989	Genome1989，32，：	1
18	Itraconazole pulse therapy for onychomycosis and dermatomycoses: An overview 显示文摘	De Doncker P Gupta AK Marynissen G	1997	J Am Acad Dermatol1997，37，6：	1
19	An experimental study of deformation modes of domes and large-angled frusta at different rates of compression显示文摘	Easwara P G L Gupta N K	2005	Int J Impact Eng2005，32，：	1
20	Microstructural control of aluminum sheet used in automotive applications 显示文摘	Burger G B Gupta A K Jeffrey P W	1995	35(1) :23 -391995，35，1：	1

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