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| 1 | Recombinant CC16 protein inhibits the production of pro-inflammatory cytokines via NF-KB and p38 MAPK pathways in LPS-activated RAW264,7 macrophages显示文摘积累的证据显示克莱拉房间 protein-16 (CC16 ) 有反煽动性的功能,尽管深奥分子的小径完全没被阐明。这里,我们评估了效果肿瘤坏死因素 alpha (TNF-) 的表示上的 recombinant 老鼠 CC16 (rCC16 ) , interleukin-6 (IL-6 ) ,和在 lipopolysaccharide (LPS ) 的 IL-8 刺激了老鼠巨噬细胞(RAW264.7 房间) 并且探索了内在的分子的机制。rCC16 在两个禁止了导致 LPS 的 TNF- , IL-6,和 IL-8 表示,这被发现送信人 ribonucleicacid (mRNA ) 水平和蛋白质以一种集中依赖者方式铺平,由即时反向的 transcriptase 聚合酶链反应和连接酶的 immunosorbent 试金示威了。如此的镇压效果被 transcriptional 活动和原子因素(NF ) 的脱氧核糖核酸酸绑定活动的抑制伴随 -B 然而并非使活跃之物蛋白质(AP )-1。西方的污点分析进一步表明 rCC16 禁止了原子 NF-B 和 NF-B 禁止的蛋白质 IB,和 p38 的 cytosolic NF-B, phosphorylation 和减小的减小的增加激活 mitogen 的蛋白质 kinase (MAPK ) 依赖者由在它的 p65 子单元的 Ser276 的 phosphorylation 的 NF-B 激活。而且, rCC16 被发现没另外在c6月N终端 kinase ,c6月,或c-Jun.的原子 translocation 的 phosphorylation 上有效果,TNF-的减小, IL-6 ,并且 IL-8 被颠倒内长的uteroglobin有约束力的蛋白质的水平什么时候被 RNA 干扰在 对待rCC16 、 对待LPS 的 RAW264.7 房间减少。我们的数据建议 rCC16 由在 RAW264.7 房间使 NF-B 和 p38 MAPK 然而并非 AP-1 失去活性压制调停 LPS 的煽动性的调停人 TNF- , IL-6,和 IL-8 生产。 | Min Pang Yangyang Yuan Dong Wang Ting Li Dan Wang Xiaohong Shi Min Guo Chunfang Wang Xinri Zhang Guoping Zheng Baofeng Yu Hailong Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 14 |
| 2 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 3 | Cloning and characterization of three cheB genes in Leptospira interrogans显示文摘活动性和趋化性系统为 leptospires 的毒力是批评的。有在 leptospires 定位的通常认为的趋化性相当或相同的事物的多重拷贝大染色体。从螺旋体 interrogans 紧张 Lai 的 CheB1 和 CheB3 被预言有一个全球象 CheB 一样领域,但是 CheB2 被预言仅仅有一个 C 终端受动器领域。以便验证三通常认为的 cheB 基因的功能,他们被克隆进 pQE31 向量然后分别地,在野类型的 Escherichia coli 紧张 RP437 和 cheB 有缺陷者紧张 RP4972 表示了。聚集的试金的结果和 CheB1 的预言的第三的结构和 L 的 CheB3。interrogans 紧张 Lai 建议一个 N 终端规章的领域的缺席可以是原因之一让 CheB2 的失败补充 E。coli cheB 异种。而且, CheB2 在 leptospires 的相互作用网络完全连接到 CheR1 和 CheR3。一起拿,这些结果显示 CheB2 不能独自工作,并且在某些生理的条件下面,工作可以要求 CheB3 和 CheR1。趋化性基因相当或相同的事物的多重拷贝的存在建议了那 L。interrogans 紧张 Lai 可能有一条更复杂的化学感应的小径。 | Ke Dong Qingtian Li Chang Liu Yunyi Zhang Guoping Zhao Xiaokui Guo | 2010 | Acta Biochimica et Biophysica Sinica2010，42，3： | 5 |
| 4 | Static Frame Model Validation with Small Samples Solution Using Improved Kernel Density Estimation and Confidence Level Method显示文摘An improved method using kernel density estimation (KDE) and confidence level is presented for model validation with small samples. Decision making is a challenging problem because of input uncertainty and only small samples can be used due to the high costs of experimental measurements. However, model validation provides more confidence for decision makers when improving prediction accuracy at the same time. The confidence level method is introduced and the optimum sample variance is determined using a new method in kernel density estimation to increase the credibility of model validation. As a numerical example, the static frame model validation challenge problem presented by Sandia National Laboratories has been chosen. The optimum bandwidth is selected in kernel density estimation in order to build the probability model based on the calibration data. The model assessment is achieved using validation and accreditation experimental data respectively based on the probability model. Finally, the target structure prediction is performed using validated model, which are consistent with the results obtained by other researchers. The results demonstrate that the method using the improved confidence level and kernel density estimation is an effective approach to solve the model validation problem with small samples. | ZHANG Baoqiang CHEN Guoping GUO Qintao | 2012 | Chinese Journal of Aeronautics2012，25，6： | 5 |
| 5 | Quantum computation on gate-defined semiconductor quantum dots显示文摘During the past few years, researchers have made significant progress on quantum information processing in gate controlled semiconductor quantum dots. We review the global research efforts, including works by our group, which provides pathways towards applications in quantum computation. | LI HaiOu YAO Bing TU Tao GUO GuoPing | 2012 | Chinese Science Bulletin2012，57，16： | 5 |
| 6 | Phosphate recovery with granular acid-activated neutralized red mud:Fixed-bed column performance and breakthrough curve modelling显示文摘Granular acid-activated neutralized red mud(AaN-RM)has been successfully prepared with good chemical stability and physical strength.However,its potential for industrial application remains unknown.Therefore,the performance of granular AaN-RM for phosphate recovery in a fixed-bed column was investigated.The results demonstrated that the phosphate adsorption performance of granular AaN-RM in a fixed-bed column was affected by various operational parameters,such as the bed depth,flow rate,initial solution pH and initial phosphate concentration.With the optimal empty-bed contact time(EBCT)of 24.27 min,the number of processed bed volumes and the phosphate adsorption capacity reached 496.95 and 84.80 mg/g,respectively.Then,the saturated fixed-bed column could be effectively regenerated with a0.5 mol/L HCl solution.The desorption efficiency remained as high as 83.45%with a low weight loss of 3.57%in the fifth regeneration cycle.In addition,breakthrough curve modelling showed that a 5-9-1 feed-forward artificial neural network(ANN)could be effectively applied for the optimization of the fixed-bed adsorption system;the coefficient of determination(R^2)and the root mean square error(RMSE)evaluated on the validation-testing data were 0.9987 and 0.0183,respectively.Therefore,granular AaN-RM fixed-bed adsorption exhibits promising potential for phosphate removal and recovery from polluted water. | Andong Hu Guoping Ren Jiangang Che Yulin Guo Jie Ye Shungui Zhou | 2020 | Journal of Environmental Sciences2020，32，4： | 4 |
| 7 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 8 | The mutation network for the hemagglutinin gene from the novel influenza A (H1N1) virus显示文摘A mutation network for the hemagglutinin gene(HA) of the novel type A(H1N1) influenza virus was constructed.Sequence homology analysis indicated that one HA sequence type from the viruses mainly isolated from Mexico was likely the original type in this epidemic.Based on the 658A and 1408T mutations in HA,the viruses evolving into this epidemic were divided into three categories,the Mexico,the transitional and the New York type.The three groups of viruses presented distinctive clustering features in their geographic distributions. | HE YunGang DING GuoHui BIAN Chao HUANG Zhong LAN Ke SUN Bing WANG XueCai LI YiXue WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang JIN WeiRong XIONG Hui DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenAn ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN Li | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 9 | Sharpness of some properties of weighted modulation spaces显示文摘We obtain some optimal properties on weighted modulation spaces. We find the necessary and sufficient conditions for product inequalities, convolution inequalities and embedding on weighted modulation spaces. Especially, we establish the analogue of the sharp Sobolev embedding theorem on weighted modulation spaces. | GUO WeiChao FAN DaShan WU HuoXiong ZHAO GuoPing | 2016 | Science China Mathematics2016，59，1： | 3 |
| 10 | Radio-frequency measurement in semiconductor quantum computation显示文摘Semiconductor quantum dots have attracted wide interest for the potential realization of quantum computation.To realize efficient quantum computation,fast manipulation and the corresponding readout are necessary.In the past few decades,considerable progress of quantum manipulation has been achieved experimentally.To meet the requirements of high-speed readout,radio-frequency(RF)measurement has been developed in recent years,such as RF-QPC(radio-frequency quantum point contact)and RF-DGS(radio-frequency dispersive gate sensor).Here we specifically demonstrate the principle of the radio-frequency refiectometry,then review the development and applications of RF measurement,which provides a feasible way to achieve high-bandwidth readout in quantum coherent control and also enriches the methods to study these artificial mesoscopic quantum systems.Finally,we prospect the future usage of radio-frequency refiectometry in scaling-up of the quantum computing models. | TianYi Han MingBo Chen Gang Cao HaiOu Li Ming Xiao GuoPing Guo | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 2 |
| 11 | Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus显示文摘In recent months,a novel influenza virus H1N1 broke out around the world.With bioinformatics technology,the 3D structure of HA protein was obtained,and the epitope residues were predicted with the method developed in our group for this novel flu virus.58 amino acids were identified as potential epitope residues,the majority of which clustered at the surface of the globular head of HA protein.Although it is located at the similar position,the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses. | WU Di XU TianLei SUN Jing DAI JianXin DING GuoHui HE YunGang ZHOU ZhengFeng XIONG Hui DONG Hui JIN WeiRong BIAN Chao JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang WANG Hao CHE XiaoYan HUANG Zhong LAN Ke SUN Bing WU Fan YUAN ZhenAn ZHANG Xi ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi GUO YaJun ZHAO GuoPing LI YiXue CAO ZhiWei | 2009 | Chinese Science Bulletin2009，54，13： | 2 |
| 12 | Biosorption and biotransformation of crystal violet by Aeromonas hydrophila DN322p显示文摘DN322p, Aeromonas hydrophila DN322 的一个后代,有能力同时在废水吸附并且将脱色三苯代甲烷染料。作为普通三苯代甲烷染料,水晶紫(CV ) 被选择测试 DN322p 的 decolorization 特征。在 0.5 h 以内,紧张 DN322p 吸附了大量 CV,生产一个深有颜色的房间小团和无色上层清液。随着时间的过去减轻的房间小团和上层清液的颜色。上层清液和房间小团的 dichloromethane 摘录两个都显示出明显的 CV 和 leuco CV (LCV ) 特征分别地,吸收度在 590 nm 和 260 nm 达到顶点在紫外力光谱分析。这发现显示 DN322p 房间能吸附二染料。一 99%(w/w ) decolorization 率与在 30id 状态反应性质摇晃在 2.5 h 以内被完成包括 Kirkendall 虚空的形成,也被执行在以后回流与 Sn-3.0 Ag-0.5 Cu 焊接焊接球。在在 125osphate 的固态的变老实验,更多是 effectiv 吗?? | Tao PAN | 2013 | Frontiers of Environmental Science & Engineering2013，7，2： | 2 |
| 13 | Modified pretreatment method for total microbial DNA extraction from contaminated river sediment显示文摘从污染环境样品的高质量的微生物引起的 DNA 的抽取是在微生物引起的生态的学习的必要的步。为土壤和沉积样品基于以前出版的方法,一个修改预告的处理方法为经由最佳的预告的处理参数的选择从重重地污染的河沉积样品提取微生物引起的 DNA 被开发(即,试剂答案,反应持续时间,和温度) 。预告的处理过程涉及与包含有效技术的 0.1 摩尔在废水消除危险、有毒、高度集中的有机化合物的一个答案在三次洗河沉积样品。在纸,多围的碳 nanotubes ( MWCNT ),由 O 的 functionalized <潜水艇class=“ a-plus-plus ”> 3 ,当任何金属不在时被用作催化剂在酚的催化湿空气氧化( CWAO )调查催化活动,硝基苯( NB )和在温和操作的苯胺调节( 155 | Yun FANG Meiying XU Xingjuan CHEN Guoping SUN Jun GUO Weimin WU Xueduan LIU | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 2 |
| 14 | Protective role and related mechanism of Gnaq n neural cells damaged by oxidative stress显示文摘Gnaq 是 G 蛋白质家庭的一个成员并且富于大脑织物。它由于它变化的高比率在黑瘤吸引了许多研究人员的注意。我们以前报导了在老鼠前脑外皮的 Gnaq 的表示水平显著地与年龄被减少。氧化应力(OS ) 是导致大脑老化和相关疾病的主要原因。在在大脑的 antioxidation 的 Gnaq 的角色和机制充分没被探索。在现在的学习,基因 recombinant 技术和 lentivirus transfection 技术被用来产生结合的一个 Gnaq-overexpression 房间模型(Gnaq-SY5Y ) H 2 造一个 OS 模型的 O 2 。细胞,反应的氧种类(ROS ) 的集中, apoptosis 相关的蛋白质(Bcl-2 和 Bax ) ,和信号小径(NF-B 和 Erk1/2 ) 的生存能力在模型细胞和控制细胞之间被比较。结果证明 Gnaq-SY5Y 房间的抗氧化的能力显著地被改进。附随地,在 Gnaq-SY5Y 房间的 ROS 水平显著地被减少房间是否服从于到 H 2 O 2 处理。Anti-apoptotic 蛋白质 Bcl-2 是起来调整的,支持 apoptosis 蛋白质 Bax 在在有 H 2 O 2 。NF-B 和 phosphorylated Erk1/2 (p-Erk1/2 ) 在 Gnaq-SY5Y 房间是显著地下面调整的。H 2 O 2 处理减少了 Gnaq 表示但是在 Gnaq-SY5Y 房间的增加的 NF-B 和 p-Erk1/2 表情。Gnaq 在神经房间在 antioxidation 起一个枢轴的作用,这因此被结束。为这的机制将是 overexpressed Gnaq 禁止细胞的损坏效果的可能的 A 由 NF-B 和 Erk1/2 信号小径调停了。 | Nannan Jia Guoping Li Pu Huang Jiazhi Guo Lugang Wei Di Lu Shaochun Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 2 |
| 15 | Study on Spatial Variation of Soil Moisture in Coal Mining Subsidence Area in Mu Us Sandy Land显示文摘In order to explore the spatial distribution and variation characteristics of soil moisture in coal mining subsidence area in Mu Us sandy Land,and provide theoretical basis for the restoration of the mining area,experiments based on a linear sampling and classic statistical and geostatistical methods were conducted. Spatial distribution characteristics and variation of soil moisture in the typical 0 to 100 cm dune area in the subsidence area and the non-subsidence area( control) were studied. The results showed that in the typical sand dune location of nonsubsidence area( control),the probability distribution curves of soil moisture changes in all layers along vertical and horizontal directions were all normal distribution,and it was consistent with the temporal and spatial variation characteristics of soil moisture in conventional dunes in Mu Us sandy land. By contrast,two years after the coal mine collapsed,the variations of soil moisture in different layers along vertical and horizontal directions were different,and soil moisture loss was more serious than that of control dune by nearly 10% to 30%,and the standard deviation varied from 0. 54 to 1. 05,increasing by 52. 08% compared with the non-subsidence area( control). The probability of positive and negative deviation greater than 1 was over 50%,and the coefficient of variation varied from 0. 14 to 0. 28,which was 80% higher than that of nonsubsidence area( control). After collapsing,the average level of soil moisture,standard deviation,variance and variation coefficient had greatly changed,and influence of coal mining subsidence on soil moisture was the most in the middle layer( 30-70 cm),and was not obvious in the surface( 0-20 cm) and lower layer( 80-100 cm). In coal mining subsidence area,the dispersion degree of soil moisture in different layers along the vertical and horizontal direction was greatly improved,which increased spatial variation of soil moisture. | Guoping ZHAO Haiyan WANG Junbao LI Hui GUO | 2018 | Asian Agricultural Research2018，10，3： | 2 |
| 16 | Re-characterization of an extrachromosomal circular plasmid in the pathogenic Leptospira interrogans serovar Lai strain 56601显示文摘在中国,(str.56601 ) 螺旋体 interrogans serovar Lai 紧张 56601 是在人和动物引起严重细螺旋体病的主要病原的紧张之一。完全在 2003 定序的这 organismwas 的染色体。在 2011,然而,我们由于广泛地在螺旋体染色体散布的重复序列在 str.56601 染色体识别了并且改正一些集会错误。在这研究,我们重新分析以前报导在染色体 andrectified 的活动、噬菌体相关的 genomic 岛用各种各样的试验性的方法在 plasmid 和染色体详细说明了顺序信息。分开的圆形的 extrachromosomal plasmid 也是的 presenceof 证实岛在 L 报导了,并且它在 genomic 区域的地点是到 genomic 的 determinedrelative。由基于的脉搏地胶化电气泳动和 plasmid 的联合的 interrogans serovar Lai 基于抽取的南部的污点 analysis.This 报告证实分开的 extrachromosomal 通报 plasmid 不集成于 L 的染色体。interrogans str.56601 并且显著地改进了我们 L 的 genomic 组织,进化,和致病的理解。interrogans。特别地,这 extrachromosomal 通报 plasmid 的描述将在病原的螺旋体种类贡献 geneticmanipulation 系统的开发。 | Lili Huang Weinan Zhui Ping He Yan Zhang Xuran Zhuang Guoping Zhao Xiaokui Guo Jinhong Qin Yongzhang Zhu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 1 |
| 17 | Quantum memory for individual polarized photons显示文摘 | Guo Guoping Guo Guangcan | 2003 | Physical Letters A2003，318，45： | 1 |
| 18 | Leptospira interrogans encodes an ROK family glucokinase involved in a cryptic glucose utilization pathway显示文摘尽管螺旋体 interrogans 是不能的作为它的碳 / 精力利用葡萄糖,采购原料, L 的 LA_1437 基因。interrogans serovar Lai 潜在地编码组 III glucokinase (GLK ) 。L。interrogans GLK (LiGLK ) 不同类地在 Escherichia 表示了 coli 被净化并且证明了是有它 12.3 的特定的活动的 homodimeric 酶 ? 桴 ? 慰瑲慩?? 潤慭湩愠摮渠牯慭?? 整浲湩獵? 獩猠潨瑲牥琠慨 ? 偁 ? 湡 ??? 戠 ? 桴 ? 敲獡湯漠 ? 敧敮映慲敭桳晩 ? 畭慴楴湯搠牵湩? | Qing Zhang Yunyi Zhang Yi Zhong Jun Ma Nanqiu Peng Xingjun Cao Chen Yang RongZeng Xiaokui Guo Guoping Zhao | 2011 | Acta Biochimica et Biophysica Sinica2011，43，8： | 1 |
| 19 | Quantum secret sharing without entang-lement显示文摘 | Guo Guoping Guo Guangcan | 2003 | Physics Letters A2003，310，4： | 1 |
| 20 | Differential biofilms characteristics of Shewanella decolorationis microbial fuel ceils under open and closed circuit conditions显示文摘 | Yang Yonggang Sun Guoping Guo Jun | | 0，，14： | 1 |
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