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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Phosphorylation and assembly ofglutamate receptors after brain ischemia显示文摘 | Zhang F Guo AL Liu CL | 2013 | Stroke2013，44，1： | 1 |
| 3 | Irreversible striatal neu- roimaging abnormalities secondary to prolonged, uncon- trolled diabetes mellitus in the setting of progressive focal neurological symptoms 显示文摘 | Tung CS Guo YC Lai CL | 2010 | Neurol Sci2010，31，1： | 1 |
| 4 | Inhibitory effects of Cen- tella asiatica water extract and asiaticoside on inducible ni- tric oxide synthase during gastric ulcer healing in rats显示文摘 | Guo JS Cheng CL Koo MW | 2004 | Planta Med2004，70，12： | 1 |
| 5 | The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats显示文摘 | Cheng CL Guo J S Luk J | 2004 | Life Sci2004，74，18： | 1 |
| 6 | Novel pH-and Temperature-Responsive Block Copolymers with Tunable pH-Responsive Range显示文摘 | He CL Zhao CW Chen XS Guo ZJ Zhuang XL and Jing XB | | 0，，： | 1 |
| 7 | Isolation of PAH-degrading bacteria from mangrove sediments and their biodegradation potential显示文摘 | Guo CL Zhou HW Wong YS | 2005 | Marine Pollution Bull2005，51，： | 1 |
| 8 | The role of Th17 ceils in adult patients with chronic idiopathic thrombocyto- penic purpura显示文摘 | Guo ZX Chen ZP Zheng CL | 2009 | Eur J Haematol2009，82，6： | 1 |
| 9 | Downregulation of Thyl in retinal ganglion cells in experimental glaucoma显示文摘 | Huang W Fileta J Guo Y Grosskreutz CL | 2005 | Curt Eye Res2005，31，3： | 1 |
| 10 | Preliminary report on hand searching results of 15 Chinese dental journals from the earliest first volume of 1953 to the volumes of 2000显示文摘 | Shi ZD Guo CL Chen E Zhang WL Xia F Chen L | 2003 | Chin J Evidence-based medicine2003，3，1： | 1 |
| 11 | Effects of zinc supplementation on plasma cop- per/zinc ratios, oxidative stress, and immunological status in hemo- dialysis patients显示文摘 | Guo CH Wang CL | 2013 | lnt J Med Sci2013，10，1： | 1 |
| 12 | CDC Growth Charts for theUnited States:methods and development显示文摘 | Kuczmarski RJ Ogden CL Guo SS | 2002 | Vital Health Stat2002，，246： | 1 |
| 13 | STAT3 Activation in Acute Lung Injury显示文摘 | Guo RF Speyer CL | 2004 | J Immunol2004，172，1： | 1 |
| 14 | Purification of an active fragment of Crylle toxin from Bacillus thuringieusis 显示文摘 | Guo SY Zhang CL Lin XY | 2011 | Protein Expression and Purification2011，78，： | 1 |
| 15 | A study on the induction of differentiation of human leukemic ceils by harringtonine combined with cytarabine 显示文摘 | Huang CL Deng ML Guo R J | 1988 | Leukemia1988，2，8： | 1 |
| 16 | Evaluation of coronary arterystent patencyby using 64- slice multi-detector computed tomography and conventional coronary angiography: A comparison with intravascular ultrasonography显示文摘 | Hang CL Lee YW Guo GB | 2013 | Int J Cardiol2013，166，1： | 1 |
| 17 | Predictors of sinus rthythm control by amiodarone and electrical cardioversion in patients undergoing percutaneous transluminal mitral valvuloplasty for rheumatic atrial fibrillation显示文摘 | Guo GB Hang CL Chang HW | 2007 | Circ J2007，71，： | 1 |
| 18 | The berry constituents quercetin,kaempferol,and pterostilbene synergistically attenuate reactive oxygen species:Involvement of the Nrf2-ARE signaling pathway显示文摘 | Saw CL Guo Y Yang AY | 2014 | Food Chem Toxicol2014，72，： | 1 |
| 19 | The anti-fatty liver effects of garlic oil on acute ethanol-exposed mice显示文摘 | Zeng T Guo FF Zhang CL | 2008 | Chem Biol Interact2008，176，23： | 1 |
| 20 | Dorsomedial bypothalamlc nucleus neurons integrate important peripheral feeding-related signals in rats显示文摘 | Zhu JN Guo CL Li HZ | 2007 | J Neurosci Res2007，85，14： | 1 |
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