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| 1 | A comparison between intravenous and peritoneal route on liver targeted uptake and expression of plasmid delivered by Glyco-poly-L-lysine显示文摘AIM To compare the effects of intravenous routeand peritoneal route on liver targeted uptake andexpression of plasmid delivered by galactose-terminal glyco-poly-L-lysine(G-PLL).METHODS The plasmid pTM/MMP-1 which couldbe expressed in eukaryotic cells was bound to G-PLL,and was then transferred into Wistar rats byintravenous and intraperitoneal injection.Theexpression and distribution of the plasmid wereobserved at different time periods by in situhybridization and immunohistochemistry.RESULTS The plasmid could be expressedsignificantly within 24 h after being transferred invivo by both intravenous and intraperitonealroutes.One week later the expression began todecrease,and could still be observed three weekslater.Although both the intravenous andintraperitoneal route could target-specificallydeliver the plasmid to the liver,the effect of theformer was better as compared to that of the latter.CONCLUSION Intravenous route is better for livertargeted uptake and expression of G-PLL-boundplasmids than the peritoneal route. | Yang CQ Wang JY Fang GT Liu JJ Guo JS | 2000 | World Journal of Gastroenterology2000，6，4： | 4 |
| 2 | Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat liver显示文摘AIM To compare the effects of liposomes andglyco-poly-L-lysine on liver targeted uptake andexpression of plasmid in rat liver.METHODS After binding with lipofectamine orgalactose-terminal glyco-poly-L-lysine,theplasmid could be expressed in eukaryotic cellswhen injected into Wistar rats by intravenousroute.At different time intervals after the injection,the distribution and expression of the plasmid inliver of rats were observed and compared using insitu hybridization and immunohistochemistry.RESULTS The expression of the plasmid bindingto liposomes or G-PLL could be markedly observed24 h later,and began to decrease one week later,but it still could be observed up to three weeks.Both liposomes and G-PLL could deliver theplasmid to the liver effectively,but the effect of thelatter was better than the former concerning thedistribution and expression of the plasmid targeteduptake in the liver.CONCLUSION G-PLL is better than liposome asthe targeted carrier for delivering exogenous genesto the liver. | Yang, CQ Wang, JY He, BM Liu, JJ Guo, JS | 2000 | World Journal of Gastroenterology2000，6，4： | 3 |
| 3 | Chemoradiotherapy of locally advanced esophageal cancer : long - term follow - up of a prospective randomized trial( RTOG 85 -01 ) 显示文摘 | Cooper JS Guo MD Herskovic | 1999 | JAMA1999，281，17： | 1 |
| 4 | Mammalian microRNAs predominantly act to decrease target mRNA levels 显示文摘 | Guo H Ingolia NT Weissman JS | 2010 | Nature2010，466，7308： | 1 |
| 5 | Bevacizumab:a potential agent for prevention and treatment of hypertrophic scar 显示文摘 | Diao JS Xia WS Guo SZ | 2010 | Bums2010，36，7： | 1 |
| 6 | Endoscopic treatment of ectopic pregnancy in a cesarean scar显示文摘 | Li H Guo HY Han JS | 2011 | J Minim lnvasive Gynecol2011，18，1： | 1 |
| 7 | Two - stage surgical management u- sing posterior instrumentation, anterior debridement and allografting for tuberculosis of the lower lumbar spine in children of elementary school age : minimum 3 - year follow - up of lg patients显示文摘 | Zhang HQ Li JS Guo CF | 2012 | Arch Or- thop Trauma Surg2012，132，9： | 1 |
| 8 | Inhibitory effects of Cen- tella asiatica water extract and asiaticoside on inducible ni- tric oxide synthase during gastric ulcer healing in rats显示文摘 | Guo JS Cheng CL Koo MW | 2004 | Planta Med2004，70，12： | 1 |
| 9 | Chemoradiotherapy of locally advanced esophageal cancer:long-term follow-up of aprospective randomized trial(RTOG 85-01)Radiation Therapy On eology Group显示文摘 | Guo MD Herskovic A | 1999 | JAMA1999，281，17： | 1 |
| 10 | Chemoradiotherapy of loca-lly advanced esophageal cancer:long-term follow-up of a prosp-ective randomized trial(RTOG 85-01)显示文摘 | Cooper JS Guo MD Herskovic A | 1999 | JAMA1999，281，17： | 1 |
| 11 | Mass production and high photocatalytic activity of ZnS nanoporous nanoparticles显示文摘 | Hu JS Ren LL Guo YG Liang HP Cao AM Wan LJ | 2005 | Angew Chem Int Ed2005，44，1： | 1 |
| 12 | Wedge-shaped excision and modified vertical mattress suture fully buried in a multilayered and tensioned wound closure 显示文摘 | Zhang X Diao JS Guo SZ | 2009 | Aesthetic Plast Surg2009，33，3： | 1 |
| 13 | Two-stage surgical management using posterior instrumentation, anterior debridement and allografting for tuberculosis of the lower lumbar spine in children of elementary school age: minimum 3-year follow-up of 14 patients显示文摘 | Zhang HQ Li JS Guo CF | 2012 | Arch Orthop Trauma Surg2012，132，9： | 1 |
| 14 | Cotransplant of neural stem cells and NT-3 gene modified Schwann cells promote the recovery of transected spinal cord injury显示文摘 | Guo JS Zeng YS Li HB | | 0，，： | 1 |
| 15 | Mammalian microRNAs pre- dominantly act to d - ecrease target mRNA levels 显示文摘 | Guo H Ingolia NT Weissman JS | 2010 | Nature2010，7308，466： | 1 |
| 16 | Synergistic anti-tumor ac- tivity of paclitaxel-incorporated conjugated linoleic ac- id-coupled poloxamer thermosensitive hydrogel in vitro and in vivo显示文摘 | Guo DD Xu CX Quan JS etal | 2009 | Biomaterials2009，30，： | 1 |
| 17 | Chemoradith- erapy of locally esophageal cancer: Long - term follow - up of a prospective randomized trial ( RTOG 8501 ) Radiation Therapy Oncology Group 显示文摘 | Cooper JS Guo MD Herskovic A | 1999 | JAMA1999，281，： | 1 |
| 18 | Cotransplant of neural stem cells and NT-3 gene modified Schwann cells promote the recovery of transected spinal cord injury显示文摘 | Guo JS Zeng YS Li HB | 2007 | Spinal Cord2007，45，1： | 1 |
| 19 | Isolation and Genetic Characteristics of Human Genotype 1 Japanese Encephalitis Virus, China, 2009显示文摘 | Zhang JS Zhao QM Guo XF | 2011 | PLOSOne2011，6，16： | 1 |
| 20 | Endoscopic treatment of ec-topic pregnancy in a cesarean scar显示文摘 | LI H GUO HY HAN JS | 2011 | J Minim Invasive Gy-necol2011，18，1： | 1 |
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