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| 1 | LSECtin on tumor-associated macrophages enhances breast cancer sternness via interaction with its receptor BTN3A3显示文摘Macrophages have bee n suggested to con tribute to con structing a cancer stem cell(CSC)niche.However,whether and how macrophages regulate the activity of CSCs through juxtacrine signaling are poorly understood.Here we report LSECtin,a transmembrane protein highly expressed on tumor-associated macrophages(TAMs),enhances sternness of breast cancer cells(BCCs).We identified BTN3A3,a B7 family member with previously unknown functions as the receptor for LSECtin on BCCs responsible for stemness-promoting effect of LSECtin.In mice bearing human tumor xenografts,either macrophage-specific ablation of LSECtin or silencing of BTN3A3 in BCCs decreased CSC frequency and tumor growth.Admixture of LSECtin-positive macrophages increased the tumorigenic activity of BCCs dependent on BTN3A3.Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 mAb has a therapeutic effect on breast cancer.These findings define a juxtacrine signaling mechanism by which TAMs promote cancer stemness.Targeting this axis in the CSC niche may provide potential therapies to breast cancer. | Di Liu Qian Lu Xing Wang Jun Wang Ning Lu Zefei Jiang Xiaopeng Hao Jianbin Li Jing Liu Pengbo Cao Guilin Peng Yuandong Tao Dianyuan Zhao Fuchu He Li Tang | 2019 | Cell Research2019，29，5： | 8 |
| 2 | Connectivity in finite ad-hoc networks显示文摘Research on ad-hoc network connectivity has mainly focused on asymptotic results in the number of nodes in the network. For a one-dimensional ad-hoc network G1, assuming all the nodes are independently uniform distributed in a closed interval [0,Z](z ∈ R+), we derive a generic formula for the probability that the network is connected. The finite connected ad-hoc networks is analyzed. And we separately suggest necessary conditions to make the ad-hoc network to be connected in one and two dimensional cases, facing possible failed nodes (f-nodes). Based on the necessary condition and unit-disk assumption for the node transmission, we prove that the nodes of the connected two-dimensional ad-hoc networks (G2) can be divided into at most five different groups. For an f-node n0 in either of the five groups, we derive a close formula for the probability that there is at least one route between a pair of nodes in G2 - {n0}. | WANG HanXing LU GuiLin JIA WeiJia ZHAO Wei | 2008 | Science in China(Series F)2008，51，4： | 3 |
| 3 | Multivariate similarity clustering analysis:a new method regarding biogeography and its application in global insects显示文摘A new method,multivariate similarity clustering analysis(MSCA)method,was established for biogeographical distribution analyzing.General similarity formula(GSF),the core of MSCA method,can be used to calculate the similarity coefficients between 2 and among any≥3 geographical units.Taking the global insects as example,we introduced the steps to use of GSF and consequent clustering processes of this method in details.Firstly,geographical distributions of certain taxa(e.g.Insecta)were categorized into basic geographical units(BGUs);Secondly,similarity coefficients between 2 and among n BGUs were calculated using GSF.Thirdly,hierarchical clustering was conducted according to values of similarity coefficients(from high to low);then a clustering diagram was generated.Finally,a framework of biogeographical division map was established for the target taxa(e.g.Insecta).We concluded that the MSCA method was efficiently applied in analyzing the biogeographical distribution of given biological taxa;the geographical regions regarding global insects were categorized into 7 Realms with 20 sub-Realms based on the results of MSCA method. | Xiaocheng SHEN Shujie ZHANG Qi SHEN Guilin HU Jiqi LU | 2021 | Integrative Zoology2021，16，3： | 2 |
| 4 | Virus-inspired surface-nanoengineered antimicrobial liposome:A potential system to simultaneously achieve high activity and selectivity显示文摘Enveloped viruses such as SARS-CoV-2 frequently have a highly infectious nature and are considered effective natural delivery systems exhibiting high efficiency and specificity.Since simultaneously enhancing the activity and selectivity of lipopeptides is a seemingly unsolvable problem for conventional chemistry and pharmaceutical approaches,we present a biomimetic strategy to construct lipopeptide-based mimics of viral architectures and infections to enhance their antimicrobial efficacy while avoiding side effects.Herein,a surface-nanoengineered antimicrobial liposome(SNAL)is developed with the morphological features of enveloped viruses,including a moderate size range,lipid-based membrane structure,and highly lipopeptide-enriched bilayer surface.The SNAL possesses virus-like infection to bacterial cells,which can mediate high-efficiency and high-selectivity bacteria binding,rapidly attack and invade bacteria via plasma membrane fusion pathway,and induce a local“burst”release of lipopeptide to produce irreversible damage of cell membrane.Remarkably,viral mimics are effective against multiple pathogens with low minimum inhibitory concentrations(1.6-6.3μg mL1),high bactericidal efficiency of>99%within 2 h,>10-fold enhanced selectivity over free lipopeptide,99.8%reduction in skin MRSA load after a single treatment,and negligible toxicity.This bioinspired design has significant potential to enhance the therapeutic efficacy of lipopeptides and may create new opportunities for designing next-generation antimicrobials. | Yin Shi Xiaoqian Feng Liming Lin Jing Wang Jiaying Chi Biyuan Wu Guilin Zhou Feiyuan Yu Qian Xu Daojun Liu Guilan Quan Chao Lu Xin Pan Jianfeng Cai Chuanbin Wu | 2021 | Bioactive Materials2021，6，10： | 1 |
| 5 | Infinite Three-Dimensional Coordination Polymers: Synthesis and Structures of [Cd (4,4'-bpy)_2 (H_2O)_2]_n (pic)_(2n),[Zn (4,4'-bpy)_2 (H_2O)_2]_n(pic)_(2n) (H_2O)_(2n), and [Zn (4,4'-bpy)_2 (H_2O)_2]_n (4,4'-bpy)_n(H_2O)_n (pic)_(2n)显示文摘Three Complexes of the formula [Cd (4,4’-bpy)2 (H2O)2]n. (pic)2n (1) [Zn (4,4’-bpy)2 (H2O)]n (4,4’-bpy)n(H2O)n (pic)-(2n) (2) and [Zn (4,4’-bpy)2 (H2O)]n (4,4’-bpy)n (pic)-(2n)(H2O)n (3) (4.4’-bpy = 4.4’-bipyridine. pic = picric anion ) have been synthesized and characterized by elemental analysis and single-crystal x-ray diffraction. They all have infinite three-dimensional network structure. crystallizing in the monoclinic space group C2/c (1) and Cc (2.3). | Fu Pei LIANG~1 Zi Lu CHEN~1 Rui Xiang HU~1 Hong LIANG~1 Zhao Hui ZHOU~2 (1 Department of Chemistry. Guangxi Normal University: Guilin 541004 2 Department of Chemistry. Xiamen University. Xiamen 361005) | 2000 | Chinese Chemical Letters2000，11，4： | 1 |
| 6 | Effect of heat stress on the porcine small intestine: A morphological and gene expression study显示文摘 | Jin Yu Peng Yin Fenghua Liu Guilin Cheng Kaijun Guo An Lu Xiaoyu Zhu Weili Luan Jianqin Xu | 2010 | Comparative Biochemistry and Physiology, Part A2010，，1： | 1 |
| 7 | Imprinted sol–gel electrochemical sensor for melamine direct recognition and detection显示文摘 | Guilin Xu Hongli Zhang Min Zhong Tingting Zhang Xiaojing Lu Xianwen Kan | 2014 | Journal of Electroanalytical Chemistry2014，，： | 1 |
| 8 | Effect of heat stress on the porcine small intestine: A morphological and gene expression study显示文摘 | Jin Yu Peng Yin Fenghua Liu Guilin Cheng Kaijun Guo An Lu Xiaoyu Zhu Weili Luan Jianqin Xu | 2010 | Comparative Biochemistry and Physiology Part A2010，，1： | 1 |
| 9 | A lead isotope record of shanghai atmospheric lead emissions in total suspended particles during the period of phasing out of leaded gasoline显示文摘 | Jianmin Chen Mingguang Tan Yulan Li Yuanmao Zhang Wenwei Lu Yongpeng Tong Guilin Zhang Yan Li | 2004 | Atmospheric Environment2004，，7： | 1 |
| 10 | Experimental investigation of a two-degree-of-freedom vibro-impact system显示文摘 | Wen Guilin Xu Huidong Xiao Lu | 2012 | International Journal of Bifurcation and Chaos2012，22，12： | 1 |
| 11 | Relationship between respiratory viral load and lung lesion seV erity:a study in24 cases of pandemic H1Nl 2009 influenza A pneumonia显示文摘 | LU Puxuan DENG Yingying YANG Guilin | 2012 | J Thorac Dis2012，4，4： | 1 |
| 12 | Evaluation of the protective effect of salidroside on arsenic-induced cardiac dysfunction in rats显示文摘Arsenic is a natural metal found in nature.Excessive intake of arsenic in the human body can lead to acute and chronic arsenic poisoning and even induce various diseases,such as cancers[1].According to statistics,approximately 200 million people worldwide are exposed to the toxic effects of arsenic[2].Previous studies showed that in the case of arsenic poisoning,arsenic could induce cells to produce excessive reactive oxygen species(ROs)through oxidative stress pathways,promote inflammatory reactions,and cause myocardial cell damage,leading to dysfunction of the heart[3,4].Salidroside(Sal)has been proven to have various pharmacological activities,such as anti-inflammatory,antioxidant,anticancer,antimetabolic disorders,and neuroprotective effects[5].In recent years,the cardiovascular protective effect of Sal has received attention and has been used to treat various cardiovascular diseases[6]. | Ruimeng Tian Jing Cheng Yanna Wang Chuncui Chen Lei Huang Caiyun Zhang Yifei Zhou Shanshan Dong Guilin Lu Wenjuan Qin | 2024 | Acta Biochimica et Biophysica Sinica2024，56，1： | 0 |
| 13 | A CONTROL OBSERVATION ON THERAPEUTIC EFFECTS OF INTELLIGENT(COMPUTERIZED)ELECTROACUPUNCTURE AND COMMON ELECTROACUPUNCTURE TREATING 77 CASES OF NEUROSIS显示文摘77 cases of neurosis were treated with intelligent(computerized)elec-troacupuncture(IEA)and common electroacupuncture(CEA)at two different wave forms and fre-quencies.The results showed that the markedly effective rates of IEA and CEA were respectively75% and 60% without a statistically significant difference.For different subtypes of neurosis,thetherapeutic effects of IEC in the treatment 6f neurasthenia and depressive neurosis were superior toand in the treatment of anxiety was inferior to those of CEA.For different syndromes,the curativeeffects of IEA on somatic symptom,depression and asthenic symptom were.superior to and on anxietyand sleep-disorder were not as good as those of CEA. | Luo Hechun Jia Yunkui Zhou Aimin Lu Linglin Feng Xiuqin Zhao Xueying. Institute of Mental Health,Beijing Medical University,Beijing 100083,China *Xiangfan Municipal Hospital of Mental Rehabilitation,Hubei Province,China.**The Second Guilin District Hospital,Guangxi Province,China. | 1993 | World Journal of Acupuncture-Moxibustion1993，3，2： | 0 |
| 14 | Anthropogenic footprints are invading global habitats of Indo-Pacific humpback dolphins显示文摘As ecologically fragile areas,coastal zones are affected by both anthropogenic activities and climate change.However,the impacts of these factors on large nearshore mammals,such as Indo-Pacific humpback dolphins(IPHDs,Sousa chinensis),are poorly understood.Here,modeling revealed that the suitable habitats of IPHDs are affected mainly by the sea surface temperature(SST),and the habitat suitability decreases as the distance to the nearest coastline increases.In addition,anthropogenic activities involving demersal fishing,contamination and shipping have narrowed IPHD habitats and reduced the habitat suitability.We found that climate change will further narrow suitable habitats located farther than 7 km from coastlines and trigger habitat losses in the eastern Taiwan Strait by 2090-2100 under the Representative Concentration Pathway(RCP)8.5 scenario.The projected decreases in habitat suitability and area emphasize the urgency of establishing connected marine protected areas(MPAs)while considering climate change,intergovernmental cooperation,and public involvement. | Yongquan Lu Guilin Liu William W.L.Cheung Yuyang Xian Weijia Chen Dandan Yu | 2023 | Geography and Sustainability2023，4，1： | 0 |
| 15 | Effects of Different Drying Methods on Content of Paederosidic Acid in Paederia scandens显示文摘[Objectives]To establish a method to simultaneously determine the content of paederosidic acid in Paederia scandens dried by four different methods.[Methods]Reversed-phase high performance liquid chromatography(RP-HPLC)was adopted.The chromatographic column:Thermo SCIENTIFIC Hypersil GOLD Dim.(mm);mobile phase:acetonitrile-0.1%phosphoric acid aqueous solution;gradient elution;column temperature:30℃;flow rate:1 mL/min;detection wavelength:236 nm;injection volume:10μL.[Results]The linear range of the detection injection volume of paederosidic acid was 0.64-9.60μg(R=0.9992);the limit of quantity(LOQ)was 5.10 ng,and the limit of detection(LOD)was 1.36 ng;the RSD of the precision,stability and reproducibility test was all less than 3%;the sample recovery rate was 98.87%,RSD<3.00,n=6.The results show that the content of paederosidic acid in the shade-dried P.scandens is the highest,and the order of the content is P.scandens(dry in shade)>P.scandens(dried at 50℃)>P.scandens(dried at 60℃)>P.scandens(dried at 70℃).[Conclusions]This method is sensitive,reliable and reproducible,and can be used to simultaneously determine the content of paederosidic acid in P.scandens dried by four different methods. | Jingrong LU Haisheng ZENG Silu HE Xiumei MA Dongmei HUANG Guilin YANG Chengtong LIU Qiji ZHOU | 2020 | Medicinal Plant2020，11，6： | 0 |
| 16 | Studies on the Synthesis,Characterization and Properties of the Reactive Thermotropic Liquid Crystalline Polymer显示文摘1 Introduction Four species of reactive thermotropic liquid crystalline polymer (LCMC) with different relative molecular weight were synthesized in this work (see scheme 1, n=2, 6, 10, ∞.n means number of repeat structure unit). Their structure, morphology and properties were investigated systemically by differential scanning calorimetry (DSC), Thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), Wide-angle X-ray diffraction (WAXD), polarizing opticalmicroscopy (POM) and ubb... | Chun Wei, Chi-hua Lu, Deng Xu, Yong-yang Gong, Wei-zhong LU, Ming Zeng (Key Laboratory of New Processing Technology for Nonferrous Metals and Materials, Ministry of Education, Guilin University of Technology, Guilin 541004, China) | 2007 | 复旦学报(自然科学版)2007，46，5： | 0 |
| 17 | Optimization of the Extraction Process of Rutin from Flos Sophorae by Orthogonal Experiments显示文摘[Objectives]This study was conducted to optimize the extraction process of rutin in Flos Sophorae.[Methods]With the percentage content of rutin extracted from Flos Sophorae as the evaluation index and rutin as the reference substance,the content of rutin in Flos Sophorae extracted ultrasonically was determined by high performance liquid chromatography.L_(9)(3^(4))orthogonal experiments were carried out to optimize the three factors(solvent concentration,material-to-liquid ratio,extraction time)that affect the effect of ultrasonic extraction of rutin from Flos Sophorae.[Results]The extraction effect of the crude medicinal powder was best with the methanol concentration of 80%,the ratio of material to liquid at 0.1∶30,and the extraction time of 40 min.[Conclusions]This study provides a reference for optimizing the extraction process of rutin in Flos Sophorae. | Shan LI Meiyuan LU Lin YAO Xinying MO Guilin YANG Haisheng ZENG | 2021 | Agricultural Biotechnology2021，10，4： | 0 |
| 18 | Determination of Polydatin in Rat Serum and Its Changes by UPLC Method显示文摘[Objectives]To establish a UPLC-UV method for the determination of polydatin in the serum of Wistar rats.[Methods]Acquity UPLC BEH shield RP18 column(1.7μm,2.1 mm×100 mm,Waters Corporation,USA)was used as the analytical column,acetonitrile-water(55∶45)was used as the mobile phase,the flow rate was 0.5 mL/min,and the column temperature was 30℃and the detection wavelength was 306 nm.[Results]The linear range of the established serum sample analysis method was 1.0-20.0μg/mL,and the correlation coefficient was r=0.9994;the intraday and interday RSD of Wistar rat serum was less than 3.0%,and the accuracy was higher than 90%.[Conclusions]This method is sensitive,accurate,and rapid.It is suitable for monitoring the concentration of polydatin in serum after intragastric administration,and can also be used for pharmacokinetics and bioavailability studies. | Haisheng ZENG Zhiqiang WANG Meiyuan LU Chao ZENG Mengxia YANG Guilin YANG | 2021 | Medicinal Plant2021，12，2： | 0 |
| 19 | Quantitative Evaluation of the Larval Density of Sea Potato Acaudina spp.with Mitochondrial Molecular Marker显示文摘The sea potato Acaudina spp.is a species of sea cucumber,belonging to the class Holothuroidea under Phylum Echino-dermata.It becomes blooming recently in the East Sea of China,causing serious ecological problems.However,until now there are no molecular data for its larval identification and population genetic analysis.In this study,we firstly screened a mtDNA fragment and demonstrated that it was the species-specific molecular marker for the identification of Acaudina spp.We then developed a quantitative polymerase chain reaction(PCR)method to evaluate the larval density of Acaudina spp.based on this molecular probe.Utilizing this method,we examined 116 plankton samples collected in four seasons from 13 stations along the coastal region in Fu-jian province,China.The results showed that the high larval density was presented at stations 1,2,and 3,which were near a quay in the coast.The larval density increased from April and reached the highest value in June and July,suggesting temperature might be the main environmental factor on the effects of its population distribution and density.Our work provides an important molecular tool for species identification and risk evaluation of a potentially invasive species. | LI Xiang WANG Guilin LI Yunfan LIU Wei LU Chao GUO Yuchen HUANG Wen WANG Jinhui DONG Bo | 2021 | Journal of Ocean University of China2021，20，3： | 0 |
| 20 | Strength of undisturbed and reconstituted frozen soil at temperatures close to 0 ℃显示文摘The strength of warm frozen soils in permafrost is fundamentally significant to estimate and predict the ground settlements from construction activities. A study was therefore initiated to assess the strength and its behaviors of undisturbed and reconstituted frozen soils at temperatures close to 0 ℃. A series of triaxial compression tests(TCT) were performed by using a developed testing apparatus and a matching specimen-preparation method. The confinement was applied from air pressure, the temperature in the specimen was maintained using two-end refrigeration, and multi-stage loading on a single specimen was adopted to determine the strength. The test results showed that the strength, both for the undisturbed and reconstituted frozen-soil specimens, was significantly dependent on the temperatures and independent of the applied confining pressures. Additionally, the strength of undisturbed frozen soils was about 1.6 times more than that for reconstituted frozen soils. These observations were closely associated with the structures existing between pore-ice and gravels with large diameters. | XiaoDong Zhao GuoQing Zhou GuiLin Lu Yue Wu Wei Jiao Jing Yu | 2017 | Research in Cold and Arid Regions2017，9，4： | 0 |
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