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23篇 您的检索式:作者名="Guangwei He"
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1Experimental investigation of vortex-induced vibrations of long free spans near seabed显示文摘There are many experimental studies dedicated to determining the effect of the proximity of a plane boundary on the vortex-induced vibration (VIV) of submarine pipeline spans, but they all only concerned the first mode VIV motion of the pipe. In this paper, a pipe model, 16 mm in diameter, 2.6 m in length and with a mass ratio (mass/displaced mass) of 4.30, was tested in a current tank. The reduced velocity was in the range of 0-16.7 and gap ratios at the pipe ends were 4.0, 6.0 and 8.0. The response of the model was measured using optical fiber strain gauges. Results of response amplitude and frequency were presented and the transition from the first dominant mode to the second one was shown. In the tests, it was found that the response amplitude experienced a continuous transition between the two modes, but the dramatic increase in the response frequency appeared with the shift in dominant mode from the first mode to the second one as the flow velocity increased. As the gap ratio decreased, the shift in the dominant mode took place at a higher reduced velocity.LI XiaoChao WANG YongXue LI GuangWei JIANG MeiRong HE Xu 2011Science China(Technological Sciences)2011,54,3:9
2The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer显示文摘Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous cells1 that play crucial negative regulatory roles in immune-associated diseases,including infections,2 cancer,3 transplantation4,and autoimmunity.5 We and others have shown that mTOR signaling and its downstream metabolic pathways regulate MDSC recruitment and function in inflammation and autoimmunity.Anna Jia Yuexin Wang Yufei Wang Yan Li Qiuli Yang Yejin Cao Ying He Lin Dong Yingjie Dong Yueru Hou Ruoning Wang Yujing Bi Guangwei Liu 2021Cellular & Molecular Immunology2021,18,4:7
3Engineering Covalent Organic Framework Membranes显示文摘CONSPECTUS:Membrane technology plays an increasingly important role for sustainable development of our society owing to its huge capability to tackle the energy crisis,water scarcity,environmental pollution,and carbon neutrality.To fully unlock the potential of membranes,it is in high demand to develop advanced membrane materials that significantly outperform conventional polymer membrane materials in separation performance and longterm stability.The emergent covalent organic frameworks(COFs)have been deemed as potent membrane materials because of their unique structure and properties in comparison with polymers,zeolites,and metal organic frameworks(MOFs).(i)First,the highly tunable and ordered crystalline pore structure,high porosity,and excellent stability render COFs an ideal membrane material.COFs are more stable than MOFs and,in some cases,are even more stable than zeolite.Moreover,it is easier to introduce functional groups into the COF nanochannels compared with zeolite and MOFs.Further,COFs are ideally suitable for constructing ordered nanochannels with size in the range of 0.6−3 nm which is difficult to be realized by other materials.(ii)Second,along with the unremitting discovery of diverse platform chemistries such as reticular chemistry,the in-depth understanding of nucleation/growth mechanisms of COFs as well as the rapid progress of manufacturing technologies and various routes to fabricating COF membranes with favorable physical and chemical structures inside the nanochannels are being actively exploited.COFs generally show better membrane-formation ability owing to their abundant 2D structures,which make it easier to fabricate ultrathin membranes compared with zeolite and MOFs.(iii)Last,a great number of COF membranes exhibit exceptionally high separation performance and stability,establishing their position as the next-generation membranes.In this Account,we discuss three types of engineering toward COF membranes based on Schiff base reaction for high-efficiency molecules/ion separations,i.e.,reticular engineering,crystal engineering,and nanochannel engineering.First,we discuss the reticular engineering of COF membranes with a focus on the bond types,chemical structure,and architecture design.The membraneformation ability and methods of COFs are also analyzed.Second,we discuss the crystal engineering of COF membranes with a focus on the key thermodynamical and kinetic factors to drive the disorder-to-order transition where we attempt to dig deeper into the crystallization habit of COF membranes.Third,we discuss nanochannel engineering of COF membranes with a focus on the construction and modulation of the physical and chemical microenvironments of nanochannels for efficient and selective transport of molecules/ions.Last,we conclude with a perspective on the opportunities and major challenges in the R&D of COF membranes,targeting at identifying the future directions.Guangwei He Runnan Zhang Zhongyi Jiang 2021Accounts of Materials Research2021,2,8:4
4Molecular characterization of bacterial community in aerobic granular sludge stressed by pentachlorophenol显示文摘To characterize the effects of pentachlorophenol (PCP) on the performance and microbial community of aerobic granular sludge in sequencing batch reactor (SBR), the web-based terminal restriction fragment length polymorphism (T-RFLP) and real-time PCR (RT- PCR) techniques were used to explore the bacterial community structure. When PCP increased from 0 to 50 mg/L, the COD removal rate changed little, while the ammonia removal rate dropped from 100% to 64.9%. The results of molecular characterization showed that the quantity of ammonia oxidizing bacteria (AOB) kept constantly, although the number of bacteria species decreased with the increase of PCP concentration. Significant shift in bacterial community structure at different PCP stresses was observed within aerobic granular sludge. When the PCP was absent, there are 69 strains in aerobic granular sludge detected by T-RFLP method. With the increase of PCP, most of bacteria disappeared and only 19 bacteria existed at all five PCP concentrations. These results contributed to comprehensive understanding of the microbial community structure under the PCP stress and its relationship with the performance for wastewater treatment by aerobic granular sludge.LIU, He LI, Guangwei LI, Xiufen CHEN, Jian 2008Journal of Environmental Sciences2008,20,10:4
5Tissue level microstructure and mechanical properties of the femoral head in the proximal femur of fracture patients显示文摘This study aims to investigate the regional variations of trabecular morphological parameters and mechanical parameters of the femoral head,as well as to determine the relationship between trabecular morphological and mechanical parameters.Seven femoral heads from patients with fractured proximal femur were scanned using a micro-CT system.Each femoral head was divided into 12 sub-regions according to the trabecular orientation.One 125 mm^3 trabecular cubic model was reconstructed from each sub-region.A total of 81 trabecular models were reconstructed,except three destroyed sub-regions from two femoral heads during the surgery.Trabecular morphological parameters,i.e.trabecular separation(Tb.Sp),trabecular thickness(Tb.Th),specific bone surface(BS/B V),bone volume fraction(BV/TV),structural model index(SMI),and degree of anisotropy(DA) were measured.Micro-finite element analyses were performed for each cube to obtain the apparent Young's modulus and tissue level von Mises stress distribution under 1%compressive strain along three orthogonal directions,respectively.Results revealed significant regional variations in the morphological parameters(P<0.05).Young's moduli along the trabecular orientation were significantly higher than those along the other two directions.In general,trabecular mechanical properties in the medial region were lower than those in the lateral region.Trabecular mechanical parameters along the trabecular orientation were significantly correlated with BS/BV,BV/TV,Tb.Th,and DA.In this study,regional variations of microstructural features and mechanical properties in the femoral head of patients with proximal femur fracture were thoroughly investigated at the tissue level.The results of this study will help to elucidate the mechanism of femoral head fracture for reducing fracture risk and developing treatment strategies for the elderly.Linwei Lü Guangwei Meng He Gong Dong Zhu Jiazi Gao Yubo Fan 2015Acta Mechanica Sinica2015,31,2:4
6Regorafenib-loaded poly(lactide-co-glycolide) microspheres designed to improve transarterial chemoembolization therapy for hepatocellular carcinoma显示文摘Transarterial chemoembolization(TACE)has been widely introduced to treat hepatocellular carcinoma(HCC)especially for unresectable patients for decades.However,TACE evokes an angiogenic response due to the secretion of vascular endothelial growth factor(VEGF),resulting in the formation of new blood vessels and eventually tumor recurrence.Thus,we aimed to develop regorafenib(REGO)-loaded poly(lactide-co-glycolide)(PLGA)microspheres that enabled localized and sustained drug delivery to limit proangiogenic responses following TACE in HCC treatment.REGO-loaded PLGA microspheres were prepared using the emulsion-solvent evaporation/extraction method,in which DMF was selected as an organic phase co-solvent.Accordingly,we optimized the proportion of DMF,which the optimal ratio to DCM was 1:9(v/v).After preparation,the microspheres provided high drug loading capacity of 28.6%,high loading efficiency of 91.5%,and the average particle size of 149μm for TACE.IR spectra and XRD were applied to confirming sufficient REGO entrapment.The in vitro release profiles demonstrated sustained drug release of microspheres for more than 30 d To confirm the role of REGO-loaded microspheres in TACE,the cell cytotoxic activity on HepG2 cells and anti-angiogenic effects in HUVECs Tube-formation assay were studied in combination with miriplatin.Moreover,the microspheres indicated the potential of antagonizing miriplatin resistance of HepG2 cells in vitro.Pharmacokinetics preliminary studies exhibited that REGO could be sustainably released from microspheres for more than 30d after TACE in vivo.In vivo anti-tumor efficacy was further determined in HepG2 xenograft tumor mouse model,demonstrating that REGO microspheres could improve the antitumor efficacy of miriplatin remarkably compared with miriplatin monotherapy.In conclusion,the obtained REGO microspheres demonstrated promising therapeutic effects against HCC when combined with TACE.Xiang Li Guangwei He Feng Su Zhaoxing Chu Leiming Xu Yazhong Zhang Jianping Zhou Yang Ding 2020Asian Journal of Pharmaceutical Sciences2020,15,6:4
7Thermo-Calc based multi-component micro-segregation model and solidification paths calculations显示文摘On the basis of a multi-length scale modeling, a mixture-averaged multi-component /multiphase micro-segregation model was proposed without pre-set function for the micro-scale solute profile. The model explains the effect of morphologies of solidifying phases and solid back diffusion (SBD) on segregation, and covers the two limiting solidification cases of Scheil and Lever-rule models. A commercial Thermo-Calc software package/database was linked to the algorithms via its TQ6-interface for instantaneous determination of the related thermodynamic data of the multi-component alloys. The influences of cooling rate and other parameters on the solidification path and micro-segregation behavior were numerically investigated by sample calculation of the ternary Al-Cu-Mg alloys. A parallel experimental investigation on Al-Cu-Si alloys solidified under different cooling conditions was conducted to validate the theoretical model. Reasonable agreements were gained between the predicted solidification paths and the measured results.Zhao Guangwei Li XinZhong Xu Daming Guo Jingjie Fu Hengzhi Du Yong He Yuehui 2012China Foundry2012,9,3:3
8Spatiotemporal Mapping of Salt Marshes in the Intertidal Zone of China during 1985-2019显示文摘This study mapped the areal extent,identified the species composition,and analyzed the changes of salt marshes in the intertidal zone of China during the period 1985–2019.With the aid of the cloud platform of the Google Earth Engine,we selected Landsat 5/8 and Sentinel-2 images and used the support vector machine classification method to extract salt marsh information for the years of 1985,1990,1995,2000,2005,2010,2015,and 2019.Seven major species of salt marshes:Phragmites australis,Suaeda spp.,Spartina alterniflora,Scirpus mariqueter,Tamarix chinensis,Cyperus malaccensis,and Sesuvium portulacastrum were identified.Our results showed that salt marshes are mainly distributed in Liaoning,Shandong,Jiangsu,Shanghai,and Zhejiang,with varying patterns of shrinking,expansion,or wavering in different places.The distribution of salt marshes has declined considerably from 151,324 ha in 1985 to 115,397 ha in 2019,a drop of 23.7%.During the same period,the area of native species has dropped 95.4%from 77,741 ha to 3,563 ha for Suaeda spp.and 45.1%from 60,511 ha to 33,193 ha for P.australis;on the contrary,the area of exotic species,S.alterniflora,has exhibited a sharp rise from just 99 ha to 67,527 ha.For the past 35 years,the driving factors causing salt marsh changes are mainly land reclamation,variations in water and sand fluxes,and interspecific competition and succession of salt marsh vegetation.These results provide fundamental reference information and could form the scientific basis for formulating policies for the conservation and utilization of salt marsh resources in China.Guangwei Chen Runjie Jin Zhanjiang Ye Qi Li Jiali Gu Min Luo Yongming Luo George Christakos James Morris Junyu He Dan Li Hengwei Wang Li Song Qiuxuan Wang Jiaping Wu 2022Journal of Remote Sensing2022,,1:2
9Highly conductive and robust composite anion exchange membranes by incorporating quaternized MIL-101(Cr)显示文摘With well-defined channels and tunable functionality, metal-organic frameworks(MOFs) have inspired the design of a new class of ion-conductive compounds. In contrast to the extensive studies on protonconductive MOFs and related membranes attractive for fuel cells, rare reports focus on MOFs in preparation of anion exchange membranes. In this study, chloromethylated MIL-101(Cr) was prepared and incorporated into chloromethylated poly(ether ether ketone)(PEEK) as a multifunctional filler to prepare imidazolium PEEK/imidazolium MIL-101(Cr)(Im PEEK/Im MIL-101(Cr)) anion exchange membrane after synchronous quaternization. The successful synthesis and chloromethylation of MIL-101(Cr) were verified by transmission electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy while the enhanced performance of composite membranes in hydroxide conductivity, mechanical strength and dimensional stability were evaluated by alternating-current impedance, electronic stretching machine and measurement of swelling ratio. Specifically, incorporating 5.0 wt% Im MIL-101(Cr)afforded a 71.4% increase in hydroxide conductivity at 20 °C, 100% RH. Besides, the composite membranes exhibited enhanced dimensional stability and mechanical strength due to the rigid framework of Im MIL-101(Cr). At room temperature and the Im MIL-101(Cr) content of 10 wt%, the swelling ratio of the Im PEEK/Im MIL-101(Cr) was 70.04% lower while the tensile strength was 47.5% higher than that of the pure membrane.Xueyi He Mingyue Gang Zhen Li Guangwei He Yongheng Yin Li Cao Bei Zhang Hong Wu Zhongyi Jiang 2017Science Bulletin2017,62,4:2
10Engineering HOF‑Based Mixed‑Matrix Membranes for Efficient CO_(2) Separation显示文摘Hydrogen-bonded organic frameworks(HOFs)have emerged as a new class of crystalline porous materials,and their application in membrane technology needs to be explored.Herein,for the first time,we demonstrated the utilization of HOF-based mixed-matrix membrane for CO_(2) separation.HOF-21,a unique metallo-hydrogen-bonded organic framework material,was designed and processed into nanofillers via amine modulator,uniformly dispersing with Pebax polymer.Featured with the mix-bonded framework,HOF-21 possessed moderate pore size of 0.35 nm and displayed excellent stability under humid feed gas.The chemical functions of multiple binding sites and continuous hydrogen-bonded network jointly facilitated the mass transport of CO_(2).The resulting HOF-21 mixed-matrix membrane exhibited a permeability above 750 Barrer,a selectivity of~40 for CO_(2)/CH_(4) and~60 for CO_(2)/N_(2),surpassing the 2008 Robeson upper bound.This work enlarges the family of mixed-matrix membranes and lays the foundation for HOF membrane development.Yuhan Wang Yanxiong Ren Yu Cao Xu Liang Guangwei He Hanze Ma Hongliang Dong Xiao Fang Fusheng Pan Zhongyi Jiang 2023Nano-Micro Letters2023,15,4:2
11Deoxynivalenol accumulation and detoxification in cereals and its potential role in wheat-Fusarium graminearum interactions显示文摘Deoxynivalenol(DON)is a prominent mycotoxin showing significant accumulation in cereal plants during infection by the phytopathogen Fusarium graminearum.It is a virulence factor that is important in the spread of F.graminearum within cereal heads,and it causes serious yield losses and significant contamination of cereal grains.In recent decades,genetic and genomic studies have facilitated the characterization of the molecular pathways of DON biosynthesis in F.graminearum and the environmental factors that influence DON accumulation.In addition,diverse scab resistance traits related to the repression of DON accumulation in plants have been identified,and experimental studies of wheat–pathogen interactions have contributed to understanding detoxification mechanisms in host plants.The present review illustrates and summarizes the molecular networks of DON mycotoxin production in F.graminearum and the methods of DON detoxification in plants based on the current literature,which provides molecular targets for crop improvement programs.This review also comprehensively discusses recent advances and challenges related to genetic engineering-mediated cultivar improvements to strengthen scab resistance.Furthermore,ongoing advancements in genetic engineering will enable the application of these molecular targets to develop more scab-resistant wheat cultivars with DON detoxification traits.Kun Luo Jiao Guo Dejia He Guangwei Li Thérèse Ouellet 2023aBIOTECH2023,4,2:2
12Regional Variations in Trabecular Morphological Features of Femoral Head of Patients with Proximal Femoral Fractures显示文摘Linwei Lv Guangwei Meng He Gong Dong Zhu Jiazi Gao Meisheng Zhao 2015Journal of Bionic Engineering2015,12,2:1
13One-Pot Synthesis of Chloromethylated Mesoporous Silica Nanoparticles as Multifunctional Fillers in Hybrid Anion Exchange Membranes显示文摘Xueyi He Mingyue Gang Guangwei He Yongheng Yin Li Cao Hong Wu Zhongyi Jiang 2017Chinese Journal of Chemistry2017,35,5:1
14Genetic dissection of climacteric fruit ripening in a melon population segregating for ripening behavior显示文摘Melon is as an alternative model to understand fruit ripening due to the coexistence of climacteric and non-climacteric varieties within the same species,allowing the study of the processes that regulate this complex trait with genetic approaches.We phenotyped a population of recombinant inbred lines(RILs),obtained by crossing a climacteric(Védrantais,cantalupensis type)and a non-climcteric variety(Piel de Sapo T111,inodorus type),for traits related to climacteric maturation and ethylene production.Individuals in the RIL population exhibited various combinations of phenotypes that differed in the amount of ethylene produced,the early onset of ethylene production,and other phenotypes associated with ripening.We characterized a major QTL on chromosome 8,ETHQV8.1,which is sufficient to activate climacteric ripening,and other minor QTLs that may modulate the climacteric response.The ETHQV8.1 allele was validated by using two reciprocal introgression line populations generated by crossing Védrantais and Piel de Sapo and analyzing the ETHQV8.1 region in each of the genetic backgrounds.A Genome-wide association study(GWAS)using 211 accessions of the ssp.melo further identified two regions on chromosome 8 associated with the production of aromas,one of these regions overlapping with the 154.1 kb interval containing ETHQV8.1.The ETHQV8.1 region contains several candidate genes that may be related to fruit ripening.This work sheds light into the regulation mechanisms of a complex trait such as fruit ripening.Lara Pereira Miguel Santo Domingo Valentino Ruggieri Jason Argyris Michael A.Phillips Guangwei Zhao Qun Lian Yongyang Xu Yuhua He Sanwen Huang Marta Pujol Jordi Garcia-Mas 2020Horticulture Research2020,7,1:1
15China's Tourism Industry:New Year to Bring Chances显示文摘Timeflies,andpeople'sideasofwhattodoonholidayandwherechangealmostasfastastheseasons.China'stourismindustrywillsoonbeintheyear2000andtheywillhavetomakechangestoattractandmeetpeople'sneedsinthenewmillennium.Chinahasabundantnaturalresources,alonghistory...He GuangWei(Chairman of the China State Tourism Administration) 2000World Economy & China2000,8,Z1:0
16Crucial role of histone deacetylase SIRT1 in myeloid-derived suppressor cell-mediated reprogramming of CD4^(+) T-cell differentiation显示文摘Myeloid-derived suppressor cells(MDSCs)are heterogeneous,immature myeloid cells that inhibit the immune responses of T cells.1–5 MDSCs play a crucial role in infection,6,7 transplantation,8,9 autoimmune diseases10,11,and tumors12,13 by driving the differentiation of specific T-cell subsets,but the precise regulatory mechanism is still unclear.Recently,our results showed that SIRT1,a histone deacetylase,suppresses the functions of proinflammatory MDSCs and promotes tumor growth.14 However,it remains unclear whether SIRT1 regulates the MDSC-induced differentiation of T cells.Here,we identified the regulatory effects of SIRT1 in CD11b+Gr1+MDSCs on T-cell differentiation.Lin Dong Yujing Bi Anna Jia Qing Yu Yuexin Wang Yufei Wang Qiuli Yang Yejin Cao Ying He Ruichen Liu Yan Li Guangwei Liu 2020Cellular & Molecular Immunology2020,17,7:0
17Robust THP Design with the Presence of Errors in CSIT Acquisition显示文摘In this paper, a robust THP is proposed for broadcast channel in multi-user multi-input multi-output (MU-MIMO) system, in which the channel uncertainty caused by feedback delay and mobile speed is taken into account. In order to acquire the imperfect channel state information at transmitter (CSIT), a dynamic CSIT model is introduced where the channel temporal and spatial correlations are considered. By utilizing the unchanged channel statistics and accurate outdated feedback channel information jointly, the imperfect CSIT is obtained as the channel estimate and error covariance. Based on the obtained imperfect CSIT, a Minimum Mean-Square Error (MMSE) Tomlinsion-Harashima precoding (THP) is designed and the closed-form solution is derived by the Lagrangian multiplier approach under total power constraint. Simulation results are provided to indicate the preferable performances of the robust THP. Performance analysis with respect to feedback delay and mobile speed is also given.Wang Xuzhen Niu Kai He Zhiqiang Yu Guangwei Li Hui 2010China Communications2010,7,2:0
18The haplotype-resolved T2T reference genome highlights structural variation underlying agronomic traits of melon显示文摘Melon(Cucumis melo L.)is an important vegetable crop that has an extensive history of cultivation.However,the genome of wild and semi-wild melon types that can be used for the analysis of agronomic traits is not yet available.Here we report a chromosome-level T2T genome assembly for 821(C.melo ssp.agrestis var.acidulus),a semi-wild melon with two haplotypes of∼373 Mb and∼364 Mb,respectively.Comparative genome analysis discovered a significant number of structural variants(SVs)between melo(C.melo ssp.melo)and agrestis(C.melo ssp.agrestis)genomes,including a copy number variation located in the ToLCNDV resistance locus on chromosome 11.Genome-wide association studies detected a significant signal associated with climacteric ripening and identified one candidate gene CM_ac12g14720.1(CmABA2),encoding a cytoplasmic short chain dehydrogenase/reductase,which controls the biosynthesis of abscisic acid.This study provides valuable genetic resources for future research on melon breeding.Guoli Li Lingli Tang Yuhua He Yongyang Xu Abdelhafid Bendahmane Jordi Garcia-Mas Tao Lin Guangwei Zhao 2023Horticulture Research2023,10,10:0
19Microstructure Manipulation of Covalent Organic Frameworks(COFs)-based Membrane for Efficient Separations显示文摘Covalent organic framework(COF) membranes have exhibited great potential to become the next-generation membranes for efficient separations due to the diverse structures, ordered framework pores, tunable functionality and excellent stability. This review presents the microstructure manipulation strategies for separation performance enhancement of COF membranes in recent years. Based on the three mechanisms of molecular sieving, surface diffusion, and facilitated transport, the structural modulation methods to enhance the selectivity of COF membranes are analyzed in detail. Next, strategies of realizing ultrashort mass transfer pathways and ultralow mass transfer resistance for the permeability enhancement are elaborated. Furthermore, the framework stability in COFs, interlayer stability between COF nanosheets and interfacial stability between COF layer and substrate are discussed. Finally, we discuss the existing challenges and perspectives on the future development of COF membranes, targeting at identifying the most promising strategies and directions for the engineering of COF membranes.MA Hanze WANG Shaoyu REN Yanxiong LIANG Xu WANG Yuhan ZHU Ziting HE Guangwei JIANG Zhongyi 2022Chemical Research in Chinese Universities2022,38,2:0
20R&D of BEPCII 500 MHz superconducting cavity显示文摘Beijing Electron-Positron Collider Upgrade (BEPCII) adopts two 500 MHz superconducting cavities (SCCs) in each ring for higher accelerated gradient, higher Q and lower impedance (Wang et al. The proceedings of SRF'07). There's no spare cavity due to the limited time and funding during BEPCII construction. If any serious trouble happened on either one of the two cavities and could not be recovered in a short time, the operation of BEPCII facility will be affected. Therefore, since 2009 three spare cavities have been fabricated in China to ensure reliable operation, and two of them have been successfully vertically tested in January and July 2011. This paper will briefly present the manufacture, post-process and vertical test performance of the 500 MHz spare cavities.LIU YaPing WANG GuangWei PAN WeiMin LI JiZhen LIU DeGui SUN Yi LI ZhongQuan DAI JianPing LI ShaoPeng HE Kun WANG GuoPing ZHAO GuangYuan MA Qiang LIN HaiYing SHA Peng WANG QunYao QIU Feng MENG FanBo LI Han 2011Science China(Physics,Mechanics & Astronomy)2011,54,S2:0
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