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| 1 | Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations显示文摘AIM: To explore portal hypertension and portosys-temic shunts and to stage chronic liver disease (CLD) based on the pathophysiology of portal hemodynam-ics. METHODS: Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angio-scintigraphy (LAS) on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters,the liver transit time (LTT) and the circu-lation time between right heart and liver (RHLT). LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal in? ow. We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS. RESULTS: The normal LTT value was 24 ± 1 s. Abnor-mal LTT had PPV = 100% for CLD. Twenty-seven non-cirrhotic patients had LTT increased up to 35 s (median 27 s). RHLT (42 ± 1 s) was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI < 5% (P < 0.01). PRSI > 30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the clas-sifi cation of CLD in 5 hemodynamic stages. Stage 0 is normal (LTT = 24 s,PRSI < 5%). In stage 1,LTT is increased,while PRSI remains normal. In stage 2,LTT is decreased between 16 s and 23 s,whereas PRSI is increased between 5% and 10%. In stage 3,PRSI is increased to 10%-30%,and LTT becomes undetect-able by PRPS due to the portosystemic shunts. Stage 4 includes the patients with PRSI > 30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD,stage 1 had PPV = 100% for non-cirrhotic CLD,stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis,stage 4 had PPV = 100% for cirrhosis. CONCLUSION: LTT allows the detection of early por-tal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution of portal hypertension and portosystemic shunts. It may be of use in the selection of patients for interferon therapy. | Mircea Dragoteanu Ioan A Balea Liliana A Dina Cecilia D Piglesan Ioana Grigorescu Stefan Tamas Sabin O Cotul | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 2 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 3 | Spontaneous and antiviral-induced cutaneous lesions in chronic hepatitis B virus infection显示文摘AIM:To describe spontaneous,or interferon(IFN)-or immunization-induced skin lesions in hepatitis B virus(HBV)infection.METHODS:A comprehensive literature search of all the papers presenting case reports of dermatological lesions in patients with chronic HBV infection was carried out.We included only patients with histologically proven skin lesions that appeared in the normal course of hepatitis B infection,or after immunization for hepatitis B or antiviral treatment.RESULTS:We found 44 papers on this topic,reporting 151 cases.About 2%of patients with hepatitis B infection,mainly men,presented with skin lesions.Among patients with chronic hepatitis B,vasculitis and essential mixed cryoglobulinemia seemed to be the most frequent skin lesion(53.3%),followed by papular changes,rashes and Gianotti-Crosti syndrome,skin carcinoma and Henoch-Sch?nlein purpura were rare.IFN treatment seemed to be effective against HBV-associated and immunoglobulin-complex-mediated disease(vasculitis).Two cutaneous lesions(lichen planus andgranuloma annulare)were described after hepatitis B vaccination.Systemic lupus and lupus-like lesions were the most frequently encountered lesions after antiviral treatment.Immunosuppressive and steroid therapy ameliorates lichen planus lesions in 50%of cases.CONCLUSION:Vasculitis was the most frequent spontaneous skin lesion found in chronic hepatitis B.Lichen planus was most frequent after immunization and lupus/lupus-like lesions after IFN. | Ioana Grigorescu Dan Lucian Dumitrascu | 2014 | World Journal of Gastroenterology2014，20，42： | 3 |
| 4 | Relationship between NT-proBNP and cardio-renal dysfunction in patients with ad- vanced liver eirrhosis显示文摘 | Cavasi A Cavasi E Grigorescu M | 2014 | J Gastrointestin Liver Dis2014，23，1： | 1 |
| 5 | Dynamic-mechanical and differential scanning calorimetry measurements on crosslinked poly (ester-siloxane) -urethanes显示文摘 | IOAN S GRIGORESCU G STANCIU A | 2001 | Polymer2001，42，： | 1 |
| 6 | Mortality risk factors in chronic pancreatitis显示文摘 | 0 Seicean A Tantau M Grigorescu M | | 0，，01： | 1 |
| 7 | Effect of segmented,poly (ester-siloxane) urethanes compositional parameters on differential scanning calorimetry and dynamic-mechanical measurements显示文摘 | IOAN S GRIGORESCU G STANCIU A | 2002 | Eur Polym J2002，38，： | 1 |
| 8 | International organizations and government transparency: Linking the international and domestic realms 显示文摘 | Grigorescu A | 2003 | Intemational Studies Quarterly2003，47，4： | 1 |
| 9 | Maternal characteris-tics and pregnancy outcomes after assisted reproductive technologyby infertility diagnosis : ovulatory dysfunction versus tubal obstruc-tion显示文摘 | Grigorescu V Zhang Yujia Kissin DM | 2014 | Fertility and Sterility2014，101，4： | 1 |
| 10 | Gemciabine and carboplation versus cisplatin and vinoreibine in advanced nan-small cell lung cancer stage ⅢA and Ⅳ:a Phase Ⅲ randomized trial显示文摘 | Grigorescu AC Draghici NH Nitipur C | 2002 | Lung Cancer2002，37，5： | 1 |
| 11 | Noninvasive biochemical markers of liver fibrosis 显示文摘 | GRIGORESCU M | 2006 | J Gastrointestin Liver Dis2006，15，2： | 1 |
| 12 | Comparison of texture features based on Gabor filters 显示文摘 | Grigorescu S E Petkov N Kruizinga P | 2002 | IEEE Tlmag Process2002，11，10： | 1 |
| 13 | Bioactive glass and hydroxyapatite thin films obtained by pulsed laser deposition 显示文摘 | Gyorgy E Grigorescu S Socol G | 2007 | Applied Surface Science2007，253，19： | 1 |
| 14 | Comparison of texture features based on Gabor filters显示文摘 | Grigorescu S E Petkov N Kruizinga P | 2002 | IEEE Transactions on Image Processing2002，11，10： | 1 |
| 15 | Contour detection based on nonclassical receptive field inhibition显示文摘 | Grigorescu C Petkov N Westenberg M A | 2003 | IEEE Trans on Image Processing2003，12，7： | 1 |
| 16 | Innervation of the levator ani muscles: description of the nerve branches to the pubococcygeus, iliococcygeus, and puborectalis muscles 显示文摘 | Grigorescu BA Lazarou G Olson TR | 2008 | Int Urogynecol J Pelvic Floor Dysfunct2008，19，1： | 1 |
| 17 | Mortality risk factors in chronic pancreatitis显示文摘 | Seicean A Tantau M Grigorescu M | 2006 | J Gastrointestin Liver Dis2006，15，1： | 1 |
| 18 | Electroporation and eleetrofusion in cellular and viral biology显示文摘 | Grigorescu A | 1992 | Rev Roum Virol1992，43，12： | 1 |
| 19 | Tolerance of liver biopsy in a tertiary care center: comparison of the percutaneous and the transvenous route in 143 prospectively followed patients显示文摘 | Bogdan Procopet Christophe Bureau Sophie Métivier Janick Selves Marie Angèle Robic Camille Christol Mircea Grigorescu Jean-Pierre Vinel Jean-Marie Péron | 2012 | European Journal of Gastroenterology & Hepatology2012，，10： | 1 |
| 20 | Characterization of Microcapsules: Recommended Methods Based on Roundrobin Testing显示文摘 | Rosinski S Grigorescu G Lewinska D | 2002 | J Microencapsulation2002，19，5： | 1 |
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