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| 1 | New targeted therapies in pancreatic cancer显示文摘Patients with pancreatic cancer have a poor prognosis with a median survival of 4-6 mo and a 5-year survival of less than 5%. Despite therapy with gemcitabine, patient survival does not exceed 6 mo, likely due to natural resistance to gemcitabine. Therefore, it is hoped that more favorable results can be obtained by using guided immunotherapy against molecular targets. This review summarizes the new leading targeted therapies in pancreatic cancers, focusing on passive and specific immunotherapies. Passive immunotherapy may have a role for treatment in combination with radiochemotherapy, which otherwise destroys the immune system along with tumor cells. It includes mainly therapies targeting against kinases, including epidermal growth factor receptor, Ras/Raf/mitogenactivated protein kinase cascade, human epidermal growth factor receptor 2, insulin growth factor-1 receptor, phosphoinositide 3-kinase/Akt/m TOR and hepatocyte growth factor receptor. Therapies against DNA repair genes, histone deacetylases, micro RNA, and pancreatic tumor tissue stromal elements(stromal extracellular matric and stromal pathways) are also discussed. Specific immunotherapies, such as vaccines(whole cell recombinant, peptide, and dendritic cell vaccines), adoptive cell therapy and immunotherapy targeting tumor stem cells, have the role of activating antitumor immune responses. In the future, treatments will likely include personalized medicine, tailored for numerous molecular therapeutic targets of multiple pathogenetic pathways. | Andrada Seicean Livia Petrusel Radu Seicean | 2015 | World Journal of Gastroenterology2015，21，20： | 12 |
| 2 | Endoscopic ultrasound in chronic pancreatitis: Where are we now?显示文摘Endoscopic ultrasonography (EUS) is well suited for assessment of the pancreas due to its high resolution and the proximity of the transducer to the pancreas, avoiding air in the gut. Evaluation of chronic pancreatitis (CP) was an early target for EUS, initially just for diagnosis but later for therapeutic purposes. The diagnosis of CP is still accomplished using the standard scoring based on nine criteria, all considered to be of equal value. For diagnosis of any CP, at least three or four criteria must be fulf illed, but for diagnosis of severe CP at least six criteria are necessary. The Rosemont classif ication, more restrictive, aims to standardize the criteria and assigns different values to different features, but requires further validation. EUS-f ine needle aspiration (EUS-FNA) is less advisable for diagnosis of diffuse CP due to its potential side effects. Elastography and contrast-enhanced EUS are orientation in differentiating a focal pancreatic mass in a parenchyma with features of CP, but they cannot replace EUS-FNA. The usefulness of EUS-guided celiac block for painful CP is still being debated with regard to the best technique and the indications. EUS-guided drainage of pseudocysts is preferred in non-bulging pseudocysts or in the presence of portal hypertension. EUS-guided drainage of the main pancreatic duct should be reserved for cases in which endoscopic retrograde cholangiopancreatography has failed owing to difficult cannulation of the papilla or diff icult endotherapy. It should be performed only by highly skilled endoscopists, due to the high rate of complications. | Andrada Seicean | 2010 | World Journal of Gastroenterology2010，16，34： | 10 |
| 3 | Maximizing the endosonography: The role of contrast harmonics, elastography and confocal endomicroscopy显示文摘New technologies in endoscopic ultrasound(EUS) evaluation have been developed because of the need to improve the EUS and EUS-fine needle aspiration(EUS- FNA) diagnostic rate. This paper reviews the principle, indications, main literature results, limitations and future expectations for each of the methods presented. Contrast-enhanced harmonic EUS uses a low mechanical index and highlights slowflow vascularization. This technique is useful for differentiating solid and cystic pancreatic lesions and assessing biliary neoplasms, submucosal neoplasms and lymph nodes. It is also useful for the discrimination of pancreatic masses based on their qualitative patterns; however, the quantitative assessment needs to be improved. The detection of small solid lesions is better, and the EUS-FNA guidance needs further research. The differentiation of cystic lesions of the pancreas and the identification of the associated malignancy features represent the main indications. Elastography is used to assess tissue hardness based on the measurement of elasticity. Despite its low negative predictive value, elastography might rule out the diagnosis of malignancy for pancreatic masses. Needle confocal laser endomicroscopy offers useful information about cystic lesions of the pancreas and is still under evaluation for use with solid pancreatic lesions of lymph nodes. | Andrada Seicean Ofelia Mosteanu Radu Seicean | 2017 | World Journal of Gastroenterology2017，23，1： | 6 |
| 4 | Celiac plexus neurolysis in pancreatic cancer:The endoscopic ultrasound approach显示文摘Pain in pancreatic cancer is often a major problem of treatment.Administration of opioids is frequently limited by side effects or insufficient analgesia.Endoscopic ultrasound-guided celiac plexus neurolysis(EUS-CPN)represents an alternative for the palliative treatment of visceral pain in patients with pancreatic cancer.This review focuses on the indications,technique,outcomes of EUS-CPN and predictors of pain relief.EUS-CPN should be considered as the adjunct method to standard pain management.It moderately reduces pain in pancreatic cancer,without eliminating it.Nearly all patients need to continue opioid use,often at a constant dose.The effect on quality of life is controversial and survival is not influenced.The approach could be done in the central position of the celiac axis,which is easy to perform,or in the bilateral position of the celiac axis,with similar results in terms of pain alleviation.The EUS-CPN with multiple intraganglia injection approach seems to have better results,although extended studies are still needed.Further trials are required to enable more confident conclusions regarding timing,quantity of alcohol injected and the method of choice.Severe complications have rarely been reported,and great care should be taken in choosing the site of alcohol injection. | Andrada Seicean | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 5 | Quantitative endoskopische kontrastverst?rkte harmonische Sonografie zur Differenzierung solider Pankreastumoren显示文摘 | A. Seicean R. Badea R. Stan-Iuga T. Mocan I. Gulei O. Pascu | 2010 | Ultraschall in Med2010，，06： | 1 |
| 6 | Sleep-disordered breathing and impaired glu- cose metabolism in normal-weighe and overweight/obese individuals:the sleep heart health study 显示文摘 | Seicean S | 2008 | Diabetes Care2008，31，5： | 1 |
| 7 | Arterial bleeding during EUS-guided pseudocyst drainage stopped by placement of a covered self-expandable metal stent显示文摘 | Saftoiu A Ciobanu L Seicean A | 2013 | BMC Gastroenterol2013，24，13： | 1 |
| 8 | Sleep-disordered breathing and impaired glucosemetabolism in normal-weight and overweight/obeseindividuals: the Sleep Heart Health Study显示文摘 | SEICEAN S KIRCHNER H L COTTLIEB D J etal | 2008 | Diabe-tes Care2008，31，： | 1 |
| 9 | Mortality risk factors in chronic pancreatitis显示文摘 | 0 Seicean A Tantau M Grigorescu M | | 0，，01： | 1 |
| 10 | Ulcerative colitis worsened after Clostridium difficile infection:Efficacy of infliximab显示文摘The incidence of Clostridium difficile(C.difficile)infection(CDI)is 1.8%-5.7%in admitted patients with ulcerative colitis(UC).CDI can worsen UC and increase the risk for colectomy or even death,thus necessitating therapy escalation,such as increasing the corticoid therapy or starting a biologic treatment.Several reported cases with infliximab therapy have provided favorable outcomes in UC patients with CDI,suggesting that infliximab treatment may be protective;however,the optimal infliximab treatment regimen for UC patients with CDI remains to be established.Here,we report a case of worsening UC in the presence of recurrent CDI.The patient had received prior ciprofloxacin and immunosuppressive therapy during a prolonged hospital stay.The deterioration in the patient’s condition likely resulted from the ability of C.difficile to promote relapsing of UC by activating the immune response.Ultimately,the patient was treated with a high dose of infliximab after a low trough level of infliximab at week 8was identified,yielding better clinical results.Infliximab was found to be safe after repetitive episodes of CDI.The trough level of infliximab was therefore a useful indicator to guide therapy and correlated well with the patient’s outcome. | Andrada Seicean Anca Moldovan-Pop Radu Seicean | 2014 | World Journal of Gastroenterology2014，20，17： | 1 |
| 11 | Association between short sleeping hours and overweight in adolescents:results from a US Suburban High School survey显示文摘 | Seicean A Redline S Seicean S | 2007 | Sleep Breath2007，11，： | 1 |
| 12 | Mortality risk factors in chronic pancreatitis显示文摘 | Seicean A Tantau M Grigorescu M | 2006 | J Gastrointestin Liver Dis2006，15，1： | 1 |
| 13 | Effect of statin therapy on the risk for incident heart failure in patients with breast cancer receiving anthracycline chemotherapy: an observational clinical cohort study显示文摘 | Seicean S Seicean A Plana JC | 2012 | J Am Coll Cardiol2012，60，23： | 1 |
| 14 | Relationship between cachexia and perineural invasion in pancreatic adenocarcinoma显示文摘BACKGROUND Cachexia is responsible for the low quality of life in pancreatic adenocarcinoma(PDAC).The rapid disease progression and patient deterioration seems related to perineural invasion,but the relationship between cachexia and perineural invasion for the evolution of the disease has been rarely studied.As perineural invasion is difficult to be highlighted,a biomarker such as the neurotrophic factor Midkine(MK)which promotes the neuronal differentiation and the cell migration could be helpful.Also,Activin(ACV)has been described as cachexia related to PDAC.However,their role for assessing and predicting the disease course in daily practice is not known.AIM To assess the relationship between perineural invasion and cachexia and their biomarkers,MK and ACV,respectively,and their prognostic value.METHODS This study included prospectively enrolled patients with proven adenocarcinoma and a matched group of controls without any malignancies.Patients with other causes of malnutrition were excluded.The plasma levels of ACV and MK were analyzed using western blotting and were correlated with the clinicopathological features and survival data.These results were validated by immunohistochemical analyses of the pancreatic tumor tissue of the patients included in the study and a supplementary group of surgically resected specimens from patients with a benign disease.RESULTS The study comprised 114 patients with PDAC,125 controls and a supplementary group of 14 benign pancreatic tissue samples.ACV and MK were both overexpressed more frequently in the plasma of patients with PDAC than in the controls(63% vs 32% for ACV,P<0.001;47%vs 16%for MK,P<0.001),with similar levels in pancreatic tissue the MK protein expression was closely related to the advanced clinical stage(P=0.006),the presence of metastasis(P=0.04),perineural invasion(P=0.03)and diabetes(P=0.002),but with no influence on survival.No correlation between clinicopathological factors and ACV expression was noted.Cachexia,present in 19%of patients,was unrelated to ACV or MK level.Higher ACV expression was associated with a shorter survival(P=0.008).CONCLUSION The MK was a biomarker of perineural invasion,associated with tumor stage and diabetes,but without prognostic value as ACV.Cachexia was unrelated to perineural invasion,ACV level or survival. | Livia Petrusel Ioana Rusu Daniel Corneliu Leucuta Radu Seicean Ramona Suharoschi Paula Zamfir Andrada Seicean | 2019 | World Journal of Gastrointestinal Oncology2019，11，12： | 1 |
| 15 | The Plasma homocysteine concentrations and prior myocardial infarction 显示文摘 | Agoston - Coldea L Mocan T Seicean A | 2010 | Rom J Intern Med2010，48，1： | 1 |
| 16 | Sleep disordered breathing as a risk of cardiac events in subjects with diabetes mellitus and normal exercise echocardiographie findings 显示文摘 | Seicean S Strohl KP Seicean A | 2013 | Am J Cardiol2013，111，8： | 1 |
| 17 | Autoimmune chronic pancreatitis显示文摘 | Seicean A Grigorescu M Seicean R | 2006 | RomJ Intern Med2006，44，1： | 1 |
| 18 | Surgical treatment of severe acute pancreatitis显示文摘 | Uomon G Miraglia V Seicean R | 2006 | Chirurgia(Bucur)2006，101，6： | 1 |
| 19 | Impact of Repeat Myocardial Revascularization on Outcome in Patients With Silent Ischemia After Previous Revascularization显示文摘 | Nael Aldweib Kazuaki Negishi Rory Hachamovitch Wael A. Jaber Sinziana Seicean Thomas H. Marwick | 2013 | Journal of the American College of Cardiology2013，，15： | 1 |
| 20 | Cardioprotective effect of 13-adre- noceptor blockade in patients with breast cancer undergoing chemother- apy: follow-up study of heart failure显示文摘 | Seicean S Seicean A Alan N | 2013 | Circ Heart Fail2013，6，3： | 1 |
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