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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Paramyxovirus evasion of innate immunity: Diverse strategies for common targets显示文摘The paramyxoviruses are a family of > 30 viruses that variously infect humans, other mammals and fish to cause diverse outcomes, ranging from asymptomatic to lethal disease, with the zoonotic paramyxoviruses Nipah and Hendra showing up to 70% case-fatality rate in humans. The capacity to evade host immunity is central to viral infection, and paramyxoviruses have evolved multiple strategies to overcome the host interferon(IFN)-mediated innate immune response through the activity of their IFN-antagonist proteins. Although paramyxovirus IFN antagonists generally target common factors of the IFN system, including melanoma differentiation associated factor 5, retinoic acid-inducible gene-I, signal transducers and activators of transcription(STAT)1 and STAT2, and IFN regulatory factor 3, the mechanisms of antagonism show remarkable diversity between different genera and even individual members of the same genus; the reasons for this diversity, however, are not currently understood. Here, we review the IFN antagonism strategies of paramyxoviruses, highlighting mechanistic differences observed between individual species and genera. We also discuss potential sources of this diversity, including biological differences in the host and/or tissue specificity of different paramyxoviruses, and potential effects of experimental approaches that have largely relied on in vitrosystems. Importantly, recent studies using recombinant virus systems and animal infection models are beginning to clarify the importance of certain mechanisms of IFN antagonism to in vivo infections, providing important indications not only of their critical importance to virulence, but also of their potential targeting for new therapeutic/vaccine approaches. | Michelle D Audsley Gregory W Moseley | 2013 | World Journal of Virology2013，2，2： | 2 |
| 3 | Monitoring of aggregates in flowing suspensions显示文摘 | Gregory J Nelson D W | 1986 | Colloids Surfaces1986，18，1： | 2 |
| 4 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 5 | Cooperative diversity in wireless networks: efficient protocols and outage behavior显示文摘 | Laneman J N Tse D N C Wornell Gregory W | 2004 | IEEE Transactions on Information Theory2004，50，12： | 1 |
| 6 | Results of a retrospective claims database analysis of differences in antidepressant treatment persistence associated with escitalopram and other selective serotonin reuptake inhibitors in the united states显示文摘 | DOMINICK E PETER W GREGORY D | 2009 | Clinical Therapeutics2009，3，31： | 1 |
| 7 | Aircraft Design for Mission Performance Using Nonlinear Multi-objective Optimization Methods显示文摘 | Augustine R D Gregory A W | 1991 | J Aircraft1991，27，12： | 1 |
| 8 | A study on the friction and wear behavior of PTFE filled with alumina nanoarticles显示文摘 | Gregory S W Kevin D Freudenberg | 2003 | Wear2003，254，56： | 1 |
| 9 | The dynamic response of railway track to high frequency lateral excitation显示文摘 | GRASSIE S L GREGORY R W HARRISON D | 1982 | Journal of Mechanical Engineering Science1982，24，1： | 1 |
| 10 | Real options and integrated risk management 显示文摘 | KENT D M GREGORY W H S | 2003 | Long Range Planning2003，，36： | 1 |
| 11 | Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation显示文摘 | Jin Cong Shelburne Christopher P Li Guojie Potts Erin N Riebe Kristina J Sempowski Gregory D Foster W Michael Abraham Soman N | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 12 | Cooperative Diversity in Wireless Networks: Efficient Protocols and Outage Behavior 显示文摘 | J N Laneman D Tse Gregory W Wornell | 2004 | IEEE Trans Inform Theory2004，50，12： | 1 |
| 13 | Factors irffluencing the nitrification efficiency of fluidized bed filter with a plastic bead medium 显示文摘 | SIMONEL I S GREGORY D B BARNABY J W | 2002 | Aquacuhural Engineering2002，26，1： | 1 |
| 14 | The dynamic response of railway track to high frequency vertical excitation显示文摘 | GRASSIE S L GREGORY R W HARRISON D | 1982 | Journal Mechanical Engineering Science1982，24，： | 1 |
| 15 | Antithrombotic and thrombolytic therapy for ischemic stroke 显示文摘 | Gregory W A Pierre A J D E | 2008 | Chest2008，188，6： | 1 |
| 16 | Quantitiative Structure Activity Analyses of Nitrobenzen Toxicity toTetrahy-menapyriformis显示文摘 | Cronin M T D Gregory B W Schultz T W | 1998 | Chem Res Toxical1998，11，： | 1 |
| 17 | The Multidimensional Scale of Perceived Social Support 显示文摘 | Gregory D Zimet Nancy W Dahlem Sara G Zimet | 1988 | J Pers Assess1988，52，1： | 1 |
| 18 | Risk premiums in the term structure: Evidence from artificial economies 显示文摘 | Backus D K Gregory A W Zin S E | 1989 | Journal of Monetary Economics1989，24，3： | 1 |
| 19 | Enhanced external counterpulsation for the relief of angina in patients with diabetes: safety, efficacy and 1-year clinical outcomes显示文摘 | Georgiann Linnemeier Martin K Rutter Gregory Barsness Elizabeth D Kennard Richard W Nesto | 2003 | American Heart Journal2003，，3： | 1 |
| 20 | Government Debt 显示文摘 | Elmendorf D W Gregory Mankiw N | 1999 | Hand- book of Macreeconomics1999，，1： | 1 |
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