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| 1 | Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms. | Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，36： | 8 |
| 2 | Imaging of the gastrointestinal tract-novel technologies显示文摘Imaging of the gastrointestinal tract is very useful for research and clinical studies of patients with symptoms arising from the gastrointestinal tract and in visualising anatomy and pathology. Traditional radiological techniques played a leading role in such studies for a long time. However, advances in non-invasive modalities including ultrasound (US), computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), etc, have in the last decades revolutionised the way in which the gastrointestinal tract is studied. The resolution of imaging data is constantly being improved and 3D acquisition, tools for fi ltering, enhancement, segmentation and tissue classif ication are continually being developed. Additional co-registration techniques allow multimodal data acquisition with improved classif ication of tissue pathology. Furthermore, new functional imaging techniques have become available. Altogether, the future of gastrointestinal imaging looks very promising which will be of great benef it in clinical and research studies of gastrointestinal diseases. The purpose of this review is to highlight the capabilities of the newest techniques to explore the detailed morphology, biomechanical properties, function and pathology of the gastrointestinal tract. | Jens Brφndum Frφkjr Asbjφrn Mohr Drewes Hans Gregersen | 2009 | World Journal of Gastroenterology2009，15，2： | 2 |
| 3 | Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice显示文摘 | Gregersen R Lambertsem K Finsen B | 2000 | J Cereb Blood Flow Metab2000，20，1： | 1 |
| 4 | Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice 显示文摘 | Gregersen R Lambertsem K Finsen B | 2000 | J Cereb Blood Flow Metab2000，20，1： | 1 |
| 5 | Microglial - macrophage synthesis of tumor necrosis factor after focal cerebral ischemia in mice is strain dependent 显示文摘 | Lambertsen K L Gregersen R Finsen B | 2002 | J Cereb Blood Flow Metab2002，22，： | 1 |
| 6 | A robust linkage map of the porcine autosomes based on gene-associated SNPs显示文摘 | Rikke K K Vingborg Vivi R Gregersen Bujie Zhan | 2009 | BMC Genomics2009，10，： | 1 |
| 7 | A role for interferon-gamma in focal cerebral ischemia in mice显示文摘 | LAMBERTSEN KL GREGERSEN R MELDGAARD M | 2004 | J Neuropathol Exp Neurol2004，63，9： | 1 |
| 8 | A role for interferon-gamma in focal cerebral ischemia in mice显示文摘 | Lambertsen K L Gregersen R Meldgaard M | 2004 | J Neuropathol Exp Neurol2004，63，9： | 1 |
| 9 | Focal cerebral ischemia induces increased myelin basic protein and growth-associated protein-43 gene transcription in peri-infarct areas in the rat brain显示文摘 | Gregersen R Christensen T Lehrmann E | 2001 | Exp Brain Res2001，138，3： | 1 |
| 10 | Biogas plants in Demnark:successes and setbacks显示文摘 | RAVEN R P J M GREGERSEN K H | 2007 | Renewable & Sustainable Energy Reviews2007，11，1： | 1 |
| 11 | A role for interferon-gamma in focal cerebral ischemia in mice 显示文摘 | Lambertsen K L Gregersen R Meldgaard M | 2004 | J Neuropathol Exp Neurol2004，63，9： | 1 |
| 12 | Influence of male sex on disease phenotype in familial rheumatoid arthritis 显示文摘 | Jawaaeer D Lum R F Gregersen P K Criswell L A | 2006 | Arthritis Rheum2006，54，10： | 1 |
| 13 | A role for interferon-gamma in focal cerebral ischemia in mice显示文摘 | Lambertsen KL Gregersen R Meldgaard M | 2004 | J Neuropathol Exp Neurol2004，63，9： | 1 |
| 14 | Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice 显示文摘 | Gregersen R Lambertsen K Finsen B | 2002 | Cereb Blood Flow2002，20，1： | 1 |
| 15 | Biogas plants in Denmark:successes and setbacks显示文摘 | R P J M RAVEN K H GREGERSEN | 2007 | Renewable and sustainable Energy Reviews2007，11，1： | 1 |
| 16 | Focal cerebral ischemia induces increased myelin basic proteinand growth-associated protein-43 gene transcription in pe- ri-infarct areas in the rat brain显示文摘 | Gregersen R Christensen T Lehrmann E | 2001 | Exp Brain Res2001，138，3： | 1 |
| 17 | Peptide Receptor Radionuclide Therapy with Y-DOTATOC and 177Lu-DOTATOC in Advanced Neuroendocrine Tumors: Results from a Danish Cohort Treated in Switzerland显示文摘 | Pfeifer Andreas Klaus Gregersen Tine Gr?nb?k Henning Hansen Carsten Paln?s Müller-brand Jan Herskind Bruun Karin Krogh Klaus Kj?r Andreas Knigge Ulrich | 2011 | EN2011，，3： | 1 |
| 18 | A role for interferon-gamma in focal cerebral ischemiain mice 显示文摘 | Lambertsen KL Gregersen R Meldgaard M | 2004 | J Ncuropathol Exp Neuro2004，63，9： | 1 |
| 19 | Geological reservoir characterization of a CO2 storage site: The Utsira Sand,Sleipner, northern North Sea显示文摘 | Chadwick R A Zweigel P Gregersen U | 2004 | Energy2004，29，910： | 1 |
| 20 | 显示文摘 | Gregersen R Lambertsen K Finsen B | 2000 | J Cereb Blood Flow Metab2000，20，1： | 1 |
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