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| 1 | Effect of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in colorectal liver metastases显示文摘AIM:To evaluate the influence of preoperative FOLFOX chemotherapy on CCL20/CCR6 expression in liver metastases of stage Ⅳ colorectal cancer(CRC) patients.METHODS:Using Real Time-PCR,enzyme-linked immunosorbent assay,Western Blots and immunohistochemistry,we have analyzed the expression of CCL20,CCR6 and proliferation marker Ki-67 in colorectal liver metastasis(CRLM) specimens from stage Ⅳ CRC patients who received preoperative FOLFOX chemotherapy(n = 53) and in patients who did not receive FOLFOX chemotherapy prior to liver surgery(n = 29).RESULTS:Of the 53 patients who received FOLFOX,time to liver surgery was ≤ 1 mo in 14 patients,≤ 1 year in 22 patients and > 1 year in 17 patients,respectively.In addition,we investigated the proliferation rate of CRC cells in liver metastases in the different patient groups.Both CCL20 and CCR6 mRNA and protein expression levels were significantly increased in patients who received preoperative FOLFOX chemotherapy ≤ 12 mo before liver surgery(P < 0.001) in comparison to patients who did not undergo FOLFOX treatment.Further,proliferation of CRLM cells as measured by Ki-67 was increased in patients who underwent FOLFOX treatment.CCL20 and CCR6 expression levels were significantly increased in CRLM patients who had undergone preoperative FOLFOX chemotherapy.CONCLUSION:This chemokine/receptor up-regulation could lead to increased proliferation/migration through an autocrine mechanism which might be used by surviving metastatic cells to escape cell death caused by FOLFOX. | Claudia Rubie Vilma Oliveira Frick Pirus Ghadjar Mathias Wagner Christoph Justinger Stefan Graeber Jens Sperling Otto Kollmar Martin K Schilling | 2011 | World Journal of Gastroenterology2011，17，26： | 5 |
| 2 | Comparative efficacy of positron emission tomography with fluorodeoxyglucose in evaluation of small (<1cm), intermediate (1 to 3 cm) and large (>3cm) lymph node lesions显示文摘 | Gupta N Graeber G Bishop H | 2000 | Chest2000，117，3： | 1 |
| 3 | Use of neuropathological tissue for molecular genetic studies:parameters affecting DNA extraction and polymerase chain reaction显示文摘 | Kosel S Graeber MB | 1994 | Acta Neuropathol (Berl)1994，88，1： | 1 |
| 4 | Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor,GPR30显示文摘 | Quinn JA Graeber CT Frackelton AR Jr | | 0，，07： | 1 |
| 5 | Changing face of microglia 显示文摘 | Graeber MB | 2010 | Science2010，330，6005： | 1 |
| 6 | Microglia:biology and pathology显示文摘 | Graeber MB Streit WJ | 2010 | ActaNeuropathol2010，119，1： | 1 |
| 7 | The evolution of seeds 显示文摘 | Linkies A Graeber K Knight C | 2010 | New Phytologist2010，186，4： | 1 |
| 8 | Neurodegenera- tion and aging: role of the second genome显示文摘 | Graeber MB Grasbon-Frodl E Eitzen UV | 1998 | J Neurosci Res1998，52，： | 1 |
| 9 | Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease显示文摘 | KRUGER R KUHN W MULLER T WOITALLA D GRAEBER M KOSEL S PRZUNTEK H EPPLEN J T SCHOLS L RIESS O | 1998 | Nature Genetics1998，18，2： | 1 |
| 10 | Comparative efficacy of positron emission tomography with fluorodeoxyglucose in evaluation of small (《1 cm), intermediate (1 to 3 cm), and large (》3 cm) lymph node lesions显示文摘 | Gupta NC Graeber GM Bishop HA | 2000 | Chest2000，117，3： | 1 |
| 11 | Dynamic positron emission tomography with F-18 Fluorodeoxyglucose imaging in differentiation of benign from malignant lung/mediastinal lesions显示文摘 | Gupta N Gill H Graeber G | 1998 | Chest1998，114，： | 1 |
| 12 | Retrograde transport of the transmembrane estrogen receptor,Gprotein-coupled-receptor-30(GPR30/GPER)from the plasma membrane towards the nucleus显示文摘 | CHENG Shi-bin GRAEBER C T QUINN J A | 2011 | Steroids2011，76，9： | 1 |
| 13 | Clinical pathways in general surgery, development, implementation, and eval- uation 显示文摘 | Graeber S Richter S Folz J | 2007 | Methods Inf Med2007，46，5： | 1 |
| 14 | Hypoxia-mediated selection of cells with diminished apoptosic potential in solid tumors显示文摘 | Osmanian C Jacks T | 1996 | Nature1996，379，6560： | 1 |
| 15 | Hypoxia-mediated seletion of cells with diminished apoptotic potential in solid tumors显示文摘 | Graeber T G Osmanian C Jacks T | 1996 | Nature1996，379，6560： | 1 |
| 16 | Clinical pathways in gener- al surgery: Development, implementation and Evaluation 显示文摘 | Graeber S Richter S Folz J | 2007 | MethodslnfMed2007，46，5： | 1 |
| 17 | Hypoxia induces accumulation of p53 protein,but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status显示文摘 | Graeber TG Peterson JF Tsai M | 1994 | Mol Cell Biol1994，14，9： | 1 |
| 18 | Current status of diagnosis and treatment of thymoma显示文摘 | Graeber GM Tamim W | 2000 | Semin Thorac Cardiovasc Surg2000，12，4： | 1 |
| 19 | Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours显示文摘 | Graeber TG Osmanian C Jacks T | 1996 | Nature1996，379，6560： | 1 |
| 20 | The facial nerve axotomy model显示文摘 | Moran LB Graeber MB | 2004 | Brain Res Rev2004，44，： | 1 |
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