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| 1 | Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc显示文摘The depletion of chondroitin sulfates(CSs)within the intervertebral disc(IVD)during degenerative disc disease(DDD)results in a decrease in tissue hydration,a loss of fluid movement,cell apoptosis,a loss of nerve growth inhibition and ultimately,the loss of disc function.To date,little is known with regards to the structure and content of chondroitin sulfates(CSs)during IVD ageing.The behavior of glycosaminoglycans(GAGs),specifically CSs,as well as xylosyltransferase I(XT-I)and glucuronyltransferase I(GT-I),two key enzymes involved in CS synthesis as a primer of glycosaminoglycan(GAG)chain elongation and GAG synthesis in the nucleus pulposus(NP),respectively,were evaluated in a bovine ageing IVD model.Here,we showed significant changes in the composition of GAGs during the disc ageing process(6-month-old,2-year-old and 8-year-old IVDs representing the immature to mature skeleton).The CS quantity and composition of annulus fibrosus(AF)and NP were determined.The expression of both XT-I and GT-I was detected using immunohistochemistry.A significant decrease in GAGs was observed during the ageing process.CSs are affected at both the structural and quantitative levels with important changes in sulfation observed upon maturity,which correlated with a decrease in the expression of both XT-I and GT-I.A progressive switch of the sulfation profile was noted in both NP and AF tissues from 6 months to 8 years.These changes give an appreciation of the potential impact of CSs on the disc biology and the development of therapeutic approaches for disc regeneration and repair. | Estelle C Collin Oliver Carroll Michelle Kilcoyne Marianna Peroglio Eugene See Doris Hendig Mauro Alini Sibylle Grad Abhay Pandit | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 2 |
| 2 | Effects of immobilization and dynamic compression on intervertebral disc cell gene expression in vivo显示文摘 | MacLean J Lee C Grad S | 2003 | Spine2003，28，： | 1 |
| 3 | Beneficial and detrimental effects of UV on aquatic organisms:implications of spectral variation显示文摘 | Williamson C E Neale P J Grad G | 2001 | Ecol Appl2001，11，： | 1 |
| 4 | Mapping QTL for seed protein and oil content in eight soybean populations 显示文摘 | Brummer E C Grad G L Off J R | 1997 | Crop Science1997，37，： | 1 |
| 5 | Long-term neurodevelopmental outcome of 167 children after intrauterine laser treatment for severe twin-twin transfusion syndrome显示文摘 | Grad C Ellenrieder B Hecher K | 2006 | Am J Obstet Gynecol2006，194，2： | 1 |
| 6 | Feasibility and effects of the semirecumbent position to prevent venti- lator-associated pneumonia:a randomized study显示文摘 | Van Nieuwenhoven CA Vanden breucke Grads C Van Tiel | 2006 | Crit Care Med2006，34，2： | 1 |
| 7 | Novel aspects of the diagenesis of AT-Sct-sterenes as revealed by a combined molecular mechanics calculations and laboratory simulations approach 显示文摘 | van Duin A C T Peakman T M de Leeuw J W van de Grad B | 1996 | Org Geochem1996，24，5： | 1 |
| 8 | Beneficial and detrimental effects of UV on aquatic organisim:Implica-tion of spectral variation显示文摘 | Williamson C E Neale P J Grad G | | 0，，06： | 1 |
| 9 | Extension of a Measure of Polarization,with an Application to the Income Distribution of Five OECD Countries显示文摘 | Esteban J Gradín C Ray D | 1999 | The Journal of Economic Inequality1999，，1： | 1 |
| 10 | Teaching evidence based medical care:description and evaluation显示文摘 | Grad R Macaulay A C Warner M | 2001 | Fam Med2001，33，8： | 1 |
| 11 | An Extension of a Measure of Po larization,with an Application to the Income Distribution of Five OECD Countries显示文摘 | Esteban J Gradín C Ray D | 2007 | Journal of Economic Inequality2007，5，： | 1 |
| 12 | Inhibiting and deactivating effects of water on the selective catalytic reduction of nitric oxide with ammonia over MnOx/Al2 O3 显示文摘 | Sjoerd Kijlstra W Joop C M L Daamen Jolinde M van de Grad | 1996 | Applied Catalysis B : Environmental1996，35，17： | 1 |
| 13 | Improving the assessment of literacy显示文摘 | Wino grad P Paris S Bridge C | | 0，，45： | 1 |
| 14 | Biodegradation of toxic organics: status and potential显示文摘 | Grad)' C P L Jr | 1990 | Journal of Environmental Engineering1990，116，： | 1 |
| 15 | Four Levels of Outcomes of Information Seeking: A Mixed Methods Study in Primary Health Care显示文摘 | Pluye P Grad R Repchinsky C | 2013 | Joumal of the American Society for Information Science and Technology2013，64，1： | 1 |
| 16 | Complex proximal- humerus fracturesm anagement with a humeral head pros- thesis Clinical and radiological results of a prospective study显示文摘 | Gierer P Simon C Grad IG | 2006 | Orth opade2006，35，8： | 1 |
| 17 | Polarization by Sub-populations in Spain,1973-91显示文摘 | Gradín C | 2000 | Income and Wealth2000，46，4： | 1 |
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