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| 1 | Neural progenitor cells but not astrocytes respond distally to thoracic spinal cord injury in rat models显示文摘Traumatic spinal cord injury(SCI) is a detrimental condition that causes loss of sensory and motor function in an individual. Many complex secondary injury cascades occur after SCI and they offer great potential for therapeutic targeting. In this study, we investigated the response of endogenous neural progenitor cells,astrocytes, and microglia to a localized thoracic SCI throughout the neuroaxis. Twenty-five adult female Sprague-Dawley rats underwent mild-contusion thoracic SCI(n = 9), sham surgery(n = 8), or no surgery(n = 8). Spinal cord and brain tissues were fixed and cut at six regions of the neuroaxis. Immunohistochemistry showed increased reactivity of neural progenitor cell marker nestin in the central canal at all levels of the spinal cord. Increased reactivity of astrocyte-specific marker glial fibrillary acidic protein was found only at the lesion epicenter. The number of activated microglia was significantly increased at the lesion site,and activated microglia extended to the lumbar enlargement. Phagocytic microglia and macrophages were significantly increased only at the lesion site. There were no changes in nestin, glial fibrillary acidic protein,microglia and macrophage response in the third ventricle of rats subjected to mild-contusion thoracic SCI compared to the sham surgery or no surgery. These findings indicate that neural progenitor cells, astrocytes and microglia respond differently to a localized SCI, presumably due to differences in inflammatory signaling. These different cellular responses may have implications in the way that neural progenitor cells can be manipulated for neuroregeneration after SCI. This needs to be further investigated. | Tara Nguyen Yilin Mao Theresa Sutherland Catherine Anne Gorrie | 2017 | Neural Regeneration Research2017，12，11： | 8 |
| 2 | Occurrence of Enterobacter sakazakii in food production environments and households显示文摘 | Kandhai MC Reij MW Gorris LG | 2004 | Lancet2004，363，9402： | 1 |
| 3 | Electrical Perceptual Thresh- old Testing: A Validation Study显示文摘 | Leong GW Gorrie CA Ng K | 2009 | J Spinal Cord Med2009，32，2： | 1 |
| 4 | Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy 显示文摘 | Hart TC Gorry MC Hart PS | 2002 | J Med Genet2002，39，12： | 1 |
| 5 | Factors influencing the accuracy of the plating method used to enumerate low numbers of viable micro-organisms in food显示文摘 | I. Jongenburger M.W. Reij E.P.J. Boer L.G.M. Gorris M.H. Zwietering | 2010 | International Journal of Food Microbiology2010，，1： | 1 |
| 6 | Characterization of the action of selected essential oil components on Gram-negative bacteria显示文摘 | Helander I M Alakomi H L Latva-Kala K Mattila-Sandholm T Pol I Smid E J Gorris L G M Wright A | 1998 | Journal of Agricultural and Food Chemistry1998，46，9： | 1 |
| 7 | Occurrence of Enterobacter sakazakii in food production environments and households 显示文摘 | Kandhai M C Reij M W Gorris L C | 2004 | Lancet2004，363，9402： | 1 |
| 8 | Genomic organization of the human fibroblast growth factor receptor 2 ( FGFR2 ) gene and comparative analysis of the human FGFR gene family 显示文摘 | Zhang Y Gorry MC Post JC | 1999 | Gene1999，230，1： | 1 |
| 9 | A framework for management information systems 显示文摘 | Gorry A Michael S Scott Morton | 1971 | Sloan Management Review1971，13，1： | 1 |
| 10 | Inflammation of the colonic wall induced by formalin as a model of acute visceral pain显示文摘 | Miampamba M Chry-Croze S Gorry F Berger F Chayvialle JA | 1994 | Pain1994，57，： | 1 |
| 11 | Quality of life of people with epilepsy in Iran,the gulf,and near east显示文摘 | Baker GA Jacoby A Gorry J | 2005 | Epilepsia2005，46，1： | 1 |
| 12 | Secondary plant metabolites as control agents of postharvest Penicillium rot on tulip bulbs 显示文摘 | Staid E J Witte Y Gorris G M | 1995 | Postharvest Biology and Technology1995，6，： | 1 |
| 13 | High oxygen and high carbon dioxide modified atmospheres for shelf-life extension of minimally processed carrots显示文摘 | Amanatidou A Slump R A Gorris L G M | 2000 | J Food Sci2000，65，： | 1 |
| 14 | Infertility in polycystic ovary syndrome : focus on low - dose gonadotropin treatment 显示文摘 | Gorry A White D M Franks S | 2006 | Endocrine2006，30，1： | 1 |
| 15 | Structure and sequence of human FGF8显示文摘 | Gemel J Gorry M Ehrlich G D | | 0，，05： | 1 |
| 16 | A Mutation in the SOS1 Gene Causes Hereditary Gingival Fibromatosis Type 1显示文摘 | Thomas C. Hart Yingze Zhang Michael C. Gorry P. Suzanne Hart Margaret Cooper Mary L. Marazita Jared M. Marks Jose R. Cortelli Debora Pallos | 2002 | The American Journal of Human Genetics2002，，4： | 1 |
| 17 | Effect of deposition distance and temperature on electrical, optical and structural properties of radio-frequency magnetron-sputtered gallium-doped zinc oxide 显示文摘 | Gorrie C W Sigdel A K Berry J J | 2010 | Thin Solid Films2010，519，1： | 1 |
| 18 | Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy显示文摘 | Hart TC Gorry MC Hart PS | 2002 | J Med Genet2002，39，： | 1 |
| 19 | Occurrence of Enterobacter sakazakii in food production environments and households 显示文摘 | KANDHAI M C REIJ M W Gorris L G | 2004 | Lancet2004，363，9402： | 1 |
| 20 | Electrical perceptual threshold testing: a validation study显示文摘 | Leong GW Gorrie CA Ng K | 2009 | J Spinal Cord Med2009，32，2： | 1 |
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