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| 1 | 膝关节前交叉韧带损伤及重建后肌肉力量变化的研究显示文摘对ACL陈旧性损伤、急性损伤、手术重建以及未损伤对象四个样本组 ,在等长条件下膝关节肌肉屈伸、旋内 ,旋外、内收和外展的力量情况进行了对比测试。共记录了 5 4个研究对象的 80组测试结果。结果表明各样本组肌肉力量比值在不同方向上存在显著性差异。该结果可能有助于解释ACL损伤及重建后神经肌肉系统的补偿机制 ,并提示通过选择性地训练某些肌肉可达到有效的康复效果。 | 王广志 张立群 Gordon W Nuber Mark K Bowen Jesse Butler | 2000 | 中国运动医学杂志2000，19，4： | 13 |
| 2 | 诊断性试验和策略的证据质量和推荐强度的分级显示文摘GRADE系统能对诊断性试验或策略的证据质量和推荐强度进行分级。本文旨在阐释在此过程中如何考虑患者的重要结局, | Holger J Schünemann Andrew D Oxman Jan Brozek Paul Glasziou Roman Jaeschke Gunn E Vist John W Williams Jr Regina Kunz Jonathan Craig Victor M Montori Patrick Bossuyt Gordon H Guyatt 李晓 黄程 陈耀龙 李幼平 | 2009 | 中国循证医学杂志2009，9，5： | 7 |
| 3 | Role of nanotopography in the development of tissue engineered 3D organs and tissues using mesenchymal stem cells显示文摘Recent regenerative medicine and tissue engineering strategies(using cells, scaffolds, medical devices and gene therapy) have led to fascinating progress of translation of basic research towards clinical applications. In the past decade, great deal of research has focused on developing various three dimensional(3D) organs, such as bone, skin, liver, kidney and ear,using such strategies in order to replace or regenerate damaged organs for the purpose of maintaining or restoring organs' functions that may have been lost due to aging, accident or disease. The surface properties of a material or a device are key aspects in determining the success of the implant in biomedicine, as the majority of biological reactions in human body occur on surfaces or interfaces. Furthermore, it has been established in the literature that cell adhesion and proliferation are, to a great extent, influenced by the micro- and nanosurface characteristics of biomaterials and devices. In addition, it has been shown that the functions of stem cells, mesenchymal stem cells in particular, could be regulated through physical interaction with specific nanotopographical cues. Therefore, guided stem cell proliferation, differentiation and function are of great importance in the regeneration of 3D tissues and organs using tissue engineering strategies. This review will provide an update on the impact of nanotopography on mesenchymal stem cells for the purpose of developing laboratory-based 3D organs and tissues, as well as the most recent research and case studies on this topic. | Shima Salmasi Deepak M Kalaskar Wai-Weng Yoon Gordon W Blunn Alexander M Seifalian | 2015 | World Journal of Stem Cells2015，7，2： | 4 |
| 4 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 5 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 6 | Clinical predictors of thiopurine-related adverse events in Crohn's disease显示文摘AIM: To determine the incidence and predictors of thiopurine-related adverse events. METHODS: Subjects with Crohn's disease who were followed in the Alberta Inflammatory Bowel Disease Consortium patient database registry were identified. Retrospective chart review was conducted between August 5th, 2010 and June 1st, 2012. We collected data on: age at diagnosis; sex; disease location and behaviour at time of prescribing thiopurine; perianal fistulising disease at or prior to thiopurine prescription; smoking status at time of thiopurine prescription, use of corticosteroid within 6 mo of diagnosis; dosage, age at onset, and cessation of 5-aminosalicyclic acid(5-ASA); anti-tumour necrosis factor medication exposure and intestinal resection before thiopurine prescription. The primary outcome of interest was the first adverse event that led to discontinuation of the first thiopurine medication used. Logistic regression models were used to associate clinical characteristics with outcomes after adjusting for potential confounders. Risk estimates were presented as odds ratios(OR) with 95% CI. Effect modification by age and sex were explored.RESULTS: Our cohort had a median follow-up duration of 5.8 years [interquartile range(IQR 25th-75th) 2.7-9.1]. Thiopurine therapy was discontinued in 31.3% of patients because of: hypersensitivity reactions(7.1%), acute pancreatitis(6.2%), gastrointestinal intolerance(5.4%), leucopenia(3.7%), hepatotoxicity(3.4%), infection(1.1%) and other reasons(4.3%). A higher incidence of thiopurine withdrawal was observed in patients over the age of 40(39.4%, P = 0.007). A sexby-age interaction(P = 0.04) was observed. Females older than 40 years of age had an increased risk of thiopurine discontinuation due to an adverse event(age above 40 vs age below 40, adjusted OR = 2.8; 95%CI: 1.4-5.6). In contrast, age did not influence thiopurine withdrawal in males(age above 40 vs below 40, adjusted OR = 0.9; 95%CI: 0.4-2.1). Other clinical variables(disease location and phenotype, perianal disease, smoking history, history of intestinal resection and prior 5-ASA or corticosteroid use) were not associated with an increased risk an adverse event leading to therapy cessation. CONCLUSION: Thiopurine withdrawal due to adverse events is commoner in women over the age of 40 at prescription. These findings need to be replicated in other cohorts. | Gordon W Moran Marie-France Dubeau Gilaad G Kaplan Hong Yang Bertus Eksteen Subrata Ghosh Remo Panaccione | 2015 | World Journal of Gastroenterology2015，21，25： | 2 |
| 7 | A new three dimensional model for flow in fractured rock 显示文摘 | Dershowitz W S Gordon M Kafritsas J C | 1985 | Int Assoc Hydrogeol1985，17，： | 1 |
| 8 | Effects of advancing open face tunneling on an existing loaded pile显示文摘 | GORDON T K NG C W W | 2005 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2005，131，2： | 1 |
| 9 | An infrared study of phase ]I显示文摘 | M A Bachmann W L Gordon | 1979 | J Appl Phys1979，50，61： | 1 |
| 10 | The emerging role of lysophosphatidic acid in cancer显示文摘 | GORDON B WOUTER M H MOOLENAAR W H | 2003 | Nature2003，3，8： | 1 |
| 11 | Using genetic algorithms for concept learning显示文摘 | DE JONG K A SPEARS W M GORDON F D | 1993 | Machine Learning1993，13，： | 1 |
| 12 | Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading 显示文摘 | CARLSON C J BOOTH F W GORDON S E | 1999 | Am J Physiol1999，277，： | 1 |
| 13 | Configuring marine riser tapered flexible joints used in top-supported applications 显示文摘 | GORDON C C DAREING D W | 2004 | Journal of Energy Resources Technology2004，126，3： | 1 |
| 14 | FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetux- imab 显示文摘 | Zhang W Gordon M Schultheis AM | 2007 | J Clin Oncol2007，25，24： | 1 |
| 15 | Lamellar-to-hexagonaⅢ phase transitions in the plasma membrane of isolated protoplasts after freeze-induced dehydration 显示文摘 | Gordon - Kamm W J Steponkus P L | 1984 | Proceedings of the National Academy of Sciences of the United States of America1984，81，20： | 1 |
| 16 | The classical risk model with a constant dividend Barrier: analysis of the Gerber-Shiu penalty function显示文摘 | Sheldon L X Gordon E W Steve D | 2003 | Insurance : Mathematics and Economics2003，33，3： | 1 |
| 17 | Far-feild approximation to the Kirchoff-Helmholtz representations of scattered field显示文摘 | Gordon W B | 1975 | IEEE rrans on Antennas and Propagation1975，23，4： | 1 |
| 18 | Liquid chromatographic determination of Fumonisins B1,B2, and B3 in foods and feeds显示文摘 | Eric W Sydenham Gordon S Shephard Pieter G Thiel | 1992 | Mycotoxins1992，75，： | 1 |
| 19 | Thirty-year follow-up of chemo/hormonal therapy in node-positive breast cancer 显示文摘 | Gordon NH Silverman P Lasheen W | 2007 | Breast Cancer Res Treat2007，102，3： | 1 |
| 20 | The quantity and quality of physiealaetivity among those trying to lose weight 显示文摘 | Gordon P M Heath G W Holmes A | 2000 | American Journal of Preventive Medicine2000，18，1： | 1 |
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