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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Increased cardiac BNP expression associated with myocardial ischemia显示文摘 | GOETZE J P CHRISTOFFERSEN C PERKO M | 2003 | FASEB J2003，17，： | 1 |
| 3 | Impact of American Society of Clinical Oncology/ College of American Pathologists guideline recommendations on HER2 interpretation in breast cancer显示文摘 | SHAH S S KETTERLING R P GOETZ M P | 2010 | Hum Pathol2010，41，1： | 1 |
| 4 | Increased cardiac BNP expression associated with myocardial ischemia显示文摘 | Goetze J P Christoffersen C Perko M | 2003 | FASEB J2003，17，9： | 1 |
| 5 | MDS clinical diagnostic criteria for Parkinson's disease 显示文摘 | Postuma RB Berg D Stern M Poewe W Olanow CW Oertel W Obeso J Marek K Litvan I Lang AE Halliday G Goetz CG Gasser T Dubois B Chan P Bloem BR Adler CH Deuschl G | 2015 | Mov Disord2015，30，12： | 1 |
| 6 | Polymorphisms of dopamine- beta-hydroxylase in ADHD children显示文摘 | Kopeckovd M Paclt l Goetz P | 2008 | Folia Biol (Praha)2008，54，2： | 1 |
| 7 | The Hsp90 chaperone complex as a novel target for cancer therapy显示文摘 | GOETZ M P TOFT D O AMES M M | 2003 | Ann Oncol2003，14，8： | 1 |
| 8 | Caveolin-1 in tumor progression:the good,the bad and the ugly显示文摘 | Goetz J G Lajoie P Wiseman S M | 2008 | Cancer Metastasis Rev2008，27，4： | 1 |
| 9 | The impacts and implications of an intensifying fire regime on Alaskan boreal forest composition and albedo显示文摘 | BECK P S A GOETZ S J MACK M C | 2011 | Global Change Biology2011，17，9： | 1 |
| 10 | Induction of benign symmetric lipomatosis (Launois-Bensaude syndrome) in a female patient after liver transplantation显示文摘 | GOETZE S HOMMANN M ELSNER P et at | 2008 | Dermatology2008，216，4： | 1 |
| 11 | Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes显示文摘 | GOETZ M P RAE J M SUMAN V J | 2005 | J Clin Oncol2005，23，36： | 1 |
| 12 | Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease显示文摘 | R Kiesslich C A Duckworth D Moussata A Gloeckner L G Lim M Goetz D M Pritchard P R Galle M F Neurath A J M Watson | 2012 | Gut2012，，8： | 1 |
| 13 | Image-guided ablation of painful meta static bone tumors: a new and effective approach to a difficult problem显示文摘 | Callstrom M R Charboneau J W Goetz M P Rubin J Atwell T D Farrell M A | 2006 | Skeletal Radiol2006，35，： | 1 |
| 14 | Hemangioper- icytoma:long-term outcome revisited显示文摘 | Schiafiti M Goetz P E1-Maghraby H | 2011 | J Neurosnrg2011，114，3： | 1 |
| 15 | Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase显示文摘 | Goetz R M Thatte H S Prabhakar P | 1999 | Proc Natl Acad Sci USA1999，96，6： | 1 |
| 16 | Increased cardiac BNP expression ssociated with myocardial ischemia显示文摘 | GOETZE J P CHRISTOFFERSEN C PERKO M | 2003 | FASEB J2003，17，9： | 1 |
| 17 | The effects of spatial variability in topography, vegetation cover and soil moisture on are-averaged surface fluxes: a case study using the FIFE -89 data 显示文摘 | Sellers P J Heiser M D Goetz F G | 1995 | Journal of Geophysical Resources FIFE Special Issue Ⅱ1995，100，25： | 1 |
| 18 | Increased cardiac BNP expression associated with myocardial ischemia显示文摘 | Goetze J P Christoffersen C Perko M | | 0，，09： | 1 |
| 19 | Confocal laser endoscopy:new approach to the early diagnosis of tumors of the esophagus and stomach 显示文摘 | GOETZ M HOOFFMAN A GALLE P R | 2006 | Future Oncot2006，2，4： | 1 |
| 20 | Caveolin-1 in tumor progression: the good, the bad and the ugly 显示文摘 | Goetz J G Lajoie P Wiseman S M | 2008 | Cancer Metastasis Rev2008，27，4： | 1 |
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