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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | New developments in acoustic and electroacoustic spectroscopy for characterizing concentrated dispersions 显示文摘 | DUKHIN A S GOETZ P J | 2001 | Colloids and Surfaces: A Physicochemical and Engineering Aspects2001，192，3： | 1 |
| 3 | Bonding of silicon wafers for silicon on insulator 显示文摘 | MASZARA W P GOETZ G CAVIGLIA A | 1988 | Appl Phys1988，64，15： | 1 |
| 4 | Hypoxia activates beta (1) -integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells显示文摘 | Blaschke F Stawowy P Goetze S | 2002 | Biochem Biophys Res Commun2002，296，4： | 1 |
| 5 | Pro-brain natriuretic peptide as marker of cardiovascular or pulmonary causes of dyspnea in patients with terminal parenchymal lung disease显示文摘 | GOETZE J P VIDEBAEK R BOESGAARD S | 2004 | J Heart Lung Transplant2004，23，1： | 1 |
| 6 | Discriminating between cardiac and pulmonary dysfuntion in the general population with dyspnea by plasma pro-B-type natriuretic peptide 显示文摘 | Mogelvang R Goetze JP Schnohr P | 2007 | JAm Coil Cardio2007，50，17： | 1 |
| 7 | Caveolin-1 in tumor progres- sion :the good, the bad and the ugly 显示文摘 | Goetz JG Lajoie P Wiseman SM et at | 2008 | Cancer Metastasis Rev2008，27，4： | 1 |
| 8 | Discrimination of hydrothermally altered rocks and unaltered rocks in visible and near infrared multi- spectral images显示文摘 | ROWAN L C GOETZ A F H ASHLEY R P | 1977 | Geophysics1977，42，3： | 1 |
| 9 | Hyaluronan microspheres for sustained gene delivery and site-specific targeting显示文摘 | Yun YH Goetz DJ Yellen P | 2004 | Biomaterials2004，25，1： | 1 |
| 10 | Central role of the MAPK pathway in Ang Ⅱ mediated DNA synthesis and migration in rat vascular smooth muscle cells显示文摘 | Xi X P Graf K Goetze S | 1999 | ATVB1999，19，1： | 1 |
| 11 | Hyaluro- nan microspheres for sustained gene delivery and site-specific targeting 显示文摘 | YUN Y H GOETZ D J YELLEN P | 2004 | Biomaterials2004，25，1： | 1 |
| 12 | Increased cardiac BNP expression associated with myocardial ischemia显示文摘 | Goetze J P | 2003 | FASEB J2003，17，9： | 1 |
| 13 | Increased cardiac BNP expression associated with myocardial ischemia显示文摘 | GOETZE J P CHRISTOFFERSEN C PERKO M | 2003 | FASEB J2003，17，： | 1 |
| 14 | Caveolin-I in tumor pro gression: the good, the bad and the ugly显示文摘 | Goetz JG Lajoie P Wiseman SM etal | 2008 | Cancer Metastasis Rev2008，27，4： | 1 |
| 15 | Impact of American Society of Clinical Oncology/ College of American Pathologists guideline recommendations on HER2 interpretation in breast cancer显示文摘 | SHAH S S KETTERLING R P GOETZ M P | 2010 | Hum Pathol2010，41，1： | 1 |
| 16 | Acoustic spectroscopy for concentrated polydisperse colloids with high density contrast 显示文摘 | DUKHIN A S GOETZ P J | 1996 | Langmuir1996，12，21： | 1 |
| 17 | A cat's eye multiple quantum well modulating retro-reflector 显示文摘 | RABINOVICH W S MAHON R GOETZ P G | 2003 | IEEE Photonics Technolgy Letters2003，15，3： | 1 |
| 18 | Polymeric surfactants from styrene - co - maleic - anhydride copolymers 显示文摘 | DIETRICH B RAINER S GOETZ P | 2001 | Macromolecular Symposia2001，163，： | 1 |
| 19 | Hypoxia activates beta( 1 ) - integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells显示文摘 | Blaschke F Stawowy P Goetze S | 2002 | Biochem Biophys Res Commun2002，296，4： | 1 |
| 20 | Public access defibrillation : Limited use by trained first responders and laymen 显示文摘 | MAISCH S FRIEDERICH P GOETZ AE | 2006 | Anaesthesist2006，55，： | 1 |
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