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| 1 | Acute pancreatitis at the beginning of the 21st century: The state of the art显示文摘Acute pancreatitis is an acute inflammatory disease of the pancreas which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients. Gallstones and alcohol consumption are the most frequent causes of pancreatitis in adults. The treatment of mild acute pancreatitis is conservative and supportive; however severe episodes characterized by necrosis of the pancreatic tissue may require surgical intervention. Advanced understanding of the pathology, and increased interest in assessment of disease severity are the cornerstones of future management strategies of this complex and heterogeneous disease in the 21st century. | Alfredo F Tonsi Matilde Bacchion Stefano Crippa Giuseppe Malleo Claudio Bassi | 2009 | World Journal of Gastroenterology2009，15，24： | 54 |
| 2 | Incidence of gallstone disease in Italy:Results from a multicenter,population-based Italian study (the MICOL project)显示文摘AIM:To evaluate gallstone incidence and risk factors in a large population-based study. METHODS: Gallstone incidence and risk factors, were evaluated by structured questionnaire and physical examination, respectively, in 9611 of 11 109 (86.5%) subjects who were gallstone-free at the cross-sectional study. RESULTS: Six centers throughout Italy enrolled 9611 subjects (5477 males, 4134 females, aged 30-79 years), 9517 of whom were included into analysis: 424 subjects (4.4%) had gallstones and 61 (0.6%) had been cholecystectomized yielding a cumulative incidence of 0.67% per year (0.66% in males, 0.81% in females). Increasing age, a high body mass index (BMI), a history of diabetes, peptic ulcer and angina, and low cholesterol and high triglyceride levels were identifi ed as risk factors in men while, in females, the only risk factors were increasing age and a high BMI.Increasing age and pain in the right hypocondrium in men and increasing age in females were identifi ed as predictors of gallstones. Pain in the epigastrium/ right hypocondrium was the only symptom related to gallstones; furthermore, some characteristics of pain (forcing to rest, not relieved by bowel movements) were significantly associated with gallstones. No correlation was found between gallstone characteristics and clinical manifestations, while increasing age in men and increasing age and BMI in females were predictors of pain. CONCLUSION:Increasing age and BMI represent true risk factors for gallstone disease (GD); pain in the right hypocondrium and/or epigastrium is confi rmed as the only symptom related to gallstones. | Davide Festi Ada Dormi Simona Capodicasa Tommaso Staniscia Adolfo F Attili Paola Loria Paolo Pazzi Giuseppe Mazzella Claudia Sama Enrico Roda Antonio Colecchia | 2008 | World Journal of Gastroenterology2008，14，34： | 23 |
| 3 | Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23–01): a phase 3 randomised controlled trial显示文摘 | Viviana Galimberti Bernard F Cole Stefano Zurrida Giuseppe Viale Alberto Luini Paolo Veronesi Paola Baratella Camelia Chifu Manuela Sargenti Mattia Intra Oreste Gentilini Mauro G Mastropasqua Giovanni Mazzarol Samuele Massarut Jean-Rémi Garbay Janez Zgajn | 2013 | Lancet Oncology2013，，4： | 2 |
| 4 | Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and Bcl-2 during left ventricular adaptations to chronic pressure overload in the rat显示文摘 | Gianluigi C Carmine M Giorgio S Antonella N Felicia F Giuseppe S | 1999 | Circulation1999，99，： | 1 |
| 5 | On the possible use of optical fiber Bragg gratings as strain sensors for ge odynamical monitoring显示文摘 | PIETER F GIUSEPPE DE N A | 2002 | Optics and Lasers in Engi- neering2002，37，4： | 1 |
| 6 | Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes显示文摘 | Giuseppe L Luca F Martina M | 2009 | Clin Chem Lab Med2009，47，3： | 1 |
| 7 | Systemic inhibition of NF-kappaB activation protects from silicosis 显示文摘 | Di Giuseppe M Gambel|i F Hoyle GW | 2009 | PLoS ONE2009，4，5： | 1 |
| 8 | Comparison of the usefulness of cardiac resynchronization therapy in three age-groups (<65, 65-74 and ≥75 Years) (from the InSync/InSync ICD Italian Registry)显示文摘 | Stefano F Sergio V Giuseppe B | 2011 | Am J Cardiol2011，107，10： | 1 |
| 9 | Hyperbaric oxygen therapy with short duration intratympanic steroid ther- apy for sudden hearing loss 显示文摘 | Roberto F Giuseppe A Marika V | 2012 | Acta Oto - laryngologi- ca2012，，5： | 1 |
| 10 | Solid-phase mi- croextraction as a clean-up and preconcentration proce- dures for organochlorine pesticides determination in fish tissue by gas chromatography with electron capture detec- tion显示文摘 | Natalia F U Giusepp C Elisa B G | 2003 | J Chromatogr A2003，1017，： | 1 |
| 11 | Nutritional status in hospitalized elderly patients with mild cognitive impairment 显示文摘 | GIUSEPPE O FRANCO F DOMENICO T | 2009 | Clinical Nutrition2009，10，1： | 1 |
| 12 | Preoperative lower esophageal sphincter pressure affects outcome of laparoscopic esophageal myotomy for achalasia显示文摘 | Mustafa A Arain Jeffrey H Peters Anan P Tamhankar Giuseppe Portale Gideon Almogy Steven R DeMeester Peter F Crookes Jeffrey A Hagen Cedric G Bremner Tom R DeMeester | 2004 | Journal of Gastrointestinal Surgery2004，，3： | 1 |
| 13 | Solid - phase microextraction as a clean - up and preconcentration procedure for organochlorine pesticides determination in fish tissue by gas chromatography with electron capture detection 显示文摘 | Natalia F U Giuseppe C Elisa B G | 2003 | Journal of Chromatography A2003，1017，： | 1 |
| 14 | Allergy in total knee replacement surgery:Is it a real problem?显示文摘Total knee arthroplasty is a common procedure, with extremely good clinical results. Despite this success, it produces 20% unsatisfactory results. Among the causes of these failures is metal hypersensitivity. Metal sensitization is higher in patients with a knee arthroplasty than in the general population and is even higher in patients undergoing revision surgery. However, a clear correlation between metal sensitization and symptomatic knee after surgery has not been ascertained. Surely, patients with a clear history of metal allergy must be carefully examined through dermatological and laboratory testing before surgery. There is no globally accepted diagnostic algorithm or laboratory test to diagnose metal hypersensitivity or metal reactions. The patch test is the most common test to determine metal hypersensitivity, though presenting some limitations. Several laboratory assays have been developed, with a higher sensitivity compared to patch testing, yet their clinical availability is not widespread, due to high costs and technical complexity. Symptoms of a reaction to metal implants present across a wide spectrum, ranging from pain and cutaneous dermatitis to aseptic loosening of the arthroplasty. However, although cutaneous and systemic hypersensitivity reactions to metals have arisen, thereby increasing concern after joint arthroplasties, allergies against implant materials remain quite rare and not a well-known problem. The aim of the following paper is to provide an overview on diagnosis and management of metal hypersensitivity in patients who undergo a total knee arthroplasty in order clarify its real importance. | Maristella F Saccomanno Giuseppe Sircana Giulia Masci Gianpiero Cazzato Michela Florio Luigi Capasso Marco Passiatore Giovanni Autore Giulio Maccauro Enrico Pola | 2019 | World Journal of Orthopedics2019，10，2： | 1 |
| 15 | Rare cause of odynophagia: Giant esophageal ulcer显示文摘Gastrointestinal complications are a frequent cause of morbidity after transplantation and may affect up to 40% of kidney transplant recipients. Here we report a rare case of idiopathic giant esophageal ulcer in a kidney transplant recipient. A 37-year-old female presented with a one-week history of odynophagia and weight loss. Upon admission, the patient presented cold sores, and a quantitative cytomegalovirus polymerase chain reaction was positive(105 copies/ml). An upper endoscopy demonstrated the presence of a giant ulcer. Serological test and tissue biopsies were unable to demonstrate an infectious origin of the ulcer. Immunosuppression was reduced and everolimus was introduced. An empirical i.v. therapy with acyclovir was started, resulting in a dramatic improvement in symptoms and complete healing of the ulcer. Only two cases of idiopathic giant esophageal ulcer in kidney transplant recipients have been reported in the literature; in both cases, steroid therapy was successful without recurrence of symptoms or endoscopic findings. However, this report suggests that correction of immune imbalance is mandatory to treat such a rare complication. | Massimiliano Veroux Giuseppe Aprile Francesca F Amore Daniela Corona Alessia Giaquinta Pierfrancesco Veroux | 2016 | World Journal of Gastroenterology2016，22，14： | 1 |
| 16 | 2013 ESH/ESC Guidelines for the management of arterial hypertension显示文摘 | Giuseppe M Robert F Krzysztof N | | 0，，31： | 1 |
| 17 | A Hybrid Approach to Semantic Web Services Matchmaking显示文摘 | Giuseppe F Vincenzo L Sabrina S | 2008 | International Journal of Approximate Reasoning2008，48，3： | 1 |
| 18 | Persistence of high CD40 and CD40L expression after restorative proctocolectomy for ulcerative colitis显示文摘AIM: To focus on the role of CD40 and CD40L in their pathogenesis.METHODS: We analyzed by immunohistochemistry the CD40 and CD40L expression in the pouch mucosa of 28 patients who had undergone RPC for UC, in the terminal ileum of 6 patients with UC and 11 healthy subjects. We also examined by flow cytometry the expression of CD40 by B lymphocytes and monocytes in the peripheral blood of 20 pouch patients, 15 UC patients and 11 healthy controls.RESULTS: Ileal pouch mucosa leukocytes presented a significantly higher expression of CD40 and CD40L as compared to controls. This alteration correlated with pouchitis, but was also present in the healthy pouch and in the terminal ileum of UC patients. CD40 expression of peripheral B lymphocytes was significantly higher in patients with UC and pouch, respect to controls. Increased CD40 levels in blood B cells of pouch patients correlatedwith the presence of spondyloarthropathy, but not with pouchitis, or inflammatory indices.CONCLUSION: High CD40 expression in the ileal pouch mucosa could be implied in the pathogenesis of pouchitis following proctocolectomy for UC, whereas its increased levels on peripheral blood B lymphocytes are associated with the presence of extraintestinal manifestations. | Lino Polese Imerio Angriman Giuseppe De Franchis Attilio Cecchetto Giacomo C.Sturniolo Renata D'Incà Marco Scarpa Cesare Ruffolo Lorenzo Norberto Mauro Frego Davide F D'Amico | 2005 | World Journal of Gastroenterology2005，11，34： | 1 |
| 19 | Plasticizers infant nutrition and reproductive health 显示文摘 | Giuseppe L Claudio D F Alberto V | 2004 | Reproductive Toxicology2004，19，1： | 1 |
| 20 | Effects of water garlic extracts on cell cycle and viability of HepG2 hepatoma cells显示文摘 | ANGELO D M GIUSEPPE F KATIA A | 2006 | Journal of Nutritional Biochemistry2006，17，： | 1 |
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