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| 1 | Age distribution,polyps and rectal cancer in the Egyptian population-based cancer registry显示文摘AIM:To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies.METHODS:The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998.We analyzed the data of all colorectal cancer patients included in the registry for the period of 1999-2007.All medical records of the 1364 patients diagnosed in Gharbiah during the study period were retrieved and the following information abstracted:age,residence,diagnosis date,grade,stage,topology,clinical characteristics,and histology variables.Egyptian census data for 1996 and 2006 were used to provide the general population's statistics on age,sex,residence and other related demographic factors.In addition to age-and sex-specific incidence rate analyses,we analyze the data to explore the incidence distribution by rural-urban differences among the 8 districts of the province.We also compared the incidence rates of Gharbiah to the rates of the Surveillance Epidemiology and End Results(SEER) data of the United States.RESULTS:Over the 9 year-period,1364 colorectal cancer cases were included.The disease incidence under age 40 years was relatively high(1.3/10 5) while the incidence in the age groups 40 and over was very low(12.0/10 5,19.4/10 5 and 21.2/10 5 in the age groups 40-59 years,60-69 years and > 70 years,respectively).The vast majority of tumors(97.2%) had no polyps and 37.2% of the patients presented with primary lesions in the rectum.Colorectal cancer was more common in patients from urban(55%) than rural(45%) areas.Regional differences in colon and rectal cancer incidence in the 8 districts of the study province may reflect different etiologic patterns in this population.The registry data of Egypt shows a slightly higher incidence of colorectal cancer than the United States in subjects under age 40 years.The results also shows significantly lower incidence of colorectal cancer in subjects over age 40 years compared to the same age group in the United States SEER.CONCLUSION:Low rate of polyps,low incidence in older subjects,and high rate of rectal cancer in Egypt.Future studies should explore clinical and molecular disease patterns. | Darlene Veruttipong Amr S Soliman Samuel F Gilbert Taylor S Blachley Ahmed Hablas Mohamed Ramadan Laura S Rozek Ibrahim A Seifeldin | 2012 | World Journal of Gastroenterology2012，18，30： | 12 |
| 2 | 根治性手术与短程放疗后行经肛门内镜显微手术(TEM)保留器官治疗早期直肠癌(TREC):一项随机、开放标签的可行性研究显示文摘背景:基于全直肠系膜切除(total mesorectal excision,TME)的根治性手术可能不是早期直肠癌的最佳一线治疗。选择性TME保留器官的策略可以减少治疗的不良反应,又不会显著影响肿瘤结果。该临床随机研究通过与TME比较,探讨器官保留策略的可行性。方法:TREC是一项在英国21个三级转诊中心进行的随机、开放标签的可行性研究。符合条件的受试者年龄≥18岁,分期为T2期或更早,最大直径不超过30 mm;排除淋巴结受累或转移的患者。患者按计算机随机分配(1:1)接受短程放疗保留器官,8~10周后行经肛门内镜显微手术(transanal endo⁃scopic microsurgery,TEM)或TME术。当TEM标本组织病理学特征提示局部复发风险增加时,患者被考虑计划早期转为TME。一项非随机前瞻性登记收集了认为不适合随机化的患者,因为每例患者都是按临床指征治疗的。主要终点为12、18和24个月的累积随机分组。次要结局为应用欧洲癌症研究与治疗组织(EORTC)QLQ C30和CR29量表对意向治疗人群的安全性、有效性和健康相关生活质量进行了评价。该研究已在ISRCTN注册中心注册,ISRCTN14422743。 | 佟伟华 BACH S P GILBERT A BROCK K | 2021 | 结直肠肛门外科2021，27，3： | 9 |
| 3 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 4 | Agricultural Risk Factors Influence Microbial Ecology in Honghu Lake显示文摘Agricultural activities, including stock-farming, planting industry, and fish aquaculture,can affect the physicochemical and biological characters of freshwater lakes. However, the effects of pollution producing by agricultural activities on microbial ecosystem of lakes remain unclear.Hence, in this work, we selected Honghu Lake as a typical lake that is influenced by agriculture activities. We collected water and sediment samples from 18 sites, which span a wide range of areas from impacted and less-impacted areas. We performed a geospatial analysis on the composition of microbial communities associated with physicochemical properties and antibiotic pollution of samples. The co-occurrence networks of water and sediment were also built and analyzed. Our results showed that the microbial communities of impacted and less-impacted samples of water were largely driven by the concentrations of TN, TP, NO_3^--N, and NO_2^--N, while those of sediment were affected by the concentrations of Sed-OM and Sed-TN. Antibiotics have also played important roles in shaping these microbial communities: the concentrations of oxytetracycline and tetracycline clearly reflected the variance in taxonomic diversity and predicted functional diversity between impacted and less-impacted sites in water and sediment samples, respectively. Furthermore, for samples from both water and sediment, large differences of network topology structures between impacted and less-impacted were also observed. Our results provide compelling evidence that the microbial community can be used as a sentinel of eutrophication and antibiotics pollution risk associated with agricultural activity; and that proper monitoring of this environment is vital to maintain a sustainable environment in Honghu Lake. | Maozhen Han Melissa Dsouza Chunyu Zhou Hongjun Li Junqian Zhang Chaoyun Chen Qi Yao Chaofang Zhong Hao Zhou Jack A Gilbert Zhi Wang Kang Ning | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 3 |
| 5 | Patients undergoing infrainguinal bypass to treat atherosclerotic vascular disease are underprescribed cardioprotective medications: effect on graft patency, limb salvage, and mortality显示文摘 | Peter K Henke Susan Blackburn Mary C Proctor Jeri Stevens Debabrata Mukherjee Sanjay Rajagopalin Gilbert R Upchurch James C Stanley Kim A Eagle | 2004 | Journal of Vascular Surgery2004，，： | 2 |
| 6 | Signal recovery from random measurements via orthogonal matching pursuit显示文摘 | Tropp Joel A Gilbert Anna C | | 0，，12： | 2 |
| 7 | Cytotoxic T-lymphocyte epitopes for HLA-B53 and other HLA types in the malaria vaccine candidate liver-stage antigen 3 显示文摘 | Aidoo M Lalvani A Gilbert SC | 2000 | Infect Immun2000，68，1： | 1 |
| 8 | The cytostat:a new way to study cell physiology in a precisely defined environment显示文摘 | Kacmar J Gilbert A Cockrell J | 2006 | J Biotech2006，126，2： | 1 |
| 9 | Signal recovery from random measurements via orthogonal matching pursuit显示文摘 | J A Tropp A C Gilbert | 2007 | IEEE Transactions on Information Theory2007，53，12： | 1 |
| 10 | The submerged culture of Morchella esculenta显示文摘 | Gilbert F A | 1960 | Mycologia1960，52，： | 1 |
| 11 | Physico - chemical treatment echniques for wastewater laden with heavy metals 显示文摘 | Kumiawan T A Gilbert Y S Wai H L | 2006 | Chemical Engineering Journal2006，118，12： | 1 |
| 12 | An Examination of Organizational Trust Antecedents 显示文摘 | GILBERT J A TANG T L | 1998 | Public Personnel Management1998，27，3： | 1 |
| 13 | Indicators for transboundary river management显示文摘 | Lorenz C M Gilbert A J Cofino W P | 2001 | Environmental Management2001，28，1： | 1 |
| 14 | A study of biologically active peptide sequences (P-15) on the surface of an ABM scaffold (PepGen P-15TM) using AFM and FTIR显示文摘 | HOLE B B SCHWARZ J A GILBERT J L | 2005 | J Biomed Mater Res A2005，74，4： | 1 |
| 15 | Pyrosequencing of Mytilus galloprovincialis cDNAs= tissue-specific ex pression patterns显示文摘 | Craft J A Gilbert J A Temperton B | 2010 | PLoS ONE2010，5，1： | 1 |
| 16 | A new triangular layered plate element for the non-linear analysis of reinforced concrete slabs显示文摘 | Zhang Y X Bradford M A Gilbert R I | 2005 | Communications in Numerical Methods in Engineering2005，22，7： | 1 |
| 17 | Trickle irrigation water quality and preventive maintenance显示文摘 | Bucks D A Nakayama F S Gilbert R G | 1979 | Agricultural Water Management1979，，2： | 1 |
| 18 | Carbo- hydrate-binding modules: fine-tuning polysaccharide recognition 显示文摘 | Boraston A B Bolam D N Gilbert H J | 2004 | Biochemistry Journal2004，382，： | 1 |
| 19 | Signal recovery from random measurements via orthognnal matching pursuit显示文摘 | TROPP J GILBERT A | 2007 | Trans on Information Theory2007，53，12： | 1 |
| 20 | Stacked stigma: on- cology social workersperceptions of the lung cancer ex- perience显示文摘 | Conlon A Gilbert D Jones B | 2010 | J Psychosoc Oncol2010，28，1： | 1 |
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