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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon显示文摘 | Geurts A M Wilber A Carlson C M | 2006 | BMC Biotechnol2006，6，： | 1 |
| 3 | Proteomic Mass Spectra Classification Using Decision Tree Based Ensemble Methods显示文摘 | Geurts P Fillet M Seny D | 2005 | Bioinformatics2005，21，21： | 1 |
| 4 | Isolation and Purification of ca rdiolipin from beef heart显示文摘 | Smaal EB Romijn D Geurts van kessel WS M | 1985 | J Lipid Res1985，，： | 1 |
| 5 | Dopamine receptors-physiological understanding to therapeutic intervention potential显示文摘 | Emilien G Maloteaux JM Geurts M Hoogenberg K Cragg S | | 0，，： | 1 |
| 6 | Involvement of gut mierobiota in the development of low-grade inflamnmtion and type 2 diabetes associated with obesity显示文摘 | Cani PD Osto M Geurts L | 2012 | Gut Microbes2012，3，4： | 1 |
| 7 | Surgical Decompression for Space-Occupying Cerebral Infarction Outcomes at 3 Years in the Randomized HAMLET Trial 显示文摘 | Geurts M van der Worp H B Kappelle L J | 2013 | Stroke2013，44，9： | 1 |
| 8 | Consensus recom-mendations for MS cortical lesion scoring using double inversion recovery MRI显示文摘 | Geurts JJ Roosendaal SD Calabrese M | 2011 | Neurology2011，76，5： | 1 |
| 9 | Candidate colorectal cancer predisposing gene variants in Chinese early-onset and familial cases显示文摘AIM: To investigate whether whole-exome sequencing may serve as an efficient method to identify known or novel colorectal cancer(CRC) predisposing genes in early-onset or familial CRC cases.METHODS: We performed whole-exome sequencing in 23 Chinese patients from 21 families with nonpolyposis CRC diagnosed at ≤ 40 years of age, or from multiple affected CRC families with at least 1 firstdegree relative diagnosed with CRC at ≤ 55 years of age.Genomic DNA from blood was enriched for exome sequences using the Sure Select Human All Exon Kit, version 2(Agilent Technologies) and sequencing was performed on an Illumina Hi Seq 2000 platform.Data were processed through an analytical pipeline to search for rare germline variants in known or novel CRC predisposing genes.RESULTS: In total, 32 germline variants in 23 genes were identified and confirmed by Sanger sequencing.In 6 of the 21 families(29%), we identified 7 mutations in 3 known CRC predisposing genes including MLH1(5 patients), MSH2(1 patient), and MUTYH(biallelic, 1 patient), five of which were reported as pathogenic.Inthe remaining 15 families, we identified 20 rare and novel potentially deleterious variants in 19 genes, six of which were truncating mutations.One previously unreported variant identified in a conserved region of EIF2AK4(p.Glu738_Asp739insA rgA rg) was found to represent a local Chinese variant, which was significantly enriched in our early-onset CRC patient cohort compared to a control cohort of 100 healthy Chinese individuals scored negative by colonoscopy(33.3% vs 7%, P < 0.001).CONCLUSION: Whole-exome sequencing of early-onset or familial CRC cases serves as an efficient method to identify known and potential pathogenic variants in established and novel candidate CRC predisposing genes. | Jun-Xiao Zhang Lei Fu Richarda M de Voer Marc-Manuel Hahn Peng Jin Chen-Xi Lv Eugène TP Verwiel Marjolijn JL Ligtenberg Nicoline Hoogerbrugge Roland P Kuiper Jian-Qiu Sheng Ad Geurts van Kessel | 2015 | World Journal of Gastroenterology2015，21，14： | 1 |
| 10 | 'Longituclinal study using a diode phantom for helical tomotherapy IMRT QA显示文摘 | GEURTS M GONZALEZ J SERRANO-OJEDA P | 2009 | Medical Phys- ics2009，36，11： | 1 |
| 11 | Involvement of gut microbiota in the development of low - grade inflammation and type 2 diabetes associated with obesity显示文摘 | Cani PD Osto M Geurts L | 2012 | Gut Microbes2012，3，4： | 1 |
| 12 | Recovery of standing balance in postacute stroke patients:a rehabilitation cohort study显示文摘 | de Haart M Geurts AC Huidekoper SC | 2004 | Arch Phys Med Rehabil2004，85，6： | 1 |
| 13 | The evaluation of an intervention based on the application of patient self-completion concordance forms in Dutch community pharmacies and the effect on adherence to chronic medication显示文摘 | Geurts M M Pot J L Schepers E H | 2010 | Patient Edu Couns2010，78，1： | 1 |
| 14 | The evalua-tion of an intervention based on the application of patientself-completion concordance forms in Dutch communitypharmacies and the effect on adherence to chronic medi-cadon显示文摘 | Geurts M M Pot JL Schepers E H | 2010 | Patient Educ Couns2010，78，1： | 1 |
| 15 | Measurement and clinical effect of grey matter pathology in multiple sclerosis显示文摘 | Geurts JJ Calabrese M Fisher E | 2012 | Lancet Neurol2012，1，12： | 1 |
| 16 | Theoretical Perspectives on Marketing Ethics with Implications for Managing the Glob- al Sales Force 显示文摘 | Swenson M J Geurts M D | 1992 | International Review of Retail Distri- bution and Consumer Research1992，2，7： | 1 |
| 17 | Knockout rats via embryo microinjection of zinc-finger nucleases显示文摘 | GEURTS A M COST G J FREYVERT Y | 2009 | Science2009，325，5939： | 1 |
| 18 | Knockout rats via embryo microinjection of zinc-finger nueleases 显示文摘 | Geurts A M Cost G J Freyvert Y | 2009 | Science2009，325，5939： | 1 |
| 19 | Disturbed corti-co-subcortical interactions during motor task switching in trau-matic brain injury 显示文摘 | LEUNISSEN I COXON JP GEURTS M | 2013 | Hum Brain Mapp2013，34，6： | 1 |
| 20 | Step characteristics during obstacle avoidance in hemiplegic strke 显示文摘 | Den Otter A R Geurts A C de Haart M | 2005 | Exp Brain Res2005，161，2： | 1 |
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