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| 1 | Rates and risk factors for suicidal ideation,suicide attempts and suicide deaths in persons with HIV:a systematic review and meta-analysis显示文摘Background People living with HIV/AIDS(PLWHA)must contend with a significant burden of disease.However,current studies of this demographic have yielded wide variations in the incidence of suicidality(defined as suicidal ideation,suicide attempt and suicide deaths).Aims This systematic review and meta-analysis aimed to assess the lifetime incidence and prevalence of suicidality in PLWHA.Methods Publications were identified from PubMed(MEDLINE),SCOPUS,OVID(MEDLINE),Joanna Briggs Institute EBP and Cochrane Library databases(from inception to before 1 February 2020).The search strategy included a combination of Medical Subject Headings associated with suicide and HIV.Researchers independently screened records,extracted outcome measures and assessed study quality.Data were pooled using a random-effects model.Subgroup and meta-regression analyses were conducted to explore the associated risk factors and to identify the sources of heterogeneity.Main outcomes were lifetime incidence of suicide completion and lifetime incidence and prevalence of suicidal ideation and suicide attempt.Results A total of 185199 PLWHA were identified from 40 studies(12 cohorts,27 cross-sectional and 1 nested case-control).The overall incidence of suicide completion in PLWHA was 10.2/1000 persons(95%CI:4.5 to 23.1),translating to 100-fold higher suicide deaths than the global general population rate of 0.11/1000 persons.The lifetime prevalence of suicide attempts was 158.3/1000 persons(95%CI:106.9 to 228.2)and of suicidal ideation was 228.3/1000 persons(95%CI:150.8 to 330.1).Meta-regression revealed that for every 10-percentage point increase in the proportion of people living with HIV with advanced disease(AIDS),the risk of suicide completion increased by 34 per 1000 persons.The quality of evidence by Grading of Recommendations,Assessment,Development and Evaluations for the suicide deaths was graded as‘moderate’quality.Conclusions The risk of suicide death is 100-fold higher in people living with HIV than in the general population.Lifetime incidence of suicidal ideation and attempts are substantially high.Suicide risk assessments should be a priority in PLWHA,especially for those with more advanced disease. | Matt Pelton Matt Ciarletta Holly Wisnousky Nicholas Lazzara Monica Manglani Djibril M Ba Vernon M Chinchillli Ping Du Anna E Ssentongo Paddy Ssentongo | 2021 | General Psychiatry2021，34，2： | 3 |
| 2 | Discovery, biology and therapeutic of RNA interference, microRNA and antagomirs显示文摘 | Yang M Mattes J | 2008 | Pharmacol Ther2008，117，： | 1 |
| 3 | Evaluation of Salt Tolerance of in Vitro-grown Grapevine Rootstock Varieties显示文摘 | Matte C Cantos M | 1999 | Vitis1999，38，2： | 1 |
| 4 | Computer-assisted posterior instrumentation of the cervical and cervico-thoracic spine显示文摘 | Mattes T Cakir B | 2004 | Euro-Spine J (2004) 13:50-592004，，2004： | 1 |
| 5 | Factors affecting university- industry R&D projects: The importance of searching, screeningand signaling显示文摘 | Fontana R Geuna A Matt M | 2006 | Research Policy2006，35，2： | 1 |
| 6 | Before oral agents fail:The ease for starting insulinearly显示文摘 | Matte M | 2002 | International Jottmal of Obesity& Related Metabolic Disorders:Journal of the International Association for the Study of Obesity2002，26，3： | 1 |
| 7 | Exon 11 mutations, Ki67, and p16(INKgA) as predictors of prognosis in patients with GIST 显示文摘 | Cerski M R Pereira F Matte U S | 2011 | Pathol Res Pract2011，207，11： | 1 |
| 8 | Surveying inventors listed on patents to investigate determinants of innova- tion 显示文摘 | Mattes E Stacey M C Marinova D | 2006 | Scientometrics2006，69，3： | 1 |
| 9 | Computer-assisted posterior instrumentation of the cervical and cervieo-thoracic spine显示文摘 | Richter M Mattes T Cakir B | 2004 | Eur Spine J2004，13，： | 1 |
| 10 | Regulation of microRNA by an tagomirs:a new class of pharmacological antagonists for the specific regulation of gene function显示文摘 | Mattes J Yang M Foster P S | 2007 | American Journal of Respiratory Cell and Molecular Biology2007，36，1： | 1 |
| 11 | Functional consequences of mutations in the smooth muscle myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy显示文摘 | HIROSHI YAMASHITA MATT J TYSKA DAVID M Warshaw | 2000 | J Biol Chem2000，275，28： | 1 |
| 12 | Proteomic analysis of S-nitrosylated proteins in Arabidopsis thaliana undergoing hypersensitive response显示文摘 | Romero-Puertas M C Campostrini N Matte A Righetti P G Perazolli M Zolla L Roepstorff P Delledonne M | | 0，，： | 1 |
| 13 | Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment显示文摘 | Collison A Mattes J Plank M | 2011 | Allergy Clin Immunol2011，128，1： | 1 |
| 14 | Efficacy and safety of sitagliptin versus glipizide in patients with type 2 diabetes and moderate-to-severe chronic renal insufficiency显示文摘 | Arjona Ferreira JC Matte M Barzilai N | 2013 | Diabetes Care2013，36，5： | 1 |
| 15 | Evaluation of an intensive intermittent-induction regimen and duration of short-course treatment for human immunodeficiency virus-related pulmonary tuberculosis 显示文摘 | EI-Sadr W M perlman D C Matts J P | 1998 | Clin Infect Dis1998，26，： | 1 |
| 16 | Evaluation of an intensive intermittent-induction regimen and duration of shortcourse treatment for human immunodeficiency virus-related pulmonary tuberculosis显示文摘 | El-Sadr W M Perlman D C Matts J P | 1998 | Clin Infect Dis1998，26，： | 1 |
| 17 | Discovery,biology and therapeutic potential of RNA interference,microRNA and antagomirs显示文摘 | Yang M Mattes J | 2008 | Pharmacol Ther2008，117，1： | 1 |
| 18 | Identification of HPHT-treated yellow to green diamonds 显示文摘 | Matt H Thomas M | 2000 | Gems & Gemology2000，36，2： | 1 |
| 19 | A highly sensitive ELISA D-dimer increases testing but not diagnosis of pulmonary embolism显示文摘 | Kabrhel C Matts C Mcnamara M | 2006 | Acad Emerg Med2006，13，： | 1 |
| 20 | Biomass production of 'Alamo' switchgrass in response to nitrogen,phosphorous and row spacing显示文摘 | James P M Matt A S William R O | 2001 | Agronomy Journal2001，93，4： | 1 |
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