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| 1 | 不同类型风电机组对小干扰和暂态稳定性的影响显示文摘随着风电装机容量在电力系统中渗透率的逐步提高,其对电力系统的影响越来越明显。这样,就很有必要系统地分析风电机组对电力系统小干扰和暂态稳定性的影响,以便研究针对性措施。在此背景下,对3类常见的风电机组接入后的电力系统稳定性进行了系统的比较研究。首先给出了这3类风电机组的动态模型,之后以美国西部联合电力系统(WSCC)3机9节点系统为例,采用特征值分析和动态时域仿真方法,系统地比较了在同一母线接入异步风电机组、双馈风电机组、永磁直驱风电机组与接入同等容量同步发电机组对小干扰稳定和暂态稳定性的影响。研究结果表明,3类风电机组并网对小干扰稳定和暂态稳定性的影响程度均有所不同。 | 和萍 文福拴 薛禹胜 Ledwich GER ARD 李思岑 | 2013 | 电力系统自动化2013，37，17： | 34 |
| 2 | NETosis,complement,and coagulation:a triangular relationship显示文摘NETosis is a regulated form of neutrophil cell death that contributes to the host defense against pathogens and was linked to various diseases soon after its first description in 2004.During NETosis,neutrophils release neutrophil extracellular traps(NETs),which can capture and kill bacteria and other pathogens to prevent them from spreading.Although substantial progress has been made in our understanding of NETosis,the precise mechanism underlying NETosis is still a matter of debate.Research continues to elucidate the molecular pathways involved in NETosis.In recent years,interactions with the complement and coagulation systems have become increasingly apparent.Activated complement proteins can stimulate NET formation,and NETs,in turn,can serve as a platform for complement activation.In addition,NETs can act as a scaffold for thrombus formation during coagulation.While crosstalk between the coagulation and complement systems has been previously described,NETosis appears to be a third important player in this consortium to protect the host against pathogens.This review summarizes our current knowledge on the mutual interactions between NETosis,the complement system and the coagulation system,with an emerging description of their complex triangular relationship. | Cynthia M.de Bont Wilbert C.Boelens Ger J.M.Pruijn | 2019 | Cellular & Molecular Immunology2019，16，1： | 22 |
| 3 | 碰撞试验中泡沫填充铝管的最优化设计显示文摘对泡沫填充空心方铝管进行轴向撞击粉碎试验。此外,为获得更多有关撞击过程的信息,也对试验进行了有限元模拟分析。为找到更有效轻便的撞击减震器,并达到吸收最多能量的目的,在方矩形管的优化设计中采用了多元设计优化方法(MDO)。基于管的最佳几何尺寸考虑将具有最轻重量并且吸收能量最多作为设计目标。前期研究表明,使用高密度蜂窝材料填充会使管吸收更多能量,但重量不是最轻[Zarei H R,Krger M.Optimum honey-comb filled crash absorber design.Mater Des2007,29:193-204]。因此,为了解采用不同密度的泡沫填充管的撞击性能,进行了全面的研究,。采用MDO方法寻找一种优化填充管,使其吸收的能量与最优空心管吸收的能量一样多。 | H.R.Zarei M.Krger | 2008 | 钢结构2008，23，9： | 17 |
| 4 | 温度和应变速率对双辊铸轧、轧制和热处理态AZ31镁合金流动应力行为的影响(英文)显示文摘在单轴拉伸条件下研究温度和应变速率对双辊铸轧、轧制和热处理AZ31镁合金流动应力行为的影响。结果表明,在高温下,动态回复、连续动态再结晶、晶界滑移和附加滑移系的活化使合金的延展得到改善。在473~523 K和10-2~10-1 s-1条件下,合金的断裂伸长率几乎与应变速率无关,而与应变速率依赖于临界剪切应的非基面滑移有关。由于经上述工艺加工的AZ31镁合金具有较低的临界剪切应力,因此在573 K和10-3 s-1条件下出现了孪晶。 | F.BERGE L.KRüGER H.OUAZIZ C.ULLRICH | 2015 | Transactions of Nonferrous Metals Society of China2015，25，1： | 11 |
| 5 | Microbial markers in colorectal cancer detection and/or prognosis显示文摘Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations. | Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard Delphine Boucher Mathilde Bonnet | 2018 | World Journal of Gastroenterology2018，24，22： | 10 |
| 6 | 电力变压器介质响应的测量与分析(英文)显示文摘This paper discusses approaches to measure moisture in power transformers by analyzing the dielectric response of the main insulation. Dielectric diagnostic methods deduce moisture in the solid insulation from dielectric properties like polarisation depolarisation currents and dissipation factor vs. frequency. A new instrument 'Dirana' combines time domain (PDC) and frequency domain (FDS) measurements and thus substantially shortens the measurement duration. New software was developed which bases on a new data pool,measured at new and aged pressboard samples with various moisture contents and oil impregnation. Its analysis algorithm compares measurements from a transformer to modelled dielectric responses,obtained from the so-called XY-model. To avoid overestimation of moisture for aged transformers,the analysis algorithm compensates for the influence of conductive aging by-products. Moisture especially increases the losses in the low frequency range of the dielectric response of pressboard. Thus,data on the left-hand side of the area dominated by interfacial polarization (insulation geometry) are required for reliable moisture determination. Case studies illustrate the application of moisture determination by dielectric response methods. | M. Koch M. Krger | 2009 | 高电压技术2009，35，8： | 10 |
| 7 | 蒙特卡罗等效哈密顿量的1+1维检验显示文摘用最近发展起来的蒙特卡罗等效哈密顿量新方法 ,研究了与量子场论中Φ4模型相似的 1 +1维量子力学系统V(x) =μ2 x2 +λx4(其中 μ2 <0 ,λ >0 )的低能物理特性 .计算了能谱、波函数以及热力学可观察量 .获得良好的结果 。 | 黄纯青 江俊勤 罗向前 H.Jirari H.Krger K.J.M.Moriarty | 2000 | 高能物理与核物理2000，24，6： | 8 |
| 8 | Low-grade gliomas:do changes in rCBV measurements at longitudinal perfusion-weighted MR imaging predict malignant transformation?显示文摘Radiology. 2008 Apr;247(1):170-8.PURPOSE: To prospectively perform longitudinal magnetic resonance (MR) perfusion imaging of conservatively treated low-gradegliomas to determine whether relative cerebral blood volume (rCBV) changes precede malignant transformation as defined | Danchaivijitr N Waldman AD Tozer DJ Benton CE Brasil Caseiras G Tofts PS Rees JH J?ger HR | 2008 | 中国神经肿瘤杂志2008，6，2： | 7 |
| 9 | 新型PET泡沫AIREX~ T92的性能特点试验研究显示文摘在当前复合材料夹层结构用泡沫芯材领域中,PVC泡沫由于其良好的综合力学性能占据着主导地位,PET泡沫的应用则由于其脆性而受到一定的限制,加铝(Alcan)复合材料集团芯材事业部在其AIREX(T91基础上研制的新型PET泡沫AIREX(T92成功突破了这个弱点。本文对AIREX(T92泡沫的静、动态力学性能,高温下的力学性能以及高温下的尺寸稳定性进行了试验研究。结果表明,AIREX(T92作为一款综合性能优异的结构泡沫芯材,可以用于风能、游艇和轨道交通等各个领域。 | 姚辉 Moritz Pieper Lars Massüger Roman Gtzi 李岩 | 2009 | 材料工程2009，37，S2： | 6 |
| 10 | Palliative chemotherapy for gastroesophageal cancer in old and very old patients: A retrospective cohort study at the National Center for Tumor Diseases, Heidelberg显示文摘AIM:To investigate the outcome of palliative chemotherapy in old patients with gastroesophageal cancer at the National Center for Tumor Diseases,Heidelberg.METHODS:Using a prospectively generated database,we retrospectively analyzed 55 patients≥70years under palliative chemotherapy for advanced gastroesophageal cancer at the outpatient clinic of the National Center for Tumor Diseases Heidelberg,Germany between January 2006 and December2013.Further requirements for inclusion were(1)histologically proven diagnosis of gastroesophageal cancer;(2)advanced(metastatic or inoperable)disease;and(3)no history of radiation or radiochemotherapy.The clinical information included Eastern Cooperative Oncology Group performance status(ECOG PS),presence and site of metastases at diagnosis,date of previous surgery and perioperative chemotherapy,start and stop date of first-line treatment,toxicities and consecutive dosage reductions of first-line treatment,response to first-line therapy,date of progression,usage of second-line therapies and date and cause of death.Survival times[progression-free survival(PFS),overall survival(OS)and residual survival(RS)]were calculated.Toxicity and safety were examined.Prognostic factors including ECOG PS,age and previousperioperative treatment were analyzed.RESULTS:Median age of our cohort was 76 years.86%of patients received a combination of two cytotoxic drugs.76 percent of patients had an oxaliplatin-based first-line therapy with the oxaliplatin and 5-fluorouracil regimen being the predominantely chosen regimen(69%).Drug modifications due to toxicity were necessary in 56%of patients,and 11%of patients stopped treatment due to toxicities.Survival times of our cohort are in good accordance with the major phaseⅢtrials that included mostly younger patients:PFS and OS were 5.8 and 9.5 mo,respectively.Survival differed significantly between patient groups with low(≤1)and high(≥2)ECOG PS(12.7 mo vs 3.8 mo,P<0.001).Very old patients(≥75 years)did not show a worse outcome in terms of survival.Patients receiving secondline treatment(51%)had a significantly longer RS than patients with best supportive care(6.8 vs 1.4 mo,P=0.001).Initial ECOG PS was a strong prognostic factor for PFS,OS and RS.CONCLUSION:Old patients with non-curable gastroesophageal cancer should be offered chemotherapy,and ECOG PS is a tool for balancing benefit and harm upfront.Second-line treatment is reasonable. | Anne Katrin Berger Stefanie Zschaebitz Christine Komander Dirk Jger Georg Martin Haag | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 11 | Epigenetics and pancreatic cancer:Pathophysiology and novel treatment aspects显示文摘An improvement in pancreatic cancer treatment represents an urgent medical goal.Late diagnosis and high intrinsic resistance to conventional chemotherapy has led to a dismal overall prognosis that has remained unchanged during the past decades.Increasing knowledge about the molecular pathogenesis of the disease has shown that genetic alterations,such as mutations of K-ras,and especially epigenetic dysregulation of tumor-associated genes,such as silencing of the tumor suppressor p16ink4a,are hallmarks of pancreatic cancer.Here,we describe genes that are commonly affected by epigenetic dysregulation in pancreatic cancer via DNA methylation,histone acetylation or miRNA(microRNA)expression,and review the implications on pancreatic cancer biology such as epithelial-mesenchymal transition,morphological pattern formation,or cancer stem cell regulation during carcinogenesis from PanIN(pancreatic intraepithelial lesions)to invasive cancer and resistance development.Epigenetic drugs,such as DNA methyltransferases or histone deactylase inhibitors,have shown promising preclinical results in pancreatic cancer and are currently in early phases of clinical development.Combinations of epigenetic drugs with established cytotoxic drugs or targeted therapies are promising approaches to improve the poor response and survival rate of pancreatic cancer patients. | Daniel Neureiter Tarkan Jger Matthias Ocker Tobias Kiesslich | 2014 | World Journal of Gastroenterology2014，20，24： | 6 |
| 12 | Immunity Genes and Susceptibility to Otitis Media:A Comprehensive Review显示文摘Otitis media(OM) is a middle ear infection associated with inflammation and pain.This disease frequently afflicts humans and is the major cause of hearing loss worldwide.OM continues to be one of the most challenging diseases in the medical field due to its diverse host targets and wide range of clinical manifestations.Substantial morbidity associated with OM is further exacerbated by high frequency of recurrent infections leading to chronic suppurative otitis media(CSOM).Children have greater susceptibility to,and thus,suffer most frequently from OM,which can cause significant deterioration in quality of life.Genetic factors have been demonstrated,in large part by twin and family studies,to be key determinants of OM susceptibility.In this review,we summarize the current knowledge on immunity genes and selected variants that have been associated with predisposition to OM.In particular,polymorphisms in innate immunity and cytokine genes have been strongly linked with the risk of developing OM.Future studies employing state-of-the-art technologies,including next-generation sequencing(NGS),will aid in the identification of novel genes associated with susceptibility to OM.This,in turn,will open up avenues for identifying high-risk individuals and designing novel therapeutic strategies based on precise targeting of these genes. | Rahul Mittal Giannina Robalino Robert Gerring Brandon Chan Denise Yan M'hamed Grati Xue-Zhong Liu | 2014 | Journal of Genetics and Genomics2014，41，11： | 5 |
| 13 | Targeting cell death signaling in colorectal cancer:Current strategies and future perspectives显示文摘The evasion from controlled cell death induction has been considered as one of the hallmarks of cancer cells.Defects in cell death signaling are a fundamental phenomenon in colorectal cancer.Nearly any non-invasive cancer treatment finally aims to induce cell death.However,apoptosis resistance is the major cause for insufficient therapeutic success and disease relapse in gastrointestinal oncology.Various compounds have been developed and evaluated with the aim to meet with this obstacle by triggering cell death in cancer cells.The aim of this review is to illustrate current approaches and future directions in targeting cell death signaling in colorectal cancer.The complex signaling network of apoptosis will be demonstrated and the'druggability'of targets will be identified.In detail,proteins regulating mitochondrial cell death in colorectal cancer,such as Bcl-2 and survivin,will be discussed with respect to potential therapeutic exploitation.Death receptor signaling and targeting in colorectal cancer will be outlined.Encouraging clinical trials including cell death based targeted therapies for colorectal cancer are under way and will be demonstrated.Our conceptual understanding of cell death in cancer is rapidly emerging and new types of controlled cellular death have been identified.To meet this progress in cell death research,the implication of autophagy and necroptosis for colorectal carcinogenesis and therapeutic approaches will also be depicted.The main focus of this topic highlight will be on the revelation of the complex cell death concepts in colorectal cancer and the bridging from basic research to clinical use. | Bruno Christian Koehler Dirk Jger Henning Schulze-Bergkamen | 2014 | World Journal of Gastroenterology2014，20，8： | 4 |
| 14 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 4 |
| 15 | Leitlinien für den Gebrauch von Ultraschallkontrastmitteln - Januar 2004显示文摘 | T Albrecht M Blomley L Bolondi M Claudon J.-M Correas D Cosgrove L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani L Solbiati L Thorelius F Tranquart H Weskott T Whittingham | 2004 | Ultraschall in Med2004，，04： | 3 |
| 16 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D'Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 3 |
| 17 | A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in hepatitis B virus (HBV) transgenic mice显示文摘 | Pascale Buchmann Claudia Dembek Larissa Kuklick Clemens J?ger Raindy Tedjokusumo Miriam John von Freyend Uta Drebber Zbigniew Janowicz Karl Melber Ulrike Protzer | 2013 | Vaccine2013，，8： | 3 |
| 18 | 直接挤压成形生物医用镁合金细丝(英文)显示文摘生物可降解丝可为各种生物医学应用提供承重支撑,是目前生物材料研究的新趋势。通过直接挤压制备出直径为250μm的99.92%镁丝,挤压比达1:576。单个加工步骤的总施加应变为6.36。挤压温度为230~310℃,挤压速度为0.2~0.5 mm/s。得到的金属丝具有良好的力学性能,其力学性能随挤压参数的变化而变化。室温下最大真拉应力可达228 MPa,塑性可达13%。结果表明,单步直接挤压法是一种有效的生产具有足够性能的生物医用镁丝的方法。断口分析表明,镁丝的失效可能与夹杂物(如MgO颗粒)密切相关。由于挤压温度低而导致的晶粒尺寸细小,是影响镁丝拉伸性能的主要参数。 | K.TESAŘ K.BALÍK Z.SUCHARDA A.JÄGER | 2020 | Transactions of Nonferrous Metals Society of China2020，30，2： | 3 |
| 19 | Effect of process parameters on additive-free electrospinning of regenerated silk fibroin nonwovens显示文摘Silk fibroin is a biomaterial with multiple beneficial properties for use in regenerative medicine and tissue engineering.When dissolving and processing the reconstituted silk fibroin solution by electrospinning,the arrangement and size of fibers can be manifold varied and according fiber diameters reduced to the nanometer range.Such nonwovens show high porosity as well as potential biocompatibility.Usually,electrospinning of most biomaterials demands for the application of additives,which enable stable electrospinning by adjusting viscosity,and are intended to evaporate during processing or to be washed out afterwards.However,the use of such additives increases costs and has to be taken into account in terms of biological risks when used for biomedical applications.In this study,we explored the possibilities of additive-free electrospinning of pure fibroin nonwovens and tried to optimize process parameters to enable stable processing.We used natural silk derived from the mulberry silkworm Bombyx mori.After degumming,the silk fibroin was dissolved and the viscosity of the spinning solution was controlled by partial evaporation of the initial solving agent.This way,we were able to completely avoid the use of additives and manufacture nonwovens,which potentially offer higher biocompatibility and reduced immunogenicity.Temperature and relative humidity during electrospinning were systematically varied(25–35°C,25–30%RH).In a second step,the nonwovens optionally underwent methanol treatment to initiate beta-sheet formation in order to increase structural integrity and strength.Comprehensive surface analysis on the different nonwovens was performed using scanning electron microscopy and supplemented by additional mechanical testing.Cytotoxicity was evaluated using BrdU-assay,XTT-assay,LDH-assay and live-dead staining.Our findings were,that an increase of temperature and relative humidity led to unequal fiber diameters and defective nonwovens.Resistance to penetration decreased accordingly.The most uniform fiber diameters of 998±63 nm were obtained at 30°C and 25%relative humidity,also showing the highest value for resistance to penetration(0.20 N).The according pure fibroin nonwoven also showed no signs of cytotoxicity.However,while the biological response showed statistical evidence,the material characteristics showed no statistically significant correlation to changes of the ambient conditions within the investigated ranges.We suggest that further experiments should explore additional ranges for temperature and humidity and further focus on the repeatability of material properties in dependency of suitable process windows. | Alexander Kopp Ralf Smeets Martin Gosau Nadja Kröger Sandra Fuest Marius Köpf Magnus Kruse Judith Krieger Rico Rutkowski Anders Henningsen Simon Burg | 2020 | Bioactive Materials2020，5，2： | 3 |
| 20 | Visco-plastic self-consistent modelling of a grain boundary misorientation distribution after equal-channel angular pressing in an AZ31 magnesium alloy显示文摘 | A. Ostapovets P. Molnár A. J?ger | 2013 | Journal of Materials Science2013，，5： | 2 |
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