|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diagnosis of focal liver lesions with deep learning-based multichannel analysis of hepatocyte-specific contrast-enhanced magnetic resonance imaging显示文摘BACKGROUND The nature of input data is an essential factor when training neural networks.Research concerning magnetic resonance imaging(MRI)-based diagnosis of liver tumors using deep learning has been rapidly advancing.Still,evidence to support the utilization of multi-dimensional and multi-parametric image data is lacking.Due to higher information content,three-dimensional input should presumably result in higher classification precision.Also,the differentiation between focal liver lesions(FLLs)can only be plausible with simultaneous analysis of multisequence MRI images.AIM To compare diagnostic efficiency of two-dimensional(2D)and three-dimensional(3D)-densely connected convolutional neural networks(DenseNet)for FLLs on multi-sequence MRI.METHODS We retrospectively collected T2-weighted,gadoxetate disodium-enhanced arterial phase,portal venous phase,and hepatobiliary phase MRI scans from patients with focal nodular hyperplasia(FNH),hepatocellular carcinomas(HCC)or liver metastases(MET).Our search identified 71 FNH,69 HCC and 76 MET.After volume registration,the same three most representative axial slices from all sequences were combined into four-channel images to train the 2D-DenseNet264 network.Identical bounding boxes were selected on all scans and stacked into 4D volumes to train the 3D-DenseNet264 model.The test set consisted of 10-10-10 tumors.The performance of the models was compared using area under the receiver operating characteristic curve(AUROC),specificity,sensitivity,positive predictive values(PPV),negative predictive values(NPV),and f1 scores.RESULTS The average AUC value of the 2D model(0.98)was slightly higher than that of the 3D model(0.94).Mean PPV,sensitivity,NPV,specificity and f1 scores(0.94,0.93,0.97,0.97,and 0.93)of the 2D model were also superior to metrics of the 3D model(0.84,0.83,0.92,0.92,and 0.83).The classification metrics of FNH were 0.91,1.00,1.00,0.95,and 0.95 using the 2D and 0.90,0.90,0.95,0.95,and 0.90 using the 3D models.The 2D and 3D networks'performance in the diagnosis of HCC were 1.00,0.80,0.91,1.00,and 0.89 and 0.88,0.70,0.86,0.95,and 0.78,respectively;while the evaluation of MET lesions resulted in 0.91,1.00,1.00,0.95,and 0.95 and 0.75,0.90,0.94,0.85,and 0.82 using the 2D and 3D networks,respectively.CONCLUSION Both 2D and 3D-DenseNets can differentiate FNH,HCC and MET with good accuracy when trained on hepatocyte-specific contrast-enhanced multi-sequence MRI volumes. | Róbert Stollmayer Bettina K Budai Ambrus Tóth IldikóKalina Erika Hartmann Péter Szoldán Viktor Bérczi Pál Maurovich-Horvat Pál N Kaposi | 2021 | World Journal of Gastroenterology2021，27，35： | 6 |
| 2 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 3 | High-performance waveguide-integrated germanium PIN photodiodes for optical communication applications[Invited]显示文摘This paper reports on high-performance waveguide-integrated germanium photodiodes for optical communications applications.200 mm wafers and production tools were used to fabricate the devices.Yields over 97%were obtained for three different compact photodiodes(10×10μm and intrinsic region width of 0.5,0.7,and 1μm)within the same batch of three wafers.Those photodiodes exhibit low dark currents under reverse bias with median values of 74,62,and 61 nA for intrinsic widths of 0.5,0.7,and 1μm,respectively,over a full wafer.Responsivities up to 0.78 A∕W at 1550 nm and zero bias were measured.Zero bias operation is possible for 25 and 40 Gbps with receiver sensitivity estimated to−13.9 and−12.3 dBm,respectively. | Léopold Virot Laurent Vivien Jean-Marc Fédéli Yann Bogumilowicz Jean-Michel Hartmann Frédéric Bœuf Paul Crozat Delphine Marris-Morini Eric Cassan | 2013 | Photonics Research2013，1，3： | 2 |
| 4 | The incidence end risk factors for hypotension after spinal enesthesia induction:an analysis with automated data collection显示文摘 | Hartmann B Junger A Klasen J | 2002 | Anesth Analg2002，94，6： | 1 |
| 5 | Vibration Damping with Polymer显示文摘 | Hartmann B | 1991 | Polymer News1991，16，3： | 1 |
| 6 | ERCP and MRCP in the differentiation of pancreatic tumors 显示文摘 | Hartmann D Schilling D Bassler B | 2004 | Dig Dis2004，22，1： | 1 |
| 7 | Secretion of trophic gut peptides is not different in bolusand continuously fed piglets显示文摘 | van Goudoever J B Stoll B Hartmann B | 2001 | J Nut2001，131，： | 1 |
| 8 | HPLC/MS and HPLC/NMR as hyphenated techniques for accelerated characterization of the main constituents in Chamomile (Chamomilla recu tita L Rauschert) 显示文摘 | Berthold W Herrmann M Hartmann B | 2008 | Eur Food Res Technol2008，22，6： | 1 |
| 9 | Detection of pathogenic Yersinia enterocolitica in meat using real-tinm PCR显示文摘 | FREDRIKSSON-AHOMAA M HARTMANN B SCHEU P | 2007 | Journal of Consumer Protection and Food Safety2007，2，2： | 1 |
| 10 | Expanded-bed chromatography in primary protein purification 显示文摘 | Anspanch F B Curbelo D Hartmann R | 1999 | J Chromatogra A1999，865，12： | 1 |
| 11 | Temporal and spatial trends of precipitation and river flow in the Yangtze River Basin 1961 -2000显示文摘 | Jiang T Su B D Hartmann H K | 2007 | Geomorphology2007，85，： | 1 |
| 12 | Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities 显示文摘 | Schloss PD Westcott SL Ryabin T Hall JR Hartmann M Hollister EB Lesniewski RA Oakley BB Parks DH Robinson CJ Sahl JW Stres B Thallinger GG Van Horn DJ Weber CF | 2009 | Appl Environ Microbiol2009，75，23： | 1 |
| 13 | Tissue levels and post-prandial secretion of the intestinal growth aetor,glucagon-like peptide-2,in controls and inflammatory bowel disease:comparison with peptide YY显示文摘 | Schmidt PT Ljung T Hartmann B | 2005 | Eur J Gastroenterol Hepatol2005，17，2： | 1 |
| 14 | Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN显示文摘 | Hartmann W Digon-Sontgerath B Koch A | | 0，，10： | 1 |
| 15 | Preparation of self-supporting carbon thin films显示文摘 | Lommel B Hartmann W Kindler B | 2002 | Nuclear Instruments and Methods in Physics Research A2002，480，1： | 1 |
| 16 | The value of early enteral nutrition in the prophylaxis of stress ulceration in the severely burned patient显示文摘 | Raff T Germann G Hartmann B | 1997 | Burns1997，23，4： | 1 |
| 17 | An investigation of brain processes supporting meditation显示文摘 | Klaus B. B?rentsen Hans St?dkilde-J?rgensen Bo Sommerlund Tue Hartmann Johannes Damsgaard-Madsen Mark Fosn?s Anders C. Green | | Cognitive Processing0，，： | 1 |
| 18 | Burn shock fluidresuscitation and hemodynamic monitoring显示文摘 | Czermak C Hartmann B Scheele S | | 0，，06： | 1 |
| 19 | On a new method for the genera- tion of sound waves显示文摘 | HARTMANN J TROLL B | 1922 | Physics Review1922，20，6： | 1 |
| 20 | Carboxymethyl cocoyam starch:synthesis, characterisation and influence of reaction parameters 显示文摘 | Lawal O S Lechner M D Hartmann B | 2007 | Starch/Starke2007，59，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员