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| 1 | 酪氨酸羟化酶在C型尼曼-匹克病小鼠小脑中的异常表达显示文摘目的 探讨C型尼曼 匹克病 (NPC)小脑中酪氨酸羟化酶 (TH)异常表达的时间、部位及其与临床表现的关系。 方法 应用TH抗体 ,对不同周龄NPC小鼠和正常小鼠的脑组织切片进行免疫组织化学染色 ,部分相邻切片以抗维生素D依赖性钙结合蛋白抗体染色。 结果 1~ 3周NPC小鼠小脑的浦肯野细胞 (PC)未见明显减少 ,TH染色阴性。 5周时PC开始减少 ,8~ 11周期间PC显著丢失 ,但小脑蚓小结和蚓垂有较多的PC存活。 8周后 ,部分存活的PC及其树突树出现TH免疫反应。其轴突局部球形膨大 ,树突不规则 ,弯曲、断裂、局部膨大 ,树突树萎缩。 结论 NPC1基因突变引起小脑PC严重丢失 ,存活的PC有形态改变和异常基因活动 ,提示其功能不正常 。 | 宋天保 王亚利 梁长林 German D C | 2001 | 解剖学报2001，32，4： | 2 |
| 2 | Chromatin remodeling, histone modifications and DNA methylation how does it fall together 显示文摘 | German T M Robertson K D | 2002 | J Cell Biochem2002，87，： | 1 |
| 3 | Accuracy Assessment and Validation of Classified Satellite Imagery of Texas Coastal Wetlands 显示文摘 | Hinson J M German C D Pulich W J | 1994 | Marine Technology Society Journal1994，，28： | 1 |
| 4 | 查看详情显示文摘 | Brouwer H D Schellekens M A J Klumperman B Monteiro M J German A L | | 0，，： | 1 |
| 5 | The Rainbow hydrothermal plume, 36°1S'N, MAR显示文摘 | German C Klinkhammer C P Rudnicki M D | 1996 | Geophysical Re- search Letters1996，23，21： | 1 |
| 6 | Tospoviruses:diagnosis,molecular biology,phylogeny,and vector relationships显示文摘 | GERMAN T L ULLMAN D E MOYER J W | 1992 | Ann Rev Phytopathology1992，30，： | 1 |
| 7 | Detection and spatial deline- ation of thin- sand sedimentary sequences with joint stocastic inversion of well logs and 3D prestack seismic amplitude data显示文摘 | German D M Carlos T V | 2010 | Rervoir Evaluation Engineering2010，，： | 1 |
| 8 | Tospovirus-- thrips interactions 显示文摘 | WHITFIELD A E ULLMAN D E GERMAN T L | 2005 | Annual Review of Phytopathology2005，43，： | 1 |
| 9 | Milk fat globule structure and function: nanoscience comes to milk production显示文摘 | ARGOV N LEMAY D G GERMAN J B | 2008 | Trends in Food Science & Technology2008，19，： | 1 |
| 10 | Tospoviruses: diagnosis, molecular biology, phylogeny, and vector relationships显示文摘 | German T L Ullman D E Moyer J W | 1992 | Ann Rev Phytopathology1992，30，： | 1 |
| 11 | The Rainbow hydrothermal plume, 36° 15' N, MAR 显示文摘 | German C Klinkhammer C P Rudnicki M D | 1996 | Geophysical Research Letters1996，23，21： | 1 |
| 12 | Global identification of microRNA-target RNA pairs by parallel analysis of RNA ends 显示文摘 | German M A Pillay M Jeong D H | 2008 | Nature Biotechnotogy2008，26，8： | 1 |
| 13 | Metabolomics: building on a century of biochemistry to guide human heallh 显示文摘 | German J B Hammock B D Watkins S M | 2005 | Metabolomics2005，1，1： | 1 |
| 14 | The electronic factor for outer-sphere electron-transfer reactions显示文摘 | Kuznetsov A M | 1985 | J Chem Soc Faraday Trans I1985，81，： | 1 |
| 15 | Gene expression cascades in pancreatic development显示文摘 | Wilson ME Scheel D German MS | 2003 | Mech Dev2003，120，1： | 1 |
| 16 | Copolymer of ethylene and methyl acrylate at low pressure determination of the kinetic by sequential sampling 显示文摘 | German A L Heikenks D | 1971 | J Polym Sci Part A1971，9，8： | 1 |
| 17 | 显示文摘 | | 1984 | Rev Inorgan Chem1984，5，： | 1 |
| 18 | Potential effects of flavonoids on the etiology of vascular disease 显示文摘 | Schramm Derek D German J | 1998 | J Nutri Biochem1998，9，10： | 1 |
| 19 | Molecular phylogeny and systematics of the tribe Chorisporeae(Brassicaceae)显示文摘 | GERMAN D A GRANT J R LYSAK M A | 2011 | Plant Systematics and Evolution2011，294，： | 1 |
| 20 | Acid in a Water Solution Reaction显示文摘 | German H Rossetti Enrique Decomposition of Formic Employing the Photo-Fenton D Albizzati Orlando M Alfano | 2002 | IndEng Chem Res2002，，41： | 1 |
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