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| 1 | 酪氨酸羟化酶在C型尼曼-匹克病小鼠小脑中的异常表达显示文摘目的 探讨C型尼曼 匹克病 (NPC)小脑中酪氨酸羟化酶 (TH)异常表达的时间、部位及其与临床表现的关系。 方法 应用TH抗体 ,对不同周龄NPC小鼠和正常小鼠的脑组织切片进行免疫组织化学染色 ,部分相邻切片以抗维生素D依赖性钙结合蛋白抗体染色。 结果 1~ 3周NPC小鼠小脑的浦肯野细胞 (PC)未见明显减少 ,TH染色阴性。 5周时PC开始减少 ,8~ 11周期间PC显著丢失 ,但小脑蚓小结和蚓垂有较多的PC存活。 8周后 ,部分存活的PC及其树突树出现TH免疫反应。其轴突局部球形膨大 ,树突不规则 ,弯曲、断裂、局部膨大 ,树突树萎缩。 结论 NPC1基因突变引起小脑PC严重丢失 ,存活的PC有形态改变和异常基因活动 ,提示其功能不正常 。 | 宋天保 王亚利 梁长林 German D C | 2001 | 解剖学报2001，32，4： | 2 |
| 2 | Accuracy Assessment and Validation of Classified Satellite Imagery of Texas Coastal Wetlands 显示文摘 | Hinson J M German C D Pulich W J | 1994 | Marine Technology Society Journal1994，，28： | 1 |
| 3 | The Rainbow hydrothermal plume, 36°1S'N, MAR显示文摘 | German C Klinkhammer C P Rudnicki M D | 1996 | Geophysical Re- search Letters1996，23，21： | 1 |
| 4 | The Rainbow hydrothermal plume, 36° 15' N, MAR 显示文摘 | German C Klinkhammer C P Rudnicki M D | 1996 | Geophysical Research Letters1996，23，21： | 1 |
| 5 | Calbindin- D28kcontaining neurons in the human hypothalamus :relationship to dopaminergic neurons 显示文摘 | Sanghera M K Zamora J L German D C | 1995 | N eurodegeneration1995，4，4： | 1 |
| 6 | Midbrain dopaminergic neurons in the mouse: co-localization with Calbindin-D28K and calretinin显示文摘 | Liang C L Sinton C M German D C | 1996 | Neuroscience1996，75，2： | 1 |
| 7 | Midbrain dopaminergic cell loss in Parkinson's disease: computer visualization显示文摘 | German D C Manaye K Smith W K | 1989 | Annals of Neurology1989，26，4： | 1 |
| 8 | Nonlinear image recovery with half-quadratic regularization 显示文摘 | German D Yang C | 1995 | IEEE Transactions on Image Processing1995，4，7： | 1 |
| 9 | Chronic marginal iron intakes during early development in mice result in persistent changes in dopamine metabolism and myelin composition显示文摘 | Kwik U C L Gietzen D German J B | 2000 | J Nutr2000，130，11： | 1 |
| 10 | Di- agnosis and therapy of Candida infections: joint recommen- dations of the German Speaking Mycological Society and the Paul-Ehrlich-Society for Chemotherapy 显示文摘 | Ruhnke M Rickerts V Cornely OA Buchheidt D G16ckner A Heinz W H6hl R Horr R Karthaus M Ku- jath P Willinger B Presterl E Rath P Ritter J Glasma- cher A Lass-F16rl C Groll AH German Speaking Myco- logical Society Paul-Ehrlich-Society for Chemotherapy | 2011 | Mycoses2011，54，4： | 1 |
| 11 | Optimization of an inductively coupled plasma-optical emission spectrometry method for the rapid determination of high-precision Mg/Ca and Sr/Ca in foraminiferal calcite显示文摘 | Green D R H Cooper M J German C R | 2003 | Geochemistry Geophysics Geosystems2003，4，： | 1 |
| 12 | Boredom,depressive symptoms,and HIV risk behaviors among urban injection drug users显示文摘 | German D Latkin C | | 0，，08： | 1 |
| 13 | Boredom, depressive symptoms, and HIV risk behaviors among urban injection drug users 显示文摘 | German D Latkin C A | 2012 | AIDS and Behavior2012，16，8： | 1 |
| 14 | The colour ofgold - silver - copper alloys显示文摘 | German R M Guzowski M M Wright D C | 1980 | Gold Bulletin1980，13，3： | 1 |
| 15 | Slotswap:strong and affordable location privacy in intelligent transportation systems显示文摘 | Eckhoff D German R Sommer C | 2011 | IEEE Communications Magazine2011，49，11： | 1 |
| 16 | Iron (Ⅱ) distribution and oxidation kinetics in hydrothermal plumes at the Kairei and Edmond vent sites, Indian Ocean显示文摘 | StathamT P J German C R Connelly D P | 2005 | Earth and Planetary Science Letters2005，236，： | 1 |
| 17 | RTX:A New Ruthenium Tetroxide Fuming Procedure显示文摘 | German E R Colman C D | 1991 | Journal of Forensic Identification1991，41，6： | 1 |
| 18 | Distributions of dissolved manganese and fluorescent dissolved organic matter in the Columbia River estuary and plume as determined by in situ measurement 显示文摘 | Klinkhammer G P Chin C S Wilson C Rudnicki M D German C R | 1997 | Mar Chem1997，56，12： | 1 |
| 19 | Genotyping of Toxoplasma gondii strains from immunocompromised patients reveals high prevalence of type Ⅰ strains显示文摘 | Khan A Su C German M Storch G A Clifford D B Sibley L D | | 0，，： | 1 |
| 20 | Comparison of measurements and predictions of flame structure and thermal NOx in a swirling natural gas diffusion flame显示文摘 | BOARDMAN R D EATOUGH C N GERMANE G J | 1993 | Combustion Science and Technology1993，93，： | 1 |
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