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| 1 | MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer显示文摘Colorectal cancer(CRC) is the third most common cancer in western countries. Despite significant improvement in available treatment options, CRC still remains the second leading cause of cancer-related death. Traditionally, 5-fluorouracil has been used as the main chemotherapy drug for treatment of metastatic CRC(mCRC). However, during the last two decades more effective chemotherapeutic agents such as oxaliplatin, irinotecan and the monoclonal antibodies cetuximab, panitumumab and bevacizumab have been used in clinical practice. More recently, the therapeutic armamentarium has been supplemented by the monoclonal antibodies bevacizumab, cetuximab and panitumumab as well as the protein-trap aflibercept and the smallmolecule multi-kinase inhibitor regorafenib. One of the major problems for the management of CRC is the inherent or acquired resistance to therapeutic approaches. The discovery of microRNAs(miRNAs), a class of small, endogenous, non-coding, single-stranded RNAs that play a role as post-transcriptional regulators, has added new dimensions to the diagnosis and treatment of cancer. Because miRNAs are important regulators of carcinogenesis, progression, invasion, angiogenesis and metastases in CRC, they might serve as potential predictive and prognostic factors and even as therapeutic targets themselves. Several miRNAs are already known to be dysregulated in CRCs and have been linked to biological processes involved in tumor progression and response to anti-cancer therapies. This review summarizes current therapeutic approaches for treating CRC and highlights the role of miRNAs as novel predictive biomarkers and potential drug targets in CRC patients. | Verena Stiegelbauer Samantha Perakis Alexander Deutsch Hui Ling Armin Gerger Martin Pichler | 2014 | World Journal of Gastroenterology2014，20，33： | 7 |
| 2 | Increased neutrophil- lymphocyte ratio is a poor prognostic factor in patients with primary operable and inoperable pancreatic cancer 显示文摘 | Stotz M Gerger A Eisner F | 2013 | Br J Cancer2013，109，2： | 1 |
| 3 | Diagnostic applicabilily of in vivo con- focal laser scanning microscopy in melanoeytic skin tumors显示文摘 | Gerger A KoUer S Kem T | 2005 | J Invest Demmto12005，124，3： | 1 |
| 4 | Evaluation of texture features in spatial domain for automatic discrimination of histologic tissue显示文摘 | WILTGEN M GERGER A WAGNER C | 2007 | Anal Quant Cytol Histo12007，29，4： | 1 |
| 5 | Chronic lipogranuloma (paraffin granuloma) of the eyelids and orbits after endonasal paranasal sinus operation显示文摘 | GERGER K WITSCHEL H BUTTNER C | 1993 | Laryngorhinootologie1993，72，： | 1 |
| 6 | TOM, a new aromatic degradative plasmid from Burkholderia (Pseudomonas) cepacia G4显示文摘 | Shields M S Reagin M J Gerger R R | 1995 | Appl Environ Microbiol1995，61，： | 1 |
| 7 | Isolation and synthesis of 6, 7-dihydroxy -4- ( 3,4- dihydroxyphenyl) naphthalene- 2-carboxylic acid from PeUia epiphylla显示文摘 | RISCHMANN M MUES R GERGER H | 1989 | Phytochemistry1989，28，3： | 1 |
| 8 | Efficacy of Psychological Interventions for Sexual Dysfunction: A Systematic Review and Meta-Analysis显示文摘 | Sarah Frühauf Heike Gerger Hannah Maren Schmidt Thomas Munder Jürgen Barth | 2013 | Archives of Sexual Behavior2013，，： | 1 |
| 9 | Structural characterization of strained silicon grown on a SiGe buffer layer显示文摘 | J H Jang M S Phen A Gerger K S Jones J L Hansen A N Larsen V Craciun | 2008 | Semiconductor Science and Technology2008，，3： | 1 |
| 10 | Integrin alpha-2 and beta-3 gene polymorphisms and coloreetal cancer risk显示文摘 | Gerger A Hofmann G Langsenlehner U | 2009 | Int J Colorectal Dis2009，24，2： | 1 |
| 11 | Confocal examination of untreated Fresh specimens from basal cell carcinoma:implications for microscopically guide,surgery显示文摘 | Gerger A Horn M Koller S | 2005 | Arch Dermatol2005，141，10： | 1 |
| 12 | The CXCR2 Antagonist, SCH-527123, Shows Antitumor Activity and Sensitizes Cells to Oxaliplatin in Preclinical Colon Cancer Models显示文摘 | Yan Ning Melissa J. Labonte Wu Zhang Pierre O. Bohanes Armin Gerger Dongyun Yang Leonor Benhaim David Paez David O. Rosenberg Kalyan C. Nagulapalli Venkata Stan G. Louie Nicos A. Petasis Robert D. Ladner Heinz-Josef Lenz | 2012 | Molecular Cancer Therapeutics2012，，6： | 1 |
| 13 | The lymphocyte/monocyte ratio predicts poor clinical out- come and improves the predictive accuracy in patients with soft tissue sarcomas 显示文摘 | Szkandera J Gerger A Liegl-Atzwanger B | 2014 | Int J Cancer2014，135，2： | 1 |
| 14 | Increased neutro-phil-lymphocyte ratio is a poor prognostic factor in pa- tients with primary operable and inoperable pancreatic cancer显示文摘 | Stotz M Gerger A Eisner F | 2013 | Br J Cancer2013，109，2： | 1 |
| 15 | Near-infrared spectrum qualification via mahalanobis distance determination显示文摘 | Whitfield R G Gerger M E Sharp R L | 1987 | Applied spectroscopy1987，41，7： | 1 |
| 16 | Diagnostic applicability of in vivo confocal laser scanning microscopy in melanocytic skin tumors显示文摘 | Gerger A Koller S Kern T | 2005 | J Invest Dermatol2005，124，3： | 1 |
| 17 | Differential transeriptional regulation of the two Vascular endothelial growth factor recptor genes显示文摘 | Gerger H Condotelli F Dark J | 1997 | J Biol Chem1997，272，23： | 1 |
| 18 | Near-infrared spectrum qualification via mahalanobis distance determination 显示文摘 | Whitfield R G Gerger M K Sharp R L | 1987 | Applied Spectroscopy1987，41，7： | 1 |
| 19 | In vivo confocal laser scanning microscopy of melanocytic skin tumours: diagnostic applicability using unselected tumour images显示文摘 | Gerger A Hofmann-Wellenhof Langsenlehner U | 2008 | Br J Dermatol2008，158，2： | 1 |
| 20 | Diagnostic applicability of in microscopy in melanocytic skin tu- mors显示文摘 | Gerger A Koller S Kern T vivo confocal laser scanning | 2005 | J Invest Dermatol2005，124，3： | 1 |
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