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| 1 | 数据之美——聚焦全球器官捐献发展趋势显示文摘器官移植术是20世纪出现的针对器官功能衰竭的最有效治疗方法,每年拯救全球超过12万例患者。但供器官短缺的现状,与器官移植技术和辅助药物的发展不匹配,制约了器官移植事业的发展。我国自2015年起已成为全球器官捐献和移植大国之一,2017年公民逝世后器官捐献数量超过5 000例,占全球捐献总量的15%以上。黄洁夫教授总结的器官捐献与移植'中国模式'得到了世界卫生组织、国际移植界的高度重视和充分肯定。本文通过整理全球及各国的器官捐献与移植数据,剖析全球现状与发展趋势,进一步探索我国公民器官捐献的影响因素并提出针对性的应对策略,以期实现我国器官捐献和移植的'自给自足'。 | 江文诗 Maria Paula Gomez Gloria Paez Marti Manyalich | 2019 | 中华移植杂志(电子版)2019，13，1： | 40 |
| 2 | Potential of soluble CD26 as a serum marker for colorectal cancer detection显示文摘Colorectal cancer is characterized by a low survival rate even though the basis for colon cancer development,which involves the evolution of adenomas to carcinoma,is known.Moreover,the mortality rates continue to rise in economically transitioning countries although there is the opportunity to intervene in the natural history of the adenoma–cancer sequence through risk factors,screening,and treatment.Screening in particular accounted for most of the decline in colorectal cancer mortality achieved in the USA during the period 1975-2000.Patients show a better prognosis when the neoplasm is diagnosed early.Among the variety of screening strategies,the methods range from invasive and costly procedures such as colonoscopy to more low-cost and non-invasive tests such as the fecal occult blood test(guaiac and immunochemical).As a non-invasive biological serum marker would be of great benefit because of the performance of the test,several biomarkers,including cytologic assays,DNA and mRNA,and soluble proteins,have been studied.We found that the soluble CD26(sCD26)concentration is diminished in serum of colorectal cancer patients compared to healthy donors,suggesting the potential utility of a sCD26 immunochemical detection test for early diagnosis.sCD26 originates from plasma membrane CD26 lacking its transmembrane and cytoplasmic domains.Some 90%–95%of sCD26 has been associated with serum dipeptidyl peptidase IV(DPPIV)activity.DPP-IV,assigned to the CD26 cluster,is a pleiotropic enzyme expressed mainly on epithelial cells and lymphocytes.Our studies intended to validate this test for population screening to detect colorectal cancer and advanced adenomas are reviewed here. | Oscar J Cordero Monica Imbernon Loretta De Chiara Vicenta S Martinez-Zorzano Daniel Ayude Maria Paez de la Cadena F Javier Rodriguez-Berrocal | 2011 | World Journal of Clinical Oncology2011，2，6： | 5 |
| 3 | EGFR mutations in lung cancer:correlation with clinical response to gefitinib therapy显示文摘 | Paez JG Janne PA Lee JC | | 0，，5676： | 3 |
| 4 | Successful treatment of psychosis induced by interferon alpha and ribavirin with paliperidone:first case reported显示文摘Several clinical studies have shown a large number of mental symptoms by immunomodulatory treatment with interferon (IFN). The most frequently described symptoms are depression, suicidal behaviour, manic symptoms, anxiety, psychosis and delirium, associated with other non-specific symptoms such as fatigue, irritability, psychomotor retardation, decreased libido, insomnia, difficulty in concentration and attention. Having a history of mental disorder contraindicates the use of IFN-alpha. These adverse effects that affect the mental state appear usually at the beginning of the treatment (most after 3 weeks of treatment). The incidence of psychotic episodes is low and the episodes usually remit when treatment is interrupted;only some cases require antipsychotic treatment. We present the case of a patient affected with hepatitis C who began to present self-referential delirious symptoms after receiving the treatment with IFN and who was successfully treated with paliperidone. This patient could be classified within the group of high-risk psychiatric patients given the family history of schizophrenia and his personal history of illegal drug consumption. The pharmacological actions of paliperidone are similar to other high potency atypical antipsychotics.丁he receptorbinding profile of paliperidone most closely resembles that of risperidone and ziprasidone. Paliperidone differs from risperidone and most other antipsychotics by its relatively low extent of enzymatic hepatic metabolism. To the best of our knowledge, this is the first case described that was successfully treated with paliperidone. | Carmen Maura Carrillo de Albornoz Calahorro Maria Isabel Navarrete Paez Margarita Guerrero Jimenez Luis Gutierrez Rojas | 2019 | General Psychiatry2019，32，4： | 2 |
| 5 | Antimicrobial therapy for Stenotroph- omonas maltophilia infections显示文摘 | Nicodemo AC Paez JI | 2007 | Eur J Clin Microbiol Infect Dis2007，26，4： | 1 |
| 6 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，304，5676： | 1 |
| 7 | , Detection of high risk human papillomavirus cervical infections by the hybrid capture in Asuncion, Paraguay显示文摘 | Tortes LM Paez M lnsaurralde A | 2009 | Braz J Infect Dis2009，13，3： | 1 |
| 8 | EGFR mutations in lung cancer:Correlation with clinical response to Gefitinib therapy显示文摘 | Paez JG Janne PA Lee JC | 2004 | Science2004，304，5676： | 1 |
| 9 | The Nf2 tumor suppressor,merlin,functions in Rat-dependent signaling显示文摘 | Shaw R J Paez JG Curto M | 2001 | DevCell2001，1，1： | 1 |
| 10 | Evaluation of stability of ground tire rubber-modified bitumen through solubility measurements 显示文摘 | Perez Lepe A Paez Dueiias A | 2007 | Carreteras2007，151，4： | 1 |
| 11 | The effects of firm size on wages in Colorado: a case study显示文摘 | Paul Paez | 2003 | Monthly Labor Review2003，126，7： | 1 |
| 12 | Preoperative serum alpha-L-fucosidase activity as a prognostic marker in colorectal cancer显示文摘 | Ayude D Paez De La Cadena M Martinez-Zorzano VS | 2003 | Oncology2003，64，1： | 1 |
| 13 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy 显示文摘 | Paez JG Janne PA Lee JC | 2004 | Science2004，304，5676： | 1 |
| 14 | Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema:a randomized trial显示文摘 | Masip J Betbese AJ Paez J | | 0，，： | 1 |
| 15 | Social sharing of emotion,posttraumatic growth,and emotional climate:Follow-up of Spanish citizen's response to the collective trauma of March 11th terrorist attacks in Madrid显示文摘 | Rime B Paez D Basabe N | 2010 | European Journal of Social Psychology2010，40，： | 1 |
| 16 | The role of categorization and in-group norms in judgments of groups and their members 显示文摘 | MARQUES J ABRAMS D PAEZ D | 1998 | Journal of Personality and Social Psychology1998，75，4： | 1 |
| 17 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy 显示文摘 | Paez JG Janne PA Lee JC | 2004 | Science2004，304，5676： | 1 |
| 18 | EGFR mutations in lungcancer: Correlation with clinical response to gefitinib therapy显示文摘 | Paez JG Janne PA Lee JC | 2004 | Science2004，304，5676： | 1 |
| 19 | EGFR mutations in lung cancercorrelation with clinical response to gefitinib therapy显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，304，5676： | 1 |
| 20 | Effect of polyphenols from the Mediterranean diet on proliferation and mediators of in vitro invasiveness of the MB-49 routine bladder cancer cell line 显示文摘 | Garcia Mediero JM Ferruelo Alonso A Paez Borda A | 2005 | Actas Urol Esp2005，29，8： | 1 |
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