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| 1 | 东海原甲藻修订及与相关原甲藻的分类学比较显示文摘分析了东海原甲藻 (ProrocentrumdonghaienseLu)显微结构 ,并与具齿原甲藻 (Prorocentrumden tatumStein)模式种和Schiller的钝头原甲藻的描述等进行了比较 ,结果表明 ,它们之间的形态结构和个体大小具有很大的差别 ,这些差异远超出了同种个体因环境不同所造成的形态变化范围 .从细胞形态及其表面结构可以判断 ,日本、韩国海区所记录并报道的“P .dentatum”与我国东海的东海原甲藻应属同一种 .因此可以认为 ,我国东海赤潮高发区以及在韩国、日本海区的出现的高生物量 (highbiomassbloom formingspecies)赤潮原甲藻不是Stein所发表的具齿原甲藻 ,而是东海原甲藻 ,并对其进行了进一步修订 ,其种名应为东海原甲藻ProrocentrumdonghaienseLu . | 陆斗定 齐雨藻 Jeanette Goebel 邹景忠 高亚辉 | 2003 | 应用生态学报2003，14，7： | 55 |
| 2 | FIVE RED TIDE SPECIES IN GENUS PROROCENTRUM INCLUDING THE DESCRIPTION OF PROROCENTRUM DONGHAIENSE LU SP. NOV.FROM THE EAST CHINA SEA显示文摘A new planktonic dinoflagellate, Prorocentrum donghaiense Lu sp. nov., is described in the present paper. The water sample was collected from the Changjiang Estuary, the East China Sea. The species identification is based on shape, size, surface micro morphology, ornamentation of thecal plates and the architecture of the periflagellar area and the intercalary bands as seen by light and scanning electron microscope. Prorocentrum donghaiense Lu sp. nov. is compared with other prorocentrum species with respect to morphological characteristics and bloom behavior. It is not known whether Prorocentrum donghaiense Lu sp. nov produces phycotoxins like some other Prorocentrum species. Four other red tide species in the family Prorocentraceae (Dinophyceae), namely P. balticum , P. minimum, P. micans, P. triestinum , were examined and identified by light and scanning electron microscope. They have been recorded as bloom forming species. Some aggregates of Prorocentrum are observed at the end of blooms. An event of strong discoloration caused by P. donghaiense could be detected by satellite sensor in the East China Sea in the late spring of 1995. | 陆斗定 Jeanette Goebel | 2001 | Chinese Journal of Oceanology and Limnology2001，19，4： | 46 |
| 3 | Argon reduces microglial activation and inflammatory cytokine expression in retinal ischemia/reperfusion injury显示文摘We previously found that argon exerts its neuroprotective effect in part by inhibition of the toll-like receptors(TLR)2 and 4.The downstream transcription factors signal transducer and activator of transcription 3(STAT3)and nuclear factor kappa B(NF-κB)are also affected by argon and may play a role in neuroprotection.It also has been demonstrated that argon treatment could mitigate brain damage,reduce excessive microglial activation,and subsequently attenuate brain inflammation.Despite intensive research,the further exact mechanism remains unclear.In this study,human neuroblastoma cells were damaged in vitro with rotenone over a period of 4 hours(to mimic cerebral ischemia and reperfusion damage),followed by a 2-hour post-conditioning with argon(75%).In a separate in vivo experiment,retinal ischemia/reperfusion injury was induced in rats by increasing intraocular pressure for 1 hour.Upon reperfusion,argon was administered by inhalation for 2 hours.Argon reduced the binding of the transcription factors signal transducer and activator of transcription 3,nuclear factor kappa B,activator protein 1,and nuclear factor erythroid 2-related factor 2,which are involved in regulation of neuronal damage.Flow cytometry analysis showed that argon downregulated the Fas ligand.Some transcription factors were regulated by toll-like receptors;therefore,their effects could be eliminated,at least in part,by the TLR2 and TLR4 inhibitor oxidized phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine(OxPAPC).Argon treatment reduced microglial activation after retinal ischemia/reperfusion injury.Subsequent quantitative polymerase chain reaction analysis revealed a reduction in the pro-inflammatory cytokines interleukin(IL-1α),IL-1β,IL-6,tumor necrosis factorα,and inducible nitric oxide synthase.Our results suggest that argon reduced the extent of inflammation in retinal neurons after ischemia/reperfusion injury by suppression of transcription factors crucial for microglial activation.Argon has no known side effects or narcotic properties;therefore,therapeutic use of this noble gas appears ideal for treatment of patients with neuronal damage in retinal ischemia/reperfusion injury.The animal experiments were approved by the Commission for Animal Care of the University of Freiburg(approval No.35-9185.81/G14-122)on October 19,2012. | Ulrich Goebel Stefanie Scheid Sashko Spassov Nils Schallner Jakob Wollborn Hartmut Buerkle Felix Ulbrich | 2021 | Neural Regeneration Research2021，16，1： | 8 |
| 4 | The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: future opportunities for structure-based drug design of inhibitors显示文摘The ATP-binding cassette(ABC)transporters P-glycoprotein(P-gp)and ABCG2 are multidrug transporters that confer drug resistance to numerous anti-cancer therapeutics in cell culture.These findings initially created great excitement in the medical oncology community,as inhibitors of these transporters held the promise of overcoming clinical multidrug resistance in cancer patients.However,clinical trials of P-gp and ABCG2 inhibitors in combination with cancer chemotherapeutics have not been successful due,in part,to flawed clinical trial designs resulting from an incomplete molecular understanding of the multifactorial basis of multidrug resistance(MDR)in the cancers examined.The field was also stymied by the lack of high-resolution structural information for P-gp and ABCG2 for use in the rational structure-based drug design of inhibitors.Recent advances in structural biology have led to numerous structures of both ABCG2 and P-gp that elucidated more clearly the mechanism of transport and the polyspecific nature of their substrate and inhibitor binding sites.These data should prove useful helpful for developing even more potent and specific inhibitors of both transporters.As such,although possible pharmacokinetic interactions would need to be evaluated,these inhibitors may show greater effectiveness in overcoming ABC-dependent multidrug resistance in combination with chemotherapeutics in carefully selected subsets of cancers.Another perhaps even more compelling use of these inhibitors may be in reversibly inhibiting endogenously expressed P-gp and ABCG2,which serve a protective role at various blood-tissue barriers.Inhibition of these transporters at sanctuary sites such as the brain and gut could lead to increased penetration by chemotherapeutics used to treat brain cancers or other brain disorders and increased oral bioavailability of these agents,respectively. | Jason Goebel Jean Chmielewski Christine A.Hrycyna | 2021 | Cancer Drug Resistance2021，4，4： | 3 |
| 5 | Symposia Report Immunoglobulin G for the Treatment of Chronic Pain:Report of an Expert Workshop显示文摘背景:慢性疼痛的治疗效果仍不理想。尽管现在治疗慢性疼痛的药物种类较多,但许多患者对疗效仍不满意或诉药物的副作用太大。越来越多的证据表明,免疫系统参与了伤害性和神经病理性慢性疼痛的病理过程。设计:在英国利物浦的专题会议上,专家们出示了免疫系统参与慢性疼痛的证据。近来的研究表明,静脉(IVIg)或皮下(SCIg)注射免疫调节药物——多价免疫球蛋白(Ig G)可缓解外周神经病理性疼痛和其他疼痛性疾病。专题会议讨论了IVIg和SCIg治疗的适应证、效价比及其副作用。结果:Ig G可缓解某些伤害性和神经病理性慢性疼痛,如糖尿病、干燥综合征、纤维肌痛症、复杂性区域疼痛综合征、小儿麻痹后遗症和继发于病理性自身抗体的疼痛。结论:Ig G对某些慢性疼痛具有一定的治疗前景。Ig G是一种相对安全的治疗方法,副作用少而轻,但价格较贵。今后有必要对Ig G治疗顽固性疼痛进行随机对照研究和预测性临床试验。 | Stefano Tamburin Kristian Borg Xavier J. Caro Stefano Jann Alexander J. Clark Francesca Magrinelli Gen Sobue Lars Werhagen Giampietro Zanette Haruki Koike Peter J. Spath Angela Vincent Andreas Goebel | 2014 | 中国疼痛医学杂志2014，20，11： | 3 |
| 6 | 中国东海和韩国马山湾海域2株原甲藻的形态结构和分子序列比较显示文摘对采自我国东海温岭海域和韩国南部马山湾海域的2株原甲藻进行了藻种分离、纯化培养及rDNA ITS分子序列的PCR扩增与测序,并运用显微镜、扫描电镜、Jukes-Cantor距离矩阵及构建的系统发育树,比较研究了2株原甲藻的形态结构和分子序列。结果表明:温岭藻株(LAMB090508)和马山湾藻株(PDKS0206)具有十分相近的形态结构,细胞均呈不对称梨形,大部分细胞底部呈圆卵形,老化细胞在两侧壳面连接处形成间接带,细胞核位于细胞下半部,呈圆球形,细胞内存在不规则板块状叶绿体。温岭藻株和马山湾藻株的rDNA ITS分子序列总长度均为591 bp,GC含量均为49%,相似度为99.83%,核苷酸差异值为0.002。系统发育树显示,温岭藻株、马山湾藻株和东海原甲藻Pro-rocentrum donghaiense(AY465116)聚在一起,应属同一物种,支持率为100%。综合形态结构和分子序列的比较结果表明,分布于我国东海温岭海域和韩国马山湾海域的2株原甲藻属于同一物种,且均为东海原甲藻Prorocentrum donghaiense Lu。 | 王红霞 陆斗定 黄海燕 夏平 戴鑫烽 Jeanette GOEBEL 鄭海■ | 2011 | 海洋学研究2011，29，1： | 2 |
| 7 | 转录调控蛋白PrfA对两组新近发现的单核细胞增生李斯特菌基因的体外转录作用的研究(英文)显示文摘目的研究转录调控蛋白PrfA对两组新近发现的单核细胞增生李斯特菌基因的体外转录作用。方法利用本室近年来建立的体外转录系统,对两组基于转录基因组体内研究发现的5个可能的受PrfA不同调节的单核细胞增生李斯特菌基因进行了体外转录活性的研究。结果第一组中的hpt基因的体外转录活性受PrfA正调节,而其它4个基因既不被PrfA正调节也不被负调节。结论除hpt基因外,其它4个基因体外转录结果与体内实验不相一致,说明PrfA在体内可能通过复杂多样的非直接方式、或者还需要一些目前未知的因子来调控这些新近发现的基因的表达。 | 罗勤 周青春 邓灵福 高强 刘德立 GOEBEL Werner | 2006 | 医学分子生物学杂志2006，3，5： | 2 |
| 8 | Pulse shortening causes in high power BWO and TWT micromave sources显示文摘 | Goebel D M | 1998 | IEEE Trans on Plasma Sci1998，26，3： | 2 |
| 9 | Mechanisms for the hot corrosion of nickel - base alloys 显示文摘 | GOEBEL J A PETTIT F S GOWARD G W | 1973 | Metall Trans1973，4，1： | 2 |
| 10 | Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect显示文摘The noble gas argon has the potential to protect neuronal cells from cell death.So far,this effect has been studied in treatment after acute damage.Preconditioning using argon has not yet been investigated.In this study,human neuroblastoma SH-SY5Y cells were treated with different concentrations of argon(25%,50%,and 74%;21%O_(2),5%CO_(2),balance nitrogen)at different time intervals before inflicting damage with rotenone(20μM,4 hours).Apoptosis was determined by flow cytometry after annexin V and propidium iodide staining.Surface expressions of Toll-like receptors 2 and 4 were also examined.Cells were also processed for analysis by western blot and qPCR to determine the expression of apoptotic and inflammatory proteins,such as extracellular-signal regulated kinase(ERK1/2),nuclear transcription factor-κB(NF-κB),protein kinase B(Akt),caspase-3,Bax,Bcl-2,interleukin-8,and heat shock proteins.Immunohistochemical staining was performed for TLR2 and 4 and interleukin-8.Cells were also pretreated with OxPAPC,an antagonist of TLR2 and 4 to elucidate the molecular mechanism.Results showed that argon preconditioning before rotenone application caused a dose-dependent but not a time-dependent reduction in the number of apoptotic cells.Preconditioning with 74%argon for 2 hours was used for further experiments showing the most promising results.Argon decreased the surface expression of TLR2 and 4,whereas OxPAPC treatment partially abolished the protective effect of argon.Argon increased phosphorylation of ERK1/2 but decreased NF-κB and Akt.Preconditioning inhibited mitochondrial apoptosis and the heat shock response.Argon also suppressed the expression of the pro-inflammatory cytokine interleukin-8.Immunohistochemistry confirmed the alteration of TLRs and interleukin-8.OxPAPC reversed the argon effect on ERK1/2,Bax,Bcl-2,caspase-3,and interleukin-8 expression,but not on NF-κB and the heat shock proteins.Taken together,argon preconditioning protects against apoptosis of neuronal cells and mediates its action via Toll-like receptors.Argon may represent a promising therapeutic alternative in various clinical settings,such as the treatment of stroke. | Stefanie Scheid Adrien Lejarre Jakob Wollborn Hartmut Buerkle Ulrich Goebel Felix Ulbrich | 2023 | Neural Regeneration Research2023，18，6： | 2 |
| 11 | A fixed point theorem for asymptoticaly nonexpansive mappings显示文摘 | Goebel K Kirk W A | 1972 | Proc Amer Math Soc1972，35，1： | 2 |
| 12 | Second generation sodium heat pipe solar receiver for a USAB V-160 stirling engine: evaluation of on-sun test results using the proposed IEA guidelines and analysis of heat pipe damage 显示文摘 | Laing D Goebel O | 1997 | Journal of Solar Energy Engineering1997，119，11： | 1 |
| 13 | A Survey of Data Mining and Knowledge Discovery Software Tools 显示文摘 | Goebel M Gruenwald L | 1999 | SIGKDD Explorations1999，1，5： | 1 |
| 14 | short bowel syndrome : an up-date on the therapeutic approach 显示文摘 | Strum A Layer D Goebell H | 2008 | Scand J Gastroen- terol2008，32，4： | 1 |
| 15 | Basophils supportthe survival of plasma cells in mice显示文摘 | Rodriguez GM Talke Y Goebel N etal | 2010 | Immunol2010，185，： | 1 |
| 16 | 显示文摘 | Goebel Dan M Watkins Ron M Jameson Kristina K | 2007 | Propul Power2007，23，3： | 1 |
| 17 | A Fixed Point Theorem for Asymptotically Nonexpansive Mappings 显示文摘 | GOEBEL K KIRK W A | 1972 | Proc Amer Math Soc1972，35，： | 1 |
| 18 | Impact of culture-independent studies on the emerging phylogenetic view of bacterial diversity显示文摘 | Hugenhohz P Goebel B M Pace N R | 1998 | J Bac teriol1998，180，18： | 1 |
| 19 | A new algorithm for local surface smoothing with application to chest wall nodules segmentation in lung CT data显示文摘 | Shen H Goebel B Odry B | 2004 | Medical Imaging2004，5370，5： | 1 |
| 20 | Processing by OmpT of fusion proteins carrying the HlyA transport signal during secretion by the Escherichia coli hemolysin transport system 显示文摘 | Hanke C Hess J Schumacher G Goebel W | 1992 | Mol Gen Genet1992，233，12： | 1 |
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