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| 1 | Diagnostic value of PIVKA-Ⅱ and alpha-fetoprotein in hepatitis B virus-associated hepatocellular carcinoma显示文摘AIM: To determine the cutoff values and to compare the diagnostic role of alpha-fetoprotein(AFP) and prothrombin induced by vitamin K absence-Ⅱ(PIVKA-Ⅱ) in chronic hepatitis B(CHB).METHODS: A total of 1255 patients with CHB, including 157 patients with hepatocellular carcinoma(HCC), 879 with non-cirrhotic CHB and 219 with cirrhosis without HCC, were retrospectively enrolled. The areas under the receiver operating characteristic(AUROC) curves of PIVKA-Ⅱ, AFP and their combination were calculated and compared.RESULTS: The optimal cutoff values for PIVKA-Ⅱ and AFP were 40 m AU/m L and 10 ng/m L, respectively, for the differentiation of HCC from nonmalignant CHB. The sensitivity and specificity were 73.9% and 89.7%, respectively, for PIVKA-Ⅱ and 67.5% and 90.3% for AFP, respectively. The AUROC curves of both PIVKA-Ⅱ and AFP were not significantly different(0.854 vs 0.853, P = 0.965) for the differentiation of HCC from nonmalignant CHB, whereas the AUROC of PIVKA-Ⅱ was significantly better than that of AFP in patients with cirrhosis(0.870 vs 0.812, P = 0.042). When PIVKA-Ⅱ and AFP were combined, the diagnostic power improved significantly compared to either AFP or PIVKA-Ⅱ alone for the differentiation of HCC from nonmalignant CHB(P < 0.05), especially when cirrhosis was present(P < 0.05).CONCLUSION: Serum PIVKA-Ⅱ might be a better tumor marker than AFP, and its combination with AFP may enhance the early detection of HCC in patients with CHB. | Seung In Seo Hyoung Su Kim Won Jin Kim Woon Geon Shin Doo Jin Kim Kyung Ho Kim Myoung Kuk Jang Jin Heon Lee Joo Seop Kim Hak Yang Kim Dong Joon Kim Myung Seok Lee Choong Kee Park | 2015 | World Journal of Gastroenterology2015，21，13： | 60 |
| 2 | Prevalence of premature ejaculation in young and middle-aged men in Korea: a multicenter intemet-based survey from the Korean Andrological Society显示文摘 | Hyun Jun Park Jong Kwan Park Kwangsung Park Sung Won Lee Sae-Woong Kim Dae Yul Yang DU Geon Moon Kweon-Sik Min Ki-Hak Moon Sang-Kuk Yang Jae Seog Hyun Nam Cheol Park | 2010 | Asian Journal of Andrology2010，12，6： | 5 |
| 3 | Stratified computed tomography findings improve diagnostic accuracy for appendicitis显示文摘AIM:To improve the diagnostic accuracy in patients with symptoms and signs of appendicitis,but without confirmative computed tomography(CT) findings. METHODS:We retrospectively reviewed the database of 224 patients who had been operated on for the suspicion of appendicitis,but whose CT findings were negative or equivocal for appendicitis. The patient population was divided into two groups:a pathologically proven appendicitis group(n = 177) and a nonappendicitis group(n = 47). The CT images of these patients were re-evaluated according to the characteristic CT features as described in the literature. The re-evaluations and baseline characteristics of the two groups were compared.RESULTS:The two groups showed significant differences with respect to appendiceal diameter,and the presence of periappendiceal fat stranding and intraluminal air in the appendix.A larger proportion of patients in the appendicitis group showed distended appendices larger than 6.0 mm(66.3%vs 37.0%;P<0.001),periappendiceal fat stranding(34.1%vs 8.9%;P=0.001),and the absence of intraluminal air(67.6%vs 48.9%;P=0.024)compared to the non-appendicitis group.Furthermore,the presence of two or more of these factors increased the odds ratio to 6.8 times higher than baseline(95%CI:3.013-15.454;P<0.001).CONCLUSION:Appendiceal diameter and wall thickening,fat stranding,and absence of intraluminal air can be used to increased diagnostic accuracy for appendicitis with equivocal CT findings. | Geon Park Sang Chul Lee Byung-Jo Choi Say-June Kim | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 4 | The biochemical efficacy of primary cryoablation combined with prolonged total androgen suppression compared with radiotherapy on high-risk prostate cancer: a 3-year pilot study显示文摘为了在高风险的前列腺癌症,联合本地治疗的一条综合途径和雄激素剥夺治疗(ADT ) 的管理获得有益的效果,被使用。我们比较了在与与 ADT 相结合的延长 ADT 和放射相结合的前列腺(CSAP ) 的主要 cryosurgical 脱离之间的生物化学的回答,它是在高风险的疾病的确定的形式。收到的 CSAP 在治疗以后与 ADT 相结合 3 个月在前并且直到 24 个月的 33 个高风险的病人的一个总数。这个耐心的组与另外一个被匹配为 ADT 与一样的协议经历了三维的保角的放射治疗(3D-CRT ) 的 33 个病人。生物化学的复发(BCR ) 被美国社会为治疗学的放射肿瘤学(ASTRO ) 估计 0.5 ng mL 的定义,菲尼克斯定义和前列腺特定的抗原(PSA ) 截止 ? 1。中部的后续是为 CSAP + ADT 的 11.9 个月组织的 61.0 卤和为 3D-CRT + ADT 的 15.8 个月组织的 86.0 卤。在 CSAP 组,包括 rectourethral 管和不能自制的主要复杂并发症没被注意。在 CSAP + ADT 组, 57.0% 用 ASTRO 定义有 BCR, 21.2% 使用菲尼克斯定义并且 54.5% 使用 0.5 ng mL 的 PSA 截止 ? 1。在 3D-CRT + ADT 组, 54.5% , 21.2% 和 54.5% 分别地用 ASTRO,菲尼克斯和 PSA 定义有 BCR。在 CSAP + ADT 组, BCR 免费的幸存(BRFS ) 是 54 卤用 ASTRO 定义的 10 个月, 65 卤用菲尼克斯定义的 5 个月和 51 卤用 0.5 ng mL 的 PSA 截止的 4 个月 ? 1。在 3D-CRT + ADT 组, BRFS 是 68 卤 12, 93 卤 19 和 70 卤分别地使用 ASTRO,菲尼克斯和 PSA 定义的 18 个月。由木头等级测试,为每个组的 BRFS 价值不是统计上不同的。这中间术语的结果显示与延长 ADT 相结合的主要 CSAP 在高风险的前列腺癌症与放射疗法相比提供平行生物化学的回答。 | Young Hwii Ko Seok Ho Kang Young Je Park Hong Seok Park Du Geon Moon Jeong Gu Lee Duck Ki Yoon Je Jong Kim Jun Cheon | 2010 | Asian Journal of Andrology2010，12，6： | 3 |
| 5 | Determination of surgical priorities in appendicitis based on the probability of undetected appendiceal perforation显示文摘AIM:To identify risk factors of actual appendiceal perforation when computed tomography(CT)scans suggest nonperforated appendicitis and accordingly determine surgical priority.METHODS:We collected database of 1362 patients who underwent an appendectomy for acute appendicitis between 2006 and 2013.A single radiologist selected1236 patients whose CT scans were suggestive ofnonperforated appendicitis.Patients were divided into 2 groups:actual nonperforation group and actual perforation group according to intraoperative and pathologic features.Comparison of the 2 groups were made using binary logistic regression.RESULTS:Of 1236 patients,90(7.3%)were found to have actual appendiceal perforation.Four risk factors related with actual appendiceal perforation were identified:body temperature≥37.6℃(HR=1.912,95%CI:1.161-3.149;P=0.011),out-ofhospital symptom duration≥72 h(HR=2.454,95%CI:1.292-4.662;P=0.006),age≥35 years(HR=3.358,95%CI:1.968-5.728;P<0.001),and appendiceal diameter on CT scan≥8 mm(HR=4.294,95%CI:1.034-17.832;P=0.045).Actual appendiceal perforation group showed longer operation time,later initiation of diet,longer use of parenteral narcotics,longer hospital stay,and higher incidence of postoperative complications(P<0.05).CONCLUSION:We proposed here new criteria to select patients with adverse clinical outcomes after appendectomy among the patients with radiologically nonperforated appendicitis.Surgical appendectomy outcomes could be improved by determining the surgical priority according to our criteria. | Sang Chul Lee Geon Park Byung-Jo Choi Say-June Kim | 2015 | World Journal of Gastroenterology2015，21，7： | 2 |
| 6 | Rapid species identification of pathogenic bacteria from a minute quantity exploiting three-dimensional quantitative phase imaging and artificial neural network显示文摘The healthcare industry is in dire need of rapid microbial identification techniques for treating microbial infections.Microbial infections are a major healthcare issue worldwide,as these widespread diseases often develop into deadly symptoms.While studies have shown that an early appropriate antibiotic treatment significantly reduces the mortality of an infection,this effective treatment is difficult to practice.The main obstacle to early appropriate antibiotic treatments is the long turnaround time of the routine microbial identification,which includes time-consuming sample growth.Here,we propose a microscopy-based framework that identifies the pathogen from single to few cells.Our framework obtains and exploits the morphology of the limited sample by incorporating three-dimensional quantitative phase imaging and an artificial neural network.We demonstrate the identification of 19 bacterial species that cause bloodstream infections,achieving an accuracy of 82.5%from an individual bacterial cell or cluster.This performance,comparable to that of the gold standard mass spectroscopy under a sufficient amount of sample,underpins the effectiveness of our framework in clinical applications.Furthermore,our accuracy increases with multiple measurements,reaching 99.9%with seven different measurements of cells or clusters.We believe that our framework can serve as a beneficial advisory tool for clinicians during the initial treatment of infections. | Geon Kim Daewoong Ahn Minhee Kang Jinho Park DongHun Ryu YoungJu Jo Jinyeop Song Jea Sung Ryu Gunho Choi Hyun Jung Chung Kyuseok Kim Doo Ryeon Chung In Young Yoo Hee Jae Huh Hyun-seok Min Nam Yong Lee YongKeun Park | 2022 | Light(Science & Applications)2022，11，7： | 2 |
| 7 | Identification and characterization of GLOBE, a major gene controlling fruit shape and impacting fruit size and marketability in tomato显示文摘Within large-fruited germplasm,fruit size is influenced by flat and globe shapes.Whereas flat fruits are smaller and retain better marketability,globe fruits are larger and more prone to cuticle disorders.Commercial hybrids are often developed from crosses between flat and globe shaped parents because flat shape is thought to be dominant and fruit size intermediate.The objectives of this study were to determine the genetic basis of flat/globe fruit shape in large-fruited fresh-market tomato germplasm and to characterize its effects on several fruit traits.Twenty-three advanced single plant selections from the Fla.8000×Fla.8111B cross were selectively genotyped using a genome-wide SNP array,and inclusive composite interval mapping identified a single locus on the upper arm of chromosome 12 associated with shape,which we termed globe.A 238-plant F 2 population and 69 recombinant inbred lines for this region from the same parents delimited globe to approximately 392-kilobases.A germplasm survey representing materials from multiple breeding programs demonstrated that the locus explains the flat/globe shape broadly.A single base insertion in an exon of Solyc12g006860,a gene annotated as a brassinosteroid hydroxylase,segregated completely with shape in all populations tested.CRISPR/Cas9 knock out plants confirmed this gene as underlying the globe locus.In silico analysis of the mutant allele of GLOBE among 595 wild and domesticated accessions suggested that the allele arose very late in the domestication process.Fruit measurements in three genetic backgrounds evidenced that globe impacts fruit size and several fruit shape attributes,pedicel length/width,and susceptibility of fruit to weather check.The mutant allele of GLOBE appears mostly recessive for all traits except fruit size where it acts additively. | Edgar Sierra-Orozco Reza Shekasteband Eudald Illa-Berenguer Ashley Snouffer Esther van der Knaap Tong Geon Lee Samuel F.Hutton | 2021 | Horticulture Research2021，8，1： | 2 |
| 8 | Effect of tamsulosin on ejaculatory function in BPH/LUTS显示文摘这研究被承担在 tamsulosin 的射精的功能上决定影响(0.2 mg ) 给日报(OD ) 一次 12 个星期并且到在经历这治疗的病人为射精的机能障碍识别风险因素。有国际 Prostatic 症状分数(IPSS )≥ 的男性; 8 在这研究被注册。所有参加者完成了问询表,包括 IPSS 和男性健康问询表(MSHQ ) ,和浆液有虚空以后的剩余的前列腺特定的抗原, transrectal 超声和 uroflowmetry 被测量。在开始 0.2 以后; mg OD tamsulosin,病人们在药的第四和第 12 个星期被重新估计。摆平 chi 的测试,独立 t 测试和单程的 ANOVA 被用来比较工具。二进制逻辑回归分析被用来为所有风险因素计算机会比率。177 个人的一个总数组成了学习队。没有重要差别为可勃起的函数,射精的函数,满足,性活动和愿望域在基线和后续之间被观察(EFD, EjFD, SDA 并且增加) 或为可勃起或射精的麻烦平均数分数。在 12 个星期以后,射精的机能障碍(EjD ) 的全面发生是 13.4 %。EjD (在射精的减少的频率,延期,干,减少的力量 / 力量,减少的体积,减少的快乐和疼痛) 的七种不同类型的发生是 2.4 %, 3.1 %, 3.9 %, 3.9 %, 6.3 %, 7.1 %并且 3.1 %分别地。基线 EjFD 分数比为非应答者为 IPSS 应答者是更高的(26.09 对 24.06, P=0.03 ) 。EjFD 分数减小在 IPSS 应答者是更经常的。EjD 的发生小,然而并非可以忽略并且在有不太更低的尿道症状,更小的前列腺,更高的基线 MSHQ 总数和更高的 EjFD 分数的病人是更经常的。 | Sang Hoon Song Hwancheol Son Kwang Taek Kim Sae Woong Kim Du Geon Moon Ki Hak Moon Kwangsung Park Jong Kwan Park Sung-Won Lee Jae Seog Hyun Nam Cheol Park | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 9 | Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment显示文摘 | Jae‐Hyun Park Sang Won Seo Changsoo Kim Geon Ha Kim Hyun Jin Noh Sung Tae Kim Ki‐Chang Kwak Uicheul Yoon Jong Min Lee Jong Weon Lee Ji Soo Shin Chi Hun Kim Young Noh Hanna Cho Hee Jin Kim Cindy W. Yoon Seung Jun Oh Jae Seung Kim Yearn Seong Choe Kyung‐Han | 2013 | Ann Neurol2013，，5： | 1 |
| 10 | Goals, Strategic Planning, and Performance in Government Agencies显示文摘 | ChanSu Jung Geon Lee | 2013 | Public Management Review2013，，6： | 1 |
| 11 | Morphology development and crystallization behavior of poly (ethylene terephthalate)/poly (trimethylene terephthalate) blends显示文摘 | Geon Seok Kim Jae Myoung Son Jong Kwan Lee | | 0，，： | 1 |
| 12 | An association between IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population显示文摘 | Jung-Hyun Namkung Jong-Eun Lee Eugene Kim Geon Tae Park Hee Seung Yang Hye Yoon Jang Eun-Soon Shin Eun-Young Cho Jun-Mo Yang | 2011 | Journal of Dermatological Science2011，，1： | 1 |
| 13 | Effect of Roasting Temperature on Production of Functional Wild-Rice Tea and Factors Influencing Purchase Intention Towards Wild-Rice Tea显示文摘The properties of raw wild rice were investigated to produce a functional tea,and the value of this tea was evaluated.The highest antioxidant activity[80.5%2,2-diphenyl-1-picrylhydrazyl(DPPH)radical scavenging activity]was achieved when the raw wild-rice grass was roasted at 225℃for 3 min. | Hyun Yi JUNG Kyoung Rim HAN Geon LEE Joong Kyun KIM | 2022 | Rice science2022，29，3： | 1 |
| 14 | Effects of poloxamer 407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats: Impact of decreased expression of both CYP3A1/2 and microsomal epoxide hydrelase 显示文摘 | Young Sun Lee Young Woo Kim Sang Geon Kim | 2012 | European Neuropsychopharmacology2012，22，6： | 1 |
| 15 | A new approach to molten steel refining using fine gas bubbles显示文摘 | Laihua Wang Hae - Geon LEE Peter Hayes | 1996 | ISIJ International1996，36，1： | 1 |
| 16 | Enhanced thermal conductivity of polymer composites filled with hybrid filler显示文摘 | Geon - Woong Lee Min Park Junkyung Kim | | 0，，： | 1 |
| 17 | Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment显示文摘 | Byoung Seok Ye Sang Won Seo Chi Hun Kim Seun Jeon Geon Ha Kim Young Noh Hanna Cho Cindy W. Yoon Hee Jin Kim Eun Young Jang Jeongmin Lee Jung-Hyun Kim Juhee Chin Jong Min Lee Jeong-Hun Kim Joon-kyung Seong Chang-Hun Kim Yearn Seong Choe Kyung Han Lee Duk L | 2014 | Neurobiology of Aging2014，，2： | 1 |
| 18 | Farnesoid X Receptor Protects Hepatocytes From Injury by Repressing miR-199a-3p, Which Increases Levels of LKB1显示文摘 | Chan Gyu Lee Young Woo Kim Eun Hyun Kim Zhipeng Meng Wendong Huang Se Jin Hwang Sang Geon Kim | 2012 | Gastroenterology2012，，5： | 1 |
| 19 | Reaction of De- sulphurization of Molten Pig Iron Using CaO - SiOe - A1203 - Na20 slag systems显示文摘 | Ja - Yong choi Dae - jung Kim Hae - Geon Lee | 2001 | ISIJ International2001，41，3： | 1 |
| 20 | Precontoured Locking Plate Fixation for Displaced Lateral Clavicle Fractures显示文摘 | Lee Sang Ki Lee Jae Won Song Dae Geon Choy Won Sik | 2013 | Orthopedics (Online)2013，，6： | 1 |
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