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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Cytomegalovirus in inflammatory bowel disease: Asystematic review显示文摘AIM: To identify definitions of cytomegalovirus(CMV) infection and intestinal disease, in inflammatory bowel disease(IBD), to determine the prevalence associated with these definitions.METHODS: We conducted a systematic review and interrogated Pub Med, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings we used 'cytomegalovirus' OR 'CMV' OR 'cytomegalo virus' AND 'inflammatory bowel disease' OR 'IBD' OR 'ulcerative colitis' OR 'colitis ulcerosa' OR 'Crohn's disease'. Both Me SH-terms and free searches were performed. We included all types of English-language(clinical) trials concerning diagnostics and prevalence of CMV in IBD.RESULTS: The search strategy identified 924 citations, and 52 articles were eligible for inclusion. We identified 21 different definitions for CMV infection, 8 definitions for CMV intestinal disease and 3 definitions for CMV reactivation. Prevalence numbers depend on used definition, studied population and region. The highest prevalence for CMV infection was found when using positive serum PCR as a definition, whereas for CMV intestinal disease this applies to the use of tissue PCR > 10 copies/mg tissue. Most patients with CMV infection and intestinal disease had steroid refractory disease and came from East Asia.CONCLUSION: We detected multiple different definitions used for CMV infection and intestinal disease in IBD patients, which has an effect on prevalence numbers and eventually on outcome in different trials. | Tessa EH Römkens Geert J Bulte Loes HC Nissen Joost PH Drenth | 2016 | World Journal of Gastroenterology2016，22，3： | 6 |
| 3 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 4 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 5 | Three Conceptions of Quantified Societal Risk 显示文摘 | Stallen P J M Geerts R Vrijling H K | 1996 | Risk Analysis1996，16，5： | 1 |
| 6 | A prospective study of venous thromboembolism after major trauma显示文摘 | Geerts W H Code K I Jay R M | 1994 | N Engl J Med1994，331，24： | 1 |
| 7 | Methanol degradation in granular sludge reactors at sub-optimal metal concentrations:role of iron,nickel and cobalt显示文摘 | ZANDVOORT M H GEERTS R LETTINGA G | 2003 | Enzyme Microbial Technol2003，33，23： | 1 |
| 8 | A prospective study of venous thromboembolism aftermajor trauma显示文摘 | GEERTS W H CODE K I JAY R M | 1994 | N Engl J Med1994，331，24： | 1 |
| 9 | Prevention of venous thromboembolism after total hip and knee arthroplasty显示文摘 | Lieberman J R Geerts W H | 1994 | J Bone Joint Surg Am1994，76，8： | 1 |
| 10 | Prevention of venous thromboembolism in the ICU 显示文摘 | GEERTS W SELBY R | 2003 | CHEST Journal2003，124，6： | 1 |
| 11 | Three conceptions of quantified societal risk 显示文摘 | Stallen P J M Geerts R Vrijling H K | 1996 | Risk Analysis1996，16，5： | 1 |
| 12 | Does Financial Liberalization Spur Growth显示文摘 | CAPBELL R H | 2005 | Journal of Financial Economics2005，7，： | 1 |
| 13 | Probiotic bacteria as biological control agents in aquaculture显示文摘 | Laurant V Geert R Sorgeloos P | 2000 | Microbiology and Molscular Biology Reviews2000，64，4： | 1 |
| 14 | Lanthanum : a safephosphate binder 显示文摘 | Veerle P P Geert J B An R B | 2006 | Seminars in Dialysis2006，19，3： | 1 |
| 15 | Methanoldegradation in granular sludge reactors at sub-optimal metalconcentrations:role of iron,nickel and cobalt显示文摘 | ZANDVOORT M H GEERTS R LETTINGA G | 2003 | Enzyme andMicrobial Technology2003，33，23： | 1 |
| 16 | A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma显示文摘 | GEERTS W H JAY R M CODE K I | | N Engl J Med0，335，10： | 1 |
| 17 | Methanol degradation in granular sludge reactors at sub-optimal metal concentrations:role of iron,nickel and cobalt显示文摘 | Zandvoort M H Geerts R Lettinga G | 2003 | Enzyme and Microbial Technology2003，33，： | 1 |
| 18 | Color invariance 显示文摘 | J M Geusebroek R van den Boomgaard A W M Smeulders H Geerts | 2001 | IEEE Transactions on Pattern Analysis and Machine InteUigence(PAMI)2001，23，12： | 1 |
| 19 | The role of hypofracttionation radiotherapy for dif- fuse intrinsic显示文摘 | Geert O R J Janssens Corrie E M Gidding Erik J Van lindert | 2009 | lnt J Radiation Oncology Biol Phys2009，73，3： | 1 |
| 20 | Molecular mechanism of anaerobic ammonium oxidation 显示文摘 | Kartal B Maalcke W J Almeida N M Cirpus I Gloerich J Wim Geerts Camp H J M O Harhangi H R Janssen-Megens E M Francoijs K-J Stunnenberg H G Keltjens J T Jetten M S M Strous M | 2011 | Nature2011，479，： | 1 |
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